当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Centromeric binding and activity of Protein Phosphatase 4.

Centromeric binding and activity of Protein Phosphatase 4.

Abstract：

:The cell division cycle requires tight coupling between protein phosphorylation and dephosphorylation. However, understanding the cell cycle roles of multimeric protein phosphatases has been limited by the lack of knowledge of how their diverse regulatory subunits target highly conserved catalytic subunits to their sites of action. Phosphoprotein phosphatase 4 (PP4) has been recently shown to participate in the regulation of cell cycle progression. We now find that the EVH1 domain of the regulatory subunit 3 of Drosophila PP4, Falafel (Flfl), directly interacts with the centromeric protein C (CENP-C). Unlike other EVH1 domains that interact with proline-rich ligands, the crystal structure of the Flfl amino-terminal EVH1 domain bound to a CENP-C peptide reveals a new target-recognition mode for the phosphatase subunit. We also show that binding of Flfl to CENP-C is required to bring PP4 activity to centromeres to maintain CENP-C and attached core kinetochore proteins at chromosomes during mitosis.

journal_name

Nat Commun

journal_title

Nature communications

authors

Lipinszki Z,Lefevre S,Savoian MS,Singleton MR,Glover DM,Przewloka MR

doi

10.1038/ncomms6894

subject

Has Abstract

pub_date

2015-01-06 00:00:00

pages

5894

issn

2041-1723

pii

ncomms6894

journal_volume

6

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Nonreciprocal reconfigurable microwave optomechanical circuit.

    abstract：:Nonreciprocal microwave devices are ubiquitous in radar and radio communication and indispensable in the readout chains of superconducting quantum circuits. Since they commonly rely on ferrite materials requiring large magnetic fields that make them bulky and lossy, there has been significant interest in magnetic-fiel...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00447-1

    authors： Bernier NR,Tóth LD,Koottandavida A,Ioannou MA,Malz D,Nunnenkamp A,Feofanov AK,Kippenberg TJ

    更新日期：2017-09-19 00:00:00

  • Electronic spin separation induced by nuclear motion near conical intersections.

    abstract：:Though the concept of Berry force was proposed thirty years ago, little is known about the practical consequences of this force as far as chemical dynamics are concerned. Here, we report that when molecular dynamics pass near a conical intersection, a massive Berry force can appear as a result of even a small amount o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20831-8

    authors： Wu Y,Subotnik JE

    更新日期：2021-01-29 00:00:00

  • Author Correction: Adaptive individual variation in phenological responses to perceived predation levels.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-019-13715-z

    authors： Abbey-Lee RN,Dingemanse NJ

    更新日期：2019-12-06 00:00:00

  • Optical patterning of trapped charge in nitrogen-doped diamond.

    abstract：:The nitrogen-vacancy (NV) centre in diamond is emerging as a promising platform for solid-state quantum information processing and nanoscale metrology. Of interest in these applications is the manipulation of the NV charge, which can be attained by optical excitation. Here, we use two-colour optical microscopy to inve...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12660

    authors： Jayakumar H,Henshaw J,Dhomkar S,Pagliero D,Laraoui A,Manson NB,Albu R,Doherty MW,Meriles CA

    更新日期：2016-08-30 00:00:00

  • Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma.

    abstract：:Although substantial progress has been made in cancer biology and treatment, clinical outcomes of bladder carcinoma (BC) patients are still not satisfactory. The tumor microenvironment (TME) is a potential target. Here, by single-cell RNA sequencing on 8 BC tumor samples and 3 para tumor samples, we identify 19 differ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18916-5

    authors： Chen Z,Zhou L,Liu L,Hou Y,Xiong M,Yang Y,Hu J,Chen K

    更新日期：2020-10-08 00:00:00

  • Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.

    abstract：:Cleavage of transfer (t)RNA and ribosomal (r)RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified in high eukaryotes. Here, we report a mammalian tRNA/rRNA-targeting endorib...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03544-x

    authors： Yang JY,Deng XY,Li YS,Ma XC,Feng JX,Yu B,Chen Y,Luo YL,Wang X,Chen ML,Fang ZX,Zheng FX,Li YP,Zhong Q,Kang TB,Song LB,Xu RH,Zeng MS,Chen W,Zhang H,Xie W,Gao S

    更新日期：2018-03-21 00:00:00

  • High-performance reconstruction of microscopic force fields from Brownian trajectories.

