Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo.

abstract：:Carbon forms one of nature's strongest chemical bonds; its allotropes having provided some of the most exciting scientific discoveries in recent times. The possibility of inter-allotropic transformations/hybridization of carbon is hence a topic of immense fundamental and technological interest. Such modifications usua...

journal_title：Nature communications

authors： Jung HY,Araujo PT,Kim YL,Jung SM,Jia X,Hong S,Ahn CW,Kong J,Dresselhaus MS,Kar S,Jung YJ

更新日期：2014-09-15 00:00:00

abstract：:Biologists have long been fascinated by the amazing diversity of animal colour patterns. Despite much interest, the underlying evolutionary and developmental mechanisms contributing to their rich variety remain largely unknown, especially the vivid and complex colour patterns seen in vertebrates. Here, we show that co...

journal_title：Nature communications

authors： Miyazawa S,Okamoto M,Kondo S

更新日期：2010-09-07 00:00:00

abstract：:Mycobacterium tuberculosis is a pathogen with a unique cell envelope including very long fatty acids, implicated in bacterial resistance and host immune modulation. FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis....

journal_title：Nature communications

authors： Lara J,Diacovich L,Trajtenberg F,Larrieux N,Malchiodi EL,Fernández MM,Gago G,Gramajo H,Buschiazzo A

更新日期：2020-07-24 00:00:00

abstract：:Graphene nanopores are potential successors to biological and silicon-based nanopores. For sensing applications, it is however crucial to understand and block the strong nonspecific hydrophobic interactions between DNA and graphene. Here we demonstrate a novel scheme to prevent DNA-graphene interactions, based on a ta...

journal_title：Nature communications

authors： Schneider GF,Xu Q,Hage S,Luik S,Spoor JN,Malladi S,Zandbergen H,Dekker C

更新日期：2013-01-01 00:00:00

abstract：:Metal-organic frameworks (MOFs) have recently garnered consideration as an attractive solid substrate because the highly tunable MOF framework can not only serve as an inert host but also enhance the selectivity, stability, and/or activity of the enzymes. Herein, we demonstrate the advantages of using a mechanochemica...

journal_title：Nature communications

authors： Wei TH,Wu SH,Huang YD,Lo WS,Williams BP,Chen SY,Yang HC,Hsu YS,Lin ZY,Chen XH,Kuo PE,Chou LY,Tsung CK,Shieh FK

更新日期：2019-11-01 00:00:00

abstract：:Muscle-resident PDGFRβ(+) cells, which include pericytes and PW1(+) interstitial cells (PICs), play a dual role in muscular dystrophy. They can either undergo myogenesis to promote muscle regeneration or differentiate into adipocytes and other cells to compromise regeneration. How the differentiation and fate determin...

journal_title：Nature communications

authors： Yao Y,Norris EH,Mason CE,Strickland S

更新日期：2016-05-03 00:00:00

abstract：:The prokaryotic chemotaxis system is arguably the best-understood signaling pathway in biology. In all previously described species, chemoreceptors organize into a hexagonal (P6 symmetry) extended array. Here, we report an alternative symmetry (P2) of the chemotaxis apparatus that emerges from a strict linear organiza...

journal_title：Nature communications

authors： Muok AR,Ortega DR,Kurniyati K,Yang W,Maschmann ZA,Sidi Mabrouk A,Li C,Crane BR,Briegel A

更新日期：2020-11-13 00:00:00

abstract：:Among the perovskite oxide family, KTaO3 (KTO) has recently attracted considerable interest as a possible system for the realization of the Rashba effect. In this work, we report a novel conducting interface by placing KTO with another insulator, LaVO3 (LVO) and report planar Hall effect (PHE) and anisotropic magnetor...

journal_title：Nature communications

authors： Wadehra N,Tomar R,Varma RM,Gopal RK,Singh Y,Dattagupta S,Chakraverty S

更新日期：2020-02-13 00:00:00

abstract：:SecB chaperones assist protein export by binding both unfolded proteins and the SecA motor. Certain SecB homologs can also control toxin-antitoxin (TA) systems known to modulate bacterial growth in response to stress. In such TA-chaperone (TAC) systems, SecB assists the folding and prevents degradation of the antitoxi...

journal_title：Nature communications

authors： Guillet V,Bordes P,Bon C,Marcoux J,Gervais V,Sala AJ,Dos Reis S,Slama N,Mares-Mejía I,Cirinesi AM,Maveyraud L,Genevaux P,Mourey L

更新日期：2019-02-15 00:00:00

abstract：:Infrared light detection and sensing is deeply embedded in modern technology and human society and its development has always been benefitting from the discovery of various photoelectric materials. The rise of two-dimensional materials, thanks to their distinct electronic structures, extreme dimensional confinement an...

