Abstract：
:Neurons communicate through chemical synapses and electrical synapses (gap junctions). Although these two types of synapses often coexist between neurons, little is known about whether they interact, and whether any interactions between them are important to controlling synaptic strength and circuit functions. By studying chemical and electrical synapses between premotor interneurons (AVA) and downstream motor neurons (A-MNs) in the Caenorhabditis elegans escape circuit, we found that disrupting either the chemical or electrical synapses causes defective escape response. Gap junctions between AVA and A-MNs only allow antidromic current, but, curiously, disrupting them inhibits chemical transmission. In contrast, disrupting chemical synapses has no effect on the electrical coupling. These results demonstrate that gap junctions may serve as an amplifier of chemical transmission between neurons with both electrical and chemical synapses. The use of antidromic-rectifying gap junctions to amplify chemical transmission is potentially a conserved mechanism in circuit functions.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Liu P,Chen B,Mailler R,Wang ZWdoi
10.1038/ncomms14818subject
Has Abstractpub_date
2017-03-20 00:00:00pages
14818issn
2041-1723pii
ncomms14818journal_volume
8pub_type
杂志文章abstract：:Oxidation of bromide in aqueous environments initiates the formation of molecular halogen compounds, which is important for the global tropospheric ozone budget. In the aqueous bulk, oxidation of bromide by ozone involves a [Br•OOO-] complex as intermediate. Here we report liquid jet X-ray photoelectron spectroscopy m...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00823-x
更新日期：2017-09-26 00:00:00
abstract：:Liquid crystalline network (LCN) actuator normally deforms upon thermally or optically induced order-disorder phase transition, switching once between two shapes (shape 1 in LC phase and shape 2 in isotropic state) for each stimulation on/off cycle. Herein, we report an LCN actuator that deforms from shape 1 to shape ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-021-20938-6
更新日期：2021-01-27 00:00:00
abstract：:The advent of super-resolution imaging (SRI) has created a need for optimized labelling strategies. We present a new method relying on fluorophore-conjugated monomeric streptavidin (mSA) to label membrane proteins carrying a short, enzymatically biotinylated tag, compatible with SRI techniques including uPAINT, STED a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10773
更新日期：2016-03-16 00:00:00
abstract：:Omniphobic membranes are attractive for membrane distillation (MD) because of their superior wetting resistance. However, a design framework for MD membrane remains incomplete, due to the complexity of omniphobic membrane fabrication and the lack of fundamental relationship between wetting resistance and water vapor p...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11209-6
更新日期：2019-07-19 00:00:00
abstract：:Plants can produce organs throughout their entire life from pluripotent stem cells located at their growing tip, the shoot apical meristem (SAM). At the time of flowering, the SAM of Arabidopsis thaliana switches fate and starts producing flowers instead of leaves. Correct timing of flowering in part determines reprod...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15120
更新日期：2017-05-17 00:00:00
abstract：:Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation of iron in macrophages and symptoms of iron deficiency anemia. He...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19458-6
更新日期：2020-11-10 00:00:00
abstract：:The endoplasmic reticulum-mitochondria encounter structure (ERMES) connects the mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES, including maintenance of mitochondrial morphology, protein assembly and phospholipid homeostasis. Since the mitochondrial distribution and morphology p...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13021
更新日期：2016-10-10 00:00:00
abstract：:Single-nucleotide variants that underlie phenotypic variation can affect chromatin occupancy of transcription factors (TFs). To delineate determinants of in vivo TF binding and chromatin accessibility, we introduce an approach that compares ChIP-seq and DNase-seq data sets from genetically divergent murine erythroid c...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03082-6
更新日期：2018-02-22 00:00:00
abstract：:Monitoring of protein oligomerization has benefited greatly from Förster Resonance Energy Transfer (FRET) measurements. Although donors and acceptors are typically fluorescent molecules with different spectra, homo-FRET can occur between fluorescent molecules of the same type if the emission spectrum overlaps with the...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13843-6
更新日期：2020-01-07 00:00:00
abstract：:Emerging evidence supports roles of enhancer RNAs (eRNAs) in regulating target gene. Here, we study eRNA regulation and function during skeletal myoblast differentiation. We provide a panoramic view of enhancer transcription and categorization of eRNAs. Master transcription factor MyoD is crucial in activating eRNA pr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13598-0
更新日期：2019-12-19 00:00:00
abstract：:Topology has an increasingly important role in the physics of condensed matter, quantum systems, material science, photonics and biology, with spectacular realizations of topological concepts in liquid crystals. Here we report on long-lived hidden topological states in thermally quenched, chiral nematic droplets, form...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms14594
更新日期：2017-02-21 00:00:00
abstract：:Neural computation relies on the integration of synaptic inputs across a neuron's dendritic arbour. However, it is far from understood how different cell types tune this process to establish cell-type specific computations. Here, using two-photon imaging of dendritic Ca2+ signals, electrical recordings of somatic volt...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15867-9
更新日期：2020-04-30 00:00:00
abstract：:Recently, coherent control of the optical response of thin films in standing waves has attracted considerable attention, ranging from applications in excitation-selective spectroscopy and nonlinear optics to all-optical image processing. Here, we show that integration of metamaterial and optical fibre technologies all...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02434-y
更新日期：2018-01-12 00:00:00
abstract：:Rhinovirus (RV) infections are major triggers of acute exacerbations of severe respiratory diseases such as pre-school wheeze, asthma and chronic obstructive pulmonary disease (COPD). The occurrence of numerous RV types is a major challenge for the identification of the culprit virus types and for the improvement of v...
