Abstract:
:Muscle-resident PDGFRβ(+) cells, which include pericytes and PW1(+) interstitial cells (PICs), play a dual role in muscular dystrophy. They can either undergo myogenesis to promote muscle regeneration or differentiate into adipocytes and other cells to compromise regeneration. How the differentiation and fate determination of PDGFRβ(+) cells are regulated, however, remains unclear. Here, by utilizing a conditional knockout mouse line, we report that PDGFRβ(+) cell-derived laminin inhibits their proliferation and adipogenesis, but is indispensable for their myogenesis. In addition, we show that laminin alone is able to partially reverse the muscle dystrophic phenotype in these mice at the molecular, structural and functional levels. Further RNAseq analysis reveals that laminin regulates PDGFRβ(+) cell differentiation/fate determination via gpihbp1. These data support a critical role of laminin in the regulation of PDGFRβ(+) cell stemness, identify an innovative target for future drug development and may provide an effective treatment for muscular dystrophy.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Yao Y,Norris EH,Mason CE,Strickland Sdoi
10.1038/ncomms11415subject
Has Abstractpub_date
2016-05-03 00:00:00pages
11415issn
2041-1723pii
ncomms11415journal_volume
7pub_type
杂志文章abstract::Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13076-7
更新日期:2019-11-06 00:00:00
abstract::Plants can produce organs throughout their entire life from pluripotent stem cells located at their growing tip, the shoot apical meristem (SAM). At the time of flowering, the SAM of Arabidopsis thaliana switches fate and starts producing flowers instead of leaves. Correct timing of flowering in part determines reprod...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15120
更新日期:2017-05-17 00:00:00
abstract::Clostridium difficile is the leading cause of pseudomembranous colitis in hospitalized patients. C. difficile enterotoxins TcdA and TcdB promote this inflammatory condition via a cytotoxic response on intestinal epithelial cells (IECs), but the underlying mechanisms are incompletely understood. Additionally, TcdA and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07386-5
更新日期:2018-11-19 00:00:00
abstract::Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is ge...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13855-2
更新日期:2020-01-07 00:00:00
abstract::Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in industrialized countries. Type I interferon (IFN) is important for control of herpes simplex virus (HSV-1) in the central nervous system (CNS). Here we show that microglia are the main source of HSV-induced type I IFN expression i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13348
更新日期:2016-11-10 00:00:00
abstract::Seeded propagation of amyloid-beta (Aβ) pathology is suggested to contribute to the progression of Alzheimer's disease. Local overproduction of aggregation-prone Aβ variants could explain the focal initiation of a seeding cascade that subsequently triggers widespread pathology. Several animal models support this seedi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00579-4
更新日期:2017-09-11 00:00:00
abstract::Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease patients. Here, to ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03552-x
更新日期:2018-03-23 00:00:00
abstract::Haematopoietic stem cells (HSCs) are produced during embryogenesis from the floor of the dorsal aorta. The localization of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel. The nature of the extrinsic molecular signals that control the aortic haematopoietic niche is currently ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6588
更新日期:2014-11-27 00:00:00
abstract::Following uncontrolled proliferation, a subset of primary tumour cells acquires additional traits/mutations to trigger phenotypic changes that enhance migration and are hypothesized to be the initiators of metastasis. This study reveals an adaptive mechanism that harnesses synergistic paracrine signalling via IL-6/8, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15584
更新日期:2017-05-26 00:00:00
abstract::Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00266-4
更新日期:2017-08-04 00:00:00
abstract::Nanoporous frameworks are polymeric materials built from rigid molecules, which give rise to their nanoporous structures with applications in gas sorption and storage, catalysis and others. Conceptually new applications could emerge, should these beneficial properties be manipulated by external stimuli in a reversible...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4588
更新日期:2014-04-07 00:00:00
abstract::While main group elements have four valence orbitals accessible for bonding, quadruple bonding to main group elements is extremely rare. Here we report that main group element boron is able to form quadruple bonding interactions with iron in the BFe(CO)3- anion complex, which has been revealed by quantum chemical inve...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12767-5
更新日期:2019-10-17 00:00:00
abstract::Time-resolved photoelectron spectroscopy (TRPES) is a useful approach to elucidate the coupled electronic-nuclear quantum dynamics underlying chemical processes, but has remained limited by the use of low photon energies. Here, we demonstrate the general advantages of XUV-TRPES through an application to NO2, one of th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05292-4
更新日期:2018-08-08 00:00:00
