Balanced activity in basal ganglia projection pathways is critical for contraversive movements.

abstract：:The mathematics of gauge theories lies behind many of the most profound advances in physics in the past 200 years, from Maxwell's theory of electromagnetism to Einstein's theory of general relativity. More recently it has become clear that gauge theories also emerge in condensed matter, a prime example being the spin-...

journal_title：Nature communications

authors： Benton O,Jaubert LD,Yan H,Shannon N

更新日期：2016-05-26 00:00:00

abstract：:Type 2 diabetes (T2D) results from the combined effects of genetic and environmental factors on multiple tissues over time. Of the >100 variants associated with T2D and related traits in genome-wide association studies (GWAS), >90% occur in non-coding regions, suggesting a strong regulatory component to T2D risk. Here...

journal_title：Nature communications

authors： Scott LJ,Erdos MR,Huyghe JR,Welch RP,Beck AT,Wolford BN,Chines PS,Didion JP,Narisu N,Stringham HM,Taylor DL,Jackson AU,Vadlamudi S,Bonnycastle LL,Kinnunen L,Saramies J,Sundvall J,Albanus RD,Kiseleva A,Hensley J,Cr

更新日期：2016-06-29 00:00:00

abstract：:Perovskite quantum-dot-based light-emitting diodes (QLEDs) possess the features of wide gamut and real color expression, which have been considered as candidates for high-quality lightings and displays. However, massive defects are prone to be reproduced during the quantum dot (QD) film assembly, which would sorely af...

journal_title：Nature communications

authors： Xu L,Li J,Cai B,Song J,Zhang F,Fang T,Zeng H

更新日期：2020-08-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Song H,Béthoux O,Shin S,Donath A,Letsch H,Liu S,McKenna DD,Meng G,Misof B,Podsiadlowski L,Zhou X,Wipfler B,Simon S

更新日期：2020-11-03 00:00:00

abstract：:A nest of begging chicks invites an intuitive explanation: needy chicks want to be fed and parents want to feed them. Surprisingly, however, in a quarter of species studied, parents ignore begging chicks. Furthermore, parents in some species even neglect smaller chicks that beg more, and preferentially feed the bigges...

journal_title：Nature communications

authors： Caro SM,Griffin AS,Hinde CA,West SA

更新日期：2016-03-29 00:00:00

abstract：:Interaction between light and matter results in new quantum states whose energetics can modify chemical kinetics. In the regime of ensemble vibrational strong coupling (VSC), a macroscopic number [Formula: see text] of molecular transitions couple to each resonant cavity mode, yielding two hybrid light-matter (polarit...

journal_title：Nature communications

authors： Campos-Gonzalez-Angulo JA,Ribeiro RF,Yuen-Zhou J

更新日期：2019-10-15 00:00:00

abstract：:As influenza A viruses remain a major threat to human health worldwide, the discovery of broadly neutralizing monoclonal antibodies that recognize conserved epitopes would facilitate the development of antibody-based therapeutic strategies. Here we report that a VH4-4-encoded human mAb named 3E1 could neutralize H1 an...

journal_title：Nature communications

authors： Wang W,Sun X,Li Y,Su J,Ling Z,Zhang T,Wang F,Zhang H,Chen H,Ding J,Sun B

更新日期：2016-12-02 00:00:00

abstract：:Cell fate determination requires the cooperation between extrinsic signals and intrinsic molecules including transcription factors as well as epigenetic regulators. Nevertheless, how neural fate commitment is regulated by epigenetic modifications remains largely unclear. Here we show that transient histone deacetylati...

journal_title：Nature communications

authors： Liu P,Dou X,Liu C,Wang L,Xing C,Peng G,Chen J,Yu F,Qiao Y,Song L,Wu Y,Yue C,Li J,Han JD,Tang K,Jing N

更新日期：2015-04-23 00:00:00

abstract：:Predictable stereoselective formation of supramolecular assembly is generally believed to be an important but complicated process. Here, we show that point chirality of a ligand decisively influences its supramolecular assembly behavior. We designed three closely related chiral ligands with different point chiralities...

journal_title：Nature communications

authors： Yeung CT,Yim KH,Wong HY,Pal R,Lo WS,Yan SC,Yee-Man Wong M,Yufit D,Smiles DE,McCormick LJ,Teat SJ,Shuh DK,Wong WT,Law GL

更新日期：2017-10-24 00:00:00

abstract：:The virulence factor pyocyanin and the intracellular second messenger cyclic diguanylate monophosphate (c-di-GMP) play key roles in regulating biofilm formation and multi-drug efflux pump expression in Pseudomonas aeruginosa. However, the crosstalk between these two signaling pathways remains unclear. Here we show tha...

