An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding.

abstract：:Mutations in BLM in Bloom Syndrome patients predispose them to multiple types of cancers. Here we report that BLM is recruited in a biphasic manner to annotated DSBs. BLM recruitment is dependent on the presence of NBS1, MRE11 and ATM. While ATM activity is essential for BLM recruitment in early phase, it is dispensab...

journal_title：Nature communications

authors： Tripathi V,Agarwal H,Priya S,Batra H,Modi P,Pandey M,Saha D,Raghavan SC,Sengupta S

更新日期：2018-03-09 00:00:00

abstract：:The sigma-2 receptor, whose gene remains to be cloned, has been validated as a biomarker for tumour cell proliferation. Here we report the use of a novel photoaffinity probe, WC-21, to identify the sigma-2 receptor-binding site. WC-21, a sigma-2 ligand containing both a photoactive azide moiety and a fluorescein isoth...

journal_title：Nature communications

authors： Xu J,Zeng C,Chu W,Pan F,Rothfuss JM,Zhang F,Tu Z,Zhou D,Zeng D,Vangveravong S,Johnston F,Spitzer D,Chang KC,Hotchkiss RS,Hawkins WG,Wheeler KT,Mach RH

更新日期：2011-07-05 00:00:00

abstract：:Coalescence is an essential phenomenon that governs the equilibrium behaviour in a variety of systems from intercellular transport to planetary formation. In this report, we study coalescence pathways of circularly shaped two-dimensional colloidal membranes, which are one rod-length-thick liquid-like monolayers of ali...

journal_title：Nature communications

authors： Zakhary MJ,Gibaud T,Kaplan CN,Barry E,Oldenbourg R,Meyer RB,Dogic Z

更新日期：2014-01-01 00:00:00

abstract：:Pupylation is a posttranslational protein modification occurring in mycobacteria and other actinobacteria that is functionally analogous to ubiquitination. Here we report the crystal structures of the modification enzymes involved in this pathway, the prokaryotic ubiquitin-like protein (Pup) ligase PafA and the depupy...

journal_title：Nature communications

authors： Özcelik D,Barandun J,Schmitz N,Sutter M,Guth E,Damberger FF,Allain FH,Ban N,Weber-Ban E

更新日期：2012-01-01 00:00:00

abstract：:Rapid and, in many cases, unprecedented Arctic climate changes are having far-reaching impacts on natural and human systems. Despite state-of-the-art climate models capturing the rapid nature of Arctic climate change, termed Arctic amplification, they significantly disagree on its magnitude. Using a regional, process-...

journal_title：Nature communications

authors： Boeke RC,Taylor PC

更新日期：2018-11-27 00:00:00

abstract：:For LiMO2 (M=Co, Ni, Mn) cathode materials, lattice parameters, a(b), contract during charge. Here we report such changes in opposite directions for lithium molybdenum trioxide (Li2MoO3). A 'unit cell breathing' mechanism is proposed based on crystal and electronic structural changes of transition metal oxides during ...

journal_title：Nature communications

authors： Zhou YN,Ma J,Hu E,Yu X,Gu L,Nam KW,Chen L,Wang Z,Yang XQ

更新日期：2014-11-18 00:00:00

abstract：:Electric fields can transform materials with respect to their structure and properties, enabling various applications ranging from batteries to spintronics. Recently electrolytic gating, which can generate large electric fields and voltage-driven ion transfer, has been identified as a powerful means to achieve electri...

journal_title：Nature communications

authors： Yi D,Wang Y,van ʼt Erve OMJ,Xu L,Yuan H,Veit MJ,Balakrishnan PP,Choi Y,N'Diaye AT,Shafer P,Arenholz E,Grutter A,Xu H,Yu P,Jonker BT,Suzuki Y

更新日期：2020-02-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Yang C,Eleftheriadou M,Kelaini S,Morrison T,González MV,Caines R,Edwards N,Yacoub A,Edgar K,Moez A,Ivetic A,Zampetaki A,Zeng L,Wilkinson FL,Lois N,Stitt AW,Grieve DJ,Margariti A

更新日期：2020-09-16 00:00:00

abstract：:The functional organization of the hippocampus is distributed as a gradient along its longitudinal axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the longitudinal axis of the adult human hippocampus can be predicted within 2...

journal_title：Nature communications

authors： Vogel JW,La Joie R,Grothe MJ,Diaz-Papkovich A,Doyle A,Vachon-Presseau E,Lepage C,Vos de Wael R,Thomas RA,Iturria-Medina Y,Bernhardt B,Rabinovici GD,Evans AC

更新日期：2020-02-19 00:00:00

abstract：:Marine reserves are viewed as flagship tools to protect exploited species and to contribute to the effective management of coastal fisheries. Yet, the extent to which marine reserves are globally interconnected and able to effectively seed areas, where fisheries are most critical for food and livelihood security is la...

