Abstract:
:The original HTML version of this Article had an incorrect Published online date of 20 March 2019; it should have been 18 March 2019. This has been corrected in the HTML version of the Article. The PDF version was correct from the time of publication.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal Bdoi
10.1038/s41467-019-09797-4subject
Has Abstractpub_date
2019-04-18 00:00:00pages
1910issue
1issn
2041-1723pii
10.1038/s41467-019-09797-4journal_volume
10pub_type
已发布勘误abstract::R-loops are stable nucleic acid structures that have important physiological functions, but which also pose a significant threat to genomic stability. Increased R-loops cause replication stress and chromosome fragility and have been associated with diseases such as neurodegeneration and cancer. Although excessive R-lo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06677-1
更新日期:2018-10-19 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-020-15018-0
更新日期:2020-02-25 00:00:00
abstract::The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine essential for the virulence of many disease causing Gram-negative bacteria. At the core of the injectisome structure is the needle complex, a continuous channel formed by the highly oligomerized inner and outer membrane hollow rin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06298-8
更新日期:2018-09-21 00:00:00
abstract::Habituation and dishabituation modulate the neural resources and behavioral significance allocated to incoming stimuli across the sensory systems. We characterize these processes in the mouse olfactory bulb (OB) and uncover a role for OB acetylcholine (ACh) in physiological and behavioral olfactory dishabituation. We ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04371-w
更新日期:2018-05-14 00:00:00
abstract::The yeast Rab5 homologue, Vps21p, is known to be involved both in the vacuolar protein sorting (VPS) pathway from the trans-Golgi network to the vacuole, and in the endocytic pathway from the plasma membrane to the vacuole. However, the intracellular location at which these two pathways converge remains unclear. In ad...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4498
更新日期:2014-03-25 00:00:00
abstract::Developing physical models of complex dynamic systems showing emergent behaviour is key to informing on persistence and replication in biology, how living matter emerges from chemistry, and how to design systems with new properties. Herein we report a fully synthetic small molecule system in which a surfactant replica...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04670-2
更新日期:2018-06-08 00:00:00
abstract::Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes. We report here a cryo-electron microscopy structure of a single insulin bound to a physiologically relevant, high-affinity version of the receptor ectodomain, th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06826-6
更新日期:2018-10-24 00:00:00
abstract::The human gastric mucosa is the most active layer of the stomach wall, involved in food digestion, metabolic processes and gastric carcinogenesis. Anatomically, the human stomach is divided into seven regions, but the protein basis for cellular specialization is not well understood. Here we present a global analysis o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07960-x
更新日期:2019-01-03 00:00:00
abstract::POT1 and TPP1 are part of the shelterin complex and are essential for telomere length regulation and maintenance. Naturally occurring mutations of the telomeric POT1-TPP1 complex are implicated in familial glioma, melanoma and chronic lymphocytic leukaemia. Here we report the atomic structure of the interacting portio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14928
更新日期:2017-04-10 00:00:00
abstract::Mapping neuroanatomy is a foundational goal towards understanding brain function. Electron microscopy (EM) has been the gold standard for connectivity analysis because nanoscale resolution is necessary to unambiguously resolve synapses. However, molecular information that specifies cell types is often lost in EM recon...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18422-8
更新日期:2020-09-15 00:00:00
abstract::Tropical south-western Pacific temperatures are of vital importance to the Great Barrier Reef (GBR), but the role of sea surface temperatures (SSTs) in the growth of the GBR since the Last Glacial Maximum remains largely unknown. Here we present records of Sr/Ca and δ(18)O for Last Glacial Maximum and deglacial corals...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5102
更新日期:2014-06-17 00:00:00
abstract::Common variable immunodeficiency disorder (CVID) is the most common symptomatic primary immunodeficiency in adults, characterized by B-cell abnormalities and inadequate antibody response. CVID patients have considerable autoimmune comorbidity and we therefore hypothesized that genetic susceptibility to CVID may overla...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7804
更新日期:2015-04-20 00:00:00
abstract::Human-induced ocean acidification and warming alter seawater carbonate chemistry reducing the calcification of reef-building crustose coralline algae (CCA), which has implications for reef stability. However, due to the presence of multiple carbonate minerals with different solubilities in seawater, the algal mineralo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4310
更新日期:2014-01-01 00:00:00
abstract::Coupling vibrational transitions to resonant optical modes creates vibrational polaritons shifted from the uncoupled molecular resonances and provides a convenient way to modify the energetics of molecular vibrations. This approach is a viable method to explore controlling chemical reactivity. In this work, we report ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13504
更新日期:2016-11-22 00:00:00
