Arrays of giant octagonal and square cylinders by liquid crystalline self-assembly of X-shaped polyphilic molecules.

abstract：:Microbial fermentation of lignocellulosic biomass to produce industrial chemicals is exacerbated by the recalcitrant network of lignin, cellulose and hemicelluloses comprising the plant secondary cell wall. In this study, we show that transgenic poplar (Populus trichocarpa) lines can be solubilized without any pretrea...

journal_title：Nature communications

authors： Straub CT,Khatibi PA,Wang JP,Conway JM,Williams-Rhaesa AM,Peszlen IM,Chiang VL,Adams MWW,Kelly RM

更新日期：2019-08-07 00:00:00

abstract：:Much controversy exists regarding the structural organization of the yeast centromeric nucleosome and the role of the nonhistone protein, Scm3, in its assembly and architecture. Here we show that the substitution of H3 with its centromeric variant Cse4 results in octameric nucleosomes that organize DNA in a left-hande...

journal_title：Nature communications

authors： Dechassa ML,Wyns K,Li M,Hall MA,Wang MD,Luger K

更新日期：2011-01-01 00:00:00

abstract：:X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a dis...

journal_title：Nature communications

authors： Luijk R,Wu H,Ward-Caviness CK,Hannon E,Carnero-Montoro E,Min JL,Mandaviya P,Müller-Nurasyid M,Mei H,van der Maarel SM,BIOS Consortium.,Relton C,Mill J,Waldenberger M,Bell JT,Jansen R,Zhernakova A,Franke L,'t Hoen PAC

更新日期：2018-09-14 00:00:00

abstract：:One of the fundamental design paradigms in organic photovoltaic device engineering is based on the idea that charge separation is an extrinsically driven process requiring an interface for exciton fission. This idea has driven an enormous materials science engineering effort focused on construction of domain sizes com...

journal_title：Nature communications

authors： Labastide JA,Thompson HB,Marques SR,Colella NS,Briseno AL,Barnes MD

更新日期：2016-02-25 00:00:00

abstract：:Complex behaviours may be viewed as sequences of modular actions, each elicited by specific sensory cues in their characteristic timescales. From this perspective, we can construct models in which unitary behavioural modules are hierarchically placed in context of related actions. Here, we analyse antennal positioning...

journal_title：Nature communications

authors： Natesan D,Saxena N,Ekeberg Ö,Sane SP

更新日期：2019-12-06 00:00:00

abstract：:Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation of iron in macrophages and symptoms of iron deficiency anemia. He...

journal_title：Nature communications

authors： Pan Y,Ren Z,Gao S,Shen J,Wang L,Xu Z,Yu Y,Bachina P,Zhang H,Fan X,Laganowsky A,Yan N,Zhou M

更新日期：2020-11-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Sapkota B,Liang W,VahidMohammadi A,Karnik R,Noy A,Wanunu M

更新日期：2020-07-21 00:00:00

abstract：:It is commonly assumed that neural systems efficiently process natural sensory input. However, the mechanisms by which such efficient processing is achieved, and the consequences for perception and behaviour remain poorly understood. Here we show that small conductance calcium-activated potassium (SK) channels enable ...

journal_title：Nature communications

authors： Huang CG,Zhang ZD,Chacron MJ

更新日期：2016-04-18 00:00:00

abstract：:Many voltage-gated potassium channels open in response to membrane depolarization and then inactivate within milliseconds. Neurons use these channels to tune their excitability. In Shaker K(+) channels, inactivation is caused by the cytoplasmic amino terminus, termed the inactivation gate. Despite having four such gat...

journal_title：Nature communications

authors： Venkataraman G,Srikumar D,Holmgren M

更新日期：2014-06-09 00:00:00

abstract：:Discharge from sliding outlet glaciers controls uncertainty in projections for future sea level. Remarkably, over 90% of glacial area is subject to gravitational driving stresses below 150 kPa (median ∼70 kPa). Longstanding explanations that appeal to the shear-thinning rheology of ice tend to overpredict driving stre...

journal_title：Nature communications

authors： Meyer CR,Downey AS,Rempel AW

更新日期：2018-08-13 00:00:00

abstract：:Modulation of CD8 coreceptor levels can profoundly affect T-cell sensitivity to antigen. Here we show that the heritable downregulation of CD8 during type 2 polarization of murine CD8(+) effector T cells in vitro and in vivo is associated with CpG methylation of several regions of the Cd8a locus. These epigenetic modi...

