Abstract:
:The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alternative conformations of flavivirus NS5 proteins. The activity of this NS5 protein is verified through a de novo RdRp assay on a subgenomic ZIKV RNA template. Importantly, our structural analysis leads to the identification of a potential drug-binding site of ZIKV NS5, which might facilitate the development of novel antivirals for ZIKV.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Wang B,Tan XF,Thurmond S,Zhang ZM,Lin A,Hai R,Song Jdoi
10.1038/ncomms14763subject
Has Abstractpub_date
2017-03-27 00:00:00pages
14763issn
2041-1723pii
ncomms14763journal_volume
8pub_type
杂志文章abstract::Neisseria meningitidis (meningococcus) is an invasive bacterial pathogen that colonizes human vessels, causing thrombotic lesions and meningitis. Establishment of tight interactions with endothelial cells is crucial for meningococci to resist haemodynamic forces. Two endothelial receptors, CD147 and the β2-adrenergic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15764
更新日期:2017-06-01 00:00:00
abstract::Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear FXR. We identify ivermectin using a high-throughput compound library screening and show that it induces the transcriptional activity of the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2924
更新日期:2013-01-01 00:00:00
abstract::In response to brain injury, microglia rapidly extend processes that isolate lesion sites and protect the brain from further injury. Here we report that microglia carrying a pathogenic mutation in the Parkinson's disease (PD)-associated gene, G2019S-LRRK2 (GS-Tg microglia), show retarded ADP-induced motility and delay...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9255
更新日期:2015-09-14 00:00:00
abstract::Diverse entry inhibitors targeting the gp120 subunit of the HIV-1 envelope (Env) trimer have been developed including BMS-626529, also called temsavir, a prodrug version of which is currently in phase III clinical trials. Here we report the characterization of a panel of small-molecule inhibitors including BMS-818251,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07851-1
更新日期:2019-01-03 00:00:00
abstract::Loss of gut mucosal integrity and an aberrant gut microbiota are proposed mechanisms contributing to chronic inflammation and increased morbidity and mortality during antiretroviral-treated HIV disease. Sexual practice has recently been uncovered as a major source of microbiota variation, potentially confounding prior...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16222-8
更新日期:2020-05-15 00:00:00
abstract::Glucagon promotes hepatic gluconeogenesis and maintains whole-body glucose levels during fasting. The regulatory factors that are involved in fasting glucagon response are not well understood. Here we report a role of p52, a key activator of the noncanonical nuclear factor-kappaB signaling, in hepatic glucagon respons...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12351-x
更新日期:2019-09-20 00:00:00
abstract::Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways. Overnight fasted participants rated the palatability of food pictures ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms16052
更新日期:2017-07-18 00:00:00
abstract::The plasma membrane is uniquely enriched in phosphatidylserine (PtdSer). This anionic phospholipid is restricted almost exclusively to the inner leaflet of the plasmalemma. Because of their high density, the headgroups of anionic lipids experience electrostatic repulsion that, being exerted asymmetrically, is predicte...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01554-9
更新日期:2017-11-09 00:00:00
abstract::Sinc-shaped Nyquist pulses possess a rectangular spectrum, enabling data to be encoded in a minimum spectral bandwidth and satisfying by essence the Nyquist criterion of zero inter-symbol interference (ISI). This property makes them very attractive for communication systems since data transmission rates can be maximiz...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3898
更新日期:2013-01-01 00:00:00
abstract::In budding yeast, overcoming of a critical size to enter S phase and the mitosis/mating switch--two central cell fate events--take place in the G1 phase of the cell cycle. Here we present a mathematical model of the basic molecular mechanism controlling the G1/S transition, whose major regulatory feature is multisite ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11372
更新日期:2016-04-20 00:00:00
abstract::Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new therapeutic strategy for the in vivo delivery of nucleotides and chemical drugs. Here we describe a new tool for...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12277
更新日期:2016-07-22 00:00:00
abstract::The restricted availability, expense and toxicity of precious metal catalysts such as rhodium and palladium challenge the sustainability of synthetic chemistry. As such, nickel catalysts have garnered increasing attention as replacements for enyne cyclization reactions. On the other hand, bridged tricyclo[5.2.1.01,5]d...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15837-1
更新日期:2020-04-20 00:00:00
abstract::The accurate measurement of microscopic force fields is crucial in many branches of science and technology, from biophotonics and mechanobiology to microscopy and optomechanics. These forces are often probed by analysing their influence on the motion of Brownian particles. Here we introduce a powerful algorithm for mi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07437-x
更新日期:2018-12-04 00:00:00
abstract::Deformation twins are three-dimensional domains, traditionally viewed as ellipsoids because of their two-dimensional lenticular sections. In this work, we performed statistical analysis of twin shapes viewing along three orthogonal directions: the 'dark side' (DS) view along the twin shear direction (η1), the twinning...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10573-7
更新日期:2019-07-25 00:00:00
