Polarization maintaining single-mode low-loss hollow-core fibres.

abstract：:Choroidal neovascularization (CNV) is the major cause of vision loss in wet age-related macular degeneration (AMD). Current therapies require repeated intravitreal injections, which are painful and can cause infection, bleeding, and retinal detachment. Here we develop nanoparticles (NP-[CPP]) that can be administered ...

journal_title：Nature communications

authors： Wang Y,Liu CH,Ji T,Mehta M,Wang W,Marino E,Chen J,Kohane DS

更新日期：2019-02-18 00:00:00

abstract：:SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2 papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus maturation, dysregulation of host inflammation, and antiviral immune responses. The multiple functions of PLpro render it a promising drug targe...

journal_title：Nature communications

authors： Fu Z,Huang B,Tang J,Liu S,Liu M,Ye Y,Liu Z,Xiong Y,Zhu W,Cao D,Li J,Niu X,Zhou H,Zhao YJ,Zhang G,Huang H

更新日期：2021-01-20 00:00:00

abstract：:Using mouse optic nerve (ON) crush as a CNS injury model, we and others have found that activation of the mammalian target of rapamycin complex 1 (mTORC1) in mature retinal ganglion cells by deletion of the negative regulators, phosphatase and tensin homologue (PTEN), and tuberous sclerosis 1 promotes ON regeneration....

journal_title：Nature communications

authors： Yang L,Miao L,Liang F,Huang H,Teng X,Li S,Nuriddinov J,Selzer ME,Hu Y

更新日期：2014-11-10 00:00:00

abstract：:FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C into multiple myeloma ce...

journal_title：Nature communications

authors： Mroczek S,Chlebowska J,Kuliński TM,Gewartowska O,Gruchota J,Cysewski D,Liudkovska V,Borsuk E,Nowis D,Dziembowski A

更新日期：2017-09-20 00:00:00

abstract：:Mei (Prunus mume) is an ornamental woody plant that has been domesticated in East Asia for thousands of years. High diversity in floral traits, along with its recent genome sequence, makes mei an ideal model system for studying the evolution of woody plants. Here, we investigate the genetic architecture of floral trai...

journal_title：Nature communications

authors： Zhang Q,Zhang H,Sun L,Fan G,Ye M,Jiang L,Liu X,Ma K,Shi C,Bao F,Guan R,Han Y,Fu Y,Pan H,Chen Z,Li L,Wang J,Lv M,Zheng T,Yuan C,Zhou Y,Lee SM,Yan X,Xu X,Wu R,Chen W,Cheng T

更新日期：2018-04-27 00:00:00

abstract：:The vimentin network displays remarkable plasticity to support basic cellular functions and reorganizes during cell division. Here, we show that in several cell types vimentin filaments redistribute to the cell cortex during mitosis, forming a robust framework interwoven with cortical actin and affecting its organizat...

journal_title：Nature communications

authors： Duarte S,Viedma-Poyatos Á,Navarro-Carrasco E,Martínez AE,Pajares MA,Pérez-Sala D

更新日期：2019-09-13 00:00:00

abstract：:The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastable phenotypic variants (persisters), some of which represent ste...

journal_title：Nature communications

authors： Pisco AO,Brock A,Zhou J,Moor A,Mojtahedi M,Jackson D,Huang S

更新日期：2013-01-01 00:00:00

abstract：:Humans typically make near-optimal sensorimotor judgements but show systematic biases when making more cognitive judgements. Here we test the hypothesis that, while humans are sensitive to the noise present during early sensory encoding, the "optimality gap" arises because they are blind to noise introduced by later c...

journal_title：Nature communications

authors： Herce Castañón S,Moran R,Ding J,Egner T,Bang D,Summerfield C

更新日期：2019-04-12 00:00:00

abstract：:Marine reserves are viewed as flagship tools to protect exploited species and to contribute to the effective management of coastal fisheries. Yet, the extent to which marine reserves are globally interconnected and able to effectively seed areas, where fisheries are most critical for food and livelihood security is la...

journal_title：Nature communications

authors： Andrello M,Guilhaumon F,Albouy C,Parravicini V,Scholtens J,Verley P,Barange M,Sumaila UR,Manel S,Mouillot D

更新日期：2017-07-10 00:00:00

abstract：:Methods for site-selective chemistry on proteins are in high demand for the synthesis of chemically modified biopharmaceuticals, as well as for applications in chemical biology, biosensors and more. Inadvertent N-terminal gluconoylation has been reported during expression of proteins with an N-terminal His tag. Here w...