abstract::The development of thymic regulatory T cells (Treg) is mediated by Aire-regulated self-antigen presentation on medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), but the cooperation between these cells is still poorly understood. Here we show that signaling through Toll-like receptors (TLR) expressed...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16081-3
更新日期:2020-05-12 00:00:00
abstract::MicroRNAs play important roles in regulating tumour development, progression and metastasis. Here we show that one of the miR-200 family members, miR-141, is under-expressed in several prostate cancer (PCa) stem/progenitor cell populations in both xenograft and primary patient tumours. Enforced expression of miR-141 i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14270
更新日期:2017-01-23 00:00:00
abstract::Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed deficiency in chondrocytes causes s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12047
更新日期:2016-06-22 00:00:00
abstract::Functional variomics provides the foundation for personalized medicine by linking genetic variation to disease expression, outcome and treatment, yet its utility is dependent on appropriate assays to evaluate mutation impact on protein function. To fully assess the effects of 106 missense and nonsense variants of PTEN...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15943-0
更新日期:2020-04-29 00:00:00
abstract::Observing the crucial first few femtoseconds of photochemical reactions requires tools typically not available in the femtochemistry toolkit. Such dynamics are now within reach with the instruments provided by attosecond science. Here, we apply experimental and theoretical methods to assess the ultrafast nonadiabatic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01133-y
更新日期:2017-10-18 00:00:00
abstract::The nutritional environment to which animals are exposed in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. Here, we demonstrate that the fibroblast growth factor-21 gene (Fgf21) is subject to peroxisome proliferator-activated receptor (PPAR) α-dependent DNA de...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03038-w
更新日期:2018-02-12 00:00:00
abstract::The development of theories and methods devoted to the accurate calculation of the electronic quasi-particle states and levels of molecules, clusters and solids is of prime importance to interpret the experimental data. These quantum systems are often modelled by using the Born-Oppenheimer approximation where the coup...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11327
更新日期:2016-04-22 00:00:00
abstract::Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear receptor (NR) involved in cell growth and survival that contains both a DNA-binding domain (DBD) and a ligand-binding domain (LBD). Functionally relevant inter-domain interactions between the DBD and LBD have been observed in several other NRs, but f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06034-2
更新日期:2018-08-30 00:00:00
abstract::Animals promote their survival by avoiding rapidly approaching objects that indicate threats. In mice, looming-evoked defensive responses are triggered by the superior colliculus (SC) which receives direct retinal inputs. However, the specific neural circuits that begin in the retina and mediate this important behavio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14908
更新日期:2017-03-31 00:00:00
abstract::The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14811
更新日期:2017-05-03 00:00:00
abstract::The Dansgaard-Oeschger (DO) events, as observed in oxygen isotope ratios from the North Greenland Ice Core Project (NGRIP) record, are an outstanding example of past abrupt climate transitions. Their physical cause remains debated, and previous research indicated that they are not preceded by classical early-warning s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04881-7
更新日期:2018-07-02 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-11859-6
更新日期:2019-08-21 00:00:00
abstract::Black silicon is a synthetic nanomaterial that contains high aspect ratio nanoprotrusions on its surface, produced through a simple reactive-ion etching technique for use in photovoltaic applications. Surfaces with high aspect-ratio nanofeatures are also common in the natural world, for example, the wings of the drago...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3838
更新日期:2013-01-01 00:00:00
abstract::The global urbanization rate is accelerating; however, data limitations have far prevented robust estimations of either global urban expansion or its effects on terrestrial net primary productivity (NPP). Here, using a high resolution dataset of global land use/cover (GlobeLand30), we show that global urban areas expa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13462-1
更新日期:2019-12-05 00:00:00
abstract::Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective, transient or lack specificity. Here we report that neutrophil...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16596-9
更新日期:2020-06-02 00:00:00
abstract::Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes. We report here a cryo-electron microscopy structure of a single insulin bound to a physiologically relevant, high-affinity version of the receptor ectodomain, th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06826-6
更新日期:2018-10-24 00:00:00
abstract::Systems allowing label-free molecular detection are expected to have enormous impact on biochemical sciences. Research focuses on materials and technologies based on exploiting localized surface plasmon resonances in metallic nanostructures. The reason for this focused attention is their suitability for single-molecul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7150
更新日期:2015-02-02 00:00:00