journal_title：Nature communications

authors： Harland KL,Day EB,Apte SH,Russ BE,Doherty PC,Turner SJ,Kelso A

更新日期：2014-03-28 00:00:00

abstract：:The demand for highly scalable, low-power devices for data storage and logic operations is strongly stimulating research into resistive switching as a novel concept for future non-volatile memory devices. To meet technological requirements, it is imperative to have a set of material design rules based on fundamental m...

journal_title：Nature communications

authors： Baeumer C,Schmitz C,Ramadan AH,Du H,Skaja K,Feyer V,Müller P,Arndt B,Jia CL,Mayer J,De Souza RA,Michael Schneider C,Waser R,Dittmann R

更新日期：2015-10-19 00:00:00

abstract：:Negative gas adsorption (NGA) in ordered mesoporous solids is associated with giant contractive structural transitions traversing through metastable states. Here, by systematically downsizing the crystal dimensions of a mesoporous MOF (DUT-49) from several micrometers to less than 200 nm, counterintuitive NGA phenomen...

journal_title：Nature communications

authors： Krause S,Bon V,Senkovska I,Többens DM,Wallacher D,Pillai RS,Maurin G,Kaskel S

更新日期：2018-04-20 00:00:00

abstract：:We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outcome. An APOBEC mutat...

journal_title：Nature communications

authors： Walker BA,Wardell CP,Murison A,Boyle EM,Begum DB,Dahir NM,Proszek PZ,Melchor L,Pawlyn C,Kaiser MF,Johnson DC,Qiang YW,Jones JR,Cairns DA,Gregory WM,Owen RG,Cook G,Drayson MT,Jackson GH,Davies FE,Morgan GJ

更新日期：2015-04-23 00:00:00

abstract：:Collective cell migration mediates multiple tissue morphogenesis processes. Yet how multi-dimensional mesenchymal cell movements are coordinated remains mostly unknown. Here we report that coordinated mesenchymal cell migration during chicken feather elongation is accompanied by dynamic changes of bioelectric currents...

journal_title：Nature communications

authors： Li A,Cho JH,Reid B,Tseng CC,He L,Tan P,Yeh CY,Wu P,Li Y,Widelitz RB,Zhou Y,Zhao M,Chow RH,Chuong CM

更新日期：2018-12-18 00:00:00

abstract：:Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo. However, understanding how development varies across individuals and, in particular, the influence of common genetic variants during this process has not been characte...

journal_title：Nature communications

authors： Cuomo ASE,Seaton DD,McCarthy DJ,Martinez I,Bonder MJ,Garcia-Bernardo J,Amatya S,Madrigal P,Isaacson A,Buettner F,Knights A,Natarajan KN,HipSci Consortium.,Vallier L,Marioni JC,Chhatriwala M,Stegle O

更新日期：2020-02-10 00:00:00

abstract：:Shigella, the agent of bacillary dysentery, invades epithelial cells by locally inducing actin reorganization. Upon cell invasion, Shigella induces calcium (Ca(2+)) signalling, but its role in invasion has remained unclear. Here we show that components involved in inositol 1, 4, 5- trisphosphate (InsP3) signalling are...

journal_title：Nature communications

authors： Tran Van Nhieu G,Kai Liu B,Zhang J,Pierre F,Prigent S,Sansonetti P,Erneux C,Kuk Kim J,Suh PG,Dupont G,Combettes L

更新日期：2013-01-01 00:00:00

abstract：:Non-Abelian quasiparticles have been predicted to exist in a variety of condensed matter systems. Their defining property is that an adiabatic braid between two of them results in a non-trivial change of the quantum state of the system. The simplest non-Abelian quasiparticles--the Majorana bound states--can occur in o...

journal_title：Nature communications

authors： Li J,Neupert T,Bernevig BA,Yazdani A

更新日期：2016-01-21 00:00:00

abstract：:Silk and silk fibroin, the biomaterial from nature, nowadays are being widely utilized in many cutting-edge micro/nanodevices/systems via advanced micro/nanofabrication techniques. Herein, for the first time to our knowledge, we report aqueous multiphoton lithography of diversiform-regenerated-silk-fibroin-centric ink...

journal_title：Nature communications

authors： Sun YL,Li Q,Sun SM,Huang JC,Zheng BY,Chen QD,Shao ZZ,Sun HB

更新日期：2015-10-16 00:00:00

abstract：:Cells couple growth with division and regulate size in response to nutrient availability. In rod-shaped fission yeast, cell-size control occurs at mitotic commitment. An important regulator is the DYRK-family kinase Pom1, which forms gradients from cell poles and inhibits the mitotic activator Cdr2, itself localized a...

