Abstract：
:The original version of the Supplementary Information associated with this Article contained errors in Supplementary Figures 2, 12, 20 and 22. The HTML has been updated to include a corrected version of the Supplementary Information; the original incorrect versions of these Figures can be found as Supplementary Information associated with this Correction.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Eberlein C,Hénault M,Fijarczyk A,Charron G,Bouvier M,Kohn LM,Anderson JB,Landry CRdoi
10.1038/s41467-019-09702-zsubject
Has Abstractpub_date
2019-05-13 00:00:00pages
2199issue
1issn
2041-1723pii
10.1038/s41467-019-09702-zjournal_volume
10pub_type
已发布勘误abstract：:The diploid nature of the human genome is neglected in many analyses done today, where a genome is perceived as a set of unphased variants with respect to a reference genome. This lack of haplotype-level analyses can be explained by a lack of methods that can produce dense and accurate chromosome-length haplotypes at ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01389-4
更新日期：2017-11-03 00:00:00
abstract：:Proton conductive materials are of significant importance and highly desired for clean energy-related applications. Discovery of practical metal-organic frameworks (MOFs) with high proton conduction remains a challenge due to the use of toxic chemicals, inconvenient ligand preparation and complication of production at...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07414-4
更新日期：2018-11-22 00:00:00
abstract：:Inspired by mammalian skins, soft hybrids integrating the merits of elastomers and hydrogels have potential applications in diverse areas including stretchable and bio-integrated electronics, microfluidics, tissue engineering, soft robotics and biomedical devices. However, existing hydrogel-elastomer hybrids have limi...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12028
更新日期：2016-06-27 00:00:00
abstract：:COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electro...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18709-w
更新日期：2020-10-07 00:00:00
abstract：:Resident tissue macrophages (RTM) can fulfill various tasks during development, homeostasis, inflammation and repair. In the lung, non-alveolar RTM, called interstitial macrophages (IM), importantly contribute to tissue homeostasis but remain little characterized. Here we show, using single-cell RNA-sequencing (scRNA-...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11843-0
更新日期：2019-09-03 00:00:00
abstract：:Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms3846
更新日期：2013-01-01 00:00:00
abstract：:Oceanic mesoscale eddies contribute important horizontal heat and salt transports on a global scale. Here we show that eddy transports are mainly due to individual eddy movements. Theoretical and observational analyses indicate that cyclonic and anticyclonic eddies move westwards, and they also move polewards and equa...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4294
更新日期：2014-01-01 00:00:00
abstract：:Drop motility at liquid surfaces is attracting growing interest because of its potential applications in microfluidics and artificial cell design. Here we report the unique highly ordered pattern that sets in when a millimeter-size drop of dichloromethane spreads on an aqueous substrate under the influence of surface ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03201-3
更新日期：2018-02-26 00:00:00
abstract：:Understanding how cellular functions emerge from the underlying molecular mechanisms is a key challenge in biology. This will require computational models, whose predictive power is expected to increase with coverage and precision of formulation. Genome-scale models revolutionised the metabolic field and made the firs...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-08903-w
更新日期：2019-03-21 00:00:00
abstract：:Antibiotic resistance poses rapidly increasing global problems in combatting multidrug-resistant (MDR) infectious diseases like MDR tuberculosis, prompting for novel approaches including host-directed therapies (HDT). Intracellular pathogens like Salmonellae and Mycobacterium tuberculosis (Mtb) exploit host pathways t...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02777-6
更新日期：2018-01-24 00:00:00
abstract：:The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived infl...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2877
更新日期：2013-01-01 00:00:00
abstract：:DNA can form diverse higher-order structures, whose details are greatly dependent on nucleotide sequence. G-rich sequences containing four or more repeats of three guanines are expected to form G-quadruplexes. Here we show that DNA sequences with GGGAGCG repeats found in the regulatory region of the PLEKHG3 gene are c...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6831
更新日期：2014-12-15 00:00:00
abstract：:Substantial efforts have been made to understand the interactions between immune checkpoint receptors and their ligands targeted in immunotherapies against cancer. To carefully characterize the complete network of interactions involved and the binding affinities between their extracellular domains, an improved kinetic...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12220
更新日期：2016-07-22 00:00:00
abstract：:Anthropogenic CO2 emissions are causing ocean acidification, which can affect the physiology of marine organisms. Here we assess the possible effects of ocean acidification on the metabolic potential of sponge symbionts, inferred by metagenomic analyses of the microbiomes of two sponge species sampled at a shallow vol...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12156-y
