Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo.

abstract：:Metal particles supported on oxide surfaces are used as catalysts for a wide variety of processes in the chemical and energy conversion industries. For catalytic applications, metal particles are generally formed on an oxide support by physical or chemical deposition, or less commonly by exsolution from it. Although f...

journal_title：Nature communications

authors： Neagu D,Oh TS,Miller DN,Ménard H,Bukhari SM,Gamble SR,Gorte RJ,Vohs JM,Irvine JTS

更新日期：2015-09-11 00:00:00

abstract：:Reliable quantum information processing in the face of errors is a major fundamental and technological challenge. Quantum error correction protects quantum states by encoding a logical quantum bit (qubit) in multiple physical qubits. To be compatible with universal fault-tolerant computations, it is essential that sta...

journal_title：Nature communications

authors： Cramer J,Kalb N,Rol MA,Hensen B,Blok MS,Markham M,Twitchen DJ,Hanson R,Taminiau TH

更新日期：2016-05-05 00:00:00

abstract：:MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin. Here, we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness, immune stimulation and virulence. Increased expression of mcr-1 results in decreased growth rate, cell viability, competitive ability ...

journal_title：Nature communications

authors： Yang Q,Li M,Spiller OB,Andrey DO,Hinchliffe P,Li H,MacLean C,Niumsup P,Powell L,Pritchard M,Papkou A,Shen Y,Portal E,Sands K,Spencer J,Tansawai U,Thomas D,Wang S,Wang Y,Shen J,Walsh T

更新日期：2017-12-12 00:00:00

abstract：:Multimode entanglement is an essential resource for quantum information processing and quantum metrology. However, multimode entangled states are generally constructed by targeting a specific graph configuration. This yields to a fixed experimental setup that therefore exhibits reduced versatility and scalability. Her...

journal_title：Nature communications

authors： Cai Y,Roslund J,Ferrini G,Arzani F,Xu X,Fabre C,Treps N

更新日期：2017-06-06 00:00:00

abstract：:Autophagy perturbation represents an emerging therapeutic strategy in cancer. Although LATS1 and LATS2 kinases, core components of the mammalian Hippo pathway, have been shown to exert tumor suppressive activities, here we report a pro-survival role of LATS1 but not LATS2 in hepatocellular carcinoma (HCC) cells. Speci...

journal_title：Nature communications

authors： Tang F,Gao R,Jeevan-Raj B,Wyss CB,Kalathur RKR,Piscuoglio S,Ng CKY,Hindupur SK,Nuciforo S,Dazert E,Bock T,Song S,Buechel D,Morini MF,Hergovich A,Matthias P,Lim DS,Terracciano LM,Heim MH,Hall MN,Christofori G

更新日期：2019-12-17 00:00:00

abstract：:Long-range chromatin interactions are important for transcriptional regulation of genes, many of which are related to complex agronomics traits. However, the pattern of three-dimensional chromatin interactions remains unclear in plants. Here we report the generation of chromatin interaction analysis by paired-end tag ...

journal_title：Nature communications

authors： Li E,Liu H,Huang L,Zhang X,Dong X,Song W,Zhao H,Lai J

更新日期：2019-06-14 00:00:00

abstract：:Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterized by the genetic translocation t(9;22)(q34;q11.2) encoding for the BCR-ABL fusion oncogene. However, many molecular mechanisms of the disease progression still remain poorly understood. A growing body of evidence suggests that the epigenetic ...

journal_title：Nature communications

authors： Amabile G,Di Ruscio A,Müller F,Welner RS,Yang H,Ebralidze AK,Zhang H,Levantini E,Qi L,Martinelli G,Brummelkamp T,Le Beau MM,Figueroa ME,Bock C,Tenen DG

更新日期：2015-05-22 00:00:00

abstract：:In nature, plant tendrils can produce two fundamental motion modes, bending and chiral twisting (helical curling) distortions, under the stimuli of sunlight, humidity, wetting or other atmospheric conditions. To date, many artificial plant-like mechanical machines have been developed. Although some previously reported...

