Abstract：
:Under pathophysiological conditions in adults, endothelial cells (ECs) sprout from pre-existing blood vessels to form new ones by a process termed angiogenesis. During embryonic development, Apelin (APLN) is robustly expressed in vascular ECs. In adult mice, however, APLN expression in the vasculature is significantly reduced. Here we show that APLN expression is reactivated in adult ECs after ischaemia insults. In models of both injury ischaemia and tumor angiogenesis, we find that Apln-CreER genetically labels sprouting but not quiescent vasculature. By leveraging this specific activity, we demonstrate that abolishment of the VEGF-VEGFR2 signalling pathway as well as ablation of sprouting ECs diminished tumour vascularization and growth without compromising vascular homeostasis in other organs. Collectively, we show that Apln-CreER distinguishes sprouting vessels from stabilized vessels in multiple pathological settings. The Apln-CreER line described here will greatly aid future mechanistic studies in both vascular developmental biology and adult vascular diseases.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Liu Q,Hu T,He L,Huang X,Tian X,Zhang H,He L,Pu W,Zhang L,Sun H,Fang J,Yu Y,Duan S,Hu C,Hui L,Zhang H,Quertermous T,Xu Q,Red-Horse K,Wythe JD,Zhou Bdoi
10.1038/ncomms7020subject
Has Abstractpub_date
2015-01-19 00:00:00pages
6020issn
2041-1723pii
ncomms7020journal_volume
6pub_type
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