更新日期：2019-09-12 00:00:00
abstract：:Processing within the anterior cingulate cortex (ACC) is crucial for the patterning of appropriate behavior, and ACC dysfunction following chronic drug use is thought to play a major role in drug addiction. However, cortical pyramidal projection neurons can be subdivided into two major types (intratelencephalic (IT) a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20526-0
更新日期：2021-01-08 00:00:00
abstract：:Our memories enable us to form expectations for our future experiences, yet the precise neural mechanisms underlying how we compare any experience to our memory remain unknown. Here, using intracranial EEG recordings, we show that episodic memories formed after a single visual experience establish expectations for fut...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19828-0
更新日期：2020-11-27 00:00:00
abstract：:This corrects the article DOI: 10.1038/ncomms9754. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/ncomms15229
更新日期：2017-08-08 00:00:00
abstract：:Long-term stability remains a key issue impeding the commercialization of halide perovskite solar cells (HPVKSCs). The diffusion of molecules and ions causes irreversible degradation to photovoltaic device performance. Here, we demonstrate a facile strategy for producing highly stable HPVKSCs by using a thin but compa...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09167-0
更新日期：2019-03-11 00:00:00
abstract：:Previous research has focused on feeding circuits residing in the hindbrain and midbrain that govern homeostatic or hedonic control of food intake. However, the feeding circuits controlling emotional or cognitive aspects of food intake are largely unknown. Here we use chemical genetics and optogenetic techniques to di...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10188
更新日期：2015-12-15 00:00:00
abstract：:Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. Here we identify Nedd4 as an IRS-2 ubiquitin ligase. Ne...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7780
更新日期：2015-04-16 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-019-13862-3
更新日期：2020-01-14 00:00:00
abstract：:Transition metal catalyzed Sonogashira cross-coupling of terminal alkynes with aryl(vinyl) (pseudo)halides has been successfully extended to alkyl halides for the synthesis of functionalized internal alkynes. The direct alkynylation of remote unfunctionalized sp3 carbon by terminal alkynes remains difficult to realize...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14292-2
更新日期：2020-01-21 00:00:00
abstract：:The prokaryotic chemotaxis system is arguably the best-understood signaling pathway in biology. In all previously described species, chemoreceptors organize into a hexagonal (P6 symmetry) extended array. Here, we report an alternative symmetry (P2) of the chemotaxis apparatus that emerges from a strict linear organiza...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19628-6
更新日期：2020-11-13 00:00:00
abstract：:Little is known about how archaeal viruses perturb the transcription machinery of their hosts. Here we provide the first example of an archaeo-viral transcription factor that directly targets the host RNA polymerase (RNAP) and efficiently represses its activity. ORF145 from the temperate Acidianus two-tailed virus (AT...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13595
更新日期：2016-11-24 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-020-17555-0
更新日期：2020-07-28 00:00:00
abstract：:Self-induced electricity, including lightning, is often observed in dusty atmospheres. However, the physical mechanisms leading to this phenomenon remain elusive as they are remarkably challenging to determine due to the high complexity of the multi-phase turbulent flows involved. Using a fast multi-pole method in dir...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03958-7
更新日期：2018-04-26 00:00:00
abstract：:A high-sugar diet has been associated with reduced lifespan in organisms ranging from worms to mammals. However, the mechanisms underlying the harmful effects of glucose are poorly understood. Here we establish a causative relationship between endogenous glucose storage in the form of glycogen, resistance to oxidative...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15868
更新日期：2017-06-19 00:00:00
abstract：:Aneuploidy and copy-number alterations (CNAs) are a hallmark of human cancer. Although genetically engineered mouse models (GEMMs) are commonly used to model human cancer, their chromosomal landscapes remain underexplored. Here we use gene expression profiles to infer CNAs in 3,108 samples from 45 mouse models, provid...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12160
更新日期：2016-07-04 00:00:00
abstract：:Metal halide perovskites feature crystalline-like electronic band structures and liquid-like physical properties. The crystal-liquid duality enables optoelectronic devices with unprecedented performance and a unique opportunity to chemically manipulate the structure with low energy input. In this work, we leverage the...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19009-z
更新日期：2020-10-16 00:00:00
abstract：:IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory diseases. Here we demonstrate that TNF inhibitor (TNFi) drugs induce the anti-inflammatory cytokine IL-10 in CD4+ T cells including IL-17+ CD4+ T cells. TNFi-mediated induction of IL-10 in IL-17+ CD4+ T cells is Treg-/Foxp3-indepen...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4199
更新日期：2014-01-01 00:00:00
