Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo.

abstract：:Nanopatterning by molecular self-assembly has been a topic of intense research in pursuit of 'bottom-up' methods of generating structures for use in nanotechnology. The systems most widely studied have been two- and three-dimensional morphologies of block copolymers. However, T- and X-shaped polyphilic liquid crystals...

journal_title：Nature communications

authors： Liu F,Kieffer R,Zeng X,Pelz K,Prehm M,Ungar G,Tschierske C

更新日期：2012-01-01 00:00:00

abstract：:Contextual influences on choice are ubiquitous in ecological settings. Current evidence suggests that subjective values are normalized with respect to the distribution of potentially available rewards. However, how this context-sensitivity is realised in the brain remains unknown. To address this, here we examine func...

journal_title：Nature communications

authors： Rigoli F,Friston KJ,Dolan RJ

更新日期：2016-08-18 00:00:00

abstract：:Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region involved in goal-directed and habitual behaviors. This loss of LTD is associated with altered DS-dependent behavior. Given the role of the ...

journal_title：Nature communications

authors： Muñoz B,Fritz BM,Yin F,Atwood BK

更新日期：2018-04-03 00:00:00

abstract：:Oxidation of bromide in aqueous environments initiates the formation of molecular halogen compounds, which is important for the global tropospheric ozone budget. In the aqueous bulk, oxidation of bromide by ozone involves a [Br•OOO-] complex as intermediate. Here we report liquid jet X-ray photoelectron spectroscopy m...

journal_title：Nature communications

authors： Artiglia L,Edebeli J,Orlando F,Chen S,Lee MT,Corral Arroyo P,Gilgen A,Bartels-Rausch T,Kleibert A,Vazdar M,Andres Carignano M,Francisco JS,Shepson PB,Gladich I,Ammann M

更新日期：2017-09-26 00:00:00

abstract：:Solitary chemosensory cells (SCCs) are epithelial sentinels that utilize bitter Tas2r receptors and coupled taste transduction elements to detect pathogenic bacterial metabolites, triggering host defenses to control the infection. Here we report that SCCs are present in mouse gingival junctional epithelium, where they...

journal_title：Nature communications

authors： Zheng X,Tizzano M,Redding K,He J,Peng X,Jiang P,Xu X,Zhou X,Margolskee RF

更新日期：2019-10-03 00:00:00

abstract：:The decoy effect is a cognitive bias documented in behavioural economics by which the presence of a third, (partly) inferior choice causes a significant shift in people's preference for other items. Here, we performed an experiment with human volunteers who played a variant of the repeated prisoner's dilemma game in w...

journal_title：Nature communications

authors： Wang Z,Jusup M,Shi L,Lee JH,Iwasa Y,Boccaletti S

更新日期：2018-07-27 00:00:00

abstract：:Seismological findings show a complex scenario of plume upwellings from a deep thermo-chemical anomaly (superplume) beneath the East African Rift System (EARS). It is unclear if these geophysical observations represent a true picture of the superplume and its influence on magmatism along the EARS. Thus, it is essentia...

journal_title：Nature communications

authors： O'Connor JM,Jokat W,Regelous M,Kuiper KF,Miggins DP,Koppers AAP

更新日期：2019-12-02 00:00:00

abstract：:High strength and high ductility are often mutually exclusive properties for structural metallic materials. This is particularly important for aluminum (Al)-based alloys which are widely commercially employed. Here, we introduce a hierarchical nanostructured Al alloy with a structure of Al nanograins surrounded by nan...

journal_title：Nature communications

authors： Wu G,Liu C,Sun L,Wang Q,Sun B,Han B,Kai JJ,Luan J,Liu CT,Cao K,Lu Y,Cheng L,Lu J

更新日期：2019-11-08 00:00:00

abstract：:Many low-thermal-conductivity (κL) crystals show intriguing temperature (T) dependence of κL: κL ∝ T-1 (crystal-like) at intermediate temperatures whereas weak T-dependence (glass-like) at high temperatures. It has been in debate whether thermal transport can still be described by phonons at the Ioffe-Regel limit. In ...

journal_title：Nature communications

authors： Luo Y,Yang X,Feng T,Wang J,Ruan X

更新日期：2020-05-22 00:00:00

abstract：:The microbial communities living in the human intestine can have profound impact on our well-being and health. However, we have limited understanding of the mechanisms that control this complex ecosystem. Here, based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults, we identify...

journal_title：Nature communications

authors： Lahti L,Salojärvi J,Salonen A,Scheffer M,de Vos WM

更新日期：2014-07-08 00:00:00

abstract：:Ultrafast materials science promises optical control of physical properties of solids. Continuous-wave circularly polarized laser driving was predicted to induce a light-matter coupled state with an energy gap and a quantum Hall effect, coined Floquet topological insulator. Whereas the envisioned Floquet topological i...

