Conformational dynamics of the human serotonin transporter during substrate and drug binding.

abstract：:Wild boar (Sus scrofa) drastically colonized mainland Eurasia and North Africa, most likely from East Asia during the Plio-Pleistocene (2-1Mya). In recent studies, based on genome-wide information, it was hypothesized that wild boar did not replace the species it encountered, but instead exchanged genetic materials wi...

journal_title：Nature communications

authors： Liu L,Bosse M,Megens HJ,Frantz LAF,Lee YL,Irving-Pease EK,Narayan G,Groenen MAM,Madsen O

更新日期：2019-04-30 00:00:00

abstract：:Connection of tubules into larger networks is the key process for the development of circulatory systems. In Drosophila development, tip cells of the tracheal system lead the migration of each branch and connect tubules by adhering to each other and simultaneously changing into a torus-shape. We show that as adhesion ...

journal_title：Nature communications

authors： Kato K,Dong B,Wada H,Tanaka-Matakatsu M,Yagi Y,Hayashi S

更新日期：2016-04-12 00:00:00

abstract：:The original version of this Article omitted the Received and Accepted dates; they should have been 22nd January 2018 and 19th April 2018, respectively. This has been corrected in the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Wu Y,Wang G,Li Q,Xiang J,Jiang H,Wang Y

更新日期：2018-06-13 00:00:00

abstract：:ASXL1 mutations occur frequently in myeloid neoplasms and are associated with poor prognosis. However, the mechanisms by which mutant ASXL1 induces leukaemogenesis remain unclear. In this study, we report mutually reinforcing effects between a C-terminally truncated form of mutant ASXL1 (ASXL1-MT) and BAP1 in promotin...

journal_title：Nature communications

authors： Asada S,Goyama S,Inoue D,Shikata S,Takeda R,Fukushima T,Yonezawa T,Fujino T,Hayashi Y,Kawabata KC,Fukuyama T,Tanaka Y,Yokoyama A,Yamazaki S,Kozuka-Hata H,Oyama M,Kojima S,Kawazu M,Mano H,Kitamura T

更新日期：2018-07-16 00:00:00

abstract：:Transport of nanoscale energy in the form of excitons is at the core of photosynthesis and the operation of a wide range of nanostructured optoelectronic devices such as solar cells, light-emitting diodes and excitonic transistors. Of particular importance is the relationship between exciton transport and nanoscale di...

journal_title：Nature communications

authors： Akselrod GM,Deotare PB,Thompson NJ,Lee J,Tisdale WA,Baldo MA,Menon VM,Bulović V

更新日期：2014-04-16 00:00:00

abstract：:Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural and functional properties of lymph nodes (LNs). Here we show that YAP and TAZ (YAP/TAZ), the final effectors of Hippo signaling, regulate FRC commitment and maturation. S...

journal_title：Nature communications

authors： Choi SY,Bae H,Jeong SH,Park I,Cho H,Hong SP,Lee DH,Lee CK,Park JS,Suh SH,Choi J,Yang MJ,Jang JY,Onder L,Moon JH,Jeong HS,Adams RH,Kim JM,Ludewig B,Song JH,Lim DS,Koh GY

更新日期：2020-01-24 00:00:00

abstract：:The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (E...

journal_title：Nature communications

authors： Cardenas A,Sordillo JE,Rifas-Shiman SL,Chung W,Liang L,Coull BA,Hivert MF,Lai PS,Forno E,Celedón JC,Litonjua AA,Brennan KJ,DeMeo DL,Baccarelli AA,Oken E,Gold DR

更新日期：2019-07-12 00:00:00

abstract：:Photothermal heating represents a major constraint that limits the performance of many nanoscale optoelectronic and optomechanical devices including nanolasers, quantum optomechanical resonators, and integrated photonic circuits. Here, we demonstrate the direct laser refrigeration of a semiconductor optomechanical res...

journal_title：Nature communications

authors： Pant A,Xia X,Davis EJ,Pauzauskie PJ

更新日期：2020-06-23 00:00:00

abstract：:N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibility for subtype-specific targeting by pharmacological means for treatme...

journal_title：Nature communications

authors： Wang JX,Irvine MW,Burnell ES,Sapkota K,Thatcher RJ,Li M,Simorowski N,Volianskis A,Collingridge GL,Monaghan DT,Jane DE,Furukawa H

更新日期：2020-01-22 00:00:00

abstract：:It is vital to design effective nitrogen fixation systems that operate under mild conditions, and to this end we recently reported an example of the catalytic formation of ammonia using a dinitrogen-bridged dimolybdenum complex bearing a pincer ligand, where up to twenty three equivalents of ammonia were produced base...

journal_title：Nature communications

authors： Tanaka H,Arashiba K,Kuriyama S,Sasada A,Nakajima K,Yoshizawa K,Nishibayashi Y

