Basal foot MTOC organizes pillar MTs required for coordination of beating cilia.

abstract：:Long-read sequencing technologies have greatly facilitated assemblies of large eukaryotic genomes. In this paper, Oxford Nanopore sequences generated on a MinION sequencer are combined with Bionano Genomics Direct Label and Stain (DLS) optical maps to generate a chromosome-scale de novo assembly of the repeat-rich Sor...

journal_title：Nature communications

authors： Deschamps S,Zhang Y,Llaca V,Ye L,Sanyal A,King M,May G,Lin H

更新日期：2018-11-19 00:00:00

abstract：:Osteoporosis is a devastating disease with an essential genetic component. GWAS have discovered genetic signals robustly associated with bone mineral density (BMD), but not the precise localization of effector genes. Here, we carry out physical and direct variant to gene mapping in human mesenchymal progenitor cell-de...

journal_title：Nature communications

authors： Chesi A,Wagley Y,Johnson ME,Manduchi E,Su C,Lu S,Leonard ME,Hodge KM,Pippin JA,Hankenson KD,Wells AD,Grant SFA

更新日期：2019-03-19 00:00:00

abstract：:Phylogenetic trees are essential for studying biology, but their reproducibility under identical parameter settings remains unexplored. Here, we find that 3515 (18.11%) IQ-TREE-inferred and 1813 (9.34%) RAxML-NG-inferred maximum likelihood (ML) gene trees are topologically irreproducible when executing two replicates ...

journal_title：Nature communications

authors： Shen XX,Li Y,Hittinger CT,Chen XX,Rokas A

更新日期：2020-11-30 00:00:00

abstract：:It is difficult to achieve minimally invasive injectable cell delivery while maintaining high cell retention and animal survival for in vivo stem cell therapy of myocardial infarction. Here we show that pluripotent stem cell aggregates pre-differentiated into the early cardiac lineage and encapsulated in a biocompatib...

journal_title：Nature communications

authors： Zhao S,Xu Z,Wang H,Reese BE,Gushchina LV,Jiang M,Agarwal P,Xu J,Zhang M,Shen R,Liu Z,Weisleder N,He X

更新日期：2016-10-27 00:00:00

abstract：:Aviation emissions of nitrogen oxides (NOx) alter the composition of the atmosphere, perturbing the greenhouse gases ozone and methane, resulting in positive and negative radiative forcing effects, respectively. In 1981, the International Civil Aviation Organization adopted a first certification standard for the regul...

journal_title：Nature communications

authors： Skowron A,Lee DS,De León RR,Lim LL,Owen B

更新日期：2021-01-25 00:00:00

abstract：:The original version of this Article contained errors in Figs. 1a, 2a, 3a, and 4b, in which the units on the scale bars incorrectly read 'µm' rather than the correct 'nm.' This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Babakhanova G,Turiv T,Guo Y,Hendrikx M,Wei QH,Schenning APHJ,Broer DJ,Lavrentovich OD

更新日期：2018-03-14 00:00:00

abstract：:Piezo proteins are transmembrane ion channels which transduce many forms of mechanical stimuli into electrochemical signals. Their pore, formed by the assembly of three identical subunits, opens by an unknown mechanism. Here, to probe this mechanism, we investigate the interaction of Piezo1 with the small molecule ago...

journal_title：Nature communications

authors： Lacroix JJ,Botello-Smith WM,Luo Y

更新日期：2018-05-23 00:00:00

abstract：:Scleractinian corals' microbial symbionts influence host health, yet how coral microbiomes assembled over evolution is not well understood. We survey bacterial and archaeal communities in phylogenetically diverse Australian corals representing more than 425 million years of diversification. We show that coral microbio...

journal_title：Nature communications

authors： Pollock FJ,McMinds R,Smith S,Bourne DG,Willis BL,Medina M,Thurber RV,Zaneveld JR

更新日期：2018-11-22 00:00:00

abstract：:Cell fate determination requires the cooperation between extrinsic signals and intrinsic molecules including transcription factors as well as epigenetic regulators. Nevertheless, how neural fate commitment is regulated by epigenetic modifications remains largely unclear. Here we show that transient histone deacetylati...

journal_title：Nature communications

authors： Liu P,Dou X,Liu C,Wang L,Xing C,Peng G,Chen J,Yu F,Qiao Y,Song L,Wu Y,Yue C,Li J,Han JD,Tang K,Jing N

更新日期：2015-04-23 00:00:00

abstract：:Despite the growing evidence for the regulated spindle orientation in mammals, a systematic approach for identifying the responsible genes in mammalian cells has not been established. Here we perform a kinase-targeting RNAi screen in HeLa cells and identify ABL1 as a novel regulator of spindle orientation. Knockdown o...

journal_title：Nature communications

authors： Matsumura S,Hamasaki M,Yamamoto T,Ebisuya M,Sato M,Nishida E,Toyoshima F