journal_title：Nature communications

authors： Andrello M,Guilhaumon F,Albouy C,Parravicini V,Scholtens J,Verley P,Barange M,Sumaila UR,Manel S,Mouillot D

更新日期：2017-07-10 00:00:00

abstract：:Among various flat optical devices, metasurfaces have presented their great ability in efficient manipulation of light fields and have been proposed for variety of devices with specific functionalities. However, due to the high phase dispersion of their building blocks, metasurfaces significantly suffer from large chr...

journal_title：Nature communications

authors： Wang S,Wu PC,Su VC,Lai YC,Hung Chu C,Chen JW,Lu SH,Chen J,Xu B,Kuan CH,Li T,Zhu S,Tsai DP

更新日期：2017-08-04 00:00:00

abstract：:Synchronous oscillations of thousands of cellular clocks in the suprachiasmatic nucleus (SCN), the circadian centre, are coordinated by precisely timed cell-cell communication, the principle of which is largely unknown. Here we show that the amount of RGS16 (regulator of G protein signalling 16), a protein known to in...

journal_title：Nature communications

authors： Doi M,Ishida A,Miyake A,Sato M,Komatsu R,Yamazaki F,Kimura I,Tsuchiya S,Kori H,Seo K,Yamaguchi Y,Matsuo M,Fustin JM,Tanaka R,Santo Y,Yamada H,Takahashi Y,Araki M,Nakao K,Aizawa S,Kobayashi M,Obrietan K,Tsujimo

更新日期：2011-01-01 00:00:00

abstract：:Mountain glaciers are known to be strongly affected by global climate change. Here we compute temporally consistent changes in glacier area, surface elevation and ice mass over the entire European Alps between 2000 and 2014. We apply remote sensing techniques on an extensive database of optical and radar imagery cover...

journal_title：Nature communications

authors： Sommer C,Malz P,Seehaus TC,Lippl S,Zemp M,Braun MH

更新日期：2020-06-25 00:00:00

abstract：:Much of the world's Li deposits occurs as basinal brines in magmatic orogens, particularly in continental volcanic arcs. However, the exact origin of Li enrichment in arc magmatic systems is not clear. Here, we show that, globally, primitive arc magmas have Li contents and Li/Y ratios similar to mid-ocean ridge basalt...

journal_title：Nature communications

authors： Chen C,Lee CA,Tang M,Biddle K,Sun W

更新日期：2020-10-20 00:00:00

abstract：:The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy req...

journal_title：Nature communications

authors： Rothe S,Andreyev AN,Antalic S,Borschevsky A,Capponi L,Cocolios TE,De Witte H,Eliav E,Fedorov DV,Fedosseev VN,Fink DA,Fritzsche S,Ghys L,Huyse M,Imai N,Kaldor U,Kudryavtsev Y,Köster U,Lane JF,Lassen J,Liberati V,

更新日期：2013-01-01 00:00:00

abstract：:The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here we show that either ubiquitous or osteoclas...

journal_title：Nature communications

authors： Keller J,Catala-Lehnen P,Huebner AK,Jeschke A,Heckt T,Lueth A,Krause M,Koehne T,Albers J,Schulze J,Schilling S,Haberland M,Denninger H,Neven M,Hermans-Borgmeyer I,Streichert T,Breer S,Barvencik F,Levkau B,Rathkolb B

更新日期：2014-10-21 00:00:00

abstract：:Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication. We analyse the cellular pathways in which human proviral genes are...

journal_title：Nature communications

authors： Karlas A,Berre S,Couderc T,Varjak M,Braun P,Meyer M,Gangneux N,Karo-Astover L,Weege F,Raftery M,Schönrich G,Klemm U,Wurzlbauer A,Bracher F,Merits A,Meyer TF,Lecuit M

更新日期：2016-05-12 00:00:00

abstract：:Recent advances in the understanding of spin orbital effects in ultrathin magnetic heterostructures have opened new paradigms to control magnetic moments electrically. The Dzyaloshinskii-Moriya interaction (DMI) is said to play a key role in forming a Néel-type domain wall that can be driven by the spin Hall torque. H...

journal_title：Nature communications

authors： Torrejon J,Kim J,Sinha J,Mitani S,Hayashi M,Yamanouchi M,Ohno H

更新日期：2014-08-18 00:00:00

abstract：:The mammalian neocortex is subdivided into cytoarchitectural areas with distinct connectivity, gene expression and neural functions. Areal identity is initially specified by rostrocaudal and mediolateral gene expression gradients in neuroepithelial and radial glial progenitors (the 'protomap'). On further differentiat...

journal_title：Nature communications

authors： Alfano C,Magrinelli E,Harb K,Hevner RF,Studer M

更新日期：2014-12-05 00:00:00

abstract：:Methyl-specific isotope labeling is a powerful tool to study the structure, dynamics and interactions of large proteins and protein complexes by solution-state NMR. However, widespread applications of this methodology have been limited by challenges in obtaining confident resonance assignments. Here, we present Methyl...