journal_title：Nature communications

authors： Wang F,He Q,Yin J,Xu S,Hu W,Gu L

更新日期：2018-07-02 00:00:00

abstract：:The gyrotropic rotation around the equilibrium position constitutes the fundamental excitation of magnetic vortices in nanostructures. The frequency of this mode varies with material and sample geometry, but is independent of the vortex handedness and its core direction. Here, we demonstrate that this degeneracy is li...

journal_title：Nature communications

authors： Sluka V,Kákay A,Deac AM,Bürgler DE,Schneider CM,Hertel R

更新日期：2015-03-03 00:00:00

abstract：:Directed self-assemblies in water are known as the most efficient means of forming complex higher ordered structures in nature. Here we show a straightforward and robust method for particle assembly which utilises the amphiphilic tri-block co-polymer poloxamer-188 and a hydrophobic fluorophore as the two designer comp...

journal_title：Nature communications

authors： Cheung S,O'Shea DF

更新日期：2017-12-01 00:00:00

abstract：:Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating, a process critical for cellular motility and extracellular fluid flow. Axonemal dyneins are evolutionarily and biochemically distinct from cytoplasmic dyneins that transport cargo, and the mechanisms regulating their localizat...

journal_title：Nature communications

authors： Walton T,Wu H,Brown A

更新日期：2021-01-20 00:00:00

abstract：:Tpt1 is an essential agent of fungal tRNA splicing that removes the 2'-PO4 at the splice junction generated by fungal tRNA ligase. Tpt1 catalyzes a unique two-step reaction whereby the 2'-PO4 attacks NAD+ to form an RNA-2'-phospho-ADP-ribosyl intermediate that undergoes transesterification to yield 2'-OH RNA and ADP-r...

journal_title：Nature communications

authors： Banerjee A,Munir A,Abdullahu L,Damha MJ,Goldgur Y,Shuman S

更新日期：2019-01-15 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis is strongly associated with molecular subgroup, although the driver mutations that distinguish the two main subgroups remain poorly defined. Through an integrative analysis of whole genomes, exomes, and transcripto...

journal_title：Nature communications

authors： Arthur SE,Jiang A,Grande BM,Alcaide M,Cojocaru R,Rushton CK,Mottok A,Hilton LK,Lat PK,Zhao EY,Culibrk L,Ennishi D,Jessa S,Chong L,Thomas N,Pararajalingam P,Meissner B,Boyle M,Davidson J,Bushell KR,Lai D,Farinha

更新日期：2018-10-01 00:00:00

abstract：:One of the primary efforts in influenza vaccine strain recommendation is to monitor through gene sequencing the viral surface protein haemagglutinin (HA) variants that lead to viral antigenic changes. Here we have developed a computational method, denoted as PREDAC, to predict antigenic clusters of influenza A (H3N2) ...

journal_title：Nature communications

authors： Du X,Dong L,Lan Y,Peng Y,Wu A,Zhang Y,Huang W,Wang D,Wang M,Guo Y,Shu Y,Jiang T

更新日期：2012-02-28 00:00:00

abstract：:A fundamental puzzle of human evolution is how we evolved to cooperate with genetically unrelated strangers in transient interactions. Group-level selection on culturally differentiated populations is one proposed explanation. We evaluate a central untested prediction of Cultural Group Selection theory, by assessing w...

journal_title：Nature communications

authors： Handley C,Mathew S

更新日期：2020-02-04 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating resid...

journal_title：Nature communications

authors： Dallari S,Macal M,Loureiro ME,Jo Y,Swanson L,Hesser C,Ghosh P,Zuniga EI

更新日期：2017-04-03 00:00:00

abstract：:The worldwide dissemination of metallo-β-lactamases (MBLs), mediating resistance to carbapenem antibiotics, is a major public health problem. The extent of dissemination of MBLs such as VIM-2, SPM-1 and NDM among Gram-negative pathogens cannot be explained solely based on the associated mobile genetic elements or the ...

journal_title：Nature communications

authors： López C,Ayala JA,Bonomo RA,González LJ,Vila AJ

更新日期：2019-08-09 00:00:00

abstract：:Natural killer (NK) cells are reported to have immunological memory, with CD49a+ liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7Rα, are generated in the l...

journal_title：Nature communications

authors： Wang X,Peng H,Cong J,Wang X,Lian Z,Wei H,Sun R,Tian Z

更新日期：2018-11-19 00:00:00

abstract：:Natural killer (NK) cells are cytotoxic innate lymphoid cells that are involved in immune defense. NK cell reactivity is controlled in part by MHC class I recognition by inhibitory receptors, but the underlying molecular mechanisms remain undefined. Using a mouse model of conditional deletion in NK cells, we show here...

