The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel.

abstract：:Piezo proteins are transmembrane ion channels which transduce many forms of mechanical stimuli into electrochemical signals. Their pore, formed by the assembly of three identical subunits, opens by an unknown mechanism. Here, to probe this mechanism, we investigate the interaction of Piezo1 with the small molecule ago...

journal_title：Nature communications

authors： Lacroix JJ,Botello-Smith WM,Luo Y

更新日期：2018-05-23 00:00:00

abstract：:FeV(O)(OH) species have long been proposed to play a key role in a wide range of biomimetic and enzymatic oxidations, including as intermediates in arene dihydroxylation catalyzed by Rieske oxygenases. However, the inability to accumulate these intermediates in solution has thus far prevented their spectroscopic and c...

journal_title：Nature communications

authors： Borrell M,Andris E,Navrátil R,Roithová J,Costas M

更新日期：2019-02-22 00:00:00

abstract：:The electron deficiency and strong bonding capacity of boron have led to a vast variety of molecular structures in chemistry and materials science. Here we report the observation of highly symmetric cobalt-centered boron drum-like structures of CoB16(-), characterized by photoelectron spectroscopy and ab initio calcul...

journal_title：Nature communications

authors： Popov IA,Jian T,Lopez GV,Boldyrev AI,Wang LS

更新日期：2015-10-12 00:00:00

abstract：:Neuroimaging modalities such as MRI and EEG are able to record from the whole brain, but this comes at the price of either limited spatiotemporal resolution or limited sensitivity. Here, we show that functional ultrasound imaging (fUS) of the brain is able to assess local changes in cerebral blood volume during cognit...

journal_title：Nature communications

authors： Dizeux A,Gesnik M,Ahnine H,Blaize K,Arcizet F,Picaud S,Sahel JA,Deffieux T,Pouget P,Tanter M

更新日期：2019-03-28 00:00:00

abstract：:Across phyla, body size is linked to climate. For example, rearing fruit flies at lower temperatures results in bigger body sizes than those observed at higher temperatures. The underlying molecular basis of this effect is poorly understood. Here we provide evidence that the temperature-dependent regulation of Drosoph...

journal_title：Nature communications

authors： Li Q,Gong Z

更新日期：2015-12-09 00:00:00

abstract：:Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin α in emphysema remains unclear. Here we show that prothymosin α contributes to the pathogenesis of emphysema by in...

journal_title：Nature communications

authors： Su BH,Tseng YL,Shieh GS,Chen YC,Shiang YC,Wu P,Li KJ,Yen TH,Shiau AL,Wu CL

更新日期：2013-01-01 00:00:00

abstract：:Decoherence originates from the leakage of quantum information into external degrees of freedom. For a qubit, the two main decoherence channels are relaxation and dephasing. Here, we report an experiment on a superconducting qubit where we retrieve part of the lost information in both of these channels. We demonstrate...

journal_title：Nature communications

authors： Ficheux Q,Jezouin S,Leghtas Z,Huard B

更新日期：2018-05-15 00:00:00

abstract：:In addition to acting as a cellular energy source, ATP can also act as a damage-associated molecular pattern in both animals and plants. Stomata are leaf pores that control gas exchange and, therefore, impact critical functions such as photosynthesis, drought tolerance, and also are the preferred entry point for patho...

journal_title：Nature communications

authors： Chen D,Cao Y,Li H,Kim D,Ahsan N,Thelen J,Stacey G

更新日期：2017-12-22 00:00:00

abstract：:Centrosome number is tightly controlled during the cell cycle to ensure proper spindle assembly and cell division. However, the underlying mechanism that controls centrosome number remains largely unclear. We show herein that the DNA replication licensing factor Cdc6 is recruited to the proximal side of the centrioles...

journal_title：Nature communications

authors： Xu X,Huang S,Zhang B,Huang F,Chi W,Fu J,Wang G,Li S,Jiang Q,Zhang C

更新日期：2017-04-27 00:00:00

abstract：:Anterior pituitary is critical for endocrine systems. Its hormonal responses to positive and negative regulators are indispensable for homeostasis. For this reason, generating human anterior pituitary tissue that retains regulatory hormonal control in vitro is an important step for the development of cell transplantat...

journal_title：Nature communications

authors： Ozone C,Suga H,Eiraku M,Kadoshima T,Yonemura S,Takata N,Oiso Y,Tsuji T,Sasai Y

更新日期：2016-01-14 00:00:00

abstract：:Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for robust NK cell responses. However, the mechanisms leading to this metabolic phenotype are unclear. Here we show that the transcription facto...

