Molecular basis for PrimPol recruitment to replication forks by RPA.

abstract：:High-harmonic generation (HHG) in gases has been the main enabling technology of attosecond science since its discovery. Recently, HHG from solids has been demonstrated, opening a lively area of research. In contrast, harmonic generation from liquids has so far remained restricted to low harmonics in the visible regim...

journal_title：Nature communications

authors： Luu TT,Yin Z,Jain A,Gaumnitz T,Pertot Y,Ma J,Wörner HJ

更新日期：2018-09-13 00:00:00

abstract：:Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also fou...

journal_title：Nature communications

authors： Muliaditan T,Caron J,Okesola M,Opzoomer JW,Kosti P,Georgouli M,Gordon P,Lall S,Kuzeva DM,Pedro L,Shields JD,Gillett CE,Diebold SS,Sanz-Moreno V,Ng T,Hoste E,Arnold JN

更新日期：2018-07-27 00:00:00

abstract：:Sign epistasis is a central evolutionary constraint, but its causal factors remain difficult to predict. Here we use the notion of parameterised optima to explain epistasis within a signalling cascade, and test these predictions in Escherichia coli. We show that sign epistasis arises from the benefit of tuning phenoty...

journal_title：Nature communications

authors： Nghe P,Kogenaru M,Tans SJ

更新日期：2018-04-13 00:00:00

abstract：:Extracellular vesicles have an important function in cellular communication. Here, we show that human and mouse monocytes release TGF-β1-transporting vesicles in response to the pathogenic fungus Candida albicans. Soluble β-glucan from C. albicans binds to complement receptor 3 (CR3, also known as CD11b/CD18) on monoc...

journal_title：Nature communications

authors： Halder LD,Jo EAH,Hasan MZ,Ferreira-Gomes M,Krüger T,Westermann M,Palme DI,Rambach G,Beyersdorf N,Speth C,Jacobsen ID,Kniemeyer O,Jungnickel B,Zipfel PF,Skerka C

更新日期：2020-05-11 00:00:00

abstract：:Photosynthesis is nature's route to convert intermittent solar irradiation into storable energy, while its use for an industrial energy supply is impaired by low efficiency. Artificial photosynthesis provides a promising alternative for efficient robust carbon-neutral renewable energy generation. The approach of direc...

journal_title：Nature communications

authors： May MM,Lewerenz HJ,Lackner D,Dimroth F,Hannappel T

更新日期：2015-09-15 00:00:00

abstract：:The 'phonon-glass electron-crystal' concept has triggered most of the progress that has been achieved in inorganic thermoelectrics in the past two decades. Organic thermoelectric materials, unlike their inorganic counterparts, exhibit molecular diversity, flexible mechanical properties and easy fabrication, and are mo...

journal_title：Nature communications

authors： Liu J,van der Zee B,Alessandri R,Sami S,Dong J,Nugraha MI,Barker AJ,Rousseva S,Qiu L,Qiu X,Klasen N,Chiechi RC,Baran D,Caironi M,Anthopoulos TD,Portale G,Havenith RWA,Marrink SJ,Hummelen JC,Koster LJA

更新日期：2020-11-10 00:00:00

abstract：:Vortices play a crucial role in determining the properties of superconductors as well as their applications. Therefore, characterization and manipulation of vortices, especially at the single-vortex level, is of great importance. Among many techniques to study single vortices, scanning tunnelling microscopy (STM) stan...

journal_title：Nature communications

authors： Ge JY,Gladilin VN,Tempere J,Xue C,Devreese JT,Van de Vondel J,Zhou Y,Moshchalkov VV

更新日期：2016-12-09 00:00:00

abstract：:Stem cell transplantation is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited by inefficient interaction between potentially beneficial cells (either exogenously transplanted or endogenously recruited) and the injured tissue. Here we apply targeted nanomedicine to achieve in...

journal_title：Nature communications

authors： Cheng K,Shen D,Hensley MT,Middleton R,Sun B,Liu W,De Couto G,Marbán E

更新日期：2014-09-10 00:00:00

abstract：:Flexible organic memory devices are one of the integral components for future flexible organic electronics. However, high-density all-organic memory cell arrays on malleable substrates without cross-talk have not been demonstrated because of difficulties in their fabrication and relatively poor performances to date. H...

journal_title：Nature communications

authors： Ji Y,Zeigler DF,Lee DS,Choi H,Jen AK,Ko HC,Kim TW

更新日期：2013-01-01 00:00:00

abstract：:Tumour cells secrete exosomes that are involved in the remodelling of the tumour-stromal environment and promoting malignancy. The mechanisms governing tumour exosome release, however, remain incompletely understood. Here we show that tumour cell exosomes secretion is controlled by pyruvate kinase type M2 (PKM2), whic...

journal_title：Nature communications

authors： Wei Y,Wang D,Jin F,Bian Z,Li L,Liang H,Li M,Shi L,Pan C,Zhu D,Chen X,Hu G,Liu Y,Zhang CY,Zen K