abstract::Two-dimensional atomic crystals, such as two-dimensional oxides, have attracted much attention in energy storage because nearly all of the atoms can be exposed to the electrolyte and involved in redox reactions. However, current strategies are largely limited to intrinsically layered compounds. Here we report a genera...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11296
更新日期:2016-04-22 00:00:00
abstract::RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral fitness is not well characterized. Here we report the X-ray crystal structure of the receptor-binding domain (RBD) of the human coronavirus, HCoV-229E, in comple...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01706-x
更新日期:2017-11-23 00:00:00
abstract::The hierarchical relationships between various stem and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly understood. Conditional inactivation experiments previously demonstrated that expression of the zinc finger transcriptional repressor Blimp1/PRDM1 is essential for the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01971-w
更新日期:2017-11-20 00:00:00
abstract::The T helper 9 (Th9) cell transcriptional network is formed by an equilibrium of signals induced by cytokines and antigen presentation. Here we show that, within this network, two interferon regulatory factors (IRF), IRF1 and IRF4, display opposing effects on Th9 differentiation. IRF4 dose-dependently promotes, wherea...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15366
更新日期:2017-05-12 00:00:00
abstract::Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of glycans to cancer initiation and progression remain poorly understood. Here, from expression-based analyses across cancer lineages, we found that melanomas exhibit significant tra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05795-0
更新日期:2018-08-22 00:00:00
abstract::Very-Low-Frequency (VLF) transmitters operate worldwide mostly at frequencies of 10-30 kilohertz for submarine communications. While it has been of intense scientific interest and practical importance to understand whether VLF transmitters can affect the natural environment of charged energetic particles, for decades ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18545-y
更新日期:2020-09-24 00:00:00
abstract::The ubiquitin proteasome system (UPS) has emerged as a drug target for diverse diseases characterized by altered proteostasis, but pharmacological agents that enhance UPS activity have been challenging to establish. Here we report the Deg-On system, a genetic inverter that translates proteasomal degradation of the tra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4612
更新日期:2014-04-08 00:00:00
abstract::The number of viruses circulating in small isolated human populations may be reduced by viral extinctions and rare introductions. Here we used viral metagenomics to characterize the eukaryotic virome in feces from healthy children from a large urban center and from three Amerindian villages with minimal outside contac...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06502-9
更新日期:2018-10-15 00:00:00
abstract::The analysis of whole-genome sequencing studies is challenging due to the large number of noncoding rare variants, our limited understanding of their functional effects, and the lack of natural units for testing. Here we propose a scan statistic framework, WGScan, to simultaneously detect the existence, and estimate t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11023-0
更新日期:2019-07-09 00:00:00
abstract::Protein glycosylation is ubiquitous in biological systems and essential for cell survival. However, the heterogeneity of glycans and the low abundance of many glycoproteins complicate their global analysis. Chemical methods based on reversible covalent interactions between boronic acid and glycans have great potential...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04081-3
更新日期:2018-04-27 00:00:00
abstract::A variety of flexible and stretchable electronics have been reported for use in flexible electronic devices or biomedical applications. The practical and wider application of such flexible electronics has been limited because commercial electronic components are difficult to be directly integrated into flexible stretc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1980
更新日期:2012-01-01 00:00:00
abstract::In the original version of the Supplementary Information file associated with this Article, Supplementary Fig. 18 panel b was inadvertently replaced with a duplicate of panel a. The error has now been fixed and the corrected version of the Supplementary Information PDF is available to download from the HTML version of...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-07818-2
更新日期:2018-12-19 00:00:00
abstract::Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9009
更新日期:2015-08-18 00:00:00
abstract::Natural systems frequently exploit intricate multiscale and multiphasic structures to achieve functionalities beyond those of man-made systems. Although understanding the chemical make-up of these systems is essential, the passive and active mechanics within biological systems are crucial when considering the many nat...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/ncomms8418
更新日期:2015-07-06 00:00:00
abstract::Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential mediators of apoptosis, are thought to be regulated through similar mechanisms and act redundantly to drive apoptotic cell death. From an unbiased genome-wide CR...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07309-4
更新日期:2018-11-26 00:00:00
abstract::Polyelectrolyte gel diodes that are double layers of two oppositely charged polyelectrolyte gels, sandwiched by two symmetric electrodes, are emergent ionic devices. These diodes are designed to rectify ion currents with a physical mechanism that is analogous to conventional semiconductor diodes-the asymmetry in the p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5162
更新日期:2014-06-17 00:00:00