Abstract:
:Microbial fermentation of lignocellulosic biomass to produce industrial chemicals is exacerbated by the recalcitrant network of lignin, cellulose and hemicelluloses comprising the plant secondary cell wall. In this study, we show that transgenic poplar (Populus trichocarpa) lines can be solubilized without any pretreatment by the extreme thermophile Caldicellulosiruptor bescii that has been metabolically engineered to shift its fermentation products away from inhibitory organic acids to ethanol. Carbohydrate solubilization and conversion of unpretreated milled biomass is nearly 90% for two transgenic lines, compared to only 25% for wild-type poplar. Unexpectedly, unpretreated intact poplar stems achieved nearly 70% of the fermentation production observed with milled poplar as the substrate. The nearly quantitative microbial conversion of the carbohydrate content of unpretreated transgenic lignocellulosic biomass bodes well for full utilization of renewable biomass feedstocks.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Straub CT,Khatibi PA,Wang JP,Conway JM,Williams-Rhaesa AM,Peszlen IM,Chiang VL,Adams MWW,Kelly RMdoi
10.1038/s41467-019-11376-6subject
Has Abstractpub_date
2019-08-07 00:00:00pages
3548issue
1issn
2041-1723pii
10.1038/s41467-019-11376-6journal_volume
10pub_type
杂志文章abstract::Large-area light-emitting diodes (LEDs) fabricated by mass-production techniques are needed for low-cost flat-panel lighting. Nevertheless, it is still challenging to fabricate efficient large-area LEDs using organic small molecules (OLEDs), quantum dots (QLEDs), polymers (PLEDs), and recently-developed hybrid perovsk...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20433-4
更新日期:2021-01-08 00:00:00
abstract::Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) significantly increase loading o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02390-7
更新日期:2017-12-18 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-020-14680-8
更新日期:2020-02-19 00:00:00
abstract::Taxanes are the only chemotherapies used to treat patients with metastatic castration-resistant prostate cancer (CRPC). Despite the initial efficacy of taxanes in treating CRPC, all patients ultimately fail due to the development of drug resistance. In this study, we show that ERG overexpression in in vitro and in viv...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6548
更新日期:2014-11-25 00:00:00
abstract::A major goal of synthetic biology is to reprogram living organisms to solve pressing challenges in manufacturing, environmental remediation, and healthcare. Recombinase devices can efficiently encode complex logic in many species, yet current designs are performed on a case-by-case basis, limiting their scalability an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08391-y
更新日期:2019-01-28 00:00:00
abstract::A declining rate of recovery following disturbance has been proposed as an important early warning for impending tipping points in complex systems. Despite extensive theoretical and laboratory studies, this 'critical slowing down' remains largely untested in the complex settings of real-world ecosystems. Here, we prov...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15811
更新日期:2017-06-09 00:00:00
abstract::Excitons are spin integer particles that are predicted to condense into a coherent quantum state at sufficiently low temperature. Here by using photocurrent imaging we report experimental evidence of formation and efficient transport of non-equilibrium excitons in Bi2-xSbxSe3 nanoribbons. The photocurrent distribution...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13711-3
更新日期:2019-12-16 00:00:00
abstract::The worldwide prevalence of infections caused by antibiotic-resistant Gram-negative bacteria poses a serious threat to public health due to the limited therapeutic alternatives. Cationic peptides represent a large family of antibiotics and have attracted interest due to their diverse chemical structures and potential ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05781-6
更新日期:2018-08-16 00:00:00
abstract::The impact of liquid drops on solid surfaces is ubiquitous in nature, and of practical importance in many industrial processes. A drop hitting a flat surface retains a circular symmetry throughout the impact process. Here we show that a drop impinging on Echevaria leaves exhibits asymmetric bouncing dynamics with dist...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10034
更新日期:2015-11-25 00:00:00
abstract::Boron has become the principle proxy for the release of seawater-derived fluids into arc volcanics, linked to cross-arc variations in boron content and isotopic ratio. Because all ocean floor serpentinites so far analysed are strongly enriched in boron, it is generally assumed that if the uppermost slab mantle is hydr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07064-6
更新日期:2018-11-02 00:00:00
abstract::The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures of how essential a gene is to supporting life, as inferred from viability and phenotyping screens performed on knockout mice by the In...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14284-2
更新日期:2020-01-31 00:00:00
abstract::The study of the high pressure phase diagram of hydrogen has continued with renewed effort for about one century as it remains a fundamental challenge for experimental and theoretical techniques. Here we employ an efficient molecular dynamics based on the quantum Monte Carlo method, which can describe accurately the e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4487
更新日期:2014-03-19 00:00:00
abstract::Despite the success of current therapies for acute myocardial infarction (MI), many patients still develop adverse cardiac remodeling and heart failure. With the growing prevalence of heart failure, a new therapy is needed that can prevent remodeling and support tissue repair. Herein, we report on injectable recombina...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12748-8
更新日期:2019-10-25 00:00:00
