Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.

abstract：:Simultaneous deep brain stimulation (DBS) and functional magnetic resonance imaging (fMRI) constitutes a powerful tool for elucidating brain functional connectivity, and exploring neuromodulatory mechanisms of DBS therapies. Previous DBS-fMRI studies could not provide full activation pattern maps due to poor MRI compa...

journal_title：Nature communications

authors： Zhao S,Li G,Tong C,Chen W,Wang P,Dai J,Fu X,Xu Z,Liu X,Lu L,Liang Z,Duan X

更新日期：2020-04-14 00:00:00

abstract：:Interest in manipulating the magnetic order by ultrashort laser pulses has thrived since it was observed that such pulses can be used to alter the magnetization on a sub-picosecond timescale. Usually this involves demagnetization by laser heating or, in rare cases, a transient increase of magnetization. Here we demons...

journal_title：Nature communications

authors： Matsubara M,Schroer A,Schmehl A,Melville A,Becher C,Trujillo-Martinez M,Schlom DG,Mannhart J,Kroha J,Fiebig M

更新日期：2015-04-02 00:00:00

abstract：:The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and m...

journal_title：Nature communications

authors： Ding J,Chen K,Liu H,Huang L,Chen Y,Lv Y,Yang Q,Guo Q,Han Z,Lambon Ralph MA

更新日期：2020-05-22 00:00:00

abstract：:Providing high performance electrical nano-interconnects for micro-nano electronics that are robust in harsh environments is highly demanded. Today, electrical nano-interconnects based on metallic nanowires, e.g. Ag and Cu, are limited by their positive physicochemical reactivity and ductility under large strain (i.e....

journal_title：Nature communications

authors： Sun Y,Sun B,He J,Yang G,Wang C

更新日期：2020-01-31 00:00:00

abstract：:Plasmodium vivax poses unique challenges for malaria control and elimination, notably the potential for relapses to maintain transmission in the face of drug-based treatment and vector control strategies. We developed an individual-based mathematical model of P. vivax transmission calibrated to epidemiological data fr...

journal_title：Nature communications

authors： White MT,Walker P,Karl S,Hetzel MW,Freeman T,Waltmann A,Laman M,Robinson LJ,Ghani A,Mueller I

更新日期：2018-08-17 00:00:00

abstract：:Antibodies conjugated to bioactive compounds allow targeted delivery of therapeutics to cell types of choice based on that antibody's specificity. Here we develop a new type of conjugate that consists of a nanobody and a peptidic ligand for a G protein-coupled receptor (GPCR), fused via their C-termini. We address act...

journal_title：Nature communications

authors： Cheloha RW,Fischer FA,Woodham AW,Daley E,Suminski N,Gardella TJ,Ploegh HL

更新日期：2020-04-29 00:00:00

abstract：:Vibrio cholerae, responsible for acute gastroenteritis secretes a large multifunctional-autoprocessing repeat-in-toxin (MARTX) toxin linked to evasion of host immune system, facilitating colonization of small intestine. Unlike other effector domains of the multifunctional toxin that target cytoskeleton, the function o...

journal_title：Nature communications

authors： Agarwal S,Kim H,Chan RB,Agarwal S,Williamson R,Cho W,Paolo GD,Satchell KJ

更新日期：2015-10-26 00:00:00

abstract：:The identification of fractionalized excitations, such as Majorana quasi-particles, would be a striking signal of the realization of exotic quantum states of matter. While the paramount demonstration of such excitations would be a probe of their non-Abelian statistics via controlled braiding operations, alternative pr...

journal_title：Nature communications

authors： Laflamme C,Budich JC,Zoller P,Dalmonte M

更新日期：2016-08-02 00:00:00

abstract：:Development of efficient catalysts for selective electroreduction of CO2 to high-value products is essential for the deployment of carbon utilization technologies. Here we present a scalable method for preparing Cu electrocatalysts that favor CO2 conversion to C2+ products with faradaic efficiencies up to 72%. Grazing...

journal_title：Nature communications

authors： Kim T,Palmore GTR

更新日期：2020-07-17 00:00:00

abstract：:Both basal ganglia (BG) and orbitofrontal cortex (OFC) have been widely implicated in social and non-social decision-making. However, unlike OFC damage, BG pathology is not typically associated with disturbances in social functioning. Here we studied the behavior of patients with focal lesions to either BG or OFC in a...

journal_title：Nature communications

authors： Zhu L,Jiang Y,Scabini D,Knight RT,Hsu M

更新日期：2019-02-18 00:00:00

abstract：:Hypsodonty, the occurrence of high-crowned teeth, is widespread among mammals with diets rich in abrasive material, such as plants or soil, because it increases the durability of dentitions against wear. Hypsodont postcanine teeth evolved independently in multiple mammalian lineages and in the closely related mammalia...

