Abstract:
:Microglia and peripheral monocytes contribute to hypersensitivity in rodent models of neuropathic pain. However, the precise respective function of microglia and peripheral monocytes has not been investigated in these models. To address this question, here we combined transgenic mice and pharmacological tools to specifically and temporally control the depletion of microglia and monocytes in a mouse model of spinal nerve transection (SNT). We found that although microglia and monocytes are required during the initiation of mechanical allodynia or thermal hyperalgesia, these cells may not be as important for the maintenance of hypersensitivity. Moreover, we demonstrated that either resident microglia or peripheral monocytes are sufficient in gating neuropathic pain after SNT. We propose that resident microglia and peripheral monocytes act synergistically to initiate hypersensitivity and promote the transition from acute to chronic pain after peripheral nerve injury.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Peng J,Gu N,Zhou L,B Eyo U,Murugan M,Gan WB,Wu LJdoi
10.1038/ncomms12029subject
Has Abstractpub_date
2016-06-28 00:00:00pages
12029issn
2041-1723pii
ncomms12029journal_volume
7pub_type
杂志文章abstract::The precise measurement of forces is one way to obtain deep insight into the fundamental interactions present in nature. In the context of neutral antimatter, the gravitational interaction is of high interest, potentially revealing new forces that violate the weak equivalence principle. Here we report on a successful ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5538
更新日期:2014-07-28 00:00:00
abstract::Transcription in all living organisms is accomplished by multi-subunit RNA polymerases (msRNAPs). msRNAPs are highly conserved in evolution and invariably share a ∼400 kDa five-subunit catalytic core. Here we characterize a hypothetical ∼100 kDa single-chain protein, YonO, encoded by the SPβ prophage of Bacillus subti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15774
更新日期:2017-06-06 00:00:00
abstract::Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically and industrially important compounds, and are often clustered on chromosomes. Here, we study genomic clustering in the benzylisoquinoline alkaloid (BIA) pathway in opium poppy (Papaver somniferum), exploring relationships between g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15040-2
更新日期:2020-03-04 00:00:00
abstract::A reliable method for recording evoked synaptic events in identified neurons in Caenorhabditis elegans would greatly accelerate our understanding of its nervous system at the molecular, cellular and network levels. Here we describe a method for recording synaptic currents and potentials from identified neurons in near...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1304
更新日期:2011-01-01 00:00:00
abstract::Perovskite solar cells present one of the most prominent photovoltaic technologies, yet their stability, scalability, and engineering at the molecular level remain challenging. We demonstrate a concept of multifunctional molecular modulation of scalable and operationally stable perovskite solar cells that exhibit exce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06709-w
更新日期:2018-10-26 00:00:00
abstract::A number of marine organisms use muscle-controlled surface structures to achieve rapid changes in colour and transparency with outstanding reversibility. Inspired by these display tactics, we develop analogous deformation-controlled surface-engineering approaches via strain-dependent cracks and folds to realize the fo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11802
更新日期:2016-07-08 00:00:00
abstract::Considerable progress in the fabrication of quasicrystals demonstrates that they can be realized in a broad range of materials. However, the development of chemistries enabling direct experimental observation of early quasicrystal growth pathways remains challenging. Here, we report the synthesis of four surfactant-di...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00351-8
更新日期:2017-08-15 00:00:00
abstract::Optical tracking is often combined with conventional flat panel solar cells to maximize electrical power generation over the course of a day. However, conventional trackers are complex and often require costly and cumbersome structural components to support system weight. Here we use kirigami (the art of paper cutting...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9092
更新日期:2015-09-08 00:00:00
abstract::Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14229
更新日期:2017-02-06 00:00:00
abstract::16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18997-2
更新日期:2020-10-19 00:00:00
abstract::An invisibility cloak should completely hide an object from an observer, ideally across the visible spectrum and for all angles of incidence and polarizations of light, in three dimensions. However, until now, all such devices have been limited to either small bandwidths or have disregarded the phase of the impinging ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12813-2
更新日期:2019-10-24 00:00:00
abstract::Perisomatic inhibition of pyramidal neurons is established by fast-spiking, parvalbumin-expressing interneurons (PV cells). Failure to assemble adequate perisomatic inhibition is thought to underlie the aetiology of neurological dysfunction in seizures, autism spectrum disorders and schizophrenia. Here we show that in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12829
更新日期:2016-09-09 00:00:00
abstract::Stable water isotope records from Antarctica are key for our understanding of Quaternary climate variations. However, the exact quantitative interpretation of these important climate proxy records in terms of surface temperature, ice sheet height and other climatic changes is still a matter of debate. Here we report r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05430-y
更新日期:2018-08-30 00:00:00
abstract::Thin films comprising semiconductor nanocrystals are emerging for applications in electronic and optoelectronic devices including light emitting diodes and solar cells. Achieving high charge carrier mobility in these films requires the identification and elimination of electronic traps on the nanocrystal surfaces. Her...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6822
