Abstract:
:Most biochemical reactions in living cells rely on diffusive search for target molecules or regions in a heterogeneous overcrowded cytoplasmic medium. Rapid rearrangements of the medium constantly change the effective diffusivity felt locally by a diffusing particle and thus impact the distribution of the first-passage time to a reaction event. Here, we investigate the effect of these dynamic spatiotemporal heterogeneities onto diffusion-limited reactions. We describe a general mathematical framework to translate many results for ordinary homogeneous Brownian motion to heterogeneous diffusion. In particular, we derive the probability density of the first-passage time to a reaction event and show how the dynamic disorder broadens the distribution and increases the likelihood of both short and long trajectories to reactive targets. While the disorder slows down reaction kinetics on average, its dynamic character is beneficial for a faster search and realization of an individual reaction event triggered by a single molecule.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Lanoiselée Y,Moutal N,Grebenkov DSdoi
10.1038/s41467-018-06610-6subject
Has Abstractpub_date
2018-10-23 00:00:00pages
4398issue
1issn
2041-1723pii
10.1038/s41467-018-06610-6journal_volume
9pub_type
杂志文章abstract::Various platinum-free electrocatalysts have been explored for hydrogen evolution reaction in acidic solutions. However, in economical water-alkali electrolysers, sluggish water dissociation kinetics (Volmer step) on platinum-free electrocatalysts results in poor hydrogen-production activities. Here we report a MoNi4 e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15437
更新日期:2017-05-17 00:00:00
abstract::In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to prevent damaging collisions. Gram-positive bacteria contain a transcription factor HelD that is able to remove and recycle stalled complexes, but it was not know...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20157-5
更新日期:2020-12-18 00:00:00
abstract::While erythropoietin (EPO) constitutes the major treatment for anemia, a range of anemic disorders remain resistant to EPO treatment. The need for alternative therapeutic strategies requires the identification of mechanisms that physiologically restrain erythropoiesis. Here we show that P38α restrains erythropoiesis i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05955-2
更新日期:2018-08-29 00:00:00
abstract::Dense ceramic materials can form in nature under mild temperatures in water. By contrast, man-made ceramics often require sintering temperatures in excess of 1,400 °C for densification. Chemical strategies inspired by biomineralization processes have been demonstrated but remain limited to the fabrication of thin film...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14655
更新日期:2017-03-06 00:00:00
abstract::Helitrons are eukaryotic DNA transposons that have profoundly affected genome variability via capture and mobilization of host genomic sequences. Defining their mode of action is therefore important for understanding how genome landscapes evolve. Sequence similarities with certain prokaryotic mobile elements suggest a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03688-w
更新日期:2018-03-29 00:00:00
abstract::The poverty of disease resistance gene reservoirs limits the breeding of crops for durable resistance against evolutionary dynamic pathogens. Zymoseptoria tritici which causes Septoria tritici blotch (STB), represents one of the most genetically diverse and devastating wheat pathogens worldwide. No fully virulent Z. t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20685-0
更新日期:2021-01-19 00:00:00
abstract::Due to the surge of natural gas production, feedstocks for chemicals shift towards lighter hydrocarbons, particularly methane. The success of a Gas-to-Chemicals process via synthesis gas (CO and H2) depends on the ability of catalysts to suppress methane and carbon dioxide formation. We designed a Co/Mn/Na/S catalyst,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08019-7
更新日期:2019-01-11 00:00:00
abstract::We characterized the population-level neural coding of ensemble representations in visual working memory from human electroencephalography. Ensemble representations provide a unique opportunity to investigate structured representations of working memory because the visual system encodes high-order summary statistics a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13592-6
更新日期:2019-12-11 00:00:00
abstract::In social species, the phenotype and fitness of an individual depend in part on the genotype of its social partners. However, how these indirect genetic effects affect genotype fitness in competitive situations is poorly understood in animal societies. We therefore studied phenotypic plasticity and fitness of two clon...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4363
更新日期:2014-01-01 00:00:00
abstract::Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of neurexin and is nee...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9362
更新日期:2015-10-16 00:00:00
abstract::The prefrontal cortex and striatum form a recurrent network whose spiking activity encodes multiple types of learning-relevant information. This spike-encoded information is evident in average firing rates, but finer temporal coding might allow multiplexing and enhanced readout across the connected network. We tested ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18435-3
更新日期:2020-09-16 00:00:00
abstract::Biodiversity loss can alter ecosystem functioning; however, it remains unclear how it alters decomposition-a critical component of biogeochemical cycles in the biosphere. Here, we provide a global-scale meta-analysis to quantify how changes in the diversity of organic matter derived from plants (i.e. litter) affect ra...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/s41467-020-18296-w
更新日期:2020-09-11 00:00:00
abstract::The ability to detect and deal with errors when manipulating quantum systems is a fundamental requirement for fault-tolerant quantum computing. Unlike classical bits that are subject to only digital bit-flip errors, quantum bits are susceptible to a much larger spectrum of errors, for which any complete quantum error-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7979