更新日期：2014-04-28 00:00:00

abstract：:R-loops are stable nucleic acid structures that have important physiological functions, but which also pose a significant threat to genomic stability. Increased R-loops cause replication stress and chromosome fragility and have been associated with diseases such as neurodegeneration and cancer. Although excessive R-lo...

journal_title：Nature communications

authors： Chakraborty P,Huang JTJ,Hiom K

更新日期：2018-10-19 00:00:00

abstract：:Knowledge of the RNA three-dimensional structure, either in isolation or as part of RNP complexes, is fundamental to understand the mechanism of numerous cellular processes. Because of its flexibility, RNA represents a challenge for crystallization, while the large size of cellular complexes brings solution-state NMR ...

journal_title：Nature communications

authors： Marchanka A,Simon B,Althoff-Ospelt G,Carlomagno T

更新日期：2015-05-11 00:00:00

abstract：:How genomic and transcriptomic alterations affect the functional proteome in lung cancer is not fully understood. Here, we integrate DNA copy number, somatic mutations, RNA-sequencing, and expression proteomics in a cohort of 108 squamous cell lung cancer (SCC) patients. We identify three proteomic subtypes, two of wh...

journal_title：Nature communications

authors： Stewart PA,Welsh EA,Slebos RJC,Fang B,Izumi V,Chambers M,Zhang G,Cen L,Pettersson F,Zhang Y,Chen Z,Cheng CH,Thapa R,Thompson Z,Fellows KM,Francis JM,Saller JJ,Mesa T,Zhang C,Yoder S,DeNicola GM,Beg AA,Boyle TA

更新日期：2019-08-08 00:00:00

abstract：:The Lyme disease agent, Borrelia burgdorferi, colonizes the gut of the tick Ixodes scapularis, which transmits the pathogen to vertebrate hosts including humans. Here we show that B. burgdorferi colonization increases the expression of several tick gut genes including pixr, encoding a secreted gut protein with a Reele...

journal_title：Nature communications

authors： Narasimhan S,Schuijt TJ,Abraham NM,Rajeevan N,Coumou J,Graham M,Robson A,Wu MJ,Daffre S,Hovius JW,Fikrig E

更新日期：2017-08-04 00:00:00

abstract：:Of the many challenges in building a wireless network at terahertz frequencies, link discovery remains one of the most critical and least explored. In a network of mobile receivers using narrow directional beams, how do the nodes rapidly locate each other? This direction information is crucial for beam forming and ste...

journal_title：Nature communications

authors： Ghasempour Y,Shrestha R,Charous A,Knightly E,Mittleman DM

更新日期：2020-04-24 00:00:00

abstract：:Ruddlesden-Popper halide perovskites are 2D solution-processed quantum wells with a general formula A2A'n-1M n X3n+1, where optoelectronic properties can be tuned by varying the perovskite layer thickness (n-value), and have recently emerged as efficient semiconductors with technologically relevant stability. However,...

journal_title：Nature communications

authors： Blancon JC,Stier AV,Tsai H,Nie W,Stoumpos CC,Traoré B,Pedesseau L,Kepenekian M,Katsutani F,Noe GT,Kono J,Tretiak S,Crooker SA,Katan C,Kanatzidis MG,Crochet JJ,Even J,Mohite AD

更新日期：2018-06-08 00:00:00

abstract：:CRISPR-Cas immunity is at the forefront of antivirus defense in bacteria and archaea and specifically targets viruses carrying protospacers matching the spacers catalogued in the CRISPR arrays. Here, we perform deep sequencing of the CRISPRome-all spacers contained in a microbiome-associated with hyperthermophilic arc...

journal_title：Nature communications

authors： Medvedeva S,Liu Y,Koonin EV,Severinov K,Prangishvili D,Krupovic M

更新日期：2019-11-15 00:00:00

abstract：:Mucosal-associated invariant T (MAIT) cells are thought to detect microbial antigens presented by the HLA-Ib molecule MR1 through the exclusive use of a TRAV1-2-containing TCRα. Here we use MR1 tetramer staining and ex vivo analysis with mycobacteria-infected MR1-deficient cells to demonstrate the presence of function...

journal_title：Nature communications

authors： Meermeier EW,Laugel BF,Sewell AK,Corbett AJ,Rossjohn J,McCluskey J,Harriff MJ,Franks T,Gold MC,Lewinsohn DM

更新日期：2016-08-16 00:00:00

abstract：:Spontaneous molecular oscillations are ubiquitous in biology. But to our knowledge, periodic cell migratory patterns have not been observed. Here we report the highly regular, periodic migration of cells along rectilinear tracks generated inside three-dimensional matrices, with each excursion encompassing several cell...