    abstract：:The accurate measurement of microscopic force fields is crucial in many branches of science and technology, from biophotonics and mechanobiology to microscopy and optomechanics. These forces are often probed by analysing their influence on the motion of Brownian particles. Here we introduce a powerful algorithm for mi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07437-x

    authors： Pérez García L,Donlucas Pérez J,Volpe G,V Arzola A,Volpe G

    更新日期：2018-12-04 00:00:00

  • Network curvature as a hallmark of brain structural connectivity.

    abstract：:Although brain functionality is often remarkably robust to lesions and other insults, it may be fragile when these take place in specific locations. Previous attempts to quantify robustness and fragility sought to understand how the functional connectivity of brain networks is affected by structural changes, using eit...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12915-x

    authors： Farooq H,Chen Y,Georgiou TT,Tannenbaum A,Lenglet C

    更新日期：2019-10-30 00:00:00

  • Integrated digital inverters based on two-dimensional anisotropic ReS2 field-effect transistors.

    abstract：:Semiconducting two-dimensional transition metal dichalcogenides are emerging as top candidates for post-silicon electronics. While most of them exhibit isotropic behaviour, lowering the lattice symmetry could induce anisotropic properties, which are both scientifically interesting and potentially useful. Here we prese...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7991

    authors： Liu E,Fu Y,Wang Y,Feng Y,Liu H,Wan X,Zhou W,Wang B,Shao L,Ho CH,Huang YS,Cao Z,Wang L,Li A,Zeng J,Song F,Wang X,Shi Y,Yuan H,Hwang HY,Cui Y,Miao F,Xing D

    更新日期：2015-05-07 00:00:00

  • Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.

    abstract：:Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15922

    authors： Bicker F,Vasic V,Horta G,Ortega F,Nolte H,Kavyanifar A,Keller S,Stankovic ND,Harter PN,Benedito R,Lutz B,Bäuerle T,Hartwig J,Baumgart J,Krüger M,Radyushkin K,Alberi L,Berninger B,Schmidt MHH

    更新日期：2017-06-28 00:00:00

  • Mechanically activated switching of Si-based single-molecule junction as imaged with three-dimensional dynamic probe.

    abstract：:Understanding and extracting the full functions of single-molecule characteristics are key factors in the development of future device technologies, as well as in basic research on molecular electronics. Here we report a new methodology for realizing a three-dimensional (3D) dynamic probe of single-molecule conductanc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9465

    authors： Nakamura M,Yoshida S,Katayama T,Taninaka A,Mera Y,Okada S,Takeuchi O,Shigekawa H

    更新日期：2015-10-06 00:00:00

  • Deep long period volcanic earthquakes generated by degassing of volatile-rich basaltic magmas.

    abstract：:Deep long-period (DLP) earthquakes observed beneath active volcanoes are sometimes considered as precursors to eruptions. Their origin remains, however, unclear. Here, we present a possible DLP generating mechanism related to the rapid growth of gas bubbles in response to the slow decompression of over-saturated magma...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17759-4

    authors： Melnik O,Lyakhovsky V,Shapiro NM,Galina N,Bergal-Kuvikas O

    更新日期：2020-08-06 00:00:00

  • Observations from old forests underestimate climate change effects on tree mortality.

    abstract：:Understanding climate change-associated tree mortality is central to linking climate change impacts and forest structure and function. However, whether temporal increases in tree mortality are attributed to climate change or stand developmental processes remains uncertain. Furthermore, interpreting the climate change-...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2681

    authors： Luo Y,Chen HY

    更新日期：2013-01-01 00:00:00

  • Evolution and structure of clinically relevant gene fusions in multiple myeloma.

    abstract：:Multiple myeloma is a plasma cell blood cancer with frequent chromosomal translocations leading to gene fusions. To determine the clinical relevance of fusion events, we detect gene fusions from a cohort of 742 patients from the Multiple Myeloma Research Foundation CoMMpass Study. Patients with multiple clinic visits ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16434-y

    authors： Foltz SM,Gao Q,Yoon CJ,Sun H,Yao L,Li Y,Jayasinghe RG,Cao S,King J,Kohnen DR,Fiala MA,Ding L,Vij R

    更新日期：2020-05-29 00:00:00

  • Initial pulse of Siberian Traps sills as the trigger of the end-Permian mass extinction.