journal_title：Nature communications

authors： Yin J,Tan Z,Hong H,Wu J,Yuan H,Liu Y,Chen C,Tan C,Yao F,Li T,Chen Y,Liu Z,Liu K,Peng H

更新日期：2018-08-17 00:00:00

abstract：:Cell-cell communication and interaction is critical during fertilization and triggers free cytosolic calcium ([Ca2+]cyto) as a key signal for egg activation and a polyspermy block in animal oocytes. Fertilization in flowering plants is more complex, involving interaction of a pollen tube with egg adjoining synergid ce...

journal_title：Nature communications

authors： Denninger P,Bleckmann A,Lausser A,Vogler F,Ott T,Ehrhardt DW,Frommer WB,Sprunck S,Dresselhaus T,Grossmann G

更新日期：2014-08-22 00:00:00

abstract：:Formation of domain walls in ferroelectrics is not energetically favourable in low-dimensional systems. Instead, vortex-type structures are formed that are driven by depolarization fields occurring in such systems. Consequently, polarization vortices have only been experimentally found in systems in which these fields...

journal_title：Nature communications

authors： Peters JJP,Apachitei G,Beanland R,Alexe M,Sanchez AM

更新日期：2016-11-16 00:00:00

abstract：:Heparin-like oligosaccharides mediate numerous important biological interactions, of which many are implicated in various diseases. Synthetic improvements are central to the development of such oligosaccharides as therapeutics and, in addition, there are no methods to elucidate the pharmacokinetics of structurally def...

journal_title：Nature communications

authors： Hansen SU,Miller GJ,Cole C,Rushton G,Avizienyte E,Jayson GC,Gardiner JM

更新日期：2013-01-01 00:00:00

abstract：:Among various flat optical devices, metasurfaces have presented their great ability in efficient manipulation of light fields and have been proposed for variety of devices with specific functionalities. However, due to the high phase dispersion of their building blocks, metasurfaces significantly suffer from large chr...

journal_title：Nature communications

authors： Wang S,Wu PC,Su VC,Lai YC,Hung Chu C,Chen JW,Lu SH,Chen J,Xu B,Kuan CH,Li T,Zhu S,Tsai DP

更新日期：2017-08-04 00:00:00

abstract：:EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell surface protein involved in homotypic cell-cell adhesion via intercellular oligomerization and proliferative signalling via proteolytic cleavage. Despite its use as a diagnostic marker and being a drug target, structural details of ...

journal_title：Nature communications

authors： Pavšič M,Gunčar G,Djinović-Carugo K,Lenarčič B

更新日期：2014-08-28 00:00:00

abstract：:Distinct subtypes of ionotropic glutamate receptors can segregate to specific synaptic inputs in a given neuron. Using functional mapping by focal glutamate uncaging in CA3 pyramidal cells (PCs), we observe that kainate receptors (KARs) are strictly confined to the postsynaptic elements of mossy fibre (mf) synapses an...

journal_title：Nature communications

authors： Fièvre S,Carta M,Chamma I,Labrousse V,Thoumine O,Mulle C

更新日期：2016-09-27 00:00:00

abstract：:Dynamic disruption and reassembly of promoter-proximal nucleosomes is a conserved hallmark of transcriptionally active chromatin. Histone H3-K56 acetylation (H3K56Ac) enhances these turnover events and promotes nucleosome assembly during S phase. Here we sequence nascent transcripts to investigate the impact of H3K56A...

journal_title：Nature communications

authors： Topal S,Vasseur P,Radman-Livaja M,Peterson CL

更新日期：2019-09-26 00:00:00

abstract：:The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions of the Article. Furthermore, in the original HTML version of this...

journal_title：Nature communications

authors： Went M,Sud A,Försti A,Halvarsson BM,Weinhold N,Kimber S,van Duin M,Thorleifsson G,Holroyd A,Johnson DC,Li N,Orlando G,Law PJ,Ali M,Chen B,Mitchell JS,Gudbjartsson DF,Kuiper R,Stephens OW,Bertsch U,Broderick P,Ca

更新日期：2019-01-10 00:00:00

abstract：:Sinc-shaped Nyquist pulses possess a rectangular spectrum, enabling data to be encoded in a minimum spectral bandwidth and satisfying by essence the Nyquist criterion of zero inter-symbol interference (ISI). This property makes them very attractive for communication systems since data transmission rates can be maximiz...

journal_title：Nature communications

authors： Soto MA,Alem M,Amin Shoaie M,Vedadi A,Brès CS,Thévenaz L,Schneider T

更新日期：2013-01-01 00:00:00

abstract：:The current study uses big data to study prosocial behavior by analyzing donations made on the GoFundMe platform. In a dataset of more than $44 million in online donations, we find that 21% were made while opting to be anonymous to the public, with survey results indicating that 11% of these anonymous donations (2.3% ...

