Abstract：
:Natural killer (NK) cells are reported to have immunological memory, with CD49a+ liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7Rα, are generated in the lymph nodes (LNs) and require IL-7R signaling to maintain their longevity in the liver. Hapten sensitization initiates CXCR3-dependent recruitment of IL-7Rα+ ILC1s into skin-draining LNs, where they are primed and acquire hapten-specific memory potential. Memory IL-7Rα+ ILC1s then exit draining LNs and are preferentially recruited, via CXCR6, to reside in the liver. Moreover, long-term blockade of IL-7R signaling significantly reduces ILC1-mediated memory responses. Thus, our results identify a memory IL-7Rα+ ILC1 population and reveal a LN-liver axis that is essential for ILC1 memory generation and long-term maintenance.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Wang X,Peng H,Cong J,Wang X,Lian Z,Wei H,Sun R,Tian Zdoi
10.1038/s41467-018-07405-5subject
Has Abstractpub_date
2018-11-19 00:00:00pages
4854issue
1issn
2041-1723pii
10.1038/s41467-018-07405-5journal_volume
9pub_type
杂志文章abstract：:Van Allen radiation belts are typically two zones of energetic particles encircling the Earth separated by the slot region. How the outer radiation belt electrons are accelerated to relativistic energies remains an unanswered question. Recent studies have presented compelling evidence for the local acceleration by ver...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10096
更新日期：2015-12-22 00:00:00
abstract：:Large-scale climate patterns control variability in the global carbon sink. In Europe, the North-Atlantic Oscillation (NAO) influences vegetation activity, however the East-Atlantic (EA) pattern is known to modulate NAO strength and location. Using observation-driven and modelled data sets, we show that multi-annual v...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10315
更新日期：2016-01-18 00:00:00
abstract：:Graphene and hexagonal boron nitride are typical conductor and insulator, respectively, while their hybrids hexagonal boron carbonitride are promising as a semiconductor. Here we demonstrate a direct chemical conversion reaction, which systematically converts the hexagonal carbon lattice of graphene to boron nitride, ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4193
更新日期：2014-01-01 00:00:00
abstract：:Despite the success of current therapies for acute myocardial infarction (MI), many patients still develop adverse cardiac remodeling and heart failure. With the growing prevalence of heart failure, a new therapy is needed that can prevent remodeling and support tissue repair. Herein, we report on injectable recombina...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12748-8
更新日期：2019-10-25 00:00:00
abstract：:Various platinum-free electrocatalysts have been explored for hydrogen evolution reaction in acidic solutions. However, in economical water-alkali electrolysers, sluggish water dissociation kinetics (Volmer step) on platinum-free electrocatalysts results in poor hydrogen-production activities. Here we report a MoNi4 e...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15437
更新日期：2017-05-17 00:00:00
abstract：:Generally, a homogeneous catalyst exhibits good activity and defined active sites but it is difficult to recycle. Meanwhile, a heterogeneous catalyst can easily be reused but its active site is difficult to reveal. It is interesting to bridge the gap between homogeneous and heterogeneous catalysis via controllable con...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03834-4
更新日期：2018-04-13 00:00:00
abstract：:Molecular crystals can be bent elastically by expansion or plastically by delamination into slabs that glide along slip planes. Here we report that upon bending, terephthalic acid crystals can undergo a mechanically induced phase transition without delamination and their overall crystal integrity is retained. Such pla...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11612-z
更新日期：2019-08-19 00:00:00
abstract：:The original version of the Supplementary Information associated with this Article contained errors in Supplementary Figures 2, 12, 20 and 22. The HTML has been updated to include a corrected version of the Supplementary Information; the original incorrect versions of these Figures can be found as Supplementary Inform...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-019-09702-z
更新日期：2019-05-13 00:00:00
abstract：:International corporations in an increasingly globalized economy exert a major influence on the planet's land use and resources through their product design and material sourcing decisions. Many companies use life cycle assessment (LCA) to evaluate their sustainability, yet commonly-used LCA methodologies lack the spa...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15065
更新日期：2017-04-21 00:00:00
abstract：:Predicting ecological effects of contaminants remains challenging because of the sheer number of chemicals and their ambiguous role in biodiversity-ecosystem function relationships. We evaluate responses of experimental pond ecosystems to standardized concentrations of 12 pesticides, nested in four pesticide classes a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20192-2
更新日期：2020-12-10 00:00:00
abstract：:Microalbuminuria is an important clinical marker of several cardiovascular, metabolic, and other diseases such as diabetes, hypertension, atherosclerosis, and cancer. The accurate detection of microalbuminuria relies on albumin quantification in the urine, usually via an immunoturbidity assay; however, like many antib...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11583-1
更新日期：2019-08-09 00:00:00
abstract：:The mammary gland is a highly vascularized tissue capable of expansion and regression during development and disease. To enable mechanistic insight into the coordinated morphogenic crosstalk between the epithelium and vasculature, we introduce a 3D microfluidic platform that juxtaposes a human mammary duct in proximit...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-17102-x
更新日期：2020-07-06 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome that elevates the risk of hepatocellular carcinoma (HCC). Although alteration of lipid metabolism has been increasingly recognized as a hallmark of cancer cells, the deregulated metabolic modulation of HCC cells in the NAF...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11274-x
更新日期：2019-07-29 00:00:00
