Two-dimensional electronic transport and surface electron accumulation in MoS2.

abstract：:The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alterna...

journal_title：Nature communications

authors： Wang B,Tan XF,Thurmond S,Zhang ZM,Lin A,Hai R,Song J

更新日期：2017-03-27 00:00:00

abstract：:Many porous materials are damaged by pressure exerted by salt crystals growing in their pores. This is a serious issue in conservation science, geomorphology, geotechnical engineering and concrete materials science. In all cases, a central question is whether crystallization pressure will cause damage. Here we present...

journal_title：Nature communications

authors： Flatt RJ,Caruso F,Sanchez AM,Scherer GW

更新日期：2014-09-11 00:00:00

abstract：:Astrocytic endfeet cover the entire cerebral vasculature and serve as exchange sites for ions, metabolites and energy substrates from the blood to the brain. They maintain endothelial tight junctions that form the blood-brain barrier (BBB) and release vasoactive molecules that regulate vascular tone. Malignant gliomas...

journal_title：Nature communications

authors： Watkins S,Robel S,Kimbrough IF,Robert SM,Ellis-Davies G,Sontheimer H

更新日期：2014-06-19 00:00:00

abstract：:FoxO proteins are major targets of insulin action. To better define the role of FoxO1 in mediating insulin effects in the liver, we generated liver-specific insulin receptor knockout (LIRKO) and IR/FoxO1 double knockout (LIRFKO) mice. Here we show that LIRKO mice are severely insulin resistant based on glucose, insuli...

journal_title：Nature communications

authors： O-Sullivan I,Zhang W,Wasserman DH,Liew CW,Liu J,Paik J,DePinho RA,Stolz DB,Kahn CR,Schwartz MW,Unterman TG

更新日期：2015-05-12 00:00:00

abstract：:Inflammation is recognized as one of the drivers of cancer. Yet, the individual immune components that possess pro- and anti-tumorigenic functions in individual cancers remain largely unknown. NKG2D is a potent activating immunoreceptor that has emerged as an important player in inflammatory disorders besides its well...

journal_title：Nature communications

authors： Sheppard S,Guedes J,Mroz A,Zavitsanou AM,Kudo H,Rothery SM,Angelopoulos P,Goldin R,Guerra N

更新日期：2017-01-27 00:00:00

abstract：:Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation of iron in macrophages and symptoms of iron deficiency anemia. He...

journal_title：Nature communications

authors： Pan Y,Ren Z,Gao S,Shen J,Wang L,Xu Z,Yu Y,Bachina P,Zhang H,Fan X,Laganowsky A,Yan N,Zhou M

更新日期：2020-11-10 00:00:00

abstract：:Graphene nanoribbons (GNRs)-narrow stripes of graphene-have emerged as promising building blocks for nanoelectronic devices. Recent advances in bottom-up synthesis have allowed production of atomically well-defined armchair GNRs with different widths and doping. While all experimentally studied GNRs have exhibited wid...

journal_title：Nature communications

authors： Kimouche A,Ervasti MM,Drost R,Halonen S,Harju A,Joensuu PM,Sainio J,Liljeroth P

更新日期：2015-12-14 00:00:00

abstract：:Decision-making is often accompanied by a degree of confidence on whether a choice is correct. Decision uncertainty, or lack in confidence, may lead to change-of-mind. Studies have identified the behavioural characteristics associated with decision confidence or change-of-mind, and their neural correlates. Although se...

journal_title：Nature communications

authors： Atiya NAA,Rañó I,Prasad G,Wong-Lin K

更新日期：2019-05-23 00:00:00

abstract：:The continued development of novel drugs, proteins, and advanced materials strongly rely on our ability to self-assemble molecules in solids with the most suitable structure (polymorph) in order to exhibit desired functionalities. The search for new polymorphs remains a scientific challenge, that is at the core of cry...

journal_title：Nature communications

authors： Potticary J,Terry LR,Bell C,Papanikolopoulos AN,Christianen PC,Engelkamp H,Collins AM,Fontanesi C,Kociok-Köhn G,Crampin S,Da Como E,Hall SR

更新日期：2016-05-10 00:00:00

abstract：:Hexanucleotide repeat expansion in C9ORF72 is the most frequent cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we demonstrate that the repeat-associated non-AUG (RAN) translation of (GGGGCC) n -containing RNAs into poly-dipeptides can initiate in vivo without a 5'-cap. The pr...

journal_title：Nature communications

authors： Cheng W,Wang S,Mestre AA,Fu C,Makarem A,Xian F,Hayes LR,Lopez-Gonzalez R,Drenner K,Jiang J,Cleveland DW,Sun S

更新日期：2018-01-04 00:00:00

abstract：:Covalent organic frameworks (COFs) have emerged as a promising light-harvesting module for artificial photosynthesis and photovoltaics. For efficient generation of free charge carriers, the donor-acceptor (D-A) conjugation has been adopted for two-dimensional (2D) COFs recently. In the 2D D-A COFs, photoexcitation wou...