更新日期:2014-12-19 00:00:00
abstract::While erythropoietin (EPO) constitutes the major treatment for anemia, a range of anemic disorders remain resistant to EPO treatment. The need for alternative therapeutic strategies requires the identification of mechanisms that physiologically restrain erythropoiesis. Here we show that P38α restrains erythropoiesis i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05955-2
更新日期:2018-08-29 00:00:00
abstract::The prediction of implant behavior in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. Simulated body fluids (SBFs) have been proposed and widely used to evaluate the bone-bonding ability of implant materials. In view of its limitations, we report here a rapid in vitro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09673-1
更新日期:2019-05-02 00:00:00
abstract::Hybridomas, fusions of primary mouse B cells and myelomas, are stable, rapidly-proliferating cell lines widely utilized for antibody screening and production. Antibody specificity of a hybridoma clone is determined by the immunoglobulin sequence of the primary B cell. Here we report a platform for rapid reprogramming ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12535
更新日期:2016-08-17 00:00:00
abstract::Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new therapeutic strategy for the in vivo delivery of nucleotides and chemical drugs. Here we describe a new tool for...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12277
更新日期:2016-07-22 00:00:00
abstract::Two-dimensional electron systems have attracted attention as thermoelectric materials, which can directly convert waste heat into electricity. It has been theoretically predicted that thermoelectric power factor can be largely enhanced when the two-dimensional electron layer is far narrower than the de Broglie wavelen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04660-4
更新日期:2018-06-20 00:00:00
abstract::The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require lysis or rely on indirect assays and thus often provide an incomplete understanding of drug action. Here, we p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4946
更新日期:2014-05-28 00:00:00
abstract::Locusts are one of the world's most destructive agricultural pests and represent a useful model system in entomology. Here we present a draft 6.5 Gb genome sequence of Locusta migratoria, which is the largest animal genome sequenced so far. Our findings indicate that the large genome size of L. migratoria is likely to...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3957
更新日期:2014-01-01 00:00:00
abstract::An elusive goal in the field of driven quantum matter is the induction of long-range order. Here, we propose a mechanism based on light-induced evaporative cooling of holes in a correlated fermionic system. Since the entropy of a filled narrow band grows rapidly with hole doping, the isentropic transfer of holes from ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13557-9
更新日期:2019-12-05 00:00:00
abstract::To understand functional consequences of genetic and transcriptional aberrations in prostate cancer, the proteomic changes during disease formation and progression need to be revealed. Here we report high-throughput mass spectrometry on clinical tissue samples of benign prostatic hyperplasia (BPH), untreated primary p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03573-6
更新日期:2018-03-21 00:00:00
abstract::Bacterial autotransporters comprise a 12-stranded membrane-embedded β-barrel domain, which must be folded in a process that entraps segments of an N-terminal passenger domain. This first stage of autotransporter folding determines whether subsequent translocation can deliver the N-terminal domain to its functional for...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5239
更新日期:2014-06-26 00:00:00
abstract::Topological insulators interacting with magnetic impurities have been reported to host several unconventional effects. These phenomena are described within the framework of gapping Dirac quasiparticles due to broken time-reversal symmetry. However, the overwhelming majority of studies demonstrate the presence of a fin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12027
更新日期:2016-06-27 00:00:00
abstract::In the bottom-up synthesis of graphene nanoribbons (GNRs) from self-assembled linear polymer intermediates, surface-assisted cyclodehydrogenations usually take place on catalytic metal surfaces. Here we demonstrate the formation of GNRs from quasi-freestanding polymers assisted by hole injections from a scanning tunne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14815
更新日期:2017-03-13 00:00:00
abstract::Leads are a key feature of the Arctic ice pack during the winter owing to their substantial contribution to the surface energy balance. According to the present understanding, enhanced heat and moisture fluxes from high lead concentrations tend to produce more boundary layer clouds. However, described here in our comp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14074-5
更新日期:2020-01-10 00:00:00
abstract::Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7416
更新日期:2015-04-02 00:00:00
abstract::Fas induces apoptosis in activated T cell to maintain immune homeostasis, but the effects of non-apoptotic Fas signaling on T cells remain unclear. Here we show that Fas promotes TH9 cell differentiation by activating NF-κB via Ca2+-dependent PKC-β activation. In addition, PKC-β also phosphorylates p38 to inactivate N...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10889-4
更新日期:2019-07-02 00:00:00
abstract::Self-induced electricity, including lightning, is often observed in dusty atmospheres. However, the physical mechanisms leading to this phenomenon remain elusive as they are remarkably challenging to determine due to the high complexity of the multi-phase turbulent flows involved. Using a fast multi-pole method in dir...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03958-7
更新日期:2018-04-26 00:00:00