Abstract:
:Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic acid (DHA). However, the impact of EPA and DHA supplementation on normal cognitive function and the molecular targets of EPA and DHA are still unknown. We show that acute administration of EPA impairs learning and memory and hippocampal LTP in adult and prepubescent mice. Similar deficits are duplicated by endogenously elevating EPA in the hippocampus in the transgenic fat-1 mouse. Furthermore, the damaging effects of EPA are mediated through enhancing GABAergic transmission via the 5-HT6R. Interestingly, DHA can prevent EPA-induced impairments at a ratio of EPA to DHA similar to that in marine fish oil via the 5-HT2CR. We conclude that EPA exhibits an unexpected detrimental impact on cognitive functions, suggesting that caution must be exercised in omega-3 fatty acid supplementation and the combination of EPA and DHA at a natural ratio is critical for learning and memory and synaptic plasticity.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Liu JH,Wang Q,You QL,Li ZL,Hu NY,Wang Y,Jin ZL,Li SJ,Li XW,Yang JM,Zhu XH,Dai YF,Xu JP,Bai XC,Gao TMdoi
10.1038/s41467-020-19255-1subject
Has Abstractpub_date
2020-10-29 00:00:00pages
5465issue
1issn
2041-1723pii
10.1038/s41467-020-19255-1journal_volume
11pub_type
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