journal_title：Nature communications

authors： Kim TW,Jun S,Ha Y,Yadav RK,Kumar A,Yoo CY,Oh I,Lim HK,Shin JW,Ryoo R,Kim H,Kim J,Baeg JO,Ihee H

更新日期：2019-04-23 00:00:00

abstract：:Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a replication-coupled manner; however, additional proteolytic mechanisms...

journal_title：Nature communications

authors： Kojima Y,Machida Y,Palani S,Caulfield TR,Radisky ES,Kaufmann SH,Machida YJ

更新日期：2020-03-12 00:00:00

abstract：:The original HTML version of this Article had an incorrect Published online date of 20 March 2019; it should have been 18 March 2019. This has been corrected in the HTML version of the Article. The PDF version was correct from the time of publication. ...

journal_title：Nature communications

authors： Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal B

更新日期：2019-04-18 00:00:00

abstract：:Invasive plant species threaten native biodiversity, ecosystems, agriculture, industry and human health worldwide, lending urgency to the search for predictors of plant invasiveness outside native ranges. There is much conflicting evidence about which plant characteristics best predict invasiveness. Here we use a glob...

journal_title：Nature communications

authors： Jelbert K,Buss D,McDonald J,Townley S,Franco M,Stott I,Jones O,Salguero-Gómez R,Buckley Y,Knight T,Silk M,Sargent F,Rolph S,Wilson P,Hodgson D

更新日期：2019-12-06 00:00:00

abstract：:FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C into multiple myeloma ce...

journal_title：Nature communications

authors： Mroczek S,Chlebowska J,Kuliński TM,Gewartowska O,Gruchota J,Cysewski D,Liudkovska V,Borsuk E,Nowis D,Dziembowski A

更新日期：2017-09-20 00:00:00

abstract：:Hollow-core fibre (HCF) is a powerful technology platform offering breakthrough performance improvements in sensing, communications, higher-power pulse delivery and other applications. Free from the usual constraints on what materials can guide light, it promises qualitatively new and ideal operating regimes: precisio...

journal_title：Nature communications

authors： Fini JM,Nicholson JW,Mangan B,Meng L,Windeler RS,Monberg EM,DeSantolo A,DiMarcello FV,Mukasa K

更新日期：2014-10-28 00:00:00

abstract：:Intracellular trafficking of organelles, driven by kinesin-1 stepping along microtubules, underpins essential cellular processes. In absence of other proteins on the microtubule surface, kinesin-1 performs micron-long runs. Under crowding conditions, however, kinesin-1 motility is drastically impeded. It is thus uncle...

journal_title：Nature communications

authors： Henrichs V,Grycova L,Barinka C,Nahacka Z,Neuzil J,Diez S,Rohlena J,Braun M,Lansky Z

更新日期：2020-06-19 00:00:00

abstract：:Signal regulatory protein α (SIRPα), an immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor, is an essential negative regulator of leukocyte inflammatory responses. Here we report that SIRPα cytoplasmic signalling ITIMs in neutrophils are cleaved during active inflammation and that the loss of SI...

journal_title：Nature communications

authors： Zen K,Guo Y,Bian Z,Lv Z,Zhu D,Ohnishi H,Matozaki T,Liu Y

更新日期：2013-01-01 00:00:00

abstract：:The change of global-mean precipitation under global warming and interannual variability is predominantly controlled by the change of atmospheric longwave radiative cooling. Here we show that tightening of the ascending branch of the Hadley Circulation coupled with a decrease in tropical high cloud fraction is key in ...

journal_title：Nature communications

authors： Su H,Jiang JH,Neelin JD,Shen TJ,Zhai C,Yue Q,Wang Z,Huang L,Choi YS,Stephens GL,Yung YL

更新日期：2017-06-07 00:00:00

abstract：:The interconversion of charge and spin currents via spin-Hall effect is essential for spintronics. Energy-efficient and deterministic switching of magnetization can be achieved when spin polarizations of these spin currents are collinear with the magnetization. However, symmetry conditions generally restrict spin pola...

journal_title：Nature communications

authors： Nan T,Quintela CX,Irwin J,Gurung G,Shao DF,Gibbons J,Campbell N,Song K,Choi S-,Guo L,Johnson RD,Manuel P,Chopdekar RV,Hallsteinsen I,Tybell T,Ryan PJ,Kim J-,Choi Y,Radaelli PG,Ralph DC,Tsymbal EY,Rzchowski MS,

更新日期：2020-09-16 00:00:00

abstract：:The unique properties of ferroelectric materials enable a plethora of applications, which are hindered by the phenomenon known as ferroelectric fatigue that leads to the degradation of ferroelectric properties with polarization cycling. Multiple microscopic models explaining fatigue have been suggested; however, the c...

