Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate.

abstract：:Human hnRNP A2/B1 is an RNA-binding protein that plays important roles in many biological processes, including maturation, transport, and metabolism of mRNA, and gene regulation of long noncoding RNAs. hnRNP A2/B1 was reported to control the microRNAs sorting to exosomes and promote primary microRNA processing as a po...

journal_title：Nature communications

authors： Wu B,Su S,Patil DP,Liu H,Gan J,Jaffrey SR,Ma J

更新日期：2018-01-29 00:00:00

abstract：:The mammalian neocortex is subdivided into cytoarchitectural areas with distinct connectivity, gene expression and neural functions. Areal identity is initially specified by rostrocaudal and mediolateral gene expression gradients in neuroepithelial and radial glial progenitors (the 'protomap'). On further differentiat...

journal_title：Nature communications

authors： Alfano C,Magrinelli E,Harb K,Hevner RF,Studer M

更新日期：2014-12-05 00:00:00

abstract：:Hydrogen, the simplest element in the universe, has a surprisingly complex phase diagram. Because of applications to planetary science, inertial confinement fusion and fundamental physics, its high-pressure properties have been the subject of intense study over the past two decades. While sophisticated static experime...

journal_title：Nature communications

authors： Davis P,Döppner T,Rygg JR,Fortmann C,Divol L,Pak A,Fletcher L,Becker A,Holst B,Sperling P,Redmer R,Desjarlais MP,Celliers P,Collins GW,Landen OL,Falcone RW,Glenzer SH

更新日期：2016-04-15 00:00:00

abstract：:5S rRNA is an indispensable component of cytoplasmic ribosomes in all species. The functions of 5S rRNA and the reasons for its evolutionary preservation as an independent molecule remain unclear. Here we used ribosome engineering to investigate whether 5S rRNA autonomy is critical for ribosome function and cell survi...

journal_title：Nature communications

authors： Huang S,Aleksashin NA,Loveland AB,Klepacki D,Reier K,Kefi A,Szal T,Remme J,Jaeger L,Vázquez-Laslop N,Korostelev AA,Mankin AS

更新日期：2020-06-09 00:00:00

abstract：:The original version of this Article contained errors in the units of concentration of three reagents listed in the Methods. These errors have all been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Stepanauskas R,Fergusson EA,Brown J,Poulton NJ,Tupper B,Labonté JM,Becraft ED,Brown JM,Pachiadaki MG,Povilaitis T,Thompson BP,Mascena CJ,Bellows WK,Lubys A

更新日期：2017-12-12 00:00:00

abstract：:The intrinsic variability of switching behavior in memristors has been a major obstacle to their adoption as the next generation of universal memory. On the other hand, this natural stochasticity can be valuable for hardware security applications. Here we propose and demonstrate a novel true random number generator ut...

journal_title：Nature communications

authors： Jiang H,Belkin D,Savel'ev SE,Lin S,Wang Z,Li Y,Joshi S,Midya R,Li C,Rao M,Barnell M,Wu Q,Yang JJ,Xia Q

更新日期：2017-10-12 00:00:00

abstract：:Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer's and Parkinson's disease; thus, increasing PGRN levels is a promising therapeutic f...

journal_title：Nature communications

authors： Nicholson AM,Finch NA,Almeida M,Perkerson RB,van Blitterswijk M,Wojtas A,Cenik B,Rotondo S,Inskeep V,Almasy L,Dyer T,Peralta J,Jun G,Wood AR,Frayling TM,Fuchsberger C,Fowler S,Teslovich TM,Manning AK,Kumar S,Curra

更新日期：2016-06-30 00:00:00

abstract：:Here we report a rational strategy to orthogonally control assembly and disassembly of DNA-based nanostructures using specific IgG antibodies as molecular inputs. We first demonstrate that the binding of a specific antibody to a pair of antigen-conjugated split DNA input-strands induces their co-localization and recon...

journal_title：Nature communications

authors： Ranallo S,Sorrentino D,Ricci F

更新日期：2019-12-03 00:00:00

abstract：:Microbial fatty acid-derived fuels have emerged as promising alternatives to petroleum-based transportation fuels. Here we report a modular engineering approach that systematically removed metabolic pathway bottlenecks and led to significant titre improvements in a multi-gene fatty acid metabolic pathway. On the basis...

journal_title：Nature communications

authors： Xu P,Gu Q,Wang W,Wong L,Bower AG,Collins CH,Koffas MA

更新日期：2013-01-01 00:00:00

abstract：:Erythropoietin (Epo) supports both primitive erythropoiesis in the yolk sac and definitive erythropoiesis in the fetal liver and bone marrow. Although definitive erythropoiesis requires kidney- and liver-secreted Epo, it is unclear which cells produce Epo for primitive erythropoiesis. Here we find neural Epo-producing...