journal_title：Nature communications

authors： Loftus RM,Assmann N,Kedia-Mehta N,O'Brien KL,Garcia A,Gillespie C,Hukelmann JL,Oefner PJ,Lamond AI,Gardiner CM,Dettmer K,Cantrell DA,Sinclair LV,Finlay DK

更新日期：2018-06-14 00:00:00

abstract：:The COVID-19 epidemic hit Italy particularly hard, yielding the implementation of strict national lockdown rules. Previous modelling studies at the national level overlooked the fact that Italy is divided into administrative regions which can independently oversee their own share of the Italian National Health Service...

journal_title：Nature communications

authors： Della Rossa F,Salzano D,Di Meglio A,De Lellis F,Coraggio M,Calabrese C,Guarino A,Cardona-Rivera R,De Lellis P,Liuzza D,Lo Iudice F,Russo G,di Bernardo M

更新日期：2020-10-09 00:00:00

abstract：:Trade-offs play an important role in evolution. Without trade-offs, evolution would maximize fitness of all traits leading to a "master of all traits". The shape of trade-offs has been shown to determine evolutionary trajectories and is often assumed to be static and independent of the actual evolutionary process. Her...

journal_title：Nature communications

authors： Huang W,Traulsen A,Werner B,Hiltunen T,Becks L

更新日期：2017-12-12 00:00:00

abstract：:Optical spectroscopy is a fundamental tool in numerous areas of science and technology. Much effort has focused on miniaturizing spectrometers, but thus far at the cost of spectral resolution and broad operating range. Here we describe a compact spectrometer that achieves both high spectral resolution and broad bandwi...

journal_title：Nature communications

authors： Wan NH,Meng F,Schröder T,Shiue RJ,Chen EH,Englund D

更新日期：2015-07-23 00:00:00

abstract：:Innovations in soft material synthesis and fabrication technologies have led to the development of integrated soft electronic devices. Such soft devices offer opportunities to interact with biological cells, mimicking their soft environment. However, existing fabrication technologies cannot create the submicron-scale,...

journal_title：Nature communications

authors： Kim MG,Brown DK,Brand O

更新日期：2020-02-21 00:00:00

abstract：:Addressing the intrinsic charge transport limitation of metal oxides has been of significance for pursuing viable PEC water splitting photoelectrodes. Growing a photoelectrode with conductive nanoobjects embedded in the matrix is promising for enhanced charge transport but remains a challenge technically. We herein sh...

journal_title：Nature communications

authors： Jian J,Xu Y,Yang X,Liu W,Fu M,Yu H,Xu F,Feng F,Jia L,Friedrich D,van de Krol R,Wang H

更新日期：2019-06-13 00:00:00

abstract：:Electron transport in two-dimensional conducting materials such as graphene, with dominant electron-electron interaction, exhibits unusual vortex flow that leads to a nonlocal current-field relation (negative resistance), distinct from the classical Ohm's law. The transport behavior of these materials is best describe...

journal_title：Nature communications

authors： Mayzel J,Steinberg V,Varshney A

更新日期：2019-02-26 00:00:00

abstract：:Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers. While we previously identified KRAS mutations as molecular culprits of MPE formation, the underlying mechanism remained unknown. Here, we determine that non-canonical IKKα-RelB pathway activation of KRAS-mutant tumor cells mediat...

journal_title：Nature communications

authors： Marazioti A,Lilis I,Vreka M,Apostolopoulou H,Kalogeropoulou A,Giopanou I,Giotopoulou GA,Krontira AC,Iliopoulou M,Kanellakis NI,Agalioti T,Giannou AD,Jones-Paris C,Iwakura Y,Kardamakis D,Blackwell TS,Taraviras S,Spella M

更新日期：2018-02-14 00:00:00

abstract：:Variability in dense shelf water formation can potentially impact Antarctic Bottom Water (AABW) production, a vital component of the global climate system. In East Antarctica, the George V Land polynya system (142-150°E) is structured by the local 'icescape', promoting sea ice formation that is driven by the offshore ...

journal_title：Nature communications

authors： Tamura T,Williams GD,Fraser AD,Ohshima KI

更新日期：2012-05-08 00:00:00

abstract：:Conventional lithium-ion batteries embrace graphite anodes which operate at potential as low as metallic lithium, subjected to poor rate capability and safety issues. Among possible alternatives, oxides based on titanium redox couple, such as spinel Li4Ti5O12, have received renewed attention. Here we further expand th...

journal_title：Nature communications

authors： Zhang L,Zhang X,Tian G,Zhang Q,Knapp M,Ehrenberg H,Chen G,Shen Z,Yang G,Gu L,Du F