journal_title：Nature communications
pub_type： 临床试验,杂志文章
doi：10.1038/s41467-018-04591-0
更新日期：2018-06-18 00:00:00
abstract：:Diamond photonics is an ever-growing field of research driven by the prospects of harnessing diamond and its colour centres as suitable hardware for solid-state quantum applications. The last two decades have seen the field shaped by the nitrogen-vacancy (NV) centre with both breakthrough fundamental physics demonstra...
journal_title：Nature communications
pub_type： 杂志文章,评审
doi：10.1038/s41467-019-13332-w
更新日期：2019-12-09 00:00:00
abstract：:Protein post-translational modifications (PTMs) play important roles in the control of various biological processes including protein-protein interactions, epigenetics and cell cycle regulation. Mass spectrometry-based proteomics approaches enable comprehensive identification and quantitation of numerous types of PTMs...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9648
更新日期：2015-10-15 00:00:00
abstract：:Plasmodium vivax poses unique challenges for malaria control and elimination, notably the potential for relapses to maintain transmission in the face of drug-based treatment and vector control strategies. We developed an individual-based mathematical model of P. vivax transmission calibrated to epidemiological data fr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05860-8
更新日期：2018-08-17 00:00:00
abstract：:In the lead-up to the Cretaceous/Paleogene mass extinction, dinosaur diversity is argued to have been either in long-term decline, or thriving until their sudden demise. The latest Cretaceous (Campanian-Maastrichtian [83-66 Ma]) of North America provides the best record to address this debate, but even here diversity ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-08997-2
更新日期：2019-03-06 00:00:00
abstract：:An accurate description of the interaction of intense hard X-ray pulses with heavy atoms, which is crucial for many applications of free-electron lasers, represents a hitherto unresolved challenge for theory because of the enormous number of electronic configurations and relativistic effects, which need to be taken in...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06745-6
更新日期：2018-10-10 00:00:00
abstract：:Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Phase I/II clinical trial investigations for non-small cell lung cancer...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15761
更新日期：2017-06-08 00:00:00
abstract：:By electrochemically coupling microbial and abiotic catalysts, bioelectrochemical systems such as microbial electrolysis cells and microbial electrosynthesis systems synthesize energy-rich chemicals from energy-poor precursors with unmatched efficiency. However, to circumvent chemical incompatibilities between the mic...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04707-6
更新日期：2018-06-11 00:00:00
abstract：:Changing climate will impact species' ranges only when environmental variability directly impacts the demography of local populations. However, measurement of demographic responses to climate change has largely been limited to single species and locations. Here we show that amphibian communities are responsive to clim...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06157-6
更新日期：2018-09-25 00:00:00
abstract：:The interior of the neuronal cell nucleus is a highly organized three-dimensional (3D) structure where regions of the genome that are linearly millions of bases apart establish sub-structures with specialized functions. To investigate neuronal chromatin organization and dynamics in vivo, we generated bitransgenic mice...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5450
更新日期：2014-07-18 00:00:00
abstract：:Voltage control of magnetism in ferromagnetic semiconductor has emerged as an appealing solution to significantly reduce the power dissipation and variability beyond current CMOS technology. However, it has been proven to be very challenging to achieve a candidate with high Curie temperature (Tc), controllable ferroma...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12866
更新日期：2016-10-20 00:00:00
abstract：:Ultrasound sensors have wide applications across science and technology. However, improved sensitivity is required for both miniaturisation and increased spatial resolution. Here, we introduce cavity optomechanical ultrasound sensing, where dual optical and mechanical resonances enhance the ultrasound signal. We achie...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-08038-4
更新日期：2019-01-10 00:00:00
abstract：:The ribosome stalls on translation of polyproline sequences due to inefficient peptide bond formation between consecutive prolines. The translation factor EF-P is able to alleviate this stalling by accelerating Pro-Pro formation. However, the mechanism by which EF-P recognizes the stalled complexes and accelerates pep...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms11657
更新日期：2016-05-24 00:00:00
abstract：:This corrects the article DOI: 10.1038/ncomms15533. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/ncomms16129
更新日期：2017-07-04 00:00:00
abstract：:Plasmonics on metal-dielectric interfaces was widely seen as the main route for miniaturization of components and interconnect of photonic circuits. However recently, ultra-confined surface phonon-polaritonics in high-index chalcogenide films of nanometric thickness has emerged as an important alternative to plasmonic...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15767-y
更新日期：2020-04-20 00:00:00
abstract：:Overexpression of a drug's molecular target often increases drug resistance, offering a pathway for adaptive evolution and a tool for target identification. It is unclear though why this phenomenon applies to some drugs but not others. Here we gradually overexpressed antibiotic targets in Escherichia coli and found th...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5296
更新日期：2014-07-01 00:00:00
abstract：:The Nrf2 transcription factor controls the expression of genes involved in the antioxidant defense system. Here, we identified Nrf2 as a novel regulator of desmosomes in the epidermis through the regulation of microRNAs. On Nrf2 activation, expression of miR-29a and miR-29b increases in cultured human keratinocytes an...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6099
更新日期：2014-10-06 00:00:00