    abstract：:Mass extinction events are short-lived and characterized by catastrophic biosphere collapse and subsequent reorganization. Their abrupt nature necessitates a similarly short-lived trigger, and large igneous province magmatism is often implicated. However, large igneous provinces are long-lived compared to mass extinct...

    journal_title：Nature communications

    pub_type： 历史文章,杂志文章

    doi：10.1038/s41467-017-00083-9

    authors： Burgess SD,Muirhead JD,Bowring SA

    更新日期：2017-07-31 00:00:00

  • Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis.

    abstract：:Blood vessel expansion is driven by sprouting angiogenesis of endothelial cells, and is essential for development, wound healing and disease. Membrane-localized vascular endothelial growth factor receptor-1 (mVEGFR1) is an endothelial cell-intrinsic decoy receptor that negatively modulates blood vessel morphogenesis. ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15699

    authors： Boucher JM,Clark RP,Chong DC,Citrin KM,Wylie LA,Bautch VL

    更新日期：2017-06-07 00:00:00

  • Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival.

    abstract：:Genomic instability pathways in colorectal cancer (CRC) have been extensively studied, but the role of retrotransposition in colorectal carcinogenesis remains poorly understood. Although retrotransposons are usually repressed, they become active in several human cancers, in particular those of the gastrointestinal tra...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11770-0

    authors： Cajuso T,Sulo P,Tanskanen T,Katainen R,Taira A,Hänninen UA,Kondelin J,Forsström L,Välimäki N,Aavikko M,Kaasinen E,Ristimäki A,Koskensalo S,Lepistö A,Renkonen-Sinisalo L,Seppälä T,Kuopio T,Böhm J,Mecklin JP,Kilpivaar

    更新日期：2019-09-06 00:00:00

  • Impact of the Mertz Glacier Tongue calving on dense water formation and export.

    abstract：:Antarctic Bottom Water (AABW) is a critical component of the global climate system, occupying the abyssal layer of the World Ocean and driving the lower limb of the global meridional overturning circulation. Around East Antarctica, the dense shelf water (DSW) precursor to AABW is predominantly formed by enhanced sea i...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1156

    authors： Kusahara K,Hasumi H,Williams GD

    更新日期：2011-01-18 00:00:00

  • 3D designed and printed chemical generators for on demand reagent synthesis.

    abstract：:Modern science has developed well-defined and versatile sets of chemicals to perform many specific tasks, yet the diversity of these reagents is so large that it can be impractical for any one lab to stock everything they might need. At the same time, isssues of stability or limited supply mean these chemicals can be ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13328-6

    authors： Zalesskiy SS,Kitson PJ,Frei P,Bubliauskas A,Cronin L

    更新日期：2019-12-02 00:00:00

  • Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.

    abstract：:Diverse entry inhibitors targeting the gp120 subunit of the HIV-1 envelope (Env) trimer have been developed including BMS-626529, also called temsavir, a prodrug version of which is currently in phase III clinical trials. Here we report the characterization of a panel of small-molecule inhibitors including BMS-818251,...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07851-1

    authors： Lai YT,Wang T,O'Dell S,Louder MK,Schön A,Cheung CSF,Chuang GY,Druz A,Lin B,McKee K,Peng D,Yang Y,Zhang B,Herschhorn A,Sodroski J,Bailer RT,Doria-Rose NA,Mascola JR,Langley DR,Kwong PD

    更新日期：2019-01-03 00:00:00

  • The NMDA receptor regulates competition of epithelial cells in the Drosophila wing.

    abstract：:Cell competition is an emerging principle that eliminates suboptimal or potentially dangerous cells. For 'unfit' cells to be detected, their competitive status needs to be compared to the collective fitness of cells within a tissue. Here we report that the NMDA receptor controls cell competition of epithelial cells an...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16070-6

    authors： Banreti AR,Meier P

    更新日期：2020-05-06 00:00:00

  • 21st Century drought-related fires counteract the decline of Amazon deforestation carbon emissions.

    abstract：:Tropical carbon emissions are largely derived from direct forest clearing processes. Yet, emissions from drought-induced forest fires are, usually, not included in national-level carbon emission inventories. Here we examine Brazilian Amazon drought impacts on fire incidence and associated forest fire carbon emissions ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02771-y

    authors： Aragão LEOC,Anderson LO,Fonseca MG,Rosan TM,Vedovato LB,Wagner FH,Silva CVJ,Silva Junior CHL,Arai E,Aguiar AP,Barlow J,Berenguer E,Deeter MN,Domingues LG,Gatti L,Gloor M,Malhi Y,Marengo JA,Miller JB,Phillips OL,Sa