更新日期：2020-07-13 00:00:00

abstract：:The dominant dipolar component of the Earth's magnetic field has been steadily weakening for at least the last 170 years. Prior to these direct measurements, archaeomagnetic records show short periods of significantly elevated geomagnetic intensity. These striking phenomena are not captured by current field models and...

journal_title：Nature communications

authors： de Groot LV,Biggin AJ,Dekkers MJ,Langereis CG,Herrero-Bervera E

更新日期：2013-01-01 00:00:00

abstract：:Volcanoes are increasingly recognized as agents and recorders of global climate variability, although deciphering the linkages between planetary climate and volcanism is still in its infancy. The growth and emergence of subaqueous volcanoes produce passage zones, which are stratigraphic surfaces marking major transiti...

journal_title：Nature communications

authors： Russell JK,Edwards BR,Porritt LA

更新日期：2013-01-01 00:00:00

abstract：:Large-scale genetic and genomic data are increasingly available and the major bottleneck in their analysis is a lack of sufficiently scalable computational tools. To address this problem in the context of complex traits analysis, we present DISSECT. DISSECT is a new and freely available software that is able to exploi...

journal_title：Nature communications

authors： Canela-Xandri O,Law A,Gray A,Woolliams JA,Tenesa A

更新日期：2015-12-11 00:00:00

abstract：:There has been much research on renewable energy-harvesting techniques. However, owing to increasing energy demands, significant energy-related issues remain to be solved. Efforts aimed at reducing the amount of energy loss in electric/electronic systems are essential for reducing energy consumption and protecting the...

journal_title：Nature communications

authors： Kim T,Yong H,Kim B,Kim D,Choi D,Park YT,Lee S

更新日期：2018-04-12 00:00:00

abstract：:Polar van der Waals chalcogenophosphates exhibit unique properties, such as negative electrostriction and multi-well ferrielectricity, and enable combining dielectric and 2D electronic materials. Using low temperature piezoresponse force microscopy, we revealed coexistence of piezoelectric and non-piezoelectric phases...

journal_title：Nature communications

authors： Dziaugys A,Kelley K,Brehm JA,Tao L,Puretzky A,Feng T,O'Hara A,Neumayer S,Chyasnavichyus M,Eliseev EA,Banys J,Vysochanskii Y,Ye F,Chakoumakos BC,Susner MA,McGuire MA,Kalinin SV,Ganesh P,Balke N,Pantelides ST,Morozo

更新日期：2020-07-17 00:00:00

abstract：:Most biochemical reactions in living cells rely on diffusive search for target molecules or regions in a heterogeneous overcrowded cytoplasmic medium. Rapid rearrangements of the medium constantly change the effective diffusivity felt locally by a diffusing particle and thus impact the distribution of the first-passag...

journal_title：Nature communications

authors： Lanoiselée Y,Moutal N,Grebenkov DS

更新日期：2018-10-23 00:00:00

abstract：:Exciton dynamics can be strongly affected by lattice vibrations through electron-phonon coupling. This is rarely explored in two-dimensional magnetic semiconductors. Focusing on bilayer CrI3, we first show the presence of strong electron-phonon coupling through temperature-dependent photoluminescence and absorption sp...

journal_title：Nature communications

authors： Jin W,Kim HH,Ye Z,Ye G,Rojas L,Luo X,Yang B,Yin F,Horng JSA,Tian S,Fu Y,Xu G,Deng H,Lei H,Tsen AW,Sun K,He R,Zhao L

更新日期：2020-09-22 00:00:00

abstract：:Auditory cortex neurons nonlinearly integrate synaptic inputs from the thalamus and cortex, and generate spiking outputs for simple and complex sounds. Directly comparing synaptic and spiking activity can determine whether this input-output transformation is stimulus-dependent. We employ in vivo whole-cell recordings ...

journal_title：Nature communications

authors： Kim KX,Atencio CA,Schreiner CE

更新日期：2020-02-27 00:00:00

abstract：:In vitro fabrication of functional vascularized three-dimensional tissues has been a long-standing objective in the field of tissue engineering. Here we report a technique to engineer cardiac tissues with perfusable blood vessels in vitro. Using resected tissue with a connectable artery and vein as a vascular bed, we ...

journal_title：Nature communications

authors： Sekine H,Shimizu T,Sakaguchi K,Dobashi I,Wada M,Yamato M,Kobayashi E,Umezu M,Okano T

更新日期：2013-01-01 00:00:00

abstract：:Split spawning in coral populations occurs when gamete maturation and mass spawning are split over two consecutive months. While split spawning has been observed at many reefs, little is known about the frequency and significance of these events. Here we show that split spawning occurred frequently and predictably ove...

journal_title：Nature communications

authors： Foster T,Heyward AJ,Gilmour JP

更新日期：2018-02-19 00:00:00