Abstract:
:Neisseria meningitidis (meningococcus) is an invasive bacterial pathogen that colonizes human vessels, causing thrombotic lesions and meningitis. Establishment of tight interactions with endothelial cells is crucial for meningococci to resist haemodynamic forces. Two endothelial receptors, CD147 and the β2-adrenergic receptor (β2AR), are sequentially engaged by meningococci to adhere and promote signalling events leading to vascular colonization, but their spatiotemporal coordination is unknown. Here we report that CD147 and β2AR form constitutive hetero-oligomeric complexes. The scaffolding protein α-actinin-4 directly binds to the cytosolic tail of CD147 and governs the assembly of CD147-β2AR complexes in highly ordered clusters at bacterial adhesion sites. This multimolecular assembly process increases the binding strength of meningococci to endothelial cells under shear stress, and creates molecular platforms for the elongation of membrane protrusions surrounding adherent bacteria. Thus, the specific organization of cellular receptors has major impacts on host-pathogen interaction.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Maïssa N,Covarelli V,Janel S,Durel B,Simpson N,Bernard SC,Pardo-Lopez L,Bouzinba-Ségard H,Faure C,Scott MGH,