Vegetation recovery in tidal marshes reveals critical slowing down under increased inundation.

abstract：:Ultra-long metal nanowires and their facile fabrication have been long sought after as they promise to offer substantial improvements of performance in numerous applications. However, ultra-long metal ultrafine/nanowires are beyond the capability of current manufacturing techniques, which impose limitations on their s...

journal_title：Nature communications

authors： Hwang I,Guan Z,Cao C,Tang W,Chui CO,Li X

更新日期：2020-11-23 00:00:00

abstract：:Xylanolytic enzymes from glycoside hydrolase family 43 (GH43) are involved in the breakdown of hemicellulose, the second most abundant carbohydrate in plants. Here, we kinetically and mechanistically describe the non-reducing-end xylose-releasing exo-oligoxylanase activity and report the crystal structure of a native ...

journal_title：Nature communications

authors： Morais MAB,Coines J,Domingues MN,Pirolla RAS,Tonoli CCC,Santos CR,Correa JBL,Gozzo FC,Rovira C,Murakami MT

更新日期：2021-01-14 00:00:00

abstract：:In cancer metastasis, various environmental stressors attack the disseminating cells. The successful colonization of cancer cells in secondary sites therefore requires the ability of the cells to avoid the consequences of such exposure to the stressors. Here we show that orthotopic transplantation of a CD44 variant is...

journal_title：Nature communications

authors： Yae T,Tsuchihashi K,Ishimoto T,Motohara T,Yoshikawa M,Yoshida GJ,Wada T,Masuko T,Mogushi K,Tanaka H,Osawa T,Kanki Y,Minami T,Aburatani H,Ohmura M,Kubo A,Suematsu M,Takahashi K,Saya H,Nagano O

更新日期：2012-06-06 00:00:00

abstract：:Despite the success of current therapies for acute myocardial infarction (MI), many patients still develop adverse cardiac remodeling and heart failure. With the growing prevalence of heart failure, a new therapy is needed that can prevent remodeling and support tissue repair. Herein, we report on injectable recombina...

journal_title：Nature communications

authors： McLaughlin S,McNeill B,Podrebarac J,Hosoyama K,Sedlakova V,Cron G,Smyth D,Seymour R,Goel K,Liang W,Rayner KJ,Ruel M,Suuronen EJ,Alarcon EI

更新日期：2019-10-25 00:00:00

abstract：:Invasive plant species threaten native biodiversity, ecosystems, agriculture, industry and human health worldwide, lending urgency to the search for predictors of plant invasiveness outside native ranges. There is much conflicting evidence about which plant characteristics best predict invasiveness. Here we use a glob...

journal_title：Nature communications

authors： Jelbert K,Buss D,McDonald J,Townley S,Franco M,Stott I,Jones O,Salguero-Gómez R,Buckley Y,Knight T,Silk M,Sargent F,Rolph S,Wilson P,Hodgson D

更新日期：2019-12-06 00:00:00

abstract：:A detailed understanding of the human infectious reservoir is essential for improving malaria transmission-reducing interventions. Here we report a multi-regional assessment of population-wide malaria transmission potential based on 1209 mosquito feeding assays in endemic areas of Burkina Faso and Kenya. Across both s...

journal_title：Nature communications

authors： Gonçalves BP,Kapulu MC,Sawa P,Guelbéogo WM,Tiono AB,Grignard L,Stone W,Hellewell J,Lanke K,Bastiaens GJH,Bradley J,Nébié I,Ngoi JM,Oriango R,Mkabili D,Nyaurah M,Midega J,Wirth DF,Marsh K,Churcher TS,Bejon P,Siri

更新日期：2017-10-26 00:00:00

abstract：:Epigenetic regulation plays an important role in governing stem cell fate and tumorigenesis. Lost expression of a key DNA demethylation enzyme TET2 is associated with human cancers and has been linked to stem cell traits in vitro; however, whether and how TET2 regulates mammary stem cell fate and mammary tumorigenesis...

journal_title：Nature communications

authors： Kim MR,Wu MJ,Zhang Y,Yang JY,Chang CJ

更新日期：2020-09-15 00:00:00

abstract：:Although the pharmacological effects of fibroblast growth factor 21 (FGF21) are well-documented, uncertainty about its role in regulating excessive energy intake remains. Here, we show that FGF21 improves systemic insulin sensitivity by promoting the healthy expansion of subcutaneous adipose tissue (SAT). Serum FGF21 ...

journal_title：Nature communications

authors： Li H,Wu G,Fang Q,Zhang M,Hui X,Sheng B,Wu L,Bao Y,Li P,Xu A,Jia W

更新日期：2018-01-18 00:00:00

abstract：:Despite their importance as mechanistic models for heterogeneous Haber Bosch ammonia synthesis from dinitrogen and dihydrogen, homogeneous molecular terminal metal-nitrides are notoriously unreactive towards dihydrogen, and only a few electron-rich, low-coordinate variants demonstrate any hydrogenolysis chemistry. Her...

