Synthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib.

abstract：:In the originally published version of this Article, the affiliation details for Eric E. Schadt and Radoslav Savic incorrectly omitted 'Sema4, a Mount Sinai venture, Stamford, Connecticut, USA'. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Readhead B,Hartley BJ,Eastwood BJ,Collier DA,Evans D,Farias R,He C,Hoffman G,Sklar P,Dudley JT,Schadt EE,Savić R,Brennand KJ

更新日期：2018-11-19 00:00:00

abstract：:Iminium catalysis, involving the transformation of iminium ions to enamines, has been extensively studied in the context of a number of organic processes. However, the reverse of this process involving conversion of enamines to iminium species has not been realized. Here, we describe a new transformation-'oxidative en...

journal_title：Nature communications

authors： Zhang SL,Xie HX,Zhu J,Li H,Zhang XS,Li J,Wang W

更新日期：2011-01-01 00:00:00

abstract：:Developmental plasticity describes the influence of environmental factors on phenotypic variation. An important mediator of developmental plasticity in many animals is parental care. Here, we examine the consequences of maternal care on offspring after the initial mass provisioning of brood in the small carpenter bee,...

journal_title：Nature communications

authors： Arsenault SV,Hunt BG,Rehan SM

更新日期：2018-08-27 00:00:00

abstract：:Fear conditioning is a form of associative learning that is known to involve different brain areas, notably the amygdala, the prefrontal cortex and the periaqueductal grey (PAG). Here, we describe the functional role of pathways that link the cerebellum with the fear network. We found that the cerebellar fastigial nuc...

journal_title：Nature communications

authors： Frontera JL,Baba Aissa H,Sala RW,Mailhes-Hamon C,Georgescu IA,Léna C,Popa D

更新日期：2020-10-15 00:00:00

abstract：:Increasing aridity and drought severity forecast for many land areas could reduce the land carbon (C) sink. However, with limited long-term direct measures, it is difficult to distinguish direct drying effects from counter effects of CO2 enrichment and nitrogen (N) deposition. Here, we document a >50% decline in produ...

journal_title：Nature communications

authors： Brookshire EN,Weaver T

更新日期：2015-05-14 00:00:00

abstract：:Many glasses exhibit fractional power law (FPL) between the mean atomic volume va and the first diffraction peak position q1, i.e. [Formula: see text] with d ≃ 2.5 deviating from the space dimension D = 3, under compression or composition change. What structural change causes such FPL and whether the FPL and d are uni...

journal_title：Nature communications

authors： Zhang H,Qiao K,Han Y

更新日期：2020-04-24 00:00:00

abstract：:The ability to understand and control the electronic properties of individual molecules in a device environment is crucial for developing future technologies at the nanometre scale and below. Achieving this, however, requires the creation of three-terminal devices that allow single molecules to be both gated and image...

journal_title：Nature communications

authors： Wickenburg S,Lu J,Lischner J,Tsai HZ,Omrani AA,Riss A,Karrasch C,Bradley A,Jung HS,Khajeh R,Wong D,Watanabe K,Taniguchi T,Zettl A,Neto AHC,Louie SG,Crommie MF

更新日期：2016-11-25 00:00:00

abstract：:Carminic acid, a glucosylated anthraquinone found in scale insects like Dactylopius coccus, has since ancient times been used as a red colorant in various applications. Here we show that a membrane-bound C-glucosyltransferase, isolated from D. coccus and designated DcUGT2, catalyzes the glucosylation of flavokermesic ...

journal_title：Nature communications

authors： Kannangara R,Siukstaite L,Borch-Jensen J,Madsen B,Kongstad KT,Staerk D,Bennedsen M,Okkels FT,Rasmussen SA,Larsen TO,Frandsen RJN,Møller BL

更新日期：2017-12-07 00:00:00

abstract：:Highly sensitive and specific non-invasive molecular imaging methods are particularly desirable for the early detection of cancers. Here we report a near-infrared optical imaging probe highly specific to the hypoxic tumour microenvironment to detect tumour and cancer cells with the sensitivity to a few thousands cance...

journal_title：Nature communications

authors： Zheng X,Wang X,Mao H,Wu W,Liu B,Jiang X

更新日期：2015-01-05 00:00:00

abstract：:Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation of iron in macrophages and symptoms of iron deficiency anemia. He...

journal_title：Nature communications

authors： Pan Y,Ren Z,Gao S,Shen J,Wang L,Xu Z,Yu Y,Bachina P,Zhang H,Fan X,Laganowsky A,Yan N,Zhou M

