Abstract:
:Contextual influences on choice are ubiquitous in ecological settings. Current evidence suggests that subjective values are normalized with respect to the distribution of potentially available rewards. However, how this context-sensitivity is realised in the brain remains unknown. To address this, here we examine functional magnetic resonance imaging (fMRI) data during performance of a gambling task where blocks comprise values drawn from one of two different, but partially overlapping, reward distributions or contexts. At the beginning of each block (when information about context is provided), hippocampus is activated and this response is enhanced when contextual influence on choice increases. In addition, response to value in ventral tegmental area/substantia nigra (VTA/SN) shows context-sensitivity, an effect enhanced with an increased contextual influence on choice. Finally, greater response in hippocampus at block start is associated with enhanced context sensitivity in VTA/SN. These findings suggest that context-sensitive choice is driven by a brain circuit involving hippocampus and dopaminergic midbrain.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Rigoli F,Friston KJ,Dolan RJdoi
10.1038/ncomms12416subject
Has Abstractpub_date
2016-08-18 00:00:00pages
12416issn
2041-1723pii
ncomms12416journal_volume
7pub_type
杂志文章abstract::Tomatoes come in a multitude of shapes and flavors despite a narrow genetic pool. Here, we leverage whole-genome resequencing data available for 602 cultivated and wild accessions to determine the contribution of transposable elements (TEs) to tomato diversity. We identify 6,906 TE insertions polymorphisms (TIPs), whi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17874-2
更新日期:2020-08-13 00:00:00
abstract::Solar radio observations provide a unique diagnostic of the outer solar atmosphere. However, the inhomogeneous turbulent corona strongly affects the propagation of the emitted radio waves, so decoupling the intrinsic properties of the emitting source from the effects of radio wave propagation has long been a major cha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01307-8
更新日期:2017-11-15 00:00:00
abstract::Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/s41467-018-04109-8
更新日期:2018-06-11 00:00:00
abstract::Coordinated activity of VEGF and Notch signals guides the endothelial cell (EC) specification into tip and stalk cells during angiogenesis. Notch activation in stalk cells leads to proliferation arrest via an unknown mechanism. By using gain- and loss-of-function gene-targeting approaches, here we show that PTEN is cr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8935
更新日期:2015-07-31 00:00:00
abstract::Urban residential buildings make large contributions to energy consumption. Energy consumption per square meter is most widely used to measure energy efficiency in urban residential buildings. This study aims to explore whether it is an appropriate indicator. An extended STIRPAT model was used based on the survey data...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12852-9
更新日期:2019-10-30 00:00:00
abstract::EGFR is required for animal development, and dysregulation of EGFR is critically implicated in malignant transformation. However, the molecular mechanism underlying the regulation of EGFR expression remains poorly explored. Here we report that the zinc-finger protein ZNF516 is a transcription repressor. ZNF516 is phys...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00702-5
更新日期:2017-09-25 00:00:00
abstract::Rotational invariance strongly constrains the viscosity tensor of classical fluids. When this symmetry is broken in anisotropic materials a wide array of novel phenomena become possible. We explore electron fluid behaviors arising from the most general viscosity tensors in two and three dimensions, constrained only th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18553-y
更新日期:2020-09-18 00:00:00
abstract::High-performance piezoelectrics are lead-based solid solutions that exhibit a so-called morphotropic phase boundary, which separates two competing phases as a function of chemical composition; as a consequence, an intermediate low-symmetry phase with a strong piezoelectric effect arises. In search for environmentally ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4172
更新日期:2014-01-01 00:00:00
abstract::Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the enzyme cGAS may act anti-inflammatory. Here we report the discovery of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08620-4
更新日期:2019-05-21 00:00:00
abstract::Southern Africa is characterised by unusually elevated topography and abnormal heat flow. This can be explained by thermal perturbation of the mantle, but the origin of this is unclear. Geophysics has not detected a thermal anomaly in the upper mantle and there is no geochemical evidence of an asthenosphere mantle con...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12944-6
更新日期:2019-11-05 00:00:00
abstract::Seismological findings show a complex scenario of plume upwellings from a deep thermo-chemical anomaly (superplume) beneath the East African Rift System (EARS). It is unclear if these geophysical observations represent a true picture of the superplume and its influence on magmatism along the EARS. Thus, it is essentia...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13181-7
更新日期:2019-12-02 00:00:00
abstract::Circular RNAs are non-coding RNAs, and are enriched in the CNS. Dorsal horn neurons of the spinal cord contribute to pain-like hypersensitivity after nerve injury in rodents. Here we show that spinal nerve ligation is associated with an increase in expression of circAnks1a in dorsal horn neurons, in both the cytoplasm...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12049-0
更新日期:2019-09-11 00:00:00
abstract::CrAss-like phages are double-stranded DNA viruses that are prevalent in human gut microbiomes. Here, we analyze gut metagenomic data from mother-infant pairs and patients undergoing fecal microbiota transplantation to evaluate the patterns of acquisition, transmission and strain diversity of crAss-like phages. We find...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14103-3
更新日期:2020-01-15 00:00:00
abstract::Nanopatterning by molecular self-assembly has been a topic of intense research in pursuit of 'bottom-up' methods of generating structures for use in nanotechnology. The systems most widely studied have been two- and three-dimensional morphologies of block copolymers. However, T- and X-shaped polyphilic liquid crystals...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2096