    更新日期：2018-02-13 00:00:00

  • Strong magnetophonon oscillations in extra-large graphene.

    abstract：:Van der Waals materials and their heterostructures offer a versatile platform for studying a variety of quantum transport phenomena due to their unique crystalline properties and the exceptional ability in tuning their electronic spectrum. However, most experiments are limited to devices that have lateral dimensions o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11379-3

    authors： Kumaravadivel P,Greenaway MT,Perello D,Berdyugin A,Birkbeck J,Wengraf J,Liu S,Edgar JH,Geim AK,Eaves L,Krishna Kumar R

    更新日期：2019-07-26 00:00:00

  • A comprehensive multiscale framework for simulating optogenetics in the heart.

    abstract：:Optogenetics has emerged as an alternative method for electrical control of the heart, where illumination is used to elicit a bioelectric response in tissue modified to express photosensitive proteins (opsins). This technology promises to enable evocation of spatiotemporally precise responses in targeted cells or tiss...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3370

    authors： Boyle PM,Williams JC,Ambrosi CM,Entcheva E,Trayanova NA

    更新日期：2013-01-01 00:00:00

  • Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome.

    abstract：:Removal of internal transcribed spacer 2 (ITS2) from pre-ribosomal RNA is essential to make functional ribosomes. This complicated processing reaction begins with a single endonucleolytic cleavage followed by exonucleolytic trimming at both new cleavage sites to generate mature 5.8S and 25S rRNA. We reconstituted the ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01786-9

    authors： Fromm L,Falk S,Flemming D,Schuller JM,Thoms M,Conti E,Hurt E

    更新日期：2017-11-27 00:00:00

  • Responsive nematic gels from the self-assembly of aqueous nanofibres.

    abstract：:Aqueous nanofibres constructed by the self-assembly of small amphiphilic molecules can become entangled to form hydrogels that have a variety of applications including tissue engineering, and controlled drug delivery. The hydrogels are formed through the random physical cross-linkings of flexible nanofibres. Here we r...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1465

    authors： Huang Z,Lee H,Lee E,Kang SK,Nam JM,Lee M

    更新日期：2011-09-06 00:00:00

  • Author Correction: Interplay of protein corona and immune cells controls blood residency of liposomes.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-020-15500-9

    authors： Giulimondi F,Digiacomo L,Pozzi D,Palchetti S,Vulpis E,Capriotti AL,Chiozzi RZ,Laganà A,Amenitsch H,Masuelli L,Peruzzi G,Mahmoudi M,Screpanti I,Zingoni A,Caracciolo G

    更新日期：2020-03-31 00:00:00

  • Graphite-protected CsPbBr3 perovskite photoanodes functionalised with water oxidation catalyst for oxygen evolution in water.

    abstract：:Metal-halide perovskites have been widely investigated in the photovoltaic sector due to their promising optoelectronic properties and inexpensive fabrication techniques based on solution processing. Here we report the development of inorganic CsPbBr3-based photoanodes for direct photoelectrochemical oxygen evolution ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10124-0

    authors： Poli I,Hintermair U,Regue M,Kumar S,Sackville EV,Baker J,Watson TM,Eslava S,Cameron PJ

    更新日期：2019-05-08 00:00:00

  • Photocatalytic colour switching of redox dyes for ink-free light-printable rewritable paper.

    abstract：:The invention of paper as writing materials has greatly contributed to the development and spread of civilization. However, its large-scale production and usage have also brought significant environment and sustainability problems to modern society. To reduce paper production and consumption, it is highly desirable to...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6459

    authors： Wang W,Xie N,He L,Yin Y

    更新日期：2014-12-02 00:00:00

  • Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment.

    abstract：:Gluconeogenesis is a fundamental metabolic process that allows organisms to make sugars from non-carbohydrate stores such as lipids and protein. In eukaryotes only one gluconeogenic route has been described from organic acid intermediates and this relies on the enzyme phosphoenolpyruvate carboxykinase (PCK). Here we s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7659

    authors： Eastmond PJ,Astley HM,Parsley K,Aubry S,Williams BP,Menard GN,Craddock CP,Nunes-Nesi A,Fernie AR,Hibberd JM

    更新日期：2015-04-10 00:00:00