abstract：:Strategies to harness photosynthesis from living organisms to generate electrical power have long been considered, yet efficiency remains low. Here, we aimed to reroute photosynthetic electron flow in photosynthetic organisms without compromising their phototrophic properties. We show that 2,6-dimethyl-p-benzoquinone ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15274
更新日期：2017-05-03 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-020-15790-z
更新日期：2020-04-22 00:00:00
abstract：:The original version of this Article contained errors in Figs. 1a, 2a, 3a, and 4b, in which the units on the scale bars incorrectly read 'µm' rather than the correct 'nm.' This has been corrected in both the PDF and HTML versions of the Article. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-03634-w
更新日期：2018-03-14 00:00:00
abstract：:Secret communication over public channels is one of the central pillars of a modern information society. Using quantum key distribution this is achieved without relying on the hardness of mathematical problems, which might be compromised by improved algorithms or by future quantum computers. State-of-the-art quantum k...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9795
更新日期：2015-10-30 00:00:00
abstract：:The lack of microbial genomes and isolates from the deep seabed means that very little is known about the ecology of this vast habitat. Here, we investigate energy and carbon acquisition strategies of microbial communities from three deep seabed petroleum seeps (3 km water depth) in the Eastern Gulf of Mexico. Shotgun...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09747-0
更新日期：2019-04-18 00:00:00
abstract：:The synergistic interaction among different components in complex catalysts is one of the crucial factors in determining catalytic performance. Here we report the interactions among the three components in controlling the catalytic performance of Cu-ZnO-ZrO2 (CZZ) catalyst for CO2 hydrogenation to methanol. The in sit...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09072-6
更新日期：2019-03-11 00:00:00
abstract：:Metals and polymers are dissimilar materials in terms of their physicochemical properties, but complementary in terms of functionality. As a result, metal-organic structures can introduce a wealth of novel applications in small-scale robotics. However, current fabrication techniques are unable to process three-dimensi...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19725-6
更新日期：2020-11-24 00:00:00
abstract：:During mitosis, duplicated sister chromatids attach to microtubules emanating from opposing sides of the bipolar spindle through large protein complexes called kinetochores. In the absence of stable kinetochore-microtubule attachments, a cell surveillance mechanism known as the spindle assembly checkpoint (SAC) produc...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10036
更新日期：2015-12-01 00:00:00
abstract：:A fundamental puzzle of human evolution is how we evolved to cooperate with genetically unrelated strangers in transient interactions. Group-level selection on culturally differentiated populations is one proposed explanation. We evaluate a central untested prediction of Cultural Group Selection theory, by assessing w...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14416-8
更新日期：2020-02-04 00:00:00
abstract：:Grain rotation is a well-known phenomenon during high (homologous) temperature deformation and recrystallization of polycrystalline materials. In recent years, grain rotation has also been proposed as a plasticity mechanism at low temperatures (for example, room temperature for metals), especially for nanocrystalline ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5402
更新日期：2014-07-17 00:00:00
abstract：:DNA damage and secondary structures can stall the replication machinery. Cells possess numerous tolerance mechanisms to complete genome duplication in the presence of such impediments. In addition to translesion synthesis (TLS) polymerases, most eukaryotic cells contain a multifunctional replicative enzyme called prim...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15222
更新日期：2017-05-23 00:00:00
abstract：:Collective cell migration mediates multiple tissue morphogenesis processes. Yet how multi-dimensional mesenchymal cell movements are coordinated remains mostly unknown. Here we report that coordinated mesenchymal cell migration during chicken feather elongation is accompanied by dynamic changes of bioelectric currents...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07661-5
更新日期：2018-12-18 00:00:00
abstract：:Recent studies suggest the emerging roles of armadillo (ARM) family proteins in tumor progression. However, the functions and underlying mechanisms of ARM members in tumorigenesis and aggressiveness of neuroblastoma (NB) remain to be determined. Herein, we identify armadillo repeat containing 12 (ARMC12) as an ARM mem...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05286-2
更新日期：2018-07-19 00:00:00
abstract：:The search for a method that utilizes biological information to predict humans' place of origin has occupied scientists for millennia. Over the past four decades, scientists have employed genetic data in an effort to achieve this goal but with limited success. While biogeographical algorithms using next-generation seq...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4513
更新日期：2014-04-29 00:00:00
abstract：:Common variable immunodeficiency disorder (CVID) is the most common symptomatic primary immunodeficiency in adults, characterized by B-cell abnormalities and inadequate antibody response. CVID patients have considerable autoimmune comorbidity and we therefore hypothesized that genetic susceptibility to CVID may overla...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7804
更新日期：2015-04-20 00:00:00
abstract：:Nonsense-mediated decay (NMD) eliminates transcripts with premature termination codons. Although NMD-induced loss-of-function has been shown to contribute to the genesis of particular cancers, its global functional consequence in tumours has not been characterized. Here we develop an algorithm to predict NMD and apply...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15943
更新日期：2017-06-26 00:00:00
abstract：:There is enormous interest in engineering topological photonic systems. Despite intense activity, most works on topological photonic states (and more generally bosonic states) amount in the end to replicating a well-known fermionic single-particle Hamiltonian. Here we show how the squeezing of light can lead to the fo...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10779
更新日期：2016-03-02 00:00:00
