Abstract:
:During mitosis, duplicated sister chromatids attach to microtubules emanating from opposing sides of the bipolar spindle through large protein complexes called kinetochores. In the absence of stable kinetochore-microtubule attachments, a cell surveillance mechanism known as the spindle assembly checkpoint (SAC) produces an inhibitory signal that prevents anaphase onset. Precisely how the inhibitory SAC signal is extinguished in response to microtubule attachment remains unresolved. To address this, we induced formation of hyper-stable kinetochore-microtubule attachments in human cells using a non-phosphorylatable version of the protein Hec1, a core component of the attachment machinery. We find that stable attachments are sufficient to silence the SAC in the absence of sister kinetochore bi-orientation and strikingly in the absence of detectable microtubule pulling forces or tension. Furthermore, we find that SAC satisfaction occurs despite the absence of large changes in intra-kinetochore distance, suggesting that substantial kinetochore stretching is not required for quenching the SAC signal.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Tauchman EC,Boehm FJ,DeLuca JGdoi
10.1038/ncomms10036subject
Has Abstractpub_date
2015-12-01 00:00:00pages
10036issn
2041-1723pii
ncomms10036journal_volume
6pub_type
杂志文章abstract::The spikelet is the basal unit of inflorescence in grasses, and its formation is crucial for reproductive success and cereal yield. Here, we report a previously unknown role of the plant hormone jasmonic acid (JA) in determining rice (Oryza sativa) spikelet morphogenesis. The extra glume 1 (eg1) and eg2 mutants exhibi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4476
更新日期:2014-03-19 00:00:00
abstract::Coupling vibrational transitions to resonant optical modes creates vibrational polaritons shifted from the uncoupled molecular resonances and provides a convenient way to modify the energetics of molecular vibrations. This approach is a viable method to explore controlling chemical reactivity. In this work, we report ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13504
更新日期:2016-11-22 00:00:00
abstract::Light trapping across a wide band of frequencies is important for applications such as solar cells and photodetectors. Here, we demonstrate a new approach to light management by forming whispering-gallery resonant modes inside a spherical nanoshell structure. The geometry of the structure gives rise to a low quality-f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1664
更新日期:2012-02-07 00:00:00
abstract::Transcranial electrical stimulation has widespread clinical and research applications, yet its effect on ongoing neural activity in humans is not well established. Previous reports argue that transcranial alternating current stimulation (tACS) can entrain and enhance neural rhythms related to memory, but the evidence ...
journal_title:Nature communications
pub_type: 临床试验,杂志文章
doi:10.1038/s41467-017-01045-x
更新日期:2017-10-31 00:00:00
abstract::Recently, ferroelectric tunnel junctions have attracted much attention due to their potential applications in non-destructive readout non-volatile memories. Using a semiconductor electrode has been proven effective to enhance the tunnelling electroresistance in ferroelectric tunnel junctions. Here we report a systemat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15217
更新日期:2017-05-17 00:00:00
abstract::Muscle-resident PDGFRβ(+) cells, which include pericytes and PW1(+) interstitial cells (PICs), play a dual role in muscular dystrophy. They can either undergo myogenesis to promote muscle regeneration or differentiate into adipocytes and other cells to compromise regeneration. How the differentiation and fate determin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11415
更新日期:2016-05-03 00:00:00
abstract::Cavity quantum electrodynamics describes the fundamental interactions between light and matter, and how they can be controlled by shaping the local environment. For example, optical microcavities allow high-efficiency detection and manipulation of single atoms. In this regime, fluctuations of atom number are on the or...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1428
更新日期:2011-08-09 00:00:00
abstract::Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal fragment (IN) and C-termi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16299-1
更新日期:2020-05-15 00:00:00
abstract::The human brain is inherently limited in the information it can make consciously accessible. When people monitor a rapid stream of visual items for two targets, they typically fail to see the second target if it occurs within 200-500 ms of the first, a phenomenon called the attentional blink (AB). The neural basis for...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14107-z
更新日期:2020-01-23 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-13553-z
更新日期:2019-11-26 00:00:00
abstract::Quantum magnets provide the simplest example of strongly interacting quantum matter, yet they continue to resist a comprehensive understanding above one spatial dimension. We explore a promising framework in two dimensions, the Dirac spin liquid (DSL) - quantum electrodynamics (QED3) with 4 Dirac fermions coupled to p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11727-3
更新日期:2019-09-18 00:00:00
abstract::Metagenomic sequencing provides a window into microbial community structure and metabolic potential; however, linking these data to exogenous metabolites that microorganisms process and produce (the exometabolome) remains challenging. Previously, we observed strong exometabolite niche partitioning among bacterial isol...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02356-9
更新日期:2018-01-02 00:00:00
abstract::The Non-Proliferation Treaty and other non-proliferation agreements are in place worldwide to ensure that nuclear material and facilities are used only for peaceful purposes. Antineutrino detectors, sensitive to reactor power and fuel changes, can complement the tools already at the disposal of international agencies ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11434-z
更新日期:2019-08-06 00:00:00
abstract::Microbial biofilm formation on indwelling medical devices causes persistent infections that cannot be cured with conventional antibiotics. To address this unmet challenge, we engineer tunable active surface topographies with micron-sized pillars that can beat at a programmable frequency and force level in an electroma...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16055-5