journal_title：Nature communications

authors： Wang M,Lin BP,Yang H

更新日期：2016-12-22 00:00:00

abstract：:Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and obs...

journal_title：Nature communications

authors： Fernandez-Cuesta L,Peifer M,Lu X,Sun R,Ozretić L,Seidal D,Zander T,Leenders F,George J,Müller C,Dahmen I,Pinther B,Bosco G,Konrad K,Altmüller J,Nürnberg P,Achter V,Lang U,Schneider PM,Bogus M,Soltermann A,Brustu

更新日期：2014-03-27 00:00:00

abstract：:The secretome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasion and angiogenesis. Here we compare the secretome of human mammary normal and cancer-associated fibroblasts (CAFs). We discover that the chloride intracellular channel protein 3 (CLIC3) is an abundant componen...

journal_title：Nature communications

authors： Hernandez-Fernaud JR,Ruengeler E,Casazza A,Neilson LJ,Pulleine E,Santi A,Ismail S,Lilla S,Dhayade S,MacPherson IR,McNeish I,Ennis D,Ali H,Kugeratski FG,Al Khamici H,van den Biggelaar M,van den Berghe PV,Cloix C,McDona

更新日期：2017-02-15 00:00:00

abstract：:To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported to date. Here we completely sequence the genome of the filastere...

journal_title：Nature communications

authors： Suga H,Chen Z,de Mendoza A,Sebé-Pedrós A,Brown MW,Kramer E,Carr M,Kerner P,Vervoort M,Sánchez-Pons N,Torruella G,Derelle R,Manning G,Lang BF,Russ C,Haas BJ,Roger AJ,Nusbaum C,Ruiz-Trillo I

更新日期：2013-01-01 00:00:00

abstract：:Atmospheric iron affects the global carbon cycle by modulating ocean biogeochemistry through the deposition of soluble iron to the ocean. Iron emitted by anthropogenic (fossil fuel) combustion is a source of soluble iron that is currently considered less important than other soluble iron sources, such as mineral dust ...

journal_title：Nature communications

authors： Matsui H,Mahowald NM,Moteki N,Hamilton DS,Ohata S,Yoshida A,Koike M,Scanza RA,Flanner MG

更新日期：2018-04-23 00:00:00

abstract：:The outcome of molecule-surface collisions can be modified by pre-aligning the molecule; however, experiments accomplishing this are rare because of the difficulty of preparing molecules in aligned quantum states. Here we present a general solution to this problem based on magnetic manipulation of the rotational magne...

journal_title：Nature communications

authors： Godsi O,Corem G,Alkoby Y,Cantin JT,Krems RV,Somers MF,Meyer J,Kroes GJ,Maniv T,Alexandrowicz G

更新日期：2017-05-08 00:00:00

abstract：:Extremely metal-poor galaxies with metallicity below 10% of the solar value in the local universe are the best analogues to investigating the interstellar medium at a quasi-primitive environment in the early universe. In spite of the ongoing formation of stars in these galaxies, the presence of molecular gas (which is...

journal_title：Nature communications

authors： Shi Y,Wang J,Zhang ZY,Gao Y,Hao CN,Xia XY,Gu Q

更新日期：2016-12-09 00:00:00

abstract：:Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimer's disease (AD). Here, we present the three-dimensional structure of an Aβ oligomer formed in a membrane mimicking environment, namely an Aβ(1-42) tetramer, which comprises a six stranded β-s...

journal_title：Nature communications

authors： Ciudad S,Puig E,Botzanowski T,Meigooni M,Arango AS,Do J,Mayzel M,Bayoumi M,Chaignepain S,Maglia G,Cianferani S,Orekhov V,Tajkhorshid E,Bardiaux B,Carulla N