更新日期：2012-01-17 00:00:00

abstract：:Roughly 40% of the Earth's total heat flow is powered by radioactive decays in the crust and mantle. Geo-neutrinos produced by these decays provide important clues about the origin, formation and thermal evolution of our planet, as well as the composition of its interior. Previous measurements of geo-neutrinos have al...

journal_title：Nature communications

authors： Leyton M,Dye S,Monroe J

更新日期：2017-07-10 00:00:00

abstract：:BKM120 (Buparlisib) is one of the most advanced phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of cancer, but it interferes as an off-target effect with microtubule polymerization. Here, we developed two chemical derivatives that differ from BKM120 by only one atom. We show that these minute changes sep...

journal_title：Nature communications

authors： Bohnacker T,Prota AE,Beaufils F,Burke JE,Melone A,Inglis AJ,Rageot D,Sele AM,Cmiljanovic V,Cmiljanovic N,Bargsten K,Aher A,Akhmanova A,Díaz JF,Fabbro D,Zvelebil M,Williams RL,Steinmetz MO,Wymann MP

更新日期：2017-03-09 00:00:00

abstract：:The low-energy electronic excitations in graphene are described by massless Dirac fermions that have a linear dispersion relation. Taking advantage of this 'optics-like' electron dynamics, generic optical elements like lenses and wave guides have been proposed for electrons in graphene. Tuning of these elements relies...

journal_title：Nature communications

authors： Rickhaus P,Maurand R,Liu MH,Weiss M,Richter K,Schönenberger C

更新日期：2013-01-01 00:00:00

abstract：:Comparisons of climate model hindcasts with independent proxy data are essential for assessing model performance in non-analogue situations. However, standardized palaeoclimate data sets for assessing the spatial pattern of past climatic change across continents are lacking for some of the most dynamic episodes of Ear...

journal_title：Nature communications

authors： Heiri O,Brooks SJ,Renssen H,Bedford A,Hazekamp M,Ilyashuk B,Jeffers ES,Lang B,Kirilova E,Kuiper S,Millet L,Samartin S,Toth M,Verbruggen F,Watson JE,van Asch N,Lammertsma E,Amon L,Birks HH,Birks HJ,Mortensen MF,H

更新日期：2014-09-11 00:00:00

abstract：:The cell division cycle requires tight coupling between protein phosphorylation and dephosphorylation. However, understanding the cell cycle roles of multimeric protein phosphatases has been limited by the lack of knowledge of how their diverse regulatory subunits target highly conserved catalytic subunits to their si...

journal_title：Nature communications

authors： Lipinszki Z,Lefevre S,Savoian MS,Singleton MR,Glover DM,Przewloka MR

更新日期：2015-01-06 00:00:00

abstract：:Genome editing critically relies on selective recognition of target sites. However, despite recent progress, the underlying search mechanism of genome-editing proteins is not fully understood in the context of cellular chromatin environments. Here, we use single-molecule imaging in live cells to directly study the beh...

journal_title：Nature communications

authors： Jain S,Shukla S,Yang C,Zhang M,Fatma Z,Lingamaneni M,Abesteh S,Lane ST,Xiong X,Wang Y,Schroeder CM,Selvin PR,Zhao H

更新日期：2021-01-27 00:00:00

abstract：:Starting from the gas phase, small clusters can be produced and deposited with huge flexibility with regard to composition, materials choice and cluster size. Despite many advances in experimental characterization, a detailed morphology of such clusters is still lacking. Here we present an atomic scale observation as ...

journal_title：Nature communications

authors： Bals S,Van Aert S,Romero CP,Lauwaet K,Van Bael MJ,Schoeters B,Partoens B,Yücelen E,Lievens P,Van Tendeloo G

更新日期：2012-06-12 00:00:00

abstract：:Quantum point contacts exhibit mysterious conductance anomalies in addition to well-known conductance plateaus at multiples of 2e(2)/h. These 0.7 and zero-bias anomalies have been intensively studied, but their microscopic origin in terms of many-body effects is still highly debated. Here we use the charged tip of a s...

journal_title：Nature communications

authors： Brun B,Martins F,Faniel S,Hackens B,Bachelier G,Cavanna A,Ulysse C,Ouerghi A,Gennser U,Mailly D,Huant S,Bayot V,Sanquer M,Sellier H

更新日期：2014-06-30 00:00:00

abstract：:Glycans from microbial pathogens are well known pathogen-associated molecular patterns that are recognized by the host immunity; however, little is known about whether and how mammalian self-glycans activate the host immune response, especially in the context of autoimmune disease. Using biochemical fractionation and ...

journal_title：Nature communications

authors： Fermaintt CS,Sano K,Liu Z,Ishii N,Seino J,Dobbs N,Suzuki T,Fu YX,Lehrman MA,Matsuo I,Yan N

更新日期：2019-05-30 00:00:00

abstract：:A non-classical light source emitting pairs of identical photons represents a versatile resource of interdisciplinary importance with applications in quantum optics and quantum biology. To date, photon twins have mostly been generated using parametric downconversion sources, relying on Poissonian number distributions,...