journal_title：Nature communications

authors： Suzuki N,Hirano I,Pan X,Minegishi N,Yamamoto M

更新日期：2013-01-01 00:00:00

abstract：:Face recognition is highly proficient in humans and other social primates; it emerges in infancy, but the development of the neural mechanisms supporting this behaviour is largely unknown. We use blood-volume functional MRI to monitor longitudinally the responsiveness to faces, scrambled faces, and objects in macaque ...

journal_title：Nature communications

authors： Livingstone MS,Vincent JL,Arcaro MJ,Srihasam K,Schade PF,Savage T

更新日期：2017-03-31 00:00:00

abstract：:Metal ions at the active site of an enzyme act as cofactors, and their dynamic fluctuations can potentially influence enzyme activity. Here, we use λ-exonuclease as a model enzyme with two Mg2+ binding sites and probe activity at various concentrations of magnesium by single-molecule-FRET. We find that while MgA2+ and...

journal_title：Nature communications

authors： Hwang W,Yoo J,Lee Y,Park S,Hoang PL,Cho H,Yu J,Hoa Vo TM,Shin M,Jin MS,Park D,Hyeon C,Lee G

更新日期：2018-10-23 00:00:00

abstract：:Nucleoplasmin (Npm) is a highly conserved histone chaperone responsible for the maternal storage and zygotic release of histones H2A/H2B. Npm contains a pentameric N-terminal core domain and an intrinsically disordered C-terminal tail domain. Though intrinsically disordered regions are common among histone chaperones,...

journal_title：Nature communications

authors： Warren C,Matsui T,Karp JM,Onikubo T,Cahill S,Brenowitz M,Cowburn D,Girvin M,Shechter D

更新日期：2017-12-20 00:00:00

abstract：:Loss of seed dispersal is a key agronomical trait targeted by ancient human selection and has been regarded as a milestone of crop domestication. In this study, in the legume crop soybean Glycine max (L.) Merr. which provides vegetable oils and proteins for humans, we show that the key cellular feature of the shatteri...

journal_title：Nature communications

authors： Dong Y,Yang X,Liu J,Wang BH,Liu BL,Wang YZ

更新日期：2014-01-01 00:00:00

abstract：:Central spin decoherence caused by nuclear spin baths is often a critical issue in various quantum computing schemes, and it has also been used for sensing single-nuclear spins. Recent theoretical studies suggest that central spin decoherence can act as a probe of many-body physics in spin baths; however, identificati...

journal_title：Nature communications

authors： Ma WL,Wolfowicz G,Zhao N,Li SS,Morton JJ,Liu RB

更新日期：2014-09-10 00:00:00

abstract：:HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide ("Man9-V3") for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage ("DH270"), to visualize the epitope...

journal_title：Nature communications

authors： Fera D,Lee MS,Wiehe K,Meyerhoff RR,Piai A,Bonsignori M,Aussedat B,Walkowicz WE,Ton T,Zhou JO,Danishefsky S,Haynes BF,Harrison SC

更新日期：2018-03-16 00:00:00

abstract：:The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology, but how proteins localize differentially to these structures within a shared cytoplasm remains unclear. Here, we show that the actin-binding domains of accessory proteins can be sensitive to filament conform...

journal_title：Nature communications

authors： Harris AR,Jreij P,Belardi B,Joffe AM,Bausch AR,Fletcher DA

更新日期：2020-11-25 00:00:00

abstract：:Standard optical tweezers rely on optical forces arising when a focused laser beam interacts with a microscopic particle: scattering forces, pushing the particle along the beam direction, and gradient forces, attracting it towards the high-intensity focal spot. Importantly, the incoming laser beam is not affected by t...

journal_title：Nature communications

authors： Kalantarifard F,Elahi P,Makey G,Maragò OM,Ilday FÖ,Volpe G

更新日期：2019-06-18 00:00:00

abstract：:Metal-support interaction is of great significance for catalysis as it can induce charge transfer between metal and support, tame electronic structure of supported metals, impact adsorption energy of reaction intermediates, and eventually change the catalytic performance. Here, we report the metal size-dependent charg...

journal_title：Nature communications

authors： Yan QQ,Wu DX,Chu SQ,Chen ZQ,Lin Y,Chen MX,Zhang J,Wu XJ,Liang HW

更新日期：2019-10-31 00:00:00

abstract：:In addition to acting as a cellular energy source, ATP can also act as a damage-associated molecular pattern in both animals and plants. Stomata are leaf pores that control gas exchange and, therefore, impact critical functions such as photosynthesis, drought tolerance, and also are the preferred entry point for patho...

