Abstract:
:The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Pers TH,Karjalainen JM,Chan Y,Westra HJ,Wood AR,Yang J,Lui JC,Vedantam S,Gustafsson S,Esko T,Frayling T,Speliotes EK,Genetic Investigation of ANthropometric Traits (GIANT) Consortium.,Boehnke M,Raychaudhuri S,Fehrmann RS,doi
10.1038/ncomms6890subject
Has Abstractpub_date
2015-01-19 00:00:00pages
5890issn
2041-1723pii
ncomms6890journal_volume
6pub_type
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