更新日期：2020-11-10 00:00:00

abstract：:Cellular senescence has been perceived as a barrier against carcinogenesis. However, the senescence-associated secretory phenotype (SASP) of senescent cells can promote tumorigenesis. Here, we show senescent tumour cells are frequently present in the front region of collective invasion of papillary thyroid carcinoma (...

journal_title：Nature communications

authors： Kim YH,Choi YW,Lee J,Soh EY,Kim JH,Park TJ

更新日期：2017-05-10 00:00:00

abstract：:Supercooled liquids exhibit spatial heterogeneity in the dynamics of their fluctuating atomic arrangements. The length and time scales of the heterogeneous dynamics are central to the glass transition and influence nucleation and growth of crystals from the liquid. Here, we report direct experimental visualization of ...

journal_title：Nature communications

authors： Zhang P,Maldonis JJ,Liu Z,Schroers J,Voyles PM

更新日期：2018-03-19 00:00:00

abstract：:Identification of the optimal quantum metrological protocols in realistic many particle quantum models is in general a challenge that cannot be efficiently addressed by the state-of-the-art numerical and analytical methods. Here we provide a comprehensive framework exploiting matrix product operators (MPO) type tensor...

journal_title：Nature communications

authors： Chabuda K,Dziarmaga J,Osborne TJ,Demkowicz-Dobrzański R

更新日期：2020-01-14 00:00:00

abstract：:Nitrogen fixation by cyanobacteria supplies critical bioavailable nitrogen to marine ecosystems worldwide; however, field and lab data have demonstrated it to be limited by iron, phosphorus and/or CO2. To address unknown future interactions among these factors, we grew the nitrogen-fixing cyanobacterium Trichodesmium ...

journal_title：Nature communications

authors： Walworth NG,Fu FX,Webb EA,Saito MA,Moran D,Mcllvin MR,Lee MD,Hutchins DA

更新日期：2016-06-27 00:00:00

abstract：:Post-translational protein modification by tyrosine sulfation has an important role in extracellular protein-protein interactions. The protein tyrosine sulfation reaction is catalysed by the Golgi enzyme called the tyrosylprotein sulfotransferase. To date, no crystal structure is available for tyrosylprotein sulfotran...

journal_title：Nature communications

authors： Teramoto T,Fujikawa Y,Kawaguchi Y,Kurogi K,Soejima M,Adachi R,Nakanishi Y,Mishiro-Sato E,Liu MC,Sakakibara Y,Suiko M,Kimura M,Kakuta Y

更新日期：2013-01-01 00:00:00

abstract：:Trimethylation of histone H3 on lysine-4 (H3K4me3) is associated with gene-regulatory elements, but its transcription-independent function in cell division is unclear. CxxC-finger protein-1 (CFP1) is a major mediator of H3K4 trimethylation in mouse oocytes. Here we report that oocyte-specific knockout of Cxxc1, inhibi...

journal_title：Nature communications

authors： Sha QQ,Dai XX,Jiang JC,Yu C,Jiang Y,Liu J,Ou XH,Zhang SY,Fan HY

更新日期：2018-08-28 00:00:00

abstract：:Methane cold seep systems typically exhibit extensive buildups of authigenic carbonate minerals, resulting from local increases in alkalinity driven by methane oxidation. Here, we demonstrate that modern seep authigenic carbonates exhibit anomalously low clumped isotope values (Δ47), as much as ∼0.2‰ lower than expect...

journal_title：Nature communications

authors： Loyd SJ,Sample J,Tripati RE,Defliese WF,Brooks K,Hovland M,Torres M,Marlow J,Hancock LG,Martin R,Lyons T,Tripati AE

更新日期：2016-07-22 00:00:00

abstract：:Amplitude modes arising from symmetry breaking in materials are of broad interest in condensed matter physics. These modes reflect an oscillation in the amplitude of a complex order parameter, yet are typically unstable and decay into oscillations of the order parameter's phase. This renders stable amplitude modes rar...

journal_title：Nature communications

authors： Dally RL,Zhao Y,Xu Z,Chisnell R,Stone MB,Lynn JW,Balents L,Wilson SD

更新日期：2018-06-05 00:00:00

abstract：:Very-Low-Frequency (VLF) transmitters operate worldwide mostly at frequencies of 10-30 kilohertz for submarine communications. While it has been of intense scientific interest and practical importance to understand whether VLF transmitters can affect the natural environment of charged energetic particles, for decades ...

journal_title：Nature communications

authors： Hua M,Li W,Ni B,Ma Q,Green A,Shen X,Claudepierre SG,Bortnik J,Gu X,Fu S,Xiang Z,Reeves GD

更新日期：2020-09-24 00:00:00

abstract：:Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncy...