journal_title：Nature communications

authors： Melo TP,Ribeiro AM,Martinelli AG,Soares MB

更新日期：2019-06-28 00:00:00

abstract：:Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population. Here, we identify 3 (13q12.2, 13q22.1, and 16p12.3) gen...

journal_title：Nature communications

authors： Lin Y,Nakatochi M,Hosono Y,Ito H,Kamatani Y,Inoko A,Sakamoto H,Kinoshita F,Kobayashi Y,Ishii H,Ozaka M,Sasaki T,Matsuyama M,Sasahira N,Morimoto M,Kobayashi S,Fukushima T,Ueno M,Ohkawa S,Egawa N,Kuruma S,Mori M,

更新日期：2020-06-24 00:00:00

abstract：:Single impurities with nonzero spin and multiple ground states offer a degree of freedom that can be utilized to store the quantum information. However, Fe(2+) dopant is known for having a single nondegenerate ground state in the bulk host semiconductors and thus is of little use for spintronic applications. Here we s...

journal_title：Nature communications

authors： Smoleński T,Kazimierczuk T,Kobak J,Goryca M,Golnik A,Kossacki P,Pacuski W

更新日期：2016-01-28 00:00:00

abstract：:Methanol represents an attractive substrate for biotechnological applications. Utilization of reduced one-carbon compounds for growth is currently limited to methylotrophic organisms, and engineering synthetic methylotrophy remains a major challenge. Here we apply an in silico-guided multiple knockout approach to engi...

journal_title：Nature communications

authors： Meyer F,Keller P,Hartl J,Gröninger OG,Kiefer P,Vorholt JA

更新日期：2018-04-17 00:00:00

abstract：:Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metabolomics allows classifying the lipoprotein particles into more details. Here, we examine the impact of gut mic...

journal_title：Nature communications

authors： Vojinovic D,Radjabzadeh D,Kurilshikov A,Amin N,Wijmenga C,Franke L,Ikram MA,Uitterlinden AG,Zhernakova A,Fu J,Kraaij R,van Duijn CM

更新日期：2019-12-20 00:00:00

abstract：:Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin αMβ2, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for injury responses in diverse disease models. However, the role of Mac-1 i...

journal_title：Nature communications

authors： Wang Y,Gao H,Shi C,Erhardt PW,Pavlovsky A,A Soloviev D,Bledzka K,Ustinov V,Zhu L,Qin J,Munday AD,Lopez J,Plow E,Simon DI

更新日期：2017-05-30 00:00:00

abstract：:Complex oxide heterointerfaces and van der Waals heterostructures present two versatile but intrinsically different platforms for exploring emergent quantum phenomena and designing new functionalities. The rich opportunity offered by the synergy between these two classes of materials, however, is yet to be charted. He...

journal_title：Nature communications

authors： Li D,Huang X,Xiao Z,Chen H,Zhang L,Hao Y,Song J,Shao DF,Tsymbal EY,Lu Y,Hong X

更新日期：2020-03-17 00:00:00

abstract：:Proteins containing a Bin/Amphiphysin/Rvs (BAR) domain regulate membrane curvature in the cell. Recent simulations have revealed that BAR proteins assemble into linear aggregates, strongly affecting membrane curvature and its in-plane stress profile. Here, we explore the opposite question: do mechanical properties of ...

journal_title：Nature communications

authors： Simunovic M,Voth GA

更新日期：2015-05-26 00:00:00

abstract：:Untethered small actuators have various applications in multiple fields. However, existing small-scale actuators are very limited in their intractability with their surroundings, respond to only a single type of stimulus and are unable to achieve programmable structural changes under different stimuli. Here, we presen...

journal_title：Nature communications

authors： Dong Y,Wang J,Guo X,Yang S,Ozen MO,Chen P,Liu X,Du W,Xiao F,Demirci U,Liu BF

更新日期：2019-09-09 00:00:00

abstract：:In November 2013, a series of earthquakes began along a mapped ancient fault system near Azle, Texas. Here we assess whether it is plausible that human activity caused these earthquakes. Analysis of both lake and groundwater variations near Azle shows that no significant stress changes were associated with the shallow...

journal_title：Nature communications

authors： Hornbach MJ,DeShon HR,Ellsworth WL,Stump BW,Hayward C,Frohlich C,Oldham HR,Olson JE,Magnani MB,Brokaw C,Luetgert JH

