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Sustained micellar delivery via inducible transitions in nanostructure morphology.

Abstract：

:Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar nanocarriers with improved bioresorptive capacity and modularity for customization. Modular assembly of FMs from diverse block copolymer (BCP) chemistries allows in situ gelation into hydrogel scaffolds following subcutaneous injection into mice. Upon photo-oxidation or physiological oxidation, molecular payloads within FMs transfer to micellar vehicles during the morphological transition, as verified in vitro by electron microscopy and in vivo by flow cytometry. FMs composed of multiple distinct BCP fluorescent conjugates permit multimodal analysis of the scaffold's non-inflammatory bioresorption and micellar delivery to immune cell populations for one month. These scaffolds exhibit highly efficient bioresorption wherein all components participate in retention and transport of therapeutics, presenting previously unexplored mechanisms for controlled nanocarrier delivery.

journal_name

Nat Commun

journal_title

Nature communications

authors

Karabin NB,Allen S,Kwon HK,Bobbala S,Firlar E,Shokuhfar T,Shull KR,Scott EA

doi

10.1038/s41467-018-03001-9

subject

Has Abstract

pub_date

2018-02-12 00:00:00

pages

624

issue

1

issn

2041-1723

pii

10.1038/s41467-018-03001-9

journal_volume

9

pub_type

杂志文章

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