abstract::Compared with noble metals, semiconductors with surface plasmon resonance effect are another type of SERS substrate materials. The main obstacles so far are that the semiconducting materials are often unstable and easy to be further oxidized or decomposed by laser irradiating or contacting with corrosive substances. H...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14903
更新日期:2017-04-24 00:00:00
abstract::Fibronectin fibrils within the extracellular matrix play central roles in physiological and pathological processes, yet many structural details about their hierarchical and molecular assembly remain unknown. Here we combine site-specific protein labelling with single-molecule localization by stepwise photobleaching or...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8275
更新日期:2015-06-04 00:00:00
abstract::Essential components of animal behaviour are modulated by dopaminergic (DA) and noradrenergic circuitry. In this study, we reveal at cellular resolution the complete set of projections ('projectome') of every single type of DA and noradrenergio neurons in the central nervous system of zebrafish larvae. The most extens...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1171
更新日期:2011-01-25 00:00:00
abstract::Polymersomes are bilayer vesicles, self-assembled from amphiphilic block copolymers. They are versatile nanocapsules with adjustable properties, such as flexibility, permeability, size and functionality. However, so far no methodological approach to control their shape exists. Here we demonstrate a mechanistically ful...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12606
更新日期:2016-08-25 00:00:00
abstract::The alloy-design strategy of combining multiple elements in near-equimolar ratios has shown great potential for producing exceptional engineering materials, often known as 'high-entropy alloys'. Understanding the elemental distribution, and, thus, the evolution of the configurational entropy during solidification, is ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6964
更新日期:2015-01-20 00:00:00
abstract::Calcium ions (Ca(2+)) function as universal second messengers in eukaryotic cells, including immune cells. Ca(2+) is crucial for peripheral T-lymphocyte activation and effector functions, and influences thymocyte selection and motility in the developing thymus. However, the role of Ca(2+) signalling in early T-lymphoc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5814
更新日期:2014-09-12 00:00:00
abstract::Graphene flakes with giant shape anisotropy are extensively used to establish connectedness electrical percolation in various heterogeneous systems. However, the percolation behaviour of graphene flakes has been recently predicted to be far more complicated than generally anticipated on the basis of excluded volume ar...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9700
更新日期:2015-11-16 00:00:00
abstract::Wilms tumor gene on the X chromosome (WTX) is a putative tumor suppressor gene in Wilms tumor, but its expression and functions in other tumors are unclear. Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in women and the second leading cause in men in the United States. We demonstrated tha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07998-x
更新日期:2019-01-10 00:00:00
abstract::Spin-based devices offer non-volatile, scalable, low power and reprogrammable functionality for emerging device technologies. Here we fabricate nanoscale spintronic devices with ferromagnetic metal/single-layer graphene tunnel barriers used to generate spin accumulation and spin currents in a silicon nanowire transpor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8541
更新日期:2015-06-19 00:00:00
abstract::Identifying regions important for spreading and mediating perturbations is crucial to assess the susceptibilities of spatio-temporal complex systems such as the Earth's climate to volcanic eruptions, extreme events or geoengineering. Here a data-driven approach is introduced based on a dimension reduction, causal reco...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9502
更新日期:2015-10-07 00:00:00
abstract::Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-sign...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5926
更新日期:2014-10-29 00:00:00
abstract::Winter Eurasian cooling after the mid-1990s has been verified by numerous studies, although in recent decades, the mid-latitudes of the Northern Hemisphere have been rapidly warming globally. Because the cooling is not uniform at different spatial and temporal scales, over time, this change may not truly reflect the n...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19014-2
更新日期:2020-10-15 00:00:00
abstract::Amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release is proposed to be a crucial early event leading to synapse dysfunction in Alzheimer's disease (AD). In the present study, we report that the release probability (Pr) at the synapse between the Schaffer collateral (SC) and CA1 pyramidal neurons is signif...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09114-z
更新日期:2019-03-13 00:00:00
abstract::Carotenoid cleavage dioxygenases (CCDs) form hormones and signaling molecules. Here we show that a member of an overlooked plant CCD subfamily from rice, that we name Zaxinone Synthase (ZAS), can produce zaxinone, a novel apocarotenoid metabolite in vitro. Loss-of-function mutants (zas) contain less zaxinone, exhibit ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08461-1
更新日期:2019-02-18 00:00:00
abstract::The control of water-intake behavior is critical for life because an excessive water intake induces pathological conditions, such as hyponatremia or water intoxication. However, the brain mechanisms controlling water intake currently remain unclear. We previously reported that thirst-driving neurons (water neurons) in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19191-0
更新日期:2020-11-10 00:00:00
abstract::The original version of this Article incorrectly omitted an affiliation of Hongming Weng: "Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, 100190, Beijing, China"This has been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-06643-x
更新日期:2018-10-08 00:00:00