journal_title：Nature communications

authors： Nerli S,De Paula VS,McShan AC,Sgourakis NG

更新日期：2021-01-29 00:00:00

abstract：:Biomechanical energy harvesting textiles based on nanogenerators that convert mechanical energy into electricity have broad application prospects in next-generation wearable electronic devices. However, the difficult-to-weave structure, limited flexibility and stretchability, small device size and poor weatherability ...

journal_title：Nature communications

authors： Gong W,Hou C,Zhou J,Guo Y,Zhang W,Li Y,Zhang Q,Wang H

更新日期：2019-02-20 00:00:00

abstract：:Aerosol-cloud interactions constitute the largest source of uncertainty in global radiative forcing estimates, hampering our understanding of climate evolution. Recent empirical evidence suggests surface tension depression by organic aerosol to significantly influence the formation of cloud droplets, and hence cloud o...

journal_title：Nature communications

authors： Lowe SJ,Partridge DG,Davies JF,Wilson KR,Topping D,Riipinen I

更新日期：2019-11-18 00:00:00

abstract：:Coordination of ciliary beating is essential to ensure mucus clearance in the airway tract. The orientation and synchronization of ciliary motion responds in part to the organization of the underlying cytoskeletal networks. Using electron tomography on mouse trachea, we show that basal bodies are collectively hooked a...

journal_title：Nature communications

authors： Clare DK,Magescas J,Piolot T,Dumoux M,Vesque C,Pichard E,Dang T,Duvauchelle B,Poirier F,Delacour D

更新日期：2014-09-12 00:00:00

abstract：:Converting and storing solar energy and releasing it on demand by using solar flow batteries (SFBs) is a promising way to address the challenge of solar intermittency. Although high solar-to-output electricity efficiencies (SOEE) have been recently demonstrated in SFBs, the complex multi-junction photoelectrodes used ...

journal_title：Nature communications

authors： Fu HC,Li W,Yang Y,Lin CH,Veyssal A,He JH,Jin S

更新日期：2021-01-08 00:00:00

abstract：:Predicting ecological effects of contaminants remains challenging because of the sheer number of chemicals and their ambiguous role in biodiversity-ecosystem function relationships. We evaluate responses of experimental pond ecosystems to standardized concentrations of 12 pesticides, nested in four pesticide classes a...

journal_title：Nature communications

authors： Rumschlag SL,Mahon MB,Hoverman JT,Raffel TR,Carrick HJ,Hudson PJ,Rohr JR

更新日期：2020-12-10 00:00:00

abstract：:Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and obesity on pubertal timing are unknown. Here, we identify Sirtuin 1 (SIRT1), a fuel-sensing deacetylase, as a molecule that restrains female p...

journal_title：Nature communications

authors： Vazquez MJ,Toro CA,Castellano JM,Ruiz-Pino F,Roa J,Beiroa D,Heras V,Velasco I,Dieguez C,Pinilla L,Gaytan F,Nogueiras R,Bosch MA,Rønnekleiv OK,Lomniczi A,Ojeda SR,Tena-Sempere M

更新日期：2018-10-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Panhans M,Hutsch S,Benduhn J,Schellhammer KS,Nikolis VC,Vangerven T,Vandewal K,Ortmann F

更新日期：2020-04-22 00:00:00

abstract：:Multidrug resistance is a major challenge to cancer chemotherapy. The multidrug resistance phenotype is associated with the overexpression of the adenosine triphosphate (ATP)-driven transmembrane efflux pumps in cancer cells. Here, we report a lipid membrane-coated silica-carbon (LSC) hybrid nanoparticle that targets ...

journal_title：Nature communications

authors： Wang H,Gao Z,Liu X,Agarwal P,Zhao S,Conroy DW,Ji G,Yu J,Jaroniec CP,Liu Z,Lu X,Li X,He X

更新日期：2018-02-08 00:00:00

abstract：:Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death protein-1 (PD-1) inhibitory axis regulates a variety of immune responses...

journal_title：Nature communications

authors： Helou DG,Shafiei-Jahani P,Lo R,Howard E,Hurrell BP,Galle-Treger L,Painter JD,Lewis G,Soroosh P,Sharpe AH,Akbari O

更新日期：2020-08-10 00:00:00

abstract：:By providing broad resistance to environmental biocides, transporters from the small multidrug resistance (SMR) family drive the spread of multidrug resistance cassettes among bacterial populations. A fundamental understanding of substrate selectivity by SMR transporters is needed to identify the types of selective pr...

journal_title：Nature communications

authors： Kermani AA,Macdonald CB,Burata OE,Ben Koff B,Koide A,Denbaum E,Koide S,Stockbridge RB

更新日期：2020-11-27 00:00:00