更新日期：2017-01-09 00:00:00

abstract：:Mucosal-associated invariant T (MAIT) cells are thought to detect microbial antigens presented by the HLA-Ib molecule MR1 through the exclusive use of a TRAV1-2-containing TCRα. Here we use MR1 tetramer staining and ex vivo analysis with mycobacteria-infected MR1-deficient cells to demonstrate the presence of function...

journal_title：Nature communications

authors： Meermeier EW,Laugel BF,Sewell AK,Corbett AJ,Rossjohn J,McCluskey J,Harriff MJ,Franks T,Gold MC,Lewinsohn DM

更新日期：2016-08-16 00:00:00

abstract：:Neurotransmitter/sodium symporters (NSSs) are responsible for Na+-dependent reuptake of neurotransmitters and represent key targets for antidepressants and psychostimulants. LeuT, a prokaryotic NSS protein, constitutes a primary structural model for these transporters. Here we show that K+ inhibits Na+-dependent bindi...

journal_title：Nature communications

authors： Billesbølle CB,Mortensen JS,Sohail A,Schmidt SG,Shi L,Sitte HH,Gether U,Loland CJ

更新日期：2016-09-28 00:00:00

abstract：:Two-dimensional materials provide extraordinary opportunities for exploring phenomena arising in atomically thin crystals. Beginning with the first isolation of graphene, mechanical exfoliation has been a key to provide high-quality two-dimensional materials, but despite improvements it is still limited in yield, late...

journal_title：Nature communications

authors： Huang Y,Pan YH,Yang R,Bao LH,Meng L,Luo HL,Cai YQ,Liu GD,Zhao WJ,Zhou Z,Wu LM,Zhu ZL,Huang M,Liu LW,Liu L,Cheng P,Wu KH,Tian SB,Gu CZ,Shi YG,Guo YF,Cheng ZG,Hu JP,Zhao L,Yang GH,Sutter E,Sutter P,Wan

更新日期：2020-05-15 00:00:00

abstract：:Topological quantum matter can be realized by subjecting engineered systems to time-periodic modulations. In analogy with static systems, periodically driven quantum matter can be topologically classified by topological invariants, whose non-zero value guarantees the presence of robust edge modes. In the high-frequenc...

journal_title：Nature communications

authors： Mukherjee S,Spracklen A,Valiente M,Andersson E,Öhberg P,Goldman N,Thomson RR

更新日期：2017-01-04 00:00:00

abstract：:Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease patients. Here, to ...

journal_title：Nature communications

authors： Matic S,Jiang M,Nicholls TJ,Uhler JP,Dirksen-Schwanenland C,Polosa PL,Simard ML,Li X,Atanassov I,Rackham O,Filipovska A,Stewart JB,Falkenberg M,Larsson NG,Milenkovic D

更新日期：2018-03-23 00:00:00

abstract：:It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in Schwann cells. We found that in mice with partial sciatic nerve ligation, TRPA1 silencing in nociceptors attenuated mechanical allodynia, with...

journal_title：Nature communications

authors： De Logu F,Nassini R,Materazzi S,Carvalho Gonçalves M,Nosi D,Rossi Degl'Innocenti D,Marone IM,Ferreira J,Li Puma S,Benemei S,Trevisan G,Souza Monteiro de Araújo D,Patacchini R,Bunnett NW,Geppetti P

更新日期：2017-12-01 00:00:00

abstract：:Widely recognized as a significant carbon sink, North American forests have experienced a history of recovery and are facing an uncertain future. This growing carbon sink is dictated by recovery from land-use change, with growth trajectory modified by environmental change. To address both processes, we compiled a fore...

journal_title：Nature communications

authors： Zhu K,Zhang J,Niu S,Chu C,Luo Y

更新日期：2018-07-13 00:00:00

abstract：:The two-dimensional topological insulators host a full gap in the bulk band, induced by spin-orbit coupling (SOC) effect, together with the topologically protected gapless edge states. However, it is usually challenging to suppress the bulk conductance and thus to realize the quantum spin Hall (QSH) effect. In this st...

journal_title：Nature communications

authors： Song YH,Jia ZY,Zhang D,Zhu XY,Shi ZQ,Wang H,Zhu L,Yuan QQ,Zhang H,Xing DY,Li SC

更新日期：2018-10-04 00:00:00

abstract：:The flexibility in structural design of organic semiconductors endows organic solar cells (OSCs) not only great function-tunabilities, but also high potential toward practical application. In this work, simple non-fused-ring electron acceptors are developed through two-step synthesis from single aromatic units for con...

journal_title：Nature communications

authors： Yu ZP,Liu ZX,Chen FX,Qin R,Lau TK,Yin JL,Kong X,Lu X,Shi M,Li CZ,Chen H

更新日期：2019-05-14 00:00:00

abstract：:The synthesis of DNA nanotubes is an important area in nanobiotechnology. Different methods to assemble DNA nanotubes have been reported, and control over the width of the nanotubes has been achieved by programmed subunits of DNA tiles. Here we report the self-assembly of DNA nanotubes with controllable diameters. The...