journal_title：Nature communications

authors： Heindel T,Thoma A,von Helversen M,Schmidt M,Schlehahn A,Gschrey M,Schnauber P,Schulze JH,Strittmatter A,Beyer J,Rodt S,Carmele A,Knorr A,Reitzenstein S

更新日期：2017-04-03 00:00:00

abstract：:Modern geophysics highlights that the slip behaviour response of faults is variable in space and time and can result in slow or fast ruptures. However, the origin of this variation of the rupture velocity in nature as well as the physics behind it is still debated. Here, we first highlight how the different types of f...

journal_title：Nature communications

authors： Passelègue FX,Almakari M,Dublanchet P,Barras F,Fortin J,Violay M

更新日期：2020-10-12 00:00:00

abstract：:Plasmodium vivax poses unique challenges for malaria control and elimination, notably the potential for relapses to maintain transmission in the face of drug-based treatment and vector control strategies. We developed an individual-based mathematical model of P. vivax transmission calibrated to epidemiological data fr...

journal_title：Nature communications

authors： White MT,Walker P,Karl S,Hetzel MW,Freeman T,Waltmann A,Laman M,Robinson LJ,Ghani A,Mueller I

更新日期：2018-08-17 00:00:00

abstract：:Human activity has caused dramatic population declines in many wild species. The resulting bottlenecks have a profound impact on the genetic makeup of a species with unknown consequences for health. A key genetic factor for species survival is the evolution of deleterious mutation load, but how bottleneck strength and...

journal_title：Nature communications

authors： Grossen C,Guillaume F,Keller LF,Croll D

更新日期：2020-02-21 00:00:00

abstract：:Tomography--cross-sectional imaging based on measuring radiation transmitted through an object along different directions--enables non-invasive imaging of hidden stationary objects, such as internal bodily organs, from their sequentially measured projections. Here we adapt tomographic methods to visualize--in one lase...

journal_title：Nature communications

authors： Li Z,Zgadzaj R,Wang X,Chang YY,Downer MC

更新日期：2014-01-01 00:00:00

abstract：:The original version of this Article contained errors in Figures 1 and 3. In Fig. 1b, the label 'IP-PBP3' above the second of the three blots incorrectly read 'IP-PBP1B'. In Fig. 3b, the label 'PBP1B' under the first bar of each chart incorrectly read 'PBP1A'. These errors have been corrected in both the PDF and HTML ...

journal_title：Nature communications

authors： Pazos M,Peters K,Casanova M,Palacios P,VanNieuwenhze M,Breukink E,Vicente M,Vollmer W

更新日期：2019-01-30 00:00:00

abstract：:The extent to which the impact of regulatory genetic variants may depend on other factors, such as the expression levels of upstream transcription factors, remains poorly understood. Here we report a framework in which regulatory variants are first aggregated into sets, and using these as estimates of the total cis-ge...

journal_title：Nature communications

authors： Wragg D,Liu Q,Lin Z,Riggio V,Pugh CA,Beveridge AJ,Brown H,Hume DA,Harris SE,Deary IJ,Tenesa A,Prendergast JGD

更新日期：2020-01-17 00:00:00

abstract：:Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond c...

journal_title：Nature communications

authors： Weierstall U,James D,Wang C,White TA,Wang D,Liu W,Spence JC,Bruce Doak R,Nelson G,Fromme P,Fromme R,Grotjohann I,Kupitz C,Zatsepin NA,Liu H,Basu S,Wacker D,Han GW,Katritch V,Boutet S,Messerschmidt M,Williams GJ

更新日期：2014-01-01 00:00:00

abstract：:Turgor pressure plays pivotal roles in the growth and movement of walled cells that make up plants and fungi. However, the molecular mechanisms regulating turgor pressure and the coordination between turgor pressure and cell wall remodelling for cell growth remain poorly understood. Here, we report the characterizatio...

journal_title：Nature communications

authors： Chen LY,Shi DQ,Zhang WJ,Tang ZS,Liu J,Yang WC

更新日期：2015-01-16 00:00:00

abstract：:Cellular senescence has been perceived as a barrier against carcinogenesis. However, the senescence-associated secretory phenotype (SASP) of senescent cells can promote tumorigenesis. Here, we show senescent tumour cells are frequently present in the front region of collective invasion of papillary thyroid carcinoma (...

journal_title：Nature communications

authors： Kim YH,Choi YW,Lee J,Soh EY,Kim JH,Park TJ

更新日期：2017-05-10 00:00:00

abstract：:Circadian clock mechanisms have been extensively investigated but the main rate-limiting step that determines circadian period remains unclear. Formation of a stable complex between clock proteins and CK1 is a conserved feature in eukaryotic circadian mechanisms. Here we show that the FRQ-CK1 interaction, but not FRQ ...

journal_title：Nature communications

authors： Liu X,Chen A,Caicedo-Casso A,Cui G,Du M,He Q,Lim S,Kim HJ,Hong CI,Liu Y

更新日期：2019-09-25 00:00:00