journal_title：Nature communications

authors： Chatelain L,Louyriac E,Douair I,Lu E,Tuna F,Wooles AJ,Gardner BM,Maron L,Liddle ST

更新日期：2020-01-17 00:00:00

abstract：:Nonribosomal peptide synthetases containing starter condensation domains direct the biosynthesis of nonribosomal lipopeptides, which generally exhibit wide bioactivities. The acyl chain has strong impacts on bioactivity and toxicity, but the lack of an in-depth understanding of starter condensation domain-mediated lip...

journal_title：Nature communications

authors： Zhong L,Diao X,Zhang N,Li F,Zhou H,Chen H,Bai X,Ren X,Zhang Y,Wu D,Bian X

更新日期：2021-01-12 00:00:00

abstract：:Circadian rhythms of cell division have been observed in several lineages of eukaryotes, especially photosynthetic unicellular eukaryotes. However, the mechanism underlying the circadian regulation of the cell cycle and the nature of the advantage conferred remain unknown. Here, using the unicellular red alga Cyanidio...

journal_title：Nature communications

authors： Miyagishima SY,Fujiwara T,Sumiya N,Hirooka S,Nakano A,Kabeya Y,Nakamura M

更新日期：2014-05-08 00:00:00

abstract：:The continued development of novel drugs, proteins, and advanced materials strongly rely on our ability to self-assemble molecules in solids with the most suitable structure (polymorph) in order to exhibit desired functionalities. The search for new polymorphs remains a scientific challenge, that is at the core of cry...

journal_title：Nature communications

authors： Potticary J,Terry LR,Bell C,Papanikolopoulos AN,Christianen PC,Engelkamp H,Collins AM,Fontanesi C,Kociok-Köhn G,Crampin S,Da Como E,Hall SR

更新日期：2016-05-10 00:00:00

abstract：:In nature, individual cells contain multiple isolated compartments in which cascade enzymatic reactions occur to form essential biological products with high efficiency. Here, we report a cell-inspired design of functional hydrogel particles with multiple compartments, in which different enzymes are spatially immobili...

journal_title：Nature communications

authors： Tan H,Guo S,Dinh ND,Luo R,Jin L,Chen CH

更新日期：2017-09-22 00:00:00

abstract：:Spinal motor neurons (MNs) control diverse motor tasks including respiration, posture and locomotion that are disrupted by neurodegenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy. Methods directing MN differentiation from stem cells have been developed to enable disease modelling i...

journal_title：Nature communications

authors： Adams KL,Rousso DL,Umbach JA,Novitch BG

更新日期：2015-04-14 00:00:00

abstract：:Central nervous system (CNS) injuries persist for years, and currently there are no therapeutics that can address the complex injury cascade that develops over this time-scale. 17β-estradiol (E2) has broad tropism within the CNS, targeting and inducing beneficial phenotypic changes in myriad cells following injury. To...

journal_title：Nature communications

authors： D'Amato AR,Puhl DL,Ellman SAT,Balouch B,Gilbert RJ,Palermo EF

更新日期：2019-10-23 00:00:00

abstract：:Mass extinctions have profoundly impacted the evolution of life through not only reducing taxonomic diversity but also reshaping ecosystems and biogeographic patterns. In particular, they are considered to have driven increased biogeographic cosmopolitanism, but quantitative tests of this hypothesis are rare and have ...

journal_title：Nature communications

authors： Button DJ,Lloyd GT,Ezcurra MD,Butler RJ

更新日期：2017-10-10 00:00:00

abstract：:The reversible modification of cysteine residues by thioester formation with palmitate (S-palmitoylation) is an abundant lipid post-translational modification (PTM) in mammalian systems. S-palmitoylation has been observed on mitochondrial proteins, providing an intriguing potential connection between metabolic lipids ...

journal_title：Nature communications

authors： Kathayat RS,Cao Y,Elvira PD,Sandoz PA,Zaballa ME,Springer MZ,Drake LE,Macleod KF,van der Goot FG,Dickinson BC

更新日期：2018-01-23 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms14454. ...

journal_title：Nature communications

authors： Bengtsson NE,Hall JK,Odom GL,Phelps MP,Andrus CR,Hawkins RD,Hauschka SD,Chamberlain JR,Chamberlain JS

更新日期：2017-06-23 00:00:00

abstract：:To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported to date. Here we completely sequence the genome of the filastere...

journal_title：Nature communications

authors： Suga H,Chen Z,de Mendoza A,Sebé-Pedrós A,Brown MW,Kramer E,Carr M,Kerner P,Vervoort M,Sánchez-Pons N,Torruella G,Derelle R,Manning G,Lang BF,Russ C,Haas BJ,Roger AJ,Nusbaum C,Ruiz-Trillo I

更新日期：2013-01-01 00:00:00

abstract：:The xeroderma pigmentosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions before recruiting downstream factors. How XPC detects structurally diverse lesions embedded within normal DNA is unknown. Here we present a crystal structure that captures the yeast XPC orthologue (Rad4) on a sing...

journal_title：Nature communications

authors： Chen X,Velmurugu Y,Zheng G,Park B,Shim Y,Kim Y,Liu L,Van Houten B,He C,Ansari A,Min JH