journal_title：Nature communications

authors： Fraley SI,Feng Y,Giri A,Longmore GD,Wirtz D

更新日期：2012-03-06 00:00:00

abstract：:The efficiencies of green and red perovskite light-emitting diodes (PeLEDs) have been increased close to their theoretical upper limit, while the efficiency of blue PeLEDs is lagging far behind. Here we report enhancing the efficiency of sky-blue PeLEDs by overcoming a major hurdle of low photoluminescence quantum eff...

journal_title：Nature communications

authors： Wang Q,Wang X,Yang Z,Zhou N,Deng Y,Zhao J,Xiao X,Rudd P,Moran A,Yan Y,Huang J

更新日期：2019-12-10 00:00:00

abstract：:Terephthalic acid (TPA) is an important industrial chemical currently produced by energy intensive and potentially hazardous p-xylene (pX) oxidation process. Here we report the development of metabolically engineered Escherichia coli system for biological transformation of pX into TPA. The engineered E. coli strain ha...

journal_title：Nature communications

authors： Luo ZW,Lee SY

更新日期：2017-05-31 00:00:00

abstract：:No consensus exists regarding which are the most effective mechanisms to promote household action on climate change. We present a meta-analysis of randomised controlled trials comprising 3,092,678 observations, which estimates the effects of behavioural interventions holding other factors constant. Here we show that b...

journal_title：Nature communications

authors： Nisa CF,Bélanger JJ,Schumpe BM,Faller DG

更新日期：2019-10-04 00:00:00

abstract：:Neurons communicate through chemical synapses and electrical synapses (gap junctions). Although these two types of synapses often coexist between neurons, little is known about whether they interact, and whether any interactions between them are important to controlling synaptic strength and circuit functions. By stud...

journal_title：Nature communications

authors： Liu P,Chen B,Mailler R,Wang ZW

更新日期：2017-03-20 00:00:00

abstract：:Seeded propagation of amyloid-beta (Aβ) pathology is suggested to contribute to the progression of Alzheimer's disease. Local overproduction of aggregation-prone Aβ variants could explain the focal initiation of a seeding cascade that subsequently triggers widespread pathology. Several animal models support this seedi...

journal_title：Nature communications

authors： Sowade RF,Jahn TR

更新日期：2017-09-11 00:00:00

abstract：:The original version of this Article contained an error in the spelling of the author Woochul Song, which was incorrectly given as Woochul C. Song. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Shen YX,Song W,Barden DR,Ren T,Lang C,Feroz H,Henderson CB,Saboe PO,Tsai D,Yan H,Butler PJ,Bazan GC,Phillip WA,Hickey RJ,Cremer PS,Vashisth H,Kumar M

更新日期：2018-08-14 00:00:00

abstract：:Acoustical tweezers open major prospects in microbiology for cells and microorganisms contactless manipulation, organization and mechanical properties testing since they are biocompatible, label-free and have the potential to exert forces several orders of magnitude larger than their optical counterpart at equivalent ...

journal_title：Nature communications

authors： Baudoin M,Thomas JL,Sahely RA,Gerbedoen JC,Gong Z,Sivery A,Matar OB,Smagin N,Favreau P,Vlandas A

更新日期：2020-08-25 00:00:00

abstract：:The original version of this Article contained an error in the last sentence of the second paragraph of the 'Atmospheric rarefaction effects' section of the Results, which incorrectly read 'The other one emulates the rarefied, CO2-rich Martian atmosphere (μ♂ = 1.3 × 10-5 N s m-2) at 6.9 mbar and 210 K, which gives ρ♂ ...

journal_title：Nature communications

authors： Di Renzo M,Urzay J

更新日期：2018-05-21 00:00:00

abstract：:FeV(O)(OH) species have long been proposed to play a key role in a wide range of biomimetic and enzymatic oxidations, including as intermediates in arene dihydroxylation catalyzed by Rieske oxygenases. However, the inability to accumulate these intermediates in solution has thus far prevented their spectroscopic and c...

journal_title：Nature communications

authors： Borrell M,Andris E,Navrátil R,Roithová J,Costas M

更新日期：2019-02-22 00:00:00

abstract：:Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, such information has yet to be exploited for drug design. Here we show by nuclear magnetic resonance spectroscopy that inhibito...

journal_title：Nature communications

authors： Lee CJ,Liang X,Wu Q,Najeeb J,Zhao J,Gopalaswamy R,Titecat M,Sebbane F,Lemaitre N,Toone EJ,Zhou P

更新日期：2016-02-25 00:00:00

abstract：:The design and assembly of artificial protocell consortia displaying dynamical behaviours and systems-based properties are emerging challenges in bottom-up synthetic biology. Cellular processes such as morphogenesis and differentiation rely in part on reaction-diffusion gradients, and the ability to mimic rudimentary ...

journal_title：Nature communications

authors： Tian L,Li M,Patil AJ,Drinkwater BW,Mann S

更新日期：2019-07-25 00:00:00