journal_title：Nature communications

authors： Ezzat K,Pernemalm M,Pålsson S,Roberts TC,Järver P,Dondalska A,Bestas B,Sobkowiak MJ,Levänen B,Sköld M,Thompson EA,Saher O,Kari OK,Lajunen T,Sverremark Ekström E,Nilsson C,Ishchenko Y,Malm T,Wood MJA,Power UF,Masic

更新日期：2019-05-27 00:00:00

abstract：:The worldwide dissemination of metallo-β-lactamases (MBLs), mediating resistance to carbapenem antibiotics, is a major public health problem. The extent of dissemination of MBLs such as VIM-2, SPM-1 and NDM among Gram-negative pathogens cannot be explained solely based on the associated mobile genetic elements or the ...

journal_title：Nature communications

authors： López C,Ayala JA,Bonomo RA,González LJ,Vila AJ

更新日期：2019-08-09 00:00:00

abstract：:Incited by public fascination and engineering application, water-skipping of rigid stones and spheres has received considerable study. While these objects can be coaxed to ricochet, elastic spheres demonstrate superior water-skipping ability, but little is known about the effect of large material compliance on water i...

journal_title：Nature communications

authors： Belden J,Hurd RC,Jandron MA,Bower AF,Truscott TT

更新日期：2016-02-04 00:00:00

abstract：:It is a relatively new insight of classical statistics that empirical data can contain information about causation rather than mere correlation. First algorithms have been proposed that are capable of testing whether a presumed causal relationship is compatible with an observed distribution. However, no systematic met...

journal_title：Nature communications

authors： Chaves R,Majenz C,Gross D

更新日期：2015-01-06 00:00:00

abstract：:Thin, ultra-flexible devices that can be manufactured in a process that covers a large area will be essential to realizing low-cost, wearable electronic applications including foldable displays and medical sensors. The printing technology will be instrumental in fabricating these novel electronic devices and circuits;...

journal_title：Nature communications

authors： Fukuda K,Takeda Y,Yoshimura Y,Shiwaku R,Tran LT,Sekine T,Mizukami M,Kumaki D,Tokito S

更新日期：2014-06-20 00:00:00

abstract：:The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require lysis or rely on indirect assays and thus often provide an incomplete understanding of drug action. Here, we p...

journal_title：Nature communications

authors： Dubach JM,Vinegoni C,Mazitschek R,Fumene Feruglio P,Cameron LA,Weissleder R

更新日期：2014-05-28 00:00:00

abstract：:Protein expression evolves under greater evolutionary constraint than mRNA levels, and translation efficiency represents a primary determinant of protein levels during stimuli adaptation. This raises the question as to the translatome remodelers that titrate protein output from mRNA populations. Here, we uncover a net...

journal_title：Nature communications

authors： Ho JJD,Balukoff NC,Theodoridis PR,Wang M,Krieger JR,Schatz JH,Lee S

更新日期：2020-05-29 00:00:00

abstract：:Epigenetic regulation plays an important role in governing stem cell fate and tumorigenesis. Lost expression of a key DNA demethylation enzyme TET2 is associated with human cancers and has been linked to stem cell traits in vitro; however, whether and how TET2 regulates mammary stem cell fate and mammary tumorigenesis...

journal_title：Nature communications

authors： Kim MR,Wu MJ,Zhang Y,Yang JY,Chang CJ

更新日期：2020-09-15 00:00:00

abstract：:Systems-wide profiling of breast cancer has almost always entailed RNA and DNA analysis by microarray and sequencing techniques. Marked developments in proteomic technologies now enable very deep profiling of clinical samples, with high identification and quantification accuracy. We analysed 40 oestrogen receptor posi...

journal_title：Nature communications

authors： Tyanova S,Albrechtsen R,Kronqvist P,Cox J,Mann M,Geiger T

更新日期：2016-01-04 00:00:00

abstract：:Amontons' law defines the friction coefficient as the ratio between friction force and normal force, and assumes that both these forces depend linearly on the real contact area between the two sliding surfaces. However, experimental testing of frictional contact models has proven difficult, because few in situ experim...

journal_title：Nature communications

authors： Weber B,Suhina T,Junge T,Pastewka L,Brouwer AM,Bonn D

更新日期：2018-03-01 00:00:00

abstract：:The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effect...

journal_title：Nature communications

authors： Kim JH,Matsubara T,Lee J,Fenollar-Ferrer C,Han K,Kim D,Jia S,Chang CJ,Yang H,Nagano T,Krausz KW,Yim SH,Gonzalez FJ

更新日期：2021-01-12 00:00:00