更新日期：2015-04-21 00:00:00

abstract：:Using asymmetric catalysis to simultaneously form carbon-carbon bonds and generate single isomer products is strategically important. Suzuki-Miyaura cross-coupling is widely used in the academic and industrial sectors to synthesize drugs, agrochemicals and biologically active and advanced materials. However, widely ap...

journal_title：Nature communications

authors： Schäfer P,Palacin T,Sidera M,Fletcher SP

更新日期：2017-06-13 00:00:00

abstract：:Many cities globally are seeking strategies to counter the consequences of both a hotter and drier climate. While urban heat mitigation strategies have been shown to have beneficial effects on health, energy consumption, and greenhouse gas emissions, their implications for water conservation have not been widely exami...

journal_title：Nature communications

authors： Vahmani P,Jones AD

更新日期：2017-10-20 00:00:00

abstract：:Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers. While we previously identified KRAS mutations as molecular culprits of MPE formation, the underlying mechanism remained unknown. Here, we determine that non-canonical IKKα-RelB pathway activation of KRAS-mutant tumor cells mediat...

journal_title：Nature communications

authors： Marazioti A,Lilis I,Vreka M,Apostolopoulou H,Kalogeropoulou A,Giopanou I,Giotopoulou GA,Krontira AC,Iliopoulou M,Kanellakis NI,Agalioti T,Giannou AD,Jones-Paris C,Iwakura Y,Kardamakis D,Blackwell TS,Taraviras S,Spella M

更新日期：2018-02-14 00:00:00

abstract：:Mangrove forests hold some of the highest densities of carbon recorded in any ecosystem, but have experienced widespread deforestation through conversion to aquaculture and agriculture. Alongside deforestation, mangroves have shown simultaneous natural expansion in some parts of the world, and considerable investments...

journal_title：Nature communications

authors： Richards DR,Thompson BS,Wijedasa L

更新日期：2020-08-26 00:00:00

abstract：:Synthetic DNA-based data storage systems have received significant attention due to the promise of ultrahigh storage density and long-term stability. However, all known platforms suffer from high cost, read-write latency and error-rates that render them noncompetitive with modern storage devices. One means to avoid th...

journal_title：Nature communications

authors： Tabatabaei SK,Wang B,Athreya NBM,Enghiad B,Hernandez AG,Fields CJ,Leburton JP,Soloveichik D,Zhao H,Milenkovic O

更新日期：2020-04-08 00:00:00

abstract：:Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease patients. Here, to ...

journal_title：Nature communications

authors： Matic S,Jiang M,Nicholls TJ,Uhler JP,Dirksen-Schwanenland C,Polosa PL,Simard ML,Li X,Atanassov I,Rackham O,Filipovska A,Stewart JB,Falkenberg M,Larsson NG,Milenkovic D

更新日期：2018-03-23 00:00:00

abstract：:Xylanolytic enzymes from glycoside hydrolase family 43 (GH43) are involved in the breakdown of hemicellulose, the second most abundant carbohydrate in plants. Here, we kinetically and mechanistically describe the non-reducing-end xylose-releasing exo-oligoxylanase activity and report the crystal structure of a native ...

journal_title：Nature communications

authors： Morais MAB,Coines J,Domingues MN,Pirolla RAS,Tonoli CCC,Santos CR,Correa JBL,Gozzo FC,Rovira C,Murakami MT

更新日期：2021-01-14 00:00:00

abstract：:MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin. Here, we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness, immune stimulation and virulence. Increased expression of mcr-1 results in decreased growth rate, cell viability, competitive ability ...

journal_title：Nature communications

authors： Yang Q,Li M,Spiller OB,Andrey DO,Hinchliffe P,Li H,MacLean C,Niumsup P,Powell L,Pritchard M,Papkou A,Shen Y,Portal E,Sands K,Spencer J,Tansawai U,Thomas D,Wang S,Wang Y,Shen J,Walsh T

更新日期：2017-12-12 00:00:00

abstract：:APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication stress and DNA damage in cancer cells. While the APOBEC3A-induced vulnerability of cancers offers an opportunity for therapy, APOBEC3A protein and mRNA are difficult to quantify in tumors due to their low abundance. Here, we describe a quantitative ...

journal_title：Nature communications

authors： Jalili P,Bowen D,Langenbucher A,Park S,Aguirre K,Corcoran RB,Fleischman AG,Lawrence MS,Zou L,Buisson R

更新日期：2020-06-12 00:00:00

abstract：:Enantioselective approaches to synthesize six-membered oxacycles with multiple stereogenic centres are in high demand to enable the discovery of new therapeutic agents. Here we present a concise organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans involving s...

journal_title：Nature communications

authors： Yoneda N,Fujii Y,Matsumoto A,Asano K,Matsubara S

更新日期：2017-11-09 00:00:00