Abstract：
:Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells and neural stem cells (NSCs) of the SVZ to shape the vascular stem-cell niche. Loss of EGFL7 causes an accumulation of activated NSCs, which display enhanced activity and re-entry into the cell cycle. EGFL7 pushes activated NSCs towards quiescence and neuronal progeny towards differentiation. This is achieved by promoting Dll4-induced Notch signalling at the blood vessel-stem cell interface. Fewer inhibitory neurons form in the OB of EGFL7-knockout mice, which increases the absolute signal conducted from the mitral cell layer of the OB but decreases neuronal network synchronicity. Consequently, EGFL7-knockout mice display severe physiological defects in olfactory behaviour and perception.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Bicker F,Vasic V,Horta G,Ortega F,Nolte H,Kavyanifar A,Keller S,Stankovic ND,Harter PN,Benedito R,Lutz B,Bäuerle T,Hartwig J,Baumgart J,Krüger M,Radyushkin K,Alberi L,Berninger B,Schmidt MHHdoi
10.1038/ncomms15922subject
Has Abstractpub_date
2017-06-28 00:00:00pages
15922issn
2041-1723pii
ncomms15922journal_volume
8pub_type
杂志文章abstract：:The performance of conjugated polymer devices is largely dictated by charge transport processes. However, it is difficult to obtain a clear relationship between conjugated polymer structures and charge transport properties, due to the complexity of the structure and the dispersive nature of charge transport in conjuga...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06846-2
更新日期：2018-10-17 00:00:00
abstract：:Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed deficiency in chondrocytes causes s...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12047
更新日期：2016-06-22 00:00:00
abstract：:Genome replication is highly regulated in time and space, but the rules governing the remodeling of these programs during evolution remain largely unknown. We generated genome-wide replication timing profiles for ten Lachancea yeasts, covering a continuous evolutionary range from closely related to more divergent spec...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04628-4
更新日期：2018-06-06 00:00:00
abstract：:Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC) n -containing RNAs into poly-dipeptides can initiate in vivo without a 5'-cap. The pr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02495-z
更新日期：2018-01-04 00:00:00
abstract：:The original version of this Article contained an error in Figure 4. In panel a, the colour code for hot and cold clusters was inadvertently inverted. In the correct version of panel a, the hot clusters are blue and the cold clusters are yellow. This error has now been corrected in both the PDF and HTML versions of th...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-07155-4
更新日期：2018-11-02 00:00:00
abstract：:TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly express DR3. Here, we report that activation of DR3 signaling by an agonistic anti-DR3 antibody incr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11304-8
更新日期：2019-07-29 00:00:00
abstract：:MicroRNAs (miRNAs) are endogenous small RNAs of ∼21 nt that regulate multiple biological pathways in multicellular organisms. They derive from longer transcripts that harbor an imperfect stem-loop structure. In plants, the ribonuclease type III DICER-LIKE1 assisted by accessory proteins cleaves the precursor to releas...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19129-6
更新日期：2020-10-21 00:00:00
abstract：:Bacteriophage Q protein engages σ-dependent paused RNA polymerase (RNAP) by binding to a DNA site embedded in late gene promoter and renders RNAP resistant to termination signals. Here, we report a single-particle cryo-electron microscopy (cryo-EM) structure of an intact Q-engaged arrested complex. The structure revea...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10958-8
更新日期：2019-07-02 00:00:00
abstract：:The abundance of sodium resources indicates the potential of sodium-ion batteries as emerging energy storage devices. However, the practical application of sodium-ion batteries is hindered by the limited electrochemical performance of electrode materials, especially at the anode side. Here, we identify alkaline earth ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00211-5
更新日期：2017-09-06 00:00:00
abstract：:Although many animals have evolved intrinsic transparency for the purpose of concealment, the development of dynamic, that is, controllable and reversible, transparency for living human cells and tissues has remained elusive to date. Here, by drawing inspiration from the structures and functionalities of adaptive ceph...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16151-6
更新日期：2020-06-02 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease, characterised by increased expression of type I interferon (IFN)-regulated genes and a striking sex imbalance towards females. Through combined genetic, in silico, in vitro, and ex vivo approaches, we define CXorf21, a gene of hitherto unknown function, whic...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10106-2
更新日期：2019-05-15 00:00:00
abstract：:Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic acid (DHA). However, the impact of EPA and DHA supplementation on normal cognitive function and the molecular targets of EPA and DHA are...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19255-1
更新日期：2020-10-29 00:00:00
abstract：:The growing demand for lithium batteries with higher energy densities requires new electrode chemistries. Lithium metal is a promising candidate as the anode material due to its high theoretical specific capacity, negative electrochemical potential and favorable density. However, during cycling, low and uneven lithium...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12952-6
更新日期：2019-10-31 00:00:00
abstract：:Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines. The fusion of immun...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11157-1
更新日期：2019-07-19 00:00:00