journal_title：Nature communications

authors： Sentef MA,Claassen M,Kemper AF,Moritz B,Oka T,Freericks JK,Devereaux TP

更新日期：2015-05-11 00:00:00

abstract：:The Paris Agreement set a goal to keep global warming well below 2 °C and pursue efforts to limit it to 1.5 °C. Understanding how 0.5 °C less warming reduces impacts and risks is key for climate policies. Here, we show that both areal and population exposures to dangerous extreme precipitation events (e.g., once in 10...

journal_title：Nature communications

authors： Zhang W,Zhou T,Zou L,Zhang L,Chen X

更新日期：2018-08-08 00:00:00

abstract：:Hollow-core fibre (HCF) is a powerful technology platform offering breakthrough performance improvements in sensing, communications, higher-power pulse delivery and other applications. Free from the usual constraints on what materials can guide light, it promises qualitatively new and ideal operating regimes: precisio...

journal_title：Nature communications

authors： Fini JM,Nicholson JW,Mangan B,Meng L,Windeler RS,Monberg EM,DeSantolo A,DiMarcello FV,Mukasa K

更新日期：2014-10-28 00:00:00

abstract：:Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains whether myelination also contributes to information proces...

journal_title：Nature communications

authors： Moore S,Meschkat M,Ruhwedel T,Trevisiol A,Tzvetanova ID,Battefeld A,Kusch K,Kole MHP,Strenzke N,Möbius W,de Hoz L,Nave KA

更新日期：2020-10-30 00:00:00

abstract：:The proton-activated sodium channel ASIC1 belongs to the ENaC/Degenerins family of ion channels. Little is known about gating of the pore in any member of this class. Here we outline the shape of the ion pathway of ASIC1 in the open and closed conformations by measuring apparent rates of cysteine modification by thiol...

journal_title：Nature communications

authors： Li T,Yang Y,Canessa CM

更新日期：2011-07-19 00:00:00

abstract：:Adult neural stem cells (NSCs) reside in a specialized microenvironment, the subventricular zone (SVZ), which provides them with unique signaling cues to control their basic properties and prevent their exhaustion. While the signaling mechanisms that regulate NSC lineage progression are well characterized, the molecul...

journal_title：Nature communications

authors： Chavali M,Klingener M,Kokkosis AG,Garkun Y,Felong S,Maffei A,Aguirre A

更新日期：2018-01-02 00:00:00

abstract：:Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain. Here, we use bacterial DNA sequencing from serially collected vaginal samples from a cohort of 87 ad...

journal_title：Nature communications

authors： Mitra A,MacIntyre DA,Ntritsos G,Smith A,Tsilidis KK,Marchesi JR,Bennett PR,Moscicki AB,Kyrgiou M

更新日期：2020-04-24 00:00:00

abstract：:Microbial fatty acid-derived fuels have emerged as promising alternatives to petroleum-based transportation fuels. Here we report a modular engineering approach that systematically removed metabolic pathway bottlenecks and led to significant titre improvements in a multi-gene fatty acid metabolic pathway. On the basis...

journal_title：Nature communications

authors： Xu P,Gu Q,Wang W,Wong L,Bower AG,Collins CH,Koffas MA

更新日期：2013-01-01 00:00:00

abstract：:In cancer metastasis, various environmental stressors attack the disseminating cells. The successful colonization of cancer cells in secondary sites therefore requires the ability of the cells to avoid the consequences of such exposure to the stressors. Here we show that orthotopic transplantation of a CD44 variant is...

journal_title：Nature communications

authors： Yae T,Tsuchihashi K,Ishimoto T,Motohara T,Yoshikawa M,Yoshida GJ,Wada T,Masuko T,Mogushi K,Tanaka H,Osawa T,Kanki Y,Minami T,Aburatani H,Ohmura M,Kubo A,Suematsu M,Takahashi K,Saya H,Nagano O

更新日期：2012-06-06 00:00:00

abstract：:To learn, obtain reward and survive, humans and other animals must monitor, approach and act on objects that are associated with variable or unknown rewards. However, the neuronal mechanisms that mediate behaviours aimed at uncertain objects are poorly understood. Here we demonstrate that a set of neurons in an intern...

journal_title：Nature communications

authors： White JK,Monosov IE

更新日期：2016-09-14 00:00:00

abstract：:Molecular shape recognition for larger guest molecules (typically over 1 nm) is a difficult task because it requires cooperativity within a wide three-dimensional nanospace coincidentally probing every molecular aspect (size, outline shape, flexibility and specific groups). Although the intelligent functions of protei...