journal_title：Nature communications

authors： Chen D,Cao Y,Li H,Kim D,Ahsan N,Thelen J,Stacey G

更新日期：2017-12-22 00:00:00

abstract：:Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar ...

journal_title：Nature communications

authors： Karabin NB,Allen S,Kwon HK,Bobbala S,Firlar E,Shokuhfar T,Shull KR,Scott EA

更新日期：2018-02-12 00:00:00

abstract：:Spontaneous molecular oscillations are ubiquitous in biology. But to our knowledge, periodic cell migratory patterns have not been observed. Here we report the highly regular, periodic migration of cells along rectilinear tracks generated inside three-dimensional matrices, with each excursion encompassing several cell...

journal_title：Nature communications

authors： Fraley SI,Feng Y,Giri A,Longmore GD,Wirtz D

更新日期：2012-03-06 00:00:00

abstract：:Conventional implementations of two-dimensional electronic spectroscopy typically spatially average over ~1010 chromophores spread over ~104 micron square area, limiting their ability to characterize spatially heterogeneous samples. Here we present a variation of two-dimensional electronic spectroscopy that is capable...

journal_title：Nature communications

authors： Tiwari V,Matutes YA,Gardiner AT,Jansen TLC,Cogdell RJ,Ogilvie JP

更新日期：2018-10-11 00:00:00

abstract：:Momentum and spin represent fundamental dynamic properties of quantum particles and fields. In particular, propagating optical waves (photons) carry momentum and longitudinal spin determined by the wave vector and circular polarization, respectively. Here we show that exactly the opposite can be the case for evanescen...

journal_title：Nature communications

authors： Bliokh KY,Bekshaev AY,Nori F

更新日期：2014-03-06 00:00:00

abstract：:In vivo electronic monitoring systems are promising technology to obtain biosignals with high spatiotemporal resolution and sensitivity. Here we demonstrate the fabrication of a biocompatible highly conductive gel composite comprising multi-walled carbon nanotube-dispersed sheet with an aqueous hydrogel. This gel comp...

journal_title：Nature communications

authors： Sekitani T,Yokota T,Kuribara K,Kaltenbrunner M,Fukushima T,Inoue Y,Sekino M,Isoyama T,Abe Y,Onodera H,Someya T

更新日期：2016-04-29 00:00:00

abstract：:Replication errors are the main cause of mitochondrial DNA (mtDNA) mutations and a compelling approach to decrease mutation levels would therefore be to increase the fidelity of the catalytic subunit (POLγA) of the mtDNA polymerase. Here we genomically engineer the tamas locus, encoding fly POLγA, and introduce allele...

journal_title：Nature communications

authors： Bratic A,Kauppila TE,Macao B,Grönke S,Siibak T,Stewart JB,Baggio F,Dols J,Partridge L,Falkenberg M,Wredenberg A,Larsson NG

更新日期：2015-11-10 00:00:00

abstract：:Deep subwavelength features are expected to have minimal impact on wave transport. Here we show that in contrast to this common understanding, disorder can have a dramatic effect in a one-dimensional disordered optical system with spatial features a thousand times smaller than the wavelength. We examine a unique regim...

journal_title：Nature communications

authors： Herzig Sheinfux H,Kaminer I,Genack AZ,Segev M

更新日期：2016-10-06 00:00:00

abstract：:The same odorant can induce attractive or repulsive responses depending on its concentration in various animals including humans. However, little is understood about the neuronal basis of this behavioural phenomenon. Here we show that Caenorhabditis elegans avoids high concentrations of odorants that are attractive at...

journal_title：Nature communications

authors： Yoshida K,Hirotsu T,Tagawa T,Oda S,Wakabayashi T,Iino Y,Ishihara T

更新日期：2012-03-13 00:00:00

abstract：:Thalidomide and its derivatives exert not only therapeutic effects as immunomodulatory drugs (IMiDs) but also adverse effects such as teratogenicity, which are due in part to different C2H2 zinc-finger (ZF) transcription factors, IKZF1 (or IKZF3) and SALL4, respectively. Here, we report the structural bases for the SA...

journal_title：Nature communications

authors： Furihata H,Yamanaka S,Honda T,Miyauchi Y,Asano A,Shibata N,Tanokura M,Sawasaki T,Miyakawa T

更新日期：2020-09-14 00:00:00

abstract：:One of the most dramatic events in river environments is the natural diversion, or avulsion, of a channel across its floodplain. Though rarely witnessed, avulsions can cause massive floods, and over geologic time they create most of the fluvial stratigraphic record. Avulsions exhibit behavior ranging from reoccupying ...

journal_title：Nature communications

authors： Valenza JM,Edmonds DA,Hwang T,Roy S

更新日期：2020-04-30 00:00:00