更新日期:2020-05-05 00:00:00
abstract::The insulator-to-metal transition continues to be a challenging subject, especially when electronic correlations are strong. In layered compounds, such as La2-xSrxNiO4 and La2-xBaxCuO4, the doped charge carriers can segregate into periodically spaced charge stripes separating narrow domains of antiferromagnetic order....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4467
更新日期:2014-03-17 00:00:00
abstract::We establish a powerful poly(4-styrenesulfonate) (PSS)-treated strategy for sulfur vacancy healing in monolayer MoS2 to precisely and steadily tune its electronic state. The self-healing mechanism, in which the sulfur vacancies are healed spontaneously by the sulfur adatom clusters on the MoS2 surface through a PSS-in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15881
更新日期:2017-06-22 00:00:00
abstract::Controlling the structure of catalysts at the atomic level provides an opportunity to establish detailed understanding of the catalytic form-to-function and realize new, non-equilibrium catalytic structures. Here, advanced thin-film deposition is used to control the atomic structure of La2/3Sr1/3MnO3, a well-known cat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06503-8
更新日期:2018-10-02 00:00:00
abstract::Prolonged cell survival occurs through the expression of specific protein isoforms generated by alternate splicing of mRNA precursors in cancer cells. How alternate splicing regulates tumor development and resistance to targeted therapies in cancer remain poorly understood. Here we show that RNF113A, whose loss-of-fun...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15003-7
更新日期:2020-03-09 00:00:00
abstract::Axially chiral compounds play an important role in areas such as asymmetric catalysis. The tyrosine click-like reaction is an efficient approach for synthesis of urazoles with potential applications in pharmaceutical and asymmetric catalysis. Here we discover a class of urazole with axial chirality by restricted rotat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10677
更新日期:2016-02-11 00:00:00
abstract::Exciton dynamics can be strongly affected by lattice vibrations through electron-phonon coupling. This is rarely explored in two-dimensional magnetic semiconductors. Focusing on bilayer CrI3, we first show the presence of strong electron-phonon coupling through temperature-dependent photoluminescence and absorption sp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18627-x
更新日期:2020-09-22 00:00:00
abstract::The ~70 km-diameter Yarrabubba impact structure in Western Australia is regarded as among Earth's oldest, but has hitherto lacked precise age constraints. Here we present U-Pb ages for impact-driven shock-recrystallised accessory minerals. Shock-recrystallised monazite yields a precise impact age of 2229 ± 5 Ma, coeva...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13985-7
更新日期:2020-01-21 00:00:00
abstract::The occurrence of Oceanic Anoxic Event 2 (OAE2) 94 million years ago is considered to be one of the largest carbon cycle perturbations in the Earth's history. The marked increase in the spatial extent of the anoxic conditions in the world's oceans associated with OAE2 resulted in the mass accumulation of organic-rich ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1233
更新日期:2011-01-01 00:00:00
abstract::Macrophages are a major immune cell type infiltrating tumors and promoting tumor growth and metastasis. To elucidate the mechanism of macrophage recruitment, we utilize an overgrowth tumor model ("undead" model) in larval Drosophila imaginal discs that are attached by numerous macrophages. Here we report that changes ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17399-8
更新日期:2020-07-20 00:00:00
abstract::The change of global-mean precipitation under global warming and interannual variability is predominantly controlled by the change of atmospheric longwave radiative cooling. Here we show that tightening of the ascending branch of the Hadley Circulation coupled with a decrease in tropical high cloud fraction is key in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15771
更新日期:2017-06-07 00:00:00
abstract::Oxygenic photosynthetic organisms perform solar energy conversion of water and CO2 to O2 and sugar at a broad range of wavelengths and light intensities. These cells also metabolize sugars using a respiratory system that functionally overlaps the photosynthetic apparatus. In this study, we describe the harvesting of p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04613-x
更新日期:2018-06-04 00:00:00
abstract::14-3-3 family proteins regulate multiple signalling pathways. Understanding biological functions of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes. Here we provide evidence that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, translationally con...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11501
更新日期:2016-05-06 00:00:00
abstract::How stem cells give rise to epidermis is unclear despite the crucial role the epidermis plays in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular epidermis and find four spatially distinct stem cell populations at the top and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18075-7
更新日期:2020-08-25 00:00:00
abstract::Controlling the transmission of electrical current using a quantum point contact constriction paved a way to a large variety of experiments in mesoscopic physics. The increasing interest in heat transfer in such systems fosters questions about possible manipulations of quantum heat modes that do not carry net charge (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02433-z
更新日期:2017-12-21 00:00:00
abstract::Polyelectrolyte gel diodes that are double layers of two oppositely charged polyelectrolyte gels, sandwiched by two symmetric electrodes, are emergent ionic devices. These diodes are designed to rectify ion currents with a physical mechanism that is analogous to conventional semiconductor diodes-the asymmetry in the p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5162
更新日期:2014-06-17 00:00:00
abstract::Cosmic rays interact with the Earth's atmosphere to produce 14C, which can be absorbed by trees. Therefore, rapid increases of 14C in tree rings can be used to probe previous cosmic-ray events. By this method, three 14C rapidly increasing events have been found. Plausible causes of these events include large solar pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01698-8
更新日期:2017-11-14 00:00:00