journal_title：Nature communications

authors： Imaoka T,Kawana Y,Kurokawa T,Yamamoto K

更新日期：2013-01-01 00:00:00

abstract：:X-linked lymphoproliferative syndrome type-2 (XLP-2) is a primary immunodeficiency disease attributed to XIAP mutation and is triggered by infection. Here, we show that mouse Xiap-/- regulatory T (Treg) cells and human XIAP-deficient Treg cells are defective in suppressive function. The Xiap-/- Treg cell defect is lin...

journal_title：Nature communications

authors： Hsieh WC,Hsu TS,Chang YJ,Lai MZ

更新日期：2018-01-31 00:00:00

abstract：:Preterm birth places infants in an adverse environment that leads to abnormal brain development and cerebral injury through a poorly understood mechanism known to involve neuroinflammation. In this study, we integrate human and mouse molecular and neuroimaging data to investigate the role of microglia in preterm white...

journal_title：Nature communications

authors： Krishnan ML,Van Steenwinckel J,Schang AL,Yan J,Arnadottir J,Le Charpentier T,Csaba Z,Dournaud P,Cipriani S,Auvynet C,Titomanlio L,Pansiot J,Ball G,Boardman JP,Walley AJ,Saxena A,Mirza G,Fleiss B,Edwards AD,Petretto

更新日期：2017-09-05 00:00:00

abstract：:Human social networks are overwhelmingly homophilous: individuals tend to befriend others who are similar to them in terms of a range of physical attributes (e.g., age, gender). Do similarities among friends reflect deeper similarities in how we perceive, interpret, and respond to the world? To test whether friendship...

journal_title：Nature communications

authors： Parkinson C,Kleinbaum AM,Wheatley T

更新日期：2018-01-30 00:00:00

abstract：:A new paradigm for cellulose depolymerization by fungi focuses on an oxidative mechanism involving cellobiose dehydrogenases (CDH) and copper-dependent lytic polysaccharide monooxygenases (LPMO); however, mechanistic studies have been hampered by the lack of structural information regarding CDH. CDH contains a haem-bi...

journal_title：Nature communications

authors： Tan TC,Kracher D,Gandini R,Sygmund C,Kittl R,Haltrich D,Hällberg BM,Ludwig R,Divne C

更新日期：2015-07-07 00:00:00

abstract：:The rapidly increasing use of sensors throughout different research disciplines and the demand for more efficient devices with less power consumption depends critically on the emergence of new sensor materials and novel sensor concepts. Atomically thin transition metal dichalcogenides have a huge potential for sensor ...

journal_title：Nature communications

authors： Feierabend M,Berghäuser G,Knorr A,Malic E

更新日期：2017-03-15 00:00:00

abstract：:Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures. CCMs are thought to be initiated by endothelial cell (EC) loss of any one of the three Ccm genes: CCM1 (KRIT1), CCM2 (OSM), or CCM3 (PDCD10). Here we report that mic...

journal_title：Nature communications

authors： Zhou HJ,Qin L,Jiang Q,Murray KN,Zhang H,Li B,Lin Q,Graham M,Liu X,Grutzendler J,Min W

更新日期：2021-01-25 00:00:00

abstract：:Bone mineral density (BMD) is a measure of osteoporosis and is useful in evaluating the risk of fracture. In a genome-wide association study of BMD among 20,100 Icelanders, with follow-up in 10,091 subjects of European and East-Asian descent, we found a new BMD locus that harbours the PTCH1 gene, represented by rs2837...

journal_title：Nature communications

authors： Styrkarsdottir U,Thorleifsson G,Gudjonsson SA,Sigurdsson A,Center JR,Lee SH,Nguyen TV,Kwok TCY,Lee JSW,Ho SC,Woo J,Leung PC,Kim BJ,Rafnar T,Kiemeney LA,Ingvarsson T,Koh JM,Tang NLS,Eisman JA,Christiansen C,Sigurds

更新日期：2016-01-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Perone Y,Farrugia AJ,Rodríguez-Meira A,Győrffy B,Ion C,Uggetti A,Chronopoulos A,Marrazzo P,Faronato M,Shousha S,Davies C,Steel JH,Patel N,Del Rio Hernandez A,Coombes C,Pruneri G,Lim A,Calvo F,Magnani L

更新日期：2019-08-19 00:00:00

abstract：:Full-carbon electronics at the scale of several angstroms is an expeimental challenge, which could be overcome by exploiting the versatility of carbon allotropes. Here, we investigate charge transport through graphene/single-fullerene/graphene hybrid junctions using a single-molecule manipulation technique. Such sub-n...

journal_title：Nature communications

authors： Tan Z,Zhang D,Tian HR,Wu Q,Hou S,Pi J,Sadeghi H,Tang Z,Yang Y,Liu J,Tan YZ,Chen ZB,Shi J,Xiao Z,Lambert C,Xie SY,Hong W

更新日期：2019-04-15 00:00:00