更新日期：2015-01-06 00:00:00

abstract：:Polarization-driven resistive switching in ferroelectric tunnel junctions (FTJs)--structures composed of two electrodes separated by an ultrathin ferroelectric barrier--offers new physics and materials functionalities, as well as exciting opportunities for the next generation of non-volatile memories and logic devices...

journal_title：Nature communications

authors： Lu H,Lipatov A,Ryu S,Kim DJ,Lee H,Zhuravlev MY,Eom CB,Tsymbal EY,Sinitskii A,Gruverman A

更新日期：2014-11-24 00:00:00

abstract：:Understanding catalysts strain dynamic behaviours is crucial for the development of cost-effective, efficient, stable and long-lasting catalysts. Here, we reveal in situ three-dimensional strain evolution of single gold nanocrystals during a catalytic CO oxidation reaction under operando conditions with coherent X-ray...

journal_title：Nature communications

authors： Passos AR,Rochet A,Manente LM,Suzana AF,Harder R,Cha W,Meneau F

更新日期：2020-09-18 00:00:00

abstract：:Bacteriophage Q protein engages σ-dependent paused RNA polymerase (RNAP) by binding to a DNA site embedded in late gene promoter and renders RNAP resistant to termination signals. Here, we report a single-particle cryo-electron microscopy (cryo-EM) structure of an intact Q-engaged arrested complex. The structure revea...

journal_title：Nature communications

authors： Shi J,Gao X,Tian T,Yu Z,Gao B,Wen A,You L,Chang S,Zhang X,Zhang Y,Feng Y

更新日期：2019-07-02 00:00:00

abstract：:Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL oligomerization, membrane translocation and membrane disruption, although the precise choreography of events is incompletely understood. Her...

journal_title：Nature communications

authors： Samson AL,Zhang Y,Geoghegan ND,Gavin XJ,Davies KA,Mlodzianoski MJ,Whitehead LW,Frank D,Garnish SE,Fitzgibbon C,Hempel A,Young SN,Jacobsen AV,Cawthorne W,Petrie EJ,Faux MC,Shield-Artin K,Lalaoui N,Hildebrand JM,Silke

更新日期：2020-06-19 00:00:00

abstract：:Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that kidney function is  recovered after AKI despite substantial t...

journal_title：Nature communications

authors： Lazzeri E,Angelotti ML,Peired A,Conte C,Marschner JA,Maggi L,Mazzinghi B,Lombardi D,Melica ME,Nardi S,Ronconi E,Sisti A,Antonelli G,Becherucci F,De Chiara L,Guevara RR,Burger A,Schaefer B,Annunziato F,Anders HJ,La

更新日期：2018-04-09 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions are associated with mitochondrial disease, and also accumulate during normal human ageing. The mechanisms underlying mtDNA deletions remain unknown although several models have been proposed. Here we use deep sequencing to characterize abundant mtDNA deletions in patients with mutat...

journal_title：Nature communications

authors： Persson Ö,Muthukumar Y,Basu S,Jenninger L,Uhler JP,Berglund AK,McFarland R,Taylor RW,Gustafsson CM,Larsson E,Falkenberg M

更新日期：2019-02-15 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. ...

journal_title：Nature communications

authors： Trembinski DJ,Bink DI,Theodorou K,Sommer J,Fischer A,van Bergen A,Kuo CC,Costa IG,Schürmann C,Leisegang MS,Brandes RP,Alekseeva T,Brill B,Wietelmann A,Johnson CN,Spring-Connell A,Kaulich M,Werfel S,Engelhardt S,Hirt

更新日期：2020-04-27 00:00:00

abstract：:The basal ganglia, and the striatum in particular, have been implicated in the generation of contraversive movements. The striatum projects to downstream basal ganglia nuclei through two main circuits, originating in striatonigral and striatopallidal neurons, and different models postulate that the two pathways can wo...

journal_title：Nature communications

authors： Tecuapetla F,Matias S,Dugue GP,Mainen ZF,Costa RM

更新日期：2014-07-08 00:00:00

abstract：:Stress granules (SG) are translationally silent sites of RNA triage induced by environmental stresses including viral infection. Here we show that HIV-1 Gag blocks SG assembly irrespective of eIF2α phosphorylation and even when SG assembly is forced by overexpression of Ras-GAP SH3 domain-binding protein (G3BP1) or TI...

journal_title：Nature communications

authors： Valiente-Echeverría F,Melnychuk L,Vyboh K,Ajamian L,Gallouzi IE,Bernard N,Mouland AJ

更新日期：2014-09-17 00:00:00

abstract：:Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and obs...

journal_title：Nature communications

authors： Fernandez-Cuesta L,Peifer M,Lu X,Sun R,Ozretić L,Seidal D,Zander T,Leenders F,George J,Müller C,Dahmen I,Pinther B,Bosco G,Konrad K,Altmüller J,Nürnberg P,Achter V,Lang U,Schneider PM,Bogus M,Soltermann A,Brustu

更新日期：2014-03-27 00:00:00