journal_title：Nature communications

authors： Sisco MR,Weber EU

更新日期：2019-09-03 00:00:00

abstract：:Methanol represents an attractive substrate for biotechnological applications. Utilization of reduced one-carbon compounds for growth is currently limited to methylotrophic organisms, and engineering synthetic methylotrophy remains a major challenge. Here we apply an in silico-guided multiple knockout approach to engi...

journal_title：Nature communications

authors： Meyer F,Keller P,Hartl J,Gröninger OG,Kiefer P,Vorholt JA

更新日期：2018-04-17 00:00:00

abstract：:It has been speculated that the partial pressure of carbon dioxide (pCO2) in shelf waters may lag the rise in atmospheric CO2. Here, we show that this is the case across many shelf regions, implying a tendency for enhanced shelf uptake of atmospheric CO2. This result is based on analysis of long-term trends in the air...

journal_title：Nature communications

authors： Laruelle GG,Cai WJ,Hu X,Gruber N,Mackenzie FT,Regnier P

更新日期：2018-01-31 00:00:00

abstract：:Maize rough dwarf disease (MRDD), caused by various species of the genus Fijivirus, threatens maize production worldwide. We previously identified a quantitative locus qMrdd1 conferring recessive resistance to one causal species, rice black-streaked dwarf virus (RBSDV). Here, we show that Rab GDP dissociation inhibito...

journal_title：Nature communications

authors： Liu Q,Deng S,Liu B,Tao Y,Ai H,Liu J,Zhang Y,Zhao Y,Xu M

更新日期：2020-01-24 00:00:00

abstract：:In higher plants, the hormone auxin orchestrates a diverse array of developmental and environmental responses mainly exerted via transcriptional control. In its absence, auxin-mediated transcription is postulated to be repressed by histone deacetylases, which convert chromatin into a highly packed inactive state. Here...

journal_title：Nature communications

authors： Weiste C,Dröge-Laser W

更新日期：2014-05-27 00:00:00

abstract：:Striatum processes a wide range of functions including goal-directed behavior and habit formation, respectively encoded by the dorsomedial striatum (DMS) and dorsolateral striatum (DLS). GABAergic feedforward inhibition is known to control the integration of cortical information by striatal projection neurons (SPNs). ...

journal_title：Nature communications

authors： Fino E,Vandecasteele M,Perez S,Saudou F,Venance L

更新日期：2018-08-21 00:00:00

abstract：:When a thin film of active, nematic microtubules and kinesin motor clusters is confined on the surface of a vesicle, four +1/2 topological defects oscillate in a periodic manner between tetrahedral and planar arrangements. Here a theoretical description of nematics, coupled to the relevant hydrodynamic equations, is p...

journal_title：Nature communications

authors： Zhang R,Zhou Y,Rahimi M,de Pablo JJ

更新日期：2016-11-21 00:00:00

abstract：:Microbial symbiosis is integral to plant growth and reproduction, but its contribution to global patterns of plant distribution is unknown. Legumes (Fabaceae) are a diverse and widely distributed plant family largely dependent on symbiosis with nitrogen-fixing rhizobia, which are acquired from soil after germination. ...

journal_title：Nature communications

authors： Simonsen AK,Dinnage R,Barrett LG,Prober SM,Thrall PH

更新日期：2017-04-07 00:00:00

abstract：:Geminiviruses are major plant pathogens that threaten food security globally. They have a unique architecture built from two incomplete icosahedral particles, fused to form a geminate capsid. However, despite their importance to agricultural economies and fundamental biological interest, the details of how this is rea...

journal_title：Nature communications

authors： Hesketh EL,Saunders K,Fisher C,Potze J,Stanley J,Lomonossoff GP,Ranson NA

更新日期：2018-06-18 00:00:00

abstract：:Acoustic communication is enabled by the evolution of specialised hearing and sound producing organs. In this study, we performed a large-scale macroevolutionary study to understand how both hearing and sound production evolved and affected diversification in the insect order Orthoptera, which includes many familiar s...

journal_title：Nature communications

authors： Song H,Béthoux O,Shin S,Donath A,Letsch H,Liu S,McKenna DD,Meng G,Misof B,Podsiadlowski L,Zhou X,Wipfler B,Simon S

更新日期：2020-10-02 00:00:00

abstract：:Doping is a primary tool for the modification of the properties of materials. Occlusion of guest molecules in crystals generally reduces their symmetry by the creation of polar domains, which engender polarization and pyroelectricity in the doped crystals. Here we describe a molecular-level determination of the struct...

journal_title：Nature communications

authors： Meirzadeh E,Azuri I,Qi Y,Ehre D,Rappe AM,Lahav M,Kronik L,Lubomirsky I

更新日期：2016-11-08 00:00:00