journal_title：Nature communications

authors： Kelkar M,Martin SG

更新日期：2015-10-07 00:00:00

abstract：:Cytochrome P450 monooxygenases are versatile heme-thiolate enzymes that catalyze a wide range of reactions. Self-sufficient cytochrome P450 enzymes contain the redox partners in a single polypeptide chain. Here, we present the crystal structure of full-length CYP116B46, a self-sufficient P450. The continuous polypepti...

journal_title：Nature communications

authors： Zhang L,Xie Z,Liu Z,Zhou S,Ma L,Liu W,Huang JW,Ko TP,Li X,Hu Y,Min J,Yu X,Guo RT,Chen CC

更新日期：2020-05-29 00:00:00

abstract：:The Barbier reaction, a widely utilized reaction for carbon-carbon bond formation, has played important roles in modern organic chemistry for more than a century. Here, we show its successful introduction to polymer chemistry. Through one-pot Barbier polyaddition (both A2+B2 type and AB type) of monomers containing an...

journal_title：Nature communications

authors： Sun XL,Liu DM,Tian D,Zhang XY,Wu W,Wan WM

更新日期：2017-10-31 00:00:00

abstract：:Nacre-mimetics hold great promise as mechanical high-performance and functional materials. Here we demonstrate large progress of mechanical and functional properties of self-assembled polymer/nanoclay nacre-mimetics by using synthetic nanoclays with aspect ratios covering three orders in magnitude (25-3,500). We estab...

journal_title：Nature communications

authors： Das P,Malho JM,Rahimi K,Schacher FH,Wang B,Demco DE,Walther A

更新日期：2015-01-20 00:00:00

abstract：:Venomous animals are thought to inject the same combination of toxins for both predation and defence, presumably exploiting conserved target pharmacology across prey and predators. Remarkably, cone snails can rapidly switch between distinct venoms in response to predatory or defensive stimuli. Here, we show that the d...

journal_title：Nature communications

authors： Dutertre S,Jin AH,Vetter I,Hamilton B,Sunagar K,Lavergne V,Dutertre V,Fry BG,Antunes A,Venter DJ,Alewood PF,Lewis RJ

更新日期：2014-03-24 00:00:00

abstract：:The development of high efficiency solar cells relies on the management of electronic and optical properties that need to be accurately measured. As the conversion efficiencies increase, there is a concomitant electronic and photonic contribution that affects the overall performances. Here we show an optical method to...

journal_title：Nature communications

authors： Bercegol A,Ory D,Suchet D,Cacovich S,Fournier O,Rousset J,Lombez L

更新日期：2019-04-08 00:00:00

abstract：:Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-probe specific lineages, especially at early developmental stages prior to expression of unique molecular markers. Here, we use a genetic immortalization method to analyze t...

journal_title：Nature communications

authors： Chai PC,Cruchet S,Wigger L,Benton R

更新日期：2019-02-07 00:00:00

abstract：:Exosomes are nanometer-sized lipid vesicles present in liquid biopsies and used as biomarkers for several diseases including cancer, Alzheimer's, and central nervous system diseases. Purification and subsequent size and surface characterization are essential to exosome-based diagnostics. Sample purification is, howeve...

journal_title：Nature communications

authors： Rasmussen MK,Pedersen JN,Marie R

更新日期：2020-05-11 00:00:00

abstract：:To cause food-borne botulism, botulinum neurotoxin (BoNT) in the gastrointestinal lumen must traverse the intestinal epithelial barrier. However, the mechanism by which BoNT crosses the intestinal epithelial barrier remains unclear. BoNTs are produced along with one or more non-toxic components, with which they form p...

journal_title：Nature communications

authors： Matsumura T,Sugawara Y,Yutani M,Amatsu S,Yagita H,Kohda T,Fukuoka S,Nakamura Y,Fukuda S,Hase K,Ohno H,Fujinaga Y

更新日期：2015-02-17 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating resid...

journal_title：Nature communications

authors： Dallari S,Macal M,Loureiro ME,Jo Y,Swanson L,Hesser C,Ghosh P,Zuniga EI

更新日期：2017-04-03 00:00:00

abstract：:Neural responses in the cerebral cortex change dramatically between the 'synchronized' state during sleep and 'desynchronized' state during wakefulness. Our understanding of cortical state emerges largely from experiments performed in sensory areas of head-fixed or tethered rodents due to technical limitations of reco...

journal_title：Nature communications

authors： Milton R,Shahidi N,Dragoi V

更新日期：2020-04-23 00:00:00