abstract：:Substantial efforts have been made to understand the interactions between immune checkpoint receptors and their ligands targeted in immunotherapies against cancer. To carefully characterize the complete network of interactions involved and the binding affinities between their extracellular domains, an improved kinetic...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12220
更新日期：2016-07-22 00:00:00
abstract：:Hypoxia occurs when limited oxygen supply impairs physiological functions and is a pathological hallmark of many diseases including cancer and ischemia. Thus, detection of hypoxia can guide treatment planning and serve as a predictor of patient prognosis. Unfortunately, current methods suffer from invasiveness, poor r...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01951-0
更新日期：2017-11-27 00:00:00
abstract：:Highly regio- and enantioselective intermolecular hydroamination of alkenes is a challenging process potentially leading to valuable chiral amines. Hydroamination of alkenes via metal-catalyzed hydrogen atom transfer (HAT) with good regioselectivity and functional group tolerance has been reported, however, high enant...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14459-x
更新日期：2020-02-07 00:00:00
abstract：:Novel methods for information processing are highly desired in our information-driven society. Inspired by the brain's ability to process information, the recently introduced paradigm known as 'reservoir computing' shows that complex networks can efficiently perform computation. Here we introduce a novel architecture ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1476
更新日期：2011-09-13 00:00:00
abstract：:Bacterial autotransporters comprise a 12-stranded membrane-embedded β-barrel domain, which must be folded in a process that entraps segments of an N-terminal passenger domain. This first stage of autotransporter folding determines whether subsequent translocation can deliver the N-terminal domain to its functional for...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5239
更新日期：2014-06-26 00:00:00
abstract：:Metastasis is the main cause of cancer-related death and thus understanding the molecular and cellular mechanisms underlying this process is critical. Here, our data demonstrate, contrary to established dogma, that loss of haematopoietic-derived focal adhesion kinase (FAK) is sufficient to enhance tumour metastasis. U...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6054
更新日期：2014-10-01 00:00:00
abstract：:Long duration gamma-ray bursts (GRBs), the brightest events since the Big Bang itself, are believed to originate in an ultra-relativistic jet breaking out from a massive stellar envelope. Despite decades of study, there is still no consensus on their emission mechanism. One unresolved question is the origin of the tig...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09281-z
更新日期：2019-04-03 00:00:00
abstract：:The Sun's activity cycle governs the radiation, particle and magnetic flux in the heliosphere creating hazardous space weather. Decadal-scale variations define space climate and force the Earth's atmosphere. However, predicting the solar cycle is challenging. Current understanding indicates a short window for predicti...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07690-0
更新日期：2018-12-06 00:00:00
abstract：:It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10512
更新日期：2016-01-27 00:00:00
abstract：:Thanks to the nature of strong programmability, field-programmable gate arrays (FPGAs) have been playing a significant role in signal processing and control. With the explosive growth in digital data, big data analytics becomes an important emerging field, in which FPGAs are a major player. However, the computational ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-14249-0
更新日期：2020-01-21 00:00:00
abstract：:Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing strain. We demonstrate that TeA is synthesize...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9758
更新日期：2015-10-27 00:00:00
abstract：:Fullerene peapods, which are carbon nanotubes encapsulating fullerene molecules, can offer enhanced functionality with respect to empty nanotubes. Their prospective applications include, for example, data storage devices, single-electron transistors and spin-qubit arrays for quantum computing. However, the present inc...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1034
更新日期：2010-07-13 00:00:00
abstract：:Pattern-triggered immunity and effector-triggered immunity are two primary forms of innate immunity in land plants. The molecular components and connecting nodes of pattern-triggered immunity and effector-triggered immunity are not fully understood. Here, we report that the Arabidopsis calcium-dependent protein kinase...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20007-4
更新日期：2020-12-04 00:00:00
abstract：:Replicating biological patterns is promising for designing materials with multifaceted properties. Twisted cholesteric liquid crystal patterns are found in the iridescent tessellated cuticles of many insects and a few fruits. Their accurate replication is extremely difficult since discontinuous patterns and colors mus...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-17884-0
更新日期：2020-08-14 00:00:00
abstract：:Tandem organic solar cells are based on the device structure monolithically connecting two solar cells to broaden overall absorption spectrum and utilize the photon energy more efficiently. Herein, we demonstrate a simple strategy of inserting a double bond between the central core and end groups of the small molecule...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20431-6
更新日期：2021-01-08 00:00:00
abstract：:Exfoliated two-dimensional (2D) sheets can readily stack to form flexible, free-standing films with lamellar microstructure. The interlayer spaces in such lamellar films form a percolated network of molecularly sized, 2D nanochannels that could be used to regulate molecular transport. Here we report self-assembled cla...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms8602
更新日期：2015-07-13 00:00:00
