Abstract：
:Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate that the Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), which has been implicated in inflammation, is abundantly expressed in ECs and in atherosclerotic plaques from mice and humans. On the basis of endothelial-specific MAP4K4 gene silencing and gene ablation experiments in Apoe(-/-) mice, we show that MAP4K4 in ECs markedly promotes Western diet-induced aortic macrophage accumulation and atherosclerotic plaque development. Treatment of Apoe(-/-) and Ldlr(-/-) mice with a selective small-molecule MAP4K4 inhibitor also markedly reduces atherosclerotic lesion area. MAP4K4 silencing in cultured ECs attenuates cell surface adhesion molecule expression while reducing nuclear localization and activity of NFκB, which is critical for promoting EC activation and atherosclerosis. Taken together, these results reveal that MAP4K4 is a key signalling node that promotes immune cell recruitment in atherosclerosis.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Roth Flach RJ,Skoura A,Matevossian A,Danai LV,Zheng W,Cortes C,Bhattacharya SK,Aouadi M,Hagan N,Yawe JC,Vangala P,Menendez LG,Cooper MP,Fitzgibbons TP,Buckbinder L,Czech MPdoi
10.1038/ncomms9995subject
Has Abstractpub_date
2015-12-21 00:00:00pages
8995issn
2041-1723pii
ncomms9995journal_volume
6pub_type
杂志文章abstract：:Insulin-like growth factor 1 (IGF-1) is a critical regulator of many physiological functions, ranging from longevity to immunity. However, little is known about the role of IGF-1 in natural killer cell development and function. Here, we identify an essential role for IGF-1 in the positive regulation of human natural k...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2484
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abstract：:The challenge of monitoring in planta dynamic changes of NADP(H) and NAD(H) redox states at the subcellular level is considered a major obstacle in plant bioenergetics studies. Here, we introduced two circularly permuted yellow fluorescent protein sensors, iNAP and SoNar, into Arabidopsis thaliana to monitor the dynam...
journal_title：Nature communications
pub_type： 杂志文章
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journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15965-8
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journal_title：Nature communications
pub_type： 杂志文章
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journal_title：Nature communications
pub_type： 杂志文章
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更新日期：2020-01-03 00:00:00
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journal_title：Nature communications
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Nature communications
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
abstract：:The mechanisms underlying how cells subjected to genotoxic stress reestablish reduction-oxidation (redox) homeostasis to scavenge genotoxic stress-induced reactive oxygen species (ROS), which maintains the physiological function of cellular processes and cell survival, remain unclear. Herein, we report that, via a TCF...
journal_title：Nature communications
pub_type： 杂志文章
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更新日期：2019-08-21 00:00:00
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journal_title：Nature communications
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更新日期：2020-02-25 00:00:00
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journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1598
更新日期：2011-12-20 00:00:00
abstract：:The high-frequency dynamics of mode-coupled magnetic vortices have generated great interest for spintronic technologies, such as spin-torque nano-oscillators. While the spectroscopic characteristics of vortex oscillators have been reported, direct imaging of driven coupled magnetic quasi-particles is essential to the ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4760
更新日期：2014-04-30 00:00:00
abstract：:Accurate pathogenicity prediction of missense variants is critically important in genetic studies and clinical diagnosis. Previously published prediction methods have facilitated the interpretation of missense variants but have limited performance. Here, we describe MVP (Missense Variant Pathogenicity prediction), a n...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20847-0
更新日期：2021-01-21 00:00:00
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journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14284-2
更新日期：2020-01-31 00:00:00
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journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16818-0
更新日期：2020-06-25 00:00:00
abstract：:The originally published version of this Article contained errors in Figure 4. In panel b, the square and diamond labels associated with the uppermost survival curve were incorrectly displayed as 'n' and 'u', respectively. These errors have now been corrected in both the PDF and HTML versions of the Article. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-017-02205-9
更新日期：2018-01-10 00:00:00
abstract：:Long-chain alcohols synthesis (LAS, C5+OH) from syngas provides a promising route for the conversion of coal/biomass/natural gas into high-value chemicals. Cu-Fe binary catalysts, with the merits of cost effectiveness and high CO conversion, have attracted considerable attention. Here we report a nano-construct of a F...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13691-4
更新日期：2020-01-03 00:00:00
abstract：:Target-centric drug development strategies prioritize single-target potency in vitro and do not account for connectivity and multi-target effects within a signal transduction network. Here, we present a systems biology approach that combines transcriptomic and structural analyses with live-cell imaging to predict smal...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-08802-0
更新日期：2019-02-26 00:00:00
abstract：:The molecular mechanisms that couple glycolysis to cancer drug resistance remain unclear. Here we identify an ATP-binding motif within the NADPH oxidase isoform, NOX4, and show that ATP directly binds and negatively regulates NOX4 activity. We find that NOX4 localizes to the inner mitochondria membrane and that subcel...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01106-1
更新日期：2017-10-19 00:00:00
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journal_title：Nature communications
pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
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journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19870-y
更新日期：2020-11-27 00:00:00
abstract：:When a thin film of active, nematic microtubules and kinesin motor clusters is confined on the surface of a vesicle, four +1/2 topological defects oscillate in a periodic manner between tetrahedral and planar arrangements. Here a theoretical description of nematics, coupled to the relevant hydrodynamic equations, is p...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13483
更新日期：2016-11-21 00:00:00
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journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms8654
更新日期：2015-07-08 00:00:00
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更新日期：2018-06-18 00:00:00
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journal_title：Nature communications
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更新日期：2019-09-09 00:00:00
abstract：:Steels belong to one of the best established materials, however, the mechanisms of various phase transformations down to the nano length scale are still not fully clear. In this work, high-resolution transmission electron microscopy is combined with atomistic simulations to study the nanoscale carbide precipitation in...
journal_title：Nature communications
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
abstract：:The poverty of disease resistance gene reservoirs limits the breeding of crops for durable resistance against evolutionary dynamic pathogens. Zymoseptoria tritici which causes Septoria tritici blotch (STB), represents one of the most genetically diverse and devastating wheat pathogens worldwide. No fully virulent Z. t...
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pub_type： 杂志文章
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更新日期：2021-01-19 00:00:00
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journal_title：Nature communications
pub_type： 杂志文章
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更新日期：2020-11-26 00:00:00
abstract：:Insects have presented human society with some of its greatest development challenges by spreading diseases, consuming crops and damaging infrastructure. Despite the massive human and financial toll of invasive insects, cost estimates of their impacts remain sporadic, spatially incomplete and of questionable quality. ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12986
更新日期：2016-10-04 00:00:00