更新日期：2020-06-15 00:00:00

abstract：:Pulse oximetry is a ubiquitous non-invasive medical sensing method for measuring pulse rate and arterial blood oxygenation. Conventional pulse oximeters use expensive optoelectronic components that restrict sensing locations to finger tips or ear lobes due to their rigid form and area-scaling complexity. In this work,...

journal_title：Nature communications

authors： Lochner CM,Khan Y,Pierre A,Arias AC

更新日期：2014-12-10 00:00:00

abstract：:Functional blood vessel growth depends on generation of distinct but coordinated responses from endothelial cells. Bone morphogenetic proteins (BMP), part of the TGFβ superfamily, bind receptors to induce phosphorylation and nuclear translocation of SMAD transcription factors (R-SMAD1/5/8) and regulate vessel growth. ...

journal_title：Nature communications

authors： Mouillesseaux KP,Wiley DS,Saunders LM,Wylie LA,Kushner EJ,Chong DC,Citrin KM,Barber AT,Park Y,Kim JD,Samsa LA,Kim J,Liu J,Jin SW,Bautch VL

更新日期：2016-11-11 00:00:00

abstract：:Distinct subtypes of ionotropic glutamate receptors can segregate to specific synaptic inputs in a given neuron. Using functional mapping by focal glutamate uncaging in CA3 pyramidal cells (PCs), we observe that kainate receptors (KARs) are strictly confined to the postsynaptic elements of mossy fibre (mf) synapses an...

journal_title：Nature communications

authors： Fièvre S,Carta M,Chamma I,Labrousse V,Thoumine O,Mulle C

更新日期：2016-09-27 00:00:00

abstract：:Despite the lack of a layered neocortex and fundamental differences in endbrain organization in birds compared with mammals, intelligent species evolved from both vertebrate classes. Among birds, corvids show exceptional cognitive flexibility. Here we explore the neuronal foundation of corvid cognition by recording si...

journal_title：Nature communications

authors： Veit L,Nieder A

更新日期：2013-01-01 00:00:00

abstract：:Some two-dimensional liquid systems are theoretically predicted to have an anomalous phase transition due to unique intermolecular interactions, for example the first-order transition between two-dimensional high-density water and low-density amorphous ice. However, it has never been experimentally observed, to the be...

journal_title：Nature communications

authors： Li W,Kong L,Feng B,Fu H,Li H,Zeng XC,Wu K,Chen L

更新日期：2018-01-15 00:00:00

abstract：:The low-energy elementary excitations in frustrated quantum magnets have fascinated researchers for decades. In frustrated Ising magnets on a pyrochlore lattice possessing macroscopically degenerate spin-ice ground states, the excitations have been discussed in terms of classical magnetic monopoles, which do not conta...

journal_title：Nature communications

authors： Tokiwa Y,Yamashita T,Udagawa M,Kittaka S,Sakakibara T,Terazawa D,Shimoyama Y,Terashima T,Yasui Y,Shibauchi T,Matsuda Y

更新日期：2016-02-25 00:00:00

abstract：:The overall survival of patients with acute myeloid leukemia (AML) is poor and identification of new disease-related therapeutic targets remains a major goal for this disease. Here we show that expression of MPP1, a PDZ-domain-containing protein, highly correlated with ABCC4 in AML, is associated with worse overall su...

journal_title：Nature communications

authors： Pitre A,Ge Y,Lin W,Wang Y,Fukuda Y,Temirov J,Phillips AH,Peters JL,Fan Y,Ma J,Nourse A,Sinha C,Lin H,Kriwacki R,Downing JR,Gruber TA,Centonze VE,Naren AP,Chen T,Schuetz JD

更新日期：2017-11-16 00:00:00

abstract：:The discovery of superconductivity at 260 K in hydrogen-rich compounds like LaH10 re-invigorated the quest for room temperature superconductivity. Here, we report the temperature dependence of the upper critical fields μ0Hc2(T) of superconducting H3S under a record-high combination of applied pressures up to 160 GPa a...

