Abstract:
:Solitary chemosensory cells (SCCs) are epithelial sentinels that utilize bitter Tas2r receptors and coupled taste transduction elements to detect pathogenic bacterial metabolites, triggering host defenses to control the infection. Here we report that SCCs are present in mouse gingival junctional epithelium, where they express several Tas2rs and the taste signaling components α-gustducin (Gnat3), TrpM5, and Plcβ2. Gnat3-/- mice have altered commensal oral microbiota and accelerated naturally occurring alveolar bone loss. In ligature-induced periodontitis, knockout of taste signaling molecules or genetic absence of gingival SCCs (gSCCs) increases the bacterial load, reduces bacterial diversity, and renders the microbiota more pathogenic, leading to greater alveolar bone loss. Topical treatment with bitter denatonium to activate gSCCs upregulates the expression of antimicrobial peptides and ameliorates ligature-induced periodontitis in wild-type but not in Gnat3-/- mice. We conclude that gSCCs may provide a promising target for treating periodontitis by harnessing innate immunity to regulate the oral microbiome.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Zheng X,Tizzano M,Redding K,He J,Peng X,Jiang P,Xu X,Zhou X,Margolskee RFdoi
10.1038/s41467-019-12505-xsubject
Has Abstractpub_date
2019-10-03 00:00:00pages
4496issue
1issn
2041-1723pii
10.1038/s41467-019-12505-xjournal_volume
10pub_type
杂志文章abstract::Enterobacteria, especially Escherichia coli, are abundant in patients with inflammatory bowel disease or colorectal cancer (CRC). However, it is unclear whether cancer is promoted by inflammation-induced expansion of E. coli and/or changes in expression of specific microbial genes. Here we use longitudinal (2, 12 and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5724
更新日期:2014-09-03 00:00:00
abstract::Understanding the behaviour of thermally excited many-particle systems, composed of a single particle type having a well-defined shape and size, is important in condensed matter, notably protein crystallization. Here we observe and explain the origin of local chiral symmetry breaking in a surprisingly simple system of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1803
更新日期:2012-05-01 00:00:00
abstract::The cost, size and availability of electron accelerators are dominated by the achievable accelerating gradient. Conventional high-brightness radio-frequency accelerating structures operate with 30-50 MeV m(-1) gradients. Electron accelerators driven with optical or infrared sources have demonstrated accelerating gradi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9486
更新日期:2015-10-06 00:00:00
abstract::The development of theories and methods devoted to the accurate calculation of the electronic quasi-particle states and levels of molecules, clusters and solids is of prime importance to interpret the experimental data. These quantum systems are often modelled by using the Born-Oppenheimer approximation where the coup...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11327
更新日期:2016-04-22 00:00:00
abstract::Aortic dissection and intramural haematoma comprise an aortopathy involving separation of the aortic wall. Underlying mechanisms of the condition remain unclear. Here we show that granulocyte macrophage colony-stimulating factor (GM-CSF) is a triggering molecule for this condition. Transcription factor Krüppel-like fa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7994
更新日期:2015-04-29 00:00:00
abstract::The 2018 summit and flank eruption of Kīlauea Volcano was one of the largest volcanic events in Hawai'i in 200 years. Data suggest that a backup in the magma plumbing system at the long-lived Pu'u 'Ō'ō eruption site caused widespread pressurization in the volcano, driving magma into the lower flank. The eruption evolv...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-19190-1
更新日期:2020-11-06 00:00:00
abstract::Antiaromatic and open-shell molecules are attractive because of their distinct electronic and magnetic behaviour. However, their increased reactivity creates a challenge for probing their properties. Here, we describe the on-surface and in-solution generation and characterisation of a highly reactive antiaromatic mole...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03368-9
更新日期:2018-03-22 00:00:00
abstract::Amazonian Dark Earths (ADEs) are unusually fertile soils characterised by elevated concentrations of microscopic charcoal particles, which confer their distinctive colouration. Frequent occurrences of pre-Columbian artefacts at ADE sites led to their ubiquitous classification as Anthrosols (soils of anthropic origin)....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20184-2
更新日期:2021-01-04 00:00:00
abstract::The relationships of passerines (such as the well-studied zebra finch) with non-passerine birds is one of the great enigmas of avian phylogenetic research, because decades of extensive morphological and molecular studies yielded highly inconsistent results between and within data sets. Here we show the first applicati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1448
更新日期:2011-08-23 00:00:00
abstract::Transmission-blocking interventions aim to reduce the prevalence of infection in endemic communities by targeting Plasmodium within the insect host. Although many studies have reported the successful reduction of infection in the mosquito vector, direct evidence that there is an onward reduction in infection in the ve...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2840
更新日期:2013-01-01 00:00:00
abstract::Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of human immunodeficiency virus-1 (HIV-1) viral particles, mediates interactions between HIV-1 and Siglec1/CD169, a protein expressed on dendritic cells (DCs). Such interactions, which seem to be independent of viral envelope glycoprotein g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5136
更新日期:2014-06-20 00:00:00
abstract::Single-atom catalysts have recently been applied in many applications such as CO oxidation. Experimental in situ investigations into this reaction, however, are limited. Hereby, we present a suite of operando/in situ spectroscopic experiments for structurally well-defined atomically dispersed Rh on phosphotungstic aci...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09188-9
更新日期:2019-03-22 00:00:00
abstract::Under pathophysiological conditions in adults, endothelial cells (ECs) sprout from pre-existing blood vessels to form new ones by a process termed angiogenesis. During embryonic development, Apelin (APLN) is robustly expressed in vascular ECs. In adult mice, however, APLN expression in the vasculature is significantly...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7020
更新日期:2015-01-19 00:00:00