journal_title：Nature communications

authors： Martos-Maldonado MC,Hjuler CT,Sørensen KK,Thygesen MB,Rasmussen JE,Villadsen K,Midtgaard SR,Kol S,Schoffelen S,Jensen KJ

更新日期：2018-08-17 00:00:00

abstract：:Metal-organic frameworks (MOFs) are well known for their tunable structure and porosity. Many studies have shown they are promising for various important applications, for which their performance can be further enhanced by encapsulating functional species, such as luminescent guest molecules, within the frameworks. Al...

journal_title：Nature communications

authors： Sun CY,Wang XL,Zhang X,Qin C,Li P,Su ZM,Zhu DX,Shan GG,Shao KZ,Wu H,Li J

更新日期：2013-01-01 00:00:00

abstract：:For a cell to move forward it must convert chemical energy into mechanical propulsion. Force produced by actin polymerization can generate traction across the plasma membrane by transmission through integrins to their ligands. However, the role this force plays in integrin activation is unknown. Here we show that inte...

journal_title：Nature communications

authors： Nordenfelt P,Elliott HL,Springer TA

更新日期：2016-10-10 00:00:00

abstract：:Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond c...

journal_title：Nature communications

authors： Weierstall U,James D,Wang C,White TA,Wang D,Liu W,Spence JC,Bruce Doak R,Nelson G,Fromme P,Fromme R,Grotjohann I,Kupitz C,Zatsepin NA,Liu H,Basu S,Wacker D,Han GW,Katritch V,Boutet S,Messerschmidt M,Williams GJ

更新日期：2014-01-01 00:00:00

abstract：:Accurate prediction of an individual's phenotype from their DNA sequence is one of the great promises of genomics and precision medicine. We extend a powerful individual-level data Bayesian multiple regression model (BayesR) to one that utilises summary statistics from genome-wide association studies (GWAS), SBayesR. ...

journal_title：Nature communications

authors： Lloyd-Jones LR,Zeng J,Sidorenko J,Yengo L,Moser G,Kemper KE,Wang H,Zheng Z,Magi R,Esko T,Metspalu A,Wray NR,Goddard ME,Yang J,Visscher PM

更新日期：2019-11-08 00:00:00

abstract：:Nacre-mimetics hold great promise as mechanical high-performance and functional materials. Here we demonstrate large progress of mechanical and functional properties of self-assembled polymer/nanoclay nacre-mimetics by using synthetic nanoclays with aspect ratios covering three orders in magnitude (25-3,500). We estab...

journal_title：Nature communications

authors： Das P,Malho JM,Rahimi K,Schacher FH,Wang B,Demco DE,Walther A

更新日期：2015-01-20 00:00:00

abstract：:Recent studies suggest the emerging roles of armadillo (ARM) family proteins in tumor progression. However, the functions and underlying mechanisms of ARM members in tumorigenesis and aggressiveness of neuroblastoma (NB) remain to be determined. Herein, we identify armadillo repeat containing 12 (ARMC12) as an ARM mem...

journal_title：Nature communications

authors： Li D,Song H,Mei H,Fang E,Wang X,Yang F,Li H,Chen Y,Huang K,Zheng L,Tong Q

更新日期：2018-07-19 00:00:00

abstract：:The world's coastal zones are experiencing rapid development and an increase in storms and flooding. These hazards put coastal communities at heightened risk, which may increase with habitat loss. Here we analyse globally the role and cost effectiveness of coral reefs in risk reduction. Meta-analyses reveal that coral...

journal_title：Nature communications

authors： Ferrario F,Beck MW,Storlazzi CD,Micheli F,Shepard CC,Airoldi L

更新日期：2014-05-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Michaelis KA,Norgard MA,Zhu X,Levasseur PR,Sivagnanam S,Liudahl SM,Burfeind KG,Olson B,Pelz KR,Ramos DMA,Maurer HC,Olive KP,Coussens LM,Morgan TK,Marks DL

更新日期：2019-11-15 00:00:00

abstract：:Epitaxial films may be released from growth substrates and transferred to structurally and chemically incompatible substrates, but epitaxial films of transition metal perovskite oxides have not been transferred to electroactive substrates for voltage control of their myriad functional properties. Here we demonstrate g...

journal_title：Nature communications

authors： Pesquera D,Khestanova E,Ghidini M,Zhang S,Rooney AP,Maccherozzi F,Riego P,Farokhipoor S,Kim J,Moya X,Vickers ME,Stelmashenko NA,Haigh SJ,Dhesi SS,Mathur ND

更新日期：2020-06-24 00:00:00

abstract：:Vertebrates exhibit specific requirements for replicative H3 and non-replicative H3.3 variants during development. To disentangle whether this involves distinct modes of deposition or unique functions once incorporated into chromatin, we combined studies in Xenopus early development with chromatin assays. Here we inve...

journal_title：Nature communications

authors： Sitbon D,Boyarchuk E,Dingli F,Loew D,Almouzni G

更新日期：2020-03-09 00:00:00

abstract：:Expression of the matricellular protein CCN1 (CYR61) is associated with inflammation and is required for successful wound repair. Here, we show that CCN1 binds bacterial pathogen-associated molecular patterns including peptidoglycans of Gram-positive bacteria and lipopolysaccharides of Gram-negative bacteria. CCN1 ops...

journal_title：Nature communications

authors： Jun JI,Lau LF

更新日期：2020-03-06 00:00:00

abstract：:Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult to make. Here, we report a genome-wide association study on food allergy diagnosed by oral food challenge in 497 cases and 2387 controls. We identify five loci at genome-...

journal_title：Nature communications

authors： Marenholz I,Grosche S,Kalb B,Rüschendorf F,Blümchen K,Schlags R,Harandi N,Price M,Hansen G,Seidenberg J,Röblitz H,Yürek S,Tschirner S,Hong X,Wang X,Homuth G,Schmidt CO,Nöthen MM,Hübner N,Niggemann B,Beyer K,Lee

更新日期：2017-10-20 00:00:00

abstract：:The original version of this Article contained an error in the spelling of the author Álvaro Sebastián-Serrano, which was incorrectly given as Álvaro Sebastián Serrano. This has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Pose-Utrilla J,García-Guerra L,Del Puerto A,Martín A,Jurado-Arjona J,De León-Reyes NS,Gamir-Morralla A,Sebastián-Serrano Á,García-Gallo M,Kremer L,Fielitz J,Ireson C,Pérez-Álvarez MJ,Ferrer I,Hernández F,Ávila J,Lasa M,

更新日期：2018-01-30 00:00:00

abstract：:Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that ...

journal_title：Nature communications

authors： Joshi PK,Fischer K,Schraut KE,Campbell H,Esko T,Wilson JF

更新日期：2016-03-31 00:00:00

abstract：:Hundreds of clinical studies have demonstrated associations between the human microbiome and disease, yet fundamental questions remain on how we can generalize this knowledge. Results from individual studies can be inconsistent, and comparing published data is further complicated by a lack of standard processing and a...

journal_title：Nature communications

authors： Duvallet C,Gibbons SM,Gurry T,Irizarry RA,Alm EJ

更新日期：2017-12-05 00:00:00

abstract：:Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectric...

journal_title：Nature communications

authors： Zillikens MC,Demissie S,Hsu YH,Yerges-Armstrong LM,Chou WC,Stolk L,Livshits G,Broer L,Johnson T,Koller DL,Kutalik Z,Luan J,Malkin I,Ried JS,Smith AV,Thorleifsson G,Vandenput L,Hua Zhao J,Zhang W,Aghdassi A,Åkesson

更新日期：2017-07-19 00:00:00

abstract：:Adult neural stem cells (NSCs) reside in a specialized microenvironment, the subventricular zone (SVZ), which provides them with unique signaling cues to control their basic properties and prevent their exhaustion. While the signaling mechanisms that regulate NSC lineage progression are well characterized, the molecul...

journal_title：Nature communications

authors： Chavali M,Klingener M,Kokkosis AG,Garkun Y,Felong S,Maffei A,Aguirre A

更新日期：2018-01-02 00:00:00

abstract：:The process of crystallization is difficult to observe for transported, out-of-equilibrium systems, as the continuous energy injection increases activity and competes with ordering. In emerging fields such as microfluidics and active matter, the formation of long-range order is often frustrated by the presence of hydr...

journal_title：Nature communications

authors： Massana-Cid H,Meng F,Matsunaga D,Golestanian R,Tierno P

更新日期：2019-06-04 00:00:00

abstract：:Our memories enable us to form expectations for our future experiences, yet the precise neural mechanisms underlying how we compare any experience to our memory remain unknown. Here, using intracranial EEG recordings, we show that episodic memories formed after a single visual experience establish expectations for fut...

journal_title：Nature communications

authors： Haque RU,Inati SK,Levey AI,Zaghloul KA

更新日期：2020-11-27 00:00:00

abstract：:Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC) n -containing RNAs into poly-dipeptides can initiate in vivo without a 5'-cap. The pr...

journal_title：Nature communications

authors： Cheng W,Wang S,Mestre AA,Fu C,Makarem A,Xian F,Hayes LR,Lopez-Gonzalez R,Drenner K,Jiang J,Cleveland DW,Sun S

更新日期：2018-01-04 00:00:00