abstract::The aging myopathy manifests itself with diastolic dysfunction and preserved ejection fraction. We raised the possibility that, in a mouse model of physiological aging, defects in electromechanical properties of cardiomyocytes are important determinants of the diastolic characteristics of the myocardium, independently...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9803
更新日期:2015-11-06 00:00:00
abstract::RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral fitness is not well characterized. Here we report the X-ray crystal structure of the receptor-binding domain (RBD) of the human coronavirus, HCoV-229E, in comple...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01706-x
更新日期:2017-11-23 00:00:00
abstract::Stackable select devices such as the oxide p-n junction diode and the Schottky diode (one-way switch) have been proposed for non-volatile unipolar resistive switching devices; however, bidirectional select devices (or two-way switch) need to be developed for bipolar resistive switching devices. Here we report on a ful...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3629
更新日期:2013-01-01 00:00:00
abstract::The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alterna...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14763
更新日期:2017-03-27 00:00:00
abstract::With the development of ultrafast electron and X-ray sources it is becoming possible to study structural dynamics with atomic-level spatial and temporal resolution. Because of their short mean free path, electrons are particularly well suited for investigating surfaces and thin films, such as the challenging and impor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2700
更新日期:2013-01-01 00:00:00
abstract::Seismological findings show a complex scenario of plume upwellings from a deep thermo-chemical anomaly (superplume) beneath the East African Rift System (EARS). It is unclear if these geophysical observations represent a true picture of the superplume and its influence on magmatism along the EARS. Thus, it is essentia...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13181-7
更新日期:2019-12-02 00:00:00
abstract::Diffusion is the result of repeated random scattering. It governs a wide range of phenomena from Brownian motion, to heat flow through window panes, neutron flux in fuel rods, dispersion of light in human tissue, and electronic conduction. It is universally acknowledged that the diffusion approach to describing wave t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04242-4
更新日期:2018-05-10 00:00:00
abstract::Huntington's Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery by heat shock transcription factor 1 (HSF1) ameliorates biochemical and neurobiological defec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14405
更新日期:2017-02-13 00:00:00
abstract::In higher plants, the hormone auxin orchestrates a diverse array of developmental and environmental responses mainly exerted via transcriptional control. In its absence, auxin-mediated transcription is postulated to be repressed by histone deacetylases, which convert chromatin into a highly packed inactive state. Here...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4883
更新日期:2014-05-27 00:00:00
abstract::Pathological amino-acid substitutions in the amyloid precursor protein (APP) and chemical γ-secretase modulators affect the processing of APP by the γ-secretase complex and the production of the amyloid-beta peptide Aβ42, the accumulation of which is considered causative of Alzheimer's disease. Here we demonstrate tha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3246
更新日期:2013-01-01 00:00:00
abstract::Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7691
更新日期:2015-04-07 00:00:00
abstract::Current approaches to monitor and quantify cell division in live cells, and reliably distinguish between acytokinesis and endoreduplication, are limited and complicate determination of stem cell pool identities. Here we overcome these limitations by generating an in vivo reporter system using the scaffolding protein a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2089
更新日期:2012-01-01 00:00:00
abstract::Diatomic nitrogen is an archetypal molecular system known for its exceptional stability and complex behavior at high pressures and temperatures, including rich solid polymorphism, formation of energetic states, and an insulator-to-metal transformation coupled to a change in chemical bonding. However, the thermobaric c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05011-z
更新日期:2018-07-06 00:00:00
abstract::Diet is commonly assumed to affect the evolution of species, but few studies have directly tested its effect at macroevolutionary scales. Here we use Bayesian models of trait-dependent diversification and a comprehensive dietary database of all birds worldwide to assess speciation and extinction dynamics of avian diet...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11250
更新日期:2016-04-07 00:00:00
abstract::Networks of natural protein nanofibrils, such as cytoskeletal filaments, control the shape and the division of cells, yet mimicking this functionality in a synthetic setting has proved challenging. Here, we demonstrate that artificial networks of protein nanofibrils can induce controlled deformation and division of al...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04510-3
更新日期:2018-05-29 00:00:00
abstract::Ryanodine receptors (RyRs) form calcium release channels located in the membranes of the sarcoplasmic and endoplasmic reticulum. RyRs play a major role in excitation-contraction coupling and other Ca(2+)-dependent signalling events, and consist of several globular domains that together form a large assembly. Here we d...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8947
更新日期:2015-08-06 00:00:00
abstract::The degradation of intrinsic properties of graphene during the transfer process constitutes a major challenge in graphene device fabrication, stimulating the need for direct growth of graphene on dielectric substrates. Previous attempts of metal-induced transformation of diamond and silicon carbide into graphene suffe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12099
更新日期:2016-07-04 00:00:00