abstract::Mammalian and Drosophila genomes are partitioned into topologically associating domains (TADs). Although this partitioning has been reported to be functionally relevant, it is unclear whether TADs represent true physical units located at the same genomic positions in each cell nucleus or emerge as an average of numero...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20292-z
更新日期:2021-01-04 00:00:00
abstract::Printed electronics offer a breakthrough in the penetration of information technology into everyday life. The possibility of printing electronic circuits will further promote the spread of the Internet of Things applications. Inks based on graphene have a chance to dominate this technology, as they potentially can be ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07632-w
更新日期:2018-12-05 00:00:00
abstract::Lithium metal batteries have been considerably limited by the problems of uncontrolled dendritic lithium formation and the highly reactive nature of lithium with electrolytes. Herein, we have developed functional porous bilayer composite separators by simply blade-coating polyacrylamide-grafted graphene oxide molecula...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09211-z
更新日期:2019-03-25 00:00:00
abstract::Analysis of potentially interconnected residential water and energy demand is sparse. In a 1-in-10 random sample of Singapore households living in apartments, water use per capita declines over the socioeconomic distribution, whereas electricity use rises. Here I show that in this leading Asian city and tropical clima...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07833-3
更新日期:2018-12-20 00:00:00
abstract::Although a hydrophobic microtexture at a solid surface most often reflects rain owing to the presence of entrapped air within the texture, it is much more challenging to repel hot water. As it contacts a colder material, hot water generates condensation within the cavities at the solid surface, which eventually builds...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09456-8
更新日期:2019-03-29 00:00:00
abstract::The human gastric mucosa is the most active layer of the stomach wall, involved in food digestion, metabolic processes and gastric carcinogenesis. Anatomically, the human stomach is divided into seven regions, but the protein basis for cellular specialization is not well understood. Here we present a global analysis o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07960-x
更新日期:2019-01-03 00:00:00
abstract::The original HTML version of this Article had an incorrect Published online date of 20 March 2019; it should have been 18 March 2019. This has been corrected in the HTML version of the Article. The PDF version was correct from the time of publication. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-09797-4
更新日期:2019-04-18 00:00:00
abstract::Naturally occurring single crystals having a multidomain morphology are a counterintuitive phenonomon: the macroscopic appearance is expected to follow the symmetry of the unit cell. Growing such crystals in the lab is a great challenge, especially from organic molecules. We achieve here uniform metallo-organic crysta...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13925-5
更新日期:2020-01-20 00:00:00
abstract::Astrocytic endfeet cover the entire cerebral vasculature and serve as exchange sites for ions, metabolites and energy substrates from the blood to the brain. They maintain endothelial tight junctions that form the blood-brain barrier (BBB) and release vasoactive molecules that regulate vascular tone. Malignant gliomas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5196
更新日期:2014-06-19 00:00:00
abstract::The bacterial effector MavC catalyzes non-canonical ubiquitination of host E2 enzyme UBE2N without engaging any of the conventional ubiquitination machinery, thereby abolishing UBE2N's function in forming K63-linked ubiquitin (Ub) chains and dampening NF-кB signaling. We now report the structures of MavC in complex wi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16587-w
更新日期:2020-06-02 00:00:00
abstract::We developed a computer-aided analysis tool for quantitatively determining bioluminescent reporter distributions inside small animals. The core innovations are a body-fitting animal shuttle and a statistical mouse atlas, both of which are spatially aligned and scaled according to the animal's weight, and hence provide...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06288-w
更新日期:2018-10-15 00:00:00
abstract::Single-nucleotide substitutions are a defining characteristic of cancer genomes. Many single-nucleotide substitutions in cancer genomes arise because of errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA replication patterns help shape the mutational landscapes of normal and can...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2502
更新日期:2013-01-01 00:00:00
abstract::Zika virus is a mosquito-borne flavivirus closely related to dengue virus that can cause severe disease in humans, including microcephaly in newborns and Guillain-Barré syndrome in adults. Specific treatments and vaccines for Zika virus are not currently available. Here, we isolate and characterize four monoclonal ant...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07008-0
更新日期:2018-11-01 00:00:00
abstract::For the large-scale sustainable implementation of polymer electrolyte membrane fuel cells in vehicles, high-performance electrocatalysts with low platinum consumption are desirable for use as cathode material during the oxygen reduction reaction in fuel cells. Here we report a carbon black-supported cost-effective, ef...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15938
更新日期:2017-07-24 00:00:00
abstract::Colloidal interactions in nematic liquid crystals can be described as interactions between elastic multipoles that depend on particle shape, topology, chirality, boundary conditions and induced topological defects. Here, we describe a nematic colloidal system consisting of mesostructures of gold capable of inducing el...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14031-2
更新日期:2020-01-10 00:00:00
abstract::Tandem organic solar cells are based on the device structure monolithically connecting two solar cells to broaden overall absorption spectrum and utilize the photon energy more efficiently. Herein, we demonstrate a simple strategy of inserting a double bond between the central core and end groups of the small molecule...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20431-6
更新日期:2021-01-08 00:00:00
abstract::Recent years have seen great advances in the development of synthetic self-assembling molecular systems. Designing out-of-equilibrium architectures, however, requires a more subtle control over the thermodynamics and kinetics of reactions. We propose a mechanism for enhancing the thermodynamic drive of DNA strand-disp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16353-y
更新日期:2020-05-22 00:00:00