更新日期:2015-04-29 00:00:00
abstract::Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that the human microcephaly protein, RTTN, is recruited to the proximal end of the procentriole at early S phase, and is located at the inner luminal walls of centrioles. Further stud...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00305-0
更新日期:2017-08-15 00:00:00
abstract::The role of the histamine H3 receptor (H3R) in cerebral ischaemia/reperfusion (I/R) injury remains unknown. Here we show that H3R expression is upregulated after I/R in two mouse models. H3R antagonists and H3R knockout attenuate I/R injury, which is reversed by an H3R-selective agonist. Interestingly, H1R and H2R ant...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4334
更新日期:2014-02-25 00:00:00
abstract::Disordered mechanical systems, when strongly deformed, have complex configuration spaces with multiple stable states and pathways connecting them. The topology of such pathways determines which states are smoothly accessible from any part of configuration space. Controlling this topology would allow us to limit access...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06720-1
更新日期:2018-10-16 00:00:00
abstract::The mathematics of gauge theories lies behind many of the most profound advances in physics in the past 200 years, from Maxwell's theory of electromagnetism to Einstein's theory of general relativity. More recently it has become clear that gauge theories also emerge in condensed matter, a prime example being the spin-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11572
更新日期:2016-05-26 00:00:00
abstract::A conspicuous 60° bend of the Hawaiian-Emperor Chain in the north-western Pacific Ocean has variously been interpreted as the result of an abrupt Pacific plate motion change in the Eocene (∼47 Ma), a rapid southward drift of the Hawaiian hotspot before the formation of the bend, or a combination of these two causes. P...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15660
更新日期:2017-06-05 00:00:00
abstract::The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, dev...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-19045-9
更新日期:2020-10-16 00:00:00
abstract::How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11444-x
更新日期:2019-08-08 00:00:00
abstract::Topologically nontrivial materials host protected edge states associated with the bulk band inversion through the bulk-edge correspondence. Manipulating such edge states is highly desired for developing new functions and devices practically using their dissipation-less nature and spin-momentum locking. Here we introdu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16290-w
更新日期:2020-05-18 00:00:00
abstract::Understanding the microscopic elementary process of chemical reactions, especially in condensed phase, is highly desirable for improvement of efficiencies in industrial chemical processes. Here we show an approach to gaining new insights into elementary reactions in condensed phase by combining quantum chemical calcul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5238
更新日期:2014-06-25 00:00:00
abstract::Controlling the structure of catalysts at the atomic level provides an opportunity to establish detailed understanding of the catalytic form-to-function and realize new, non-equilibrium catalytic structures. Here, advanced thin-film deposition is used to control the atomic structure of La2/3Sr1/3MnO3, a well-known cat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06503-8
更新日期:2018-10-02 00:00:00
abstract::Molecular spins have become key enablers for exploring magnetic interactions, quantum information processes and many-body effects in metals. Metal-organic molecules, in particular, let the spin state of the core metal ion to be modified according to its organic environment, allowing localized magnetic moments to emerg...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13751
更新日期:2016-12-12 00:00:00
abstract::Complex tissue-specific and cell-specific signaling by the estrogen receptor (ER) frequently leads to the development of resistance to endocrine therapy for breast cancer. Pure ER antagonists, which completely lack tissue-specific agonist activity, hold promise for preventing and treating endocrine resistance, however...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04413-3
更新日期:2018-06-18 00:00:00
abstract::Dendrite growth threatens the safety of batteries by piercing the ion-transporting separators between the cathode and anode. Finding a dendrite-suppressing material that combines high modulus and high ionic conductance has long been considered a major technological and materials science challenge. Here we demonstrate ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7152
更新日期:2015-01-27 00:00:00
abstract::γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell recepto...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14760
更新日期:2017-03-01 00:00:00
abstract::Microbial fermentation of lignocellulosic biomass to produce industrial chemicals is exacerbated by the recalcitrant network of lignin, cellulose and hemicelluloses comprising the plant secondary cell wall. In this study, we show that transgenic poplar (Populus trichocarpa) lines can be solubilized without any pretrea...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11376-6
更新日期:2019-08-07 00:00:00
abstract::Triboelectrification is a well-known phenomenon that commonly occurs in nature and in our lives at any time and any place. Although each and every material exhibits triboelectrification, its quantification has not been standardized. A triboelectric series has been qualitatively ranked with regards to triboelectric pol...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09461-x
更新日期:2019-03-29 00:00:00
abstract::The maintenance of sensory hair cell stereocilia is critical for lifelong hearing; however, mechanisms of structural homeostasis remain poorly understood. Conflicting models propose that stereocilia F-actin cores are either continually renewed every 24-48 h via a treadmill or are stable, exceptionally long-lived struc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7873
更新日期:2015-04-21 00:00:00