Oxidation of difluorocarbene and subsequent trifluoromethoxylation.

Abstract:

:As a versatile intermediate, difluorocarbene is an electron-deficient transient species, meaning that its oxidation would be challenging. Herein we show that the oxidation of difluorocarbene could occur smoothly to generate carbonyl fluoride. The oxidation process is confirmed by successful trifluoromethoxylation, 18O-trifluoromethoxylation, the observation of AgOCF3 species, and DFT calculations.

journal_name

Nat Commun

journal_title

Nature communications

authors

Yu J,Lin JH,Yu D,Du R,Xiao JC

doi

10.1038/s41467-019-13359-z

subject

Has Abstract

pub_date

2019-11-25 00:00:00

pages

5362

issue

1

issn

2041-1723

pii

10.1038/s41467-019-13359-z

journal_volume

10

pub_type

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