journal_title：Nature communications

authors： Wilner OI,Orbach R,Henning A,Teller C,Yehezkeli O,Mertig M,Harries D,Willner I

更新日期：2011-11-15 00:00:00

abstract：:Natural products have traditionally been rich sources for drug discovery. In order to clear the road toward the discovery of unknown natural products, biologists need dereplication strategies that identify known ones. Here we report DEREPLICATOR+, an algorithm that improves on the previous approaches for identifying p...

journal_title：Nature communications

authors： Mohimani H,Gurevich A,Shlemov A,Mikheenko A,Korobeynikov A,Cao L,Shcherbin E,Nothias LF,Dorrestein PC,Pevzner PA

更新日期：2018-10-02 00:00:00

abstract：:Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, electrolyte abnormalities and metabolic waste accumulation- manifesting as acute kidney injury (A...

journal_title：Nature communications

authors： Kim JY,Bai Y,Jayne LA,Hector RD,Persaud AK,Ong SS,Rojesh S,Raj R,Feng MJHH,Chung S,Cianciolo RE,Christman JW,Campbell MJ,Gardner DS,Baker SD,Sparreboom A,Govindarajan R,Singh H,Chen T,Poi M,Susztak K,Cobb SR,P

更新日期：2020-04-21 00:00:00

abstract：:Polyelectrolyte gel diodes that are double layers of two oppositely charged polyelectrolyte gels, sandwiched by two symmetric electrodes, are emergent ionic devices. These diodes are designed to rectify ion currents with a physical mechanism that is analogous to conventional semiconductor diodes-the asymmetry in the p...

journal_title：Nature communications

authors： Yamamoto T,Doi M

更新日期：2014-06-17 00:00:00

abstract：:Acenes are an important class of polycyclic aromatic hydrocarbons which have recently gained exceptional attention due to their potential as functional organic semiconductors. Fundamentally, they are important systems to study the convergence of physico-chemical properties of all-carbon sp2-frameworks in the one-dimen...

journal_title：Nature communications

authors： Urgel JI,Mishra S,Hayashi H,Wilhelm J,Pignedoli CA,Di Giovannantonio M,Widmer R,Yamashita M,Hieda N,Ruffieux P,Yamada H,Fasel R

更新日期：2019-02-20 00:00:00

abstract：:Human activity has caused dramatic population declines in many wild species. The resulting bottlenecks have a profound impact on the genetic makeup of a species with unknown consequences for health. A key genetic factor for species survival is the evolution of deleterious mutation load, but how bottleneck strength and...

journal_title：Nature communications

authors： Grossen C,Guillaume F,Keller LF,Croll D

更新日期：2020-02-21 00:00:00

abstract：:Fear conditioning is a form of associative learning that is known to involve different brain areas, notably the amygdala, the prefrontal cortex and the periaqueductal grey (PAG). Here, we describe the functional role of pathways that link the cerebellum with the fear network. We found that the cerebellar fastigial nuc...

journal_title：Nature communications

authors： Frontera JL,Baba Aissa H,Sala RW,Mailhes-Hamon C,Georgescu IA,Léna C,Popa D

更新日期：2020-10-15 00:00:00

abstract：:For societies with writing systems, hereditary leadership is documented as one of the hallmarks of early political complexity and governance. In contrast, it is unknown whether hereditary succession played a role in the early formation of prehistoric complex societies that lacked writing. Here we use an archaeogenomic...

journal_title：Nature communications

authors： Kennett DJ,Plog S,George RJ,Culleton BJ,Watson AS,Skoglund P,Rohland N,Mallick S,Stewardson K,Kistler L,LeBlanc SA,Whiteley PM,Reich D,Perry GH

更新日期：2017-02-21 00:00:00

abstract：:In vivo electronic monitoring systems are promising technology to obtain biosignals with high spatiotemporal resolution and sensitivity. Here we demonstrate the fabrication of a biocompatible highly conductive gel composite comprising multi-walled carbon nanotube-dispersed sheet with an aqueous hydrogel. This gel comp...

journal_title：Nature communications

authors： Sekitani T,Yokota T,Kuribara K,Kaltenbrunner M,Fukushima T,Inoue Y,Sekino M,Isoyama T,Abe Y,Onodera H,Someya T

更新日期：2016-04-29 00:00:00

abstract：:Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms that drive immunological responses targeted to the CNS remain largely unknown. Here we show that fibrinogen, a central blood coagulation protein deposited in th...

journal_title：Nature communications

authors： Ryu JK,Petersen MA,Murray SG,Baeten KM,Meyer-Franke A,Chan JP,Vagena E,Bedard C,Machado MR,Rios Coronado PE,Prod'homme T,Charo IF,Lassmann H,Degen JL,Zamvil SS,Akassoglou K

更新日期：2015-09-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Liu X,Chen A,Caicedo-Casso A,Cui G,Du M,He Q,Lim S,Kim HJ,Hong CI,Liu Y

更新日期：2020-01-14 00:00:00