journal_title：Nature communications

authors： Ievlev AV,Kc S,Vasudevan RK,Kim Y,Lu X,Alexe M,Cooper VR,Kalinin SV,Ovchinnikova OS

更新日期：2019-07-11 00:00:00

abstract：:The use of hyperpolarized agents in magnetic resonance, such as (13)C-labelled compounds, enables powerful new imaging and detection modalities that stem from a 10,000-fold boost in signal. A major challenge for the future of the hyperpolarization technique is the inherently short spin-relaxation times, typically <60 ...

journal_title：Nature communications

authors： Rej E,Gaebel T,Boele T,Waddington DE,Reilly DJ

更新日期：2015-10-09 00:00:00

abstract：:One of the best performing semiconducting polymers used in bulk heterojunction devices is PCDTBT, a polycarbazole derivative with solar-conversion efficiencies as high as 7.2%. Here we report the formation of bilayer ordering in PCDTBT, and postulate that this structural motif is a direct consequence of the polymer's ...

journal_title：Nature communications

authors： Lu X,Hlaing H,Germack DS,Peet J,Jo WH,Andrienko D,Kremer K,Ocko BM

更新日期：2012-04-24 00:00:00

abstract：:Aneuploidy and copy-number alterations (CNAs) are a hallmark of human cancer. Although genetically engineered mouse models (GEMMs) are commonly used to model human cancer, their chromosomal landscapes remain underexplored. Here we use gene expression profiles to infer CNAs in 3,108 samples from 45 mouse models, provid...

journal_title：Nature communications

authors： Ben-David U,Ha G,Khadka P,Jin X,Wong B,Franke L,Golub TR

更新日期：2016-07-04 00:00:00

abstract：:The fossil record of crocodylians and their relatives (pseudosuchians) reveals a rich evolutionary history, prompting questions about causes of long-term decline to their present-day low biodiversity. We analyse climatic drivers of subsampled pseudosuchian biodiversity over their 250 million year history, using a comp...

journal_title：Nature communications

authors： Mannion PD,Benson RBJ,Carrano MT,Tennant JP,Judd J,Butler RJ

更新日期：2015-09-24 00:00:00

abstract：:Defect-free monolayers of graphene and hexagonal boron nitride are surprisingly permeable to thermal protons, despite being completely impenetrable to all gases. It remains untested whether small ions can permeate through the two-dimensional crystals. Here we show that mechanically exfoliated graphene and hexagonal bo...

journal_title：Nature communications

authors： Mogg L,Zhang S,Hao GP,Gopinadhan K,Barry D,Liu BL,Cheng HM,Geim AK,Lozada-Hidalgo M

更新日期：2019-09-18 00:00:00

abstract：:Early detection and accurate monitoring of chronic kidney disease (CKD) could improve care and retard progression to end-stage renal disease. Here, using untargeted metabolomics in 2155 participants including patients with stage 1-5 CKD and healthy controls, we identify five metabolites, including 5-methoxytryptophan ...

journal_title：Nature communications

authors： Chen DQ,Cao G,Chen H,Argyopoulos CP,Yu H,Su W,Chen L,Samuels DC,Zhuang S,Bayliss GP,Zhao S,Yu XY,Vaziri ND,Wang M,Liu D,Mao JR,Ma SX,Zhao J,Zhang Y,Shang YQ,Kang H,Ye F,Cheng XH,Li XR,Zhang L,Meng MX,G

更新日期：2019-04-01 00:00:00

abstract：:Brain-computer interfaces (BCI) are used in stroke rehabilitation to translate brain signals into intended movements of the paralyzed limb. However, the efficacy and mechanisms of BCI-based therapies remain unclear. Here we show that BCI coupled to functional electrical stimulation (FES) elicits significant, clinicall...

journal_title：Nature communications

authors： Biasiucci A,Leeb R,Iturrate I,Perdikis S,Al-Khodairy A,Corbet T,Schnider A,Schmidlin T,Zhang H,Bassolino M,Viceic D,Vuadens P,Guggisberg AG,Millán JDR

更新日期：2018-06-20 00:00:00

abstract：:The striking diversity of bird beak shapes is an outcome of natural selection, yet the relative importance of the limitations imposed by the process of beak development on generating such variation is unclear. Untangling these factors requires mapping developmental mechanisms over a phylogeny far exceeding model syste...

journal_title：Nature communications

authors： Fritz JA,Brancale J,Tokita M,Burns KJ,Hawkins MB,Abzhanov A,Brenner MP

更新日期：2014-04-16 00:00:00

abstract：:Inelastic collisions involving molecular species are key to energy transfer in gaseous environments. They are commonly governed by an energy gap law, which dictates that transitions are dominated by those between initial and final states with roughly the same ro-vibrational energy. Transitions involving rotational ine...

journal_title：Nature communications

authors： Yang D,Huang J,Hu X,Guo H,Xie D

更新日期：2019-10-11 00:00:00