journal_title：Nature communications

authors： Mozaffari S,Sun D,Minkov VS,Drozdov AP,Knyazev D,Betts JB,Einaga M,Shimizu K,Eremets MI,Balicas L,Balakirev FF

更新日期：2019-06-07 00:00:00

abstract：:The engineering of nanoscale features enables the properties of solid-state materials to be tuned. Here, we show the tunable preparation of cuprous sulfide nanocrystals ranging in internal structures from single-domain to multi-domain. The synthetic method utilizes in-situ oxidation to grow nanocrystals with a control...

journal_title：Nature communications

authors： Gong J,Jain PK

更新日期：2019-07-23 00:00:00

abstract：:Epigenetic control of enhancers alters neuronal functions and may be involved in Alzheimer's disease (AD). Here, we identify enhancers in neurons contributing to AD by comprehensive fine-mapping of DNA methylation at enhancers, genome-wide. We examine 1.2 million CpG and CpH sites in enhancers in prefrontal cortex neu...

journal_title：Nature communications

authors： Li P,Marshall L,Oh G,Jakubowski JL,Groot D,He Y,Wang T,Petronis A,Labrie V

更新日期：2019-05-21 00:00:00

abstract：:The immunosuppressive microenvironment that is shaped by hepatic metastatic pancreatic ductal adenocarcinoma (PDAC) is essential for tumor cell evasion of immune destruction. Neutrophils are important components of the metastatic tumor microenvironment and exhibit heterogeneity. However, the specific phenotypes, funct...

journal_title：Nature communications

authors： Wang X,Hu LP,Qin WT,Yang Q,Chen DY,Li Q,Zhou KX,Huang PQ,Xu CJ,Li J,Yao LL,Wang YH,Tian GA,Yang JY,Yang MW,Liu DJ,Sun YW,Jiang SH,Zhang XL,Zhang ZG

更新日期：2021-01-08 00:00:00

abstract：:Discarding by fisheries is perceived as contrary to responsible harvesting. Legislation seeking to end the practice is being introduced in many jurisdictions. However, discarded fish are food for a range of scavenging species; so, ending discarding may have ecological consequences. Here we investigate the sensitivity ...

journal_title：Nature communications

authors： Heath MR,Cook RM,Cameron AI,Morris DJ,Speirs DC

更新日期：2014-05-13 00:00:00

abstract：:Spectrally-selective monitoring of ultraviolet radiations (UVR) is of paramount importance across diverse fields, including effective monitoring of excessive solar exposure. Current UV sensors cannot differentiate between UVA, B, and C, each of which has a remarkably different impact on human health. Here we show spec...

journal_title：Nature communications

authors： Zou W,González A,Jampaiah D,Ramanathan R,Taha M,Walia S,Sriram S,Bhaskaran M,Dominguez-Vera JM,Bansal V

更新日期：2018-09-25 00:00:00

abstract：:Recently, metasurfaces composed of artificially fabricated subwavelength structures have shown remarkable potential for the manipulation of light with unprecedented functionality. Here, we first demonstrate a metasurface application to realize a compact near-eye display system for augmented reality with a wide field o...

journal_title：Nature communications

authors： Lee GY,Hong JY,Hwang S,Moon S,Kang H,Jeon S,Kim H,Jeong JH,Lee B

更新日期：2018-11-01 00:00:00

abstract：:Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-deficient cells exhibit HR defects, especially in long-tract gene c...

journal_title：Nature communications

authors： Huang JW,Acharya A,Taglialatela A,Nambiar TS,Cuella-Martin R,Leuzzi G,Hayward SB,Joseph SA,Brunette GJ,Anand R,Soni RK,Clark NL,Bernstein KA,Cejka P,Ciccia A

更新日期：2020-06-11 00:00:00