journal_title：Nature communications

authors： Viant C,Fenis A,Chicanne G,Payrastre B,Ugolini S,Vivier E

更新日期：2014-10-30 00:00:00

abstract：:Previous studies have reported that chromosome synteny in Lepidoptera has been well conserved, yet the number of haploid chromosomes varies widely from 5 to 223. Here we report the genome (393 Mb) of the Glanville fritillary butterfly (Melitaea cinxia; Nymphalidae), a widely recognized model species in metapopulation ...

journal_title：Nature communications

authors： Ahola V,Lehtonen R,Somervuo P,Salmela L,Koskinen P,Rastas P,Välimäki N,Paulin L,Kvist J,Wahlberg N,Tanskanen J,Hornett EA,Ferguson LC,Luo S,Cao Z,de Jong MA,Duplouy A,Smolander OP,Vogel H,McCoy RC,Qian K,Chong W

更新日期：2014-09-05 00:00:00

abstract：:Complex polyketides are typically associated with microbial metabolism. Here, we report that animals also make complex, microbe-like polyketides. We show there is a widespread branch of fatty acid synthase- (FAS)-like polyketide synthase (PKS) proteins, which sacoglossan animals use to synthesize complex products. The...

journal_title：Nature communications

authors： Torres JP,Lin Z,Winter JM,Krug PJ,Schmidt EW

更新日期：2020-06-08 00:00:00

abstract：:The vertebrate mineralized skeleton is known to have first emerged as an exoskeleton that extensively covered the fossil jawless fish. The evolutionary origin of this exoskeleton has long been attributed to the emergence of the neural crest, but experimental evaluation for this is still poor. Here we determine the emb...

journal_title：Nature communications

authors： Shimada A,Kawanishi T,Kaneko T,Yoshihara H,Yano T,Inohaya K,Kinoshita M,Kamei Y,Tamura K,Takeda H

更新日期：2013-01-01 00:00:00

abstract：:Mitochondria generate most cellular energy via oxidative phosphorylation. Twenty-two species of mitochondrial (mt-)tRNAs encoded in mtDNA translate essential subunits of the respiratory chain complexes. mt-tRNAs contain post-transcriptional modifications introduced by nuclear-encoded tRNA-modifying enzymes. They are r...

journal_title：Nature communications

authors： Suzuki T,Yashiro Y,Kikuchi I,Ishigami Y,Saito H,Matsuzawa I,Okada S,Mito M,Iwasaki S,Ma D,Zhao X,Asano K,Lin H,Kirino Y,Sakaguchi Y,Suzuki T

更新日期：2020-08-28 00:00:00

abstract：:The importance of singlet oxygen (1O2) in the environmental and biomedical fields has motivated research for effective 1O2 production. Electrocatalytic processes hold great potential for highly-automated and scalable 1O2 synthesis, but they are energy- and chemical-intensive. Herein, we present a Janus electrocatalyti...

journal_title：Nature communications

authors： Zhao Y,Sun M,Wang X,Wang C,Lu D,Ma W,Kube SA,Ma J,Elimelech M

更新日期：2020-12-04 00:00:00

abstract：:Emerging quantum technologies require mastering thermal management, especially at the nanoscale. It is now accepted that thermal metamaterial-based phonon manipulation is possible, especially at sub-kelvin temperatures. In these extreme limits of low temperatures and dimensions, heat conduction enters a quantum regime...

journal_title：Nature communications

authors： Tavakoli A,Lulla K,Crozes T,Mingo N,Collin E,Bourgeois O

更新日期：2018-10-16 00:00:00

abstract：:Mapping neuroanatomy is a foundational goal towards understanding brain function. Electron microscopy (EM) has been the gold standard for connectivity analysis because nanoscale resolution is necessary to unambiguously resolve synapses. However, molecular information that specifies cell types is often lost in EM recon...

journal_title：Nature communications

authors： Shen FY,Harrington MM,Walker LA,Cheng HPJ,Boyden ES,Cai D

更新日期：2020-09-15 00:00:00

abstract：:A diversity of self-propelled chemical motors, based on Marangoni propulsive forces, has been developed in recent years. However, most motors are non-functional due to poor performance, a lack of control, and the use of toxic materials. To overcome these limitations, we have developed multifunctional and biodegradable...

journal_title：Nature communications

authors： Pena-Francesch A,Giltinan J,Sitti M

更新日期：2019-07-18 00:00:00

abstract：:Superlubricity of graphite and graphene has aroused increasing interest in recent years. Yet how to obtain a long-lasting superlubricity between graphene layers, under high applied normal load in ambient atmosphere still remains a challenge but is highly desirable. Here, we report a direct measurement of sliding frict...

journal_title：Nature communications

authors： Liu SW,Wang HP,Xu Q,Ma TB,Yu G,Zhang C,Geng D,Yu Z,Zhang S,Wang W,Hu YZ,Wang H,Luo J

更新日期：2017-02-14 00:00:00