更新日期:2012-01-01 00:00:00
abstract::Owing to the advantages of integration and being magnet-free and light-weight, the switched-capacitor-convertor plays an increasing role compared to traditional transformer in some specific power supply systems. However, the high output impedance and switching loss largely reduces its power efficiency, due to imperfec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15373-y
更新日期:2020-04-20 00:00:00
abstract::Early detection and accurate monitoring of chronic kidney disease (CKD) could improve care and retard progression to end-stage renal disease. Here, using untargeted metabolomics in 2155 participants including patients with stage 1-5 CKD and healthy controls, we identify five metabolites, including 5-methoxytryptophan ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09329-0
更新日期:2019-04-01 00:00:00
abstract::Thin films comprising semiconductor nanocrystals are emerging for applications in electronic and optoelectronic devices including light emitting diodes and solar cells. Achieving high charge carrier mobility in these films requires the identification and elimination of electronic traps on the nanocrystal surfaces. Her...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6822
更新日期:2014-12-19 00:00:00
abstract::High-intensity lasers can be used to generate shockwaves, which have found applications in nuclear fusion, proton imaging, cancer therapies and materials science. Collisionless electrostatic shocks are one type of shockwave widely studied for applications involving ion acceleration. Here we show a novel mechanism for ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9905
更新日期:2015-11-13 00:00:00
abstract::FBXW2 inhibits proliferation of lung cancer cells by targeting SKP2 for degradation. Whether and how FBXW2 regulates tumor invasion and metastasis is previously unknown. Here, we report that FBXW2 is an E3 ligase for β-catenin. FBXW2 binds to β-catenin upon EGF-AKT1-mediated phosphorylation on Ser552, and promotes its...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09289-5
更新日期:2019-03-27 00:00:00
abstract::A variety of flexible and stretchable electronics have been reported for use in flexible electronic devices or biomedical applications. The practical and wider application of such flexible electronics has been limited because commercial electronic components are difficult to be directly integrated into flexible stretc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1980
更新日期:2012-01-01 00:00:00
abstract::Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), which do not contain a nucleus, and cannot perform transcription or tran...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20479-4
更新日期:2021-01-15 00:00:00
abstract::Post-transcriptional RNA modifications play a critical role in the pathogenesis of human mitochondrial disorders, but the mechanisms by which specific modifications affect mitochondrial protein synthesis remain poorly understood. Here we used a quantitative RNA sequencing approach to investigate, at nucleotide resolut...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06471-z
更新日期:2018-09-27 00:00:00
abstract::Nitrogen acquisition is a major challenge for herbivorous animals, and the repeated origins of herbivory across the ants have raised expectations that nutritional symbionts have shaped their diversification. Direct evidence for N provisioning by internally housed symbionts is rare in animals; among the ants, it has be...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03357-y
更新日期:2018-03-06 00:00:00
abstract::Systems-wide profiling of breast cancer has almost always entailed RNA and DNA analysis by microarray and sequencing techniques. Marked developments in proteomic technologies now enable very deep profiling of clinical samples, with high identification and quantification accuracy. We analysed 40 oestrogen receptor posi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10259
更新日期:2016-01-04 00:00:00
abstract::ATP-dependent chromatin remodellers are mutated in more than 20% of human cancers. The consequences of these mutations on enzyme function are poorly understood. Here, we characterise the effects of CHD4 mutations identified in endometrial carcinoma on the remodelling properties of dMi-2, the highly conserved Drosophil...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04503-2
更新日期:2018-05-29 00:00:00
abstract::For societies with writing systems, hereditary leadership is documented as one of the hallmarks of early political complexity and governance. In contrast, it is unknown whether hereditary succession played a role in the early formation of prehistoric complex societies that lacked writing. Here we use an archaeogenomic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14115
更新日期:2017-02-21 00:00:00
abstract::The development of high efficiency solar cells relies on the management of electronic and optical properties that need to be accurately measured. As the conversion efficiencies increase, there is a concomitant electronic and photonic contribution that affects the overall performances. Here we show an optical method to...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09527-w
更新日期:2019-04-08 00:00:00
abstract::Radiofrequency switches are critical components in wireless communication systems and consumer electronics. Emerging devices include switches based on microelectromechanical systems and phase-change materials. However, these devices suffer from disadvantages such as large physical dimensions and high actuation voltage...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8519
更新日期:2015-06-25 00:00:00
abstract::As a versatile intermediate, difluorocarbene is an electron-deficient transient species, meaning that its oxidation would be challenging. Herein we show that the oxidation of difluorocarbene could occur smoothly to generate carbonyl fluoride. The oxidation process is confirmed by successful trifluoromethoxylation, 18O...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13359-z
更新日期:2019-11-25 00:00:00
abstract::In the bottom-up synthesis of graphene nanoribbons (GNRs) from self-assembled linear polymer intermediates, surface-assisted cyclodehydrogenations usually take place on catalytic metal surfaces. Here we demonstrate the formation of GNRs from quasi-freestanding polymers assisted by hole injections from a scanning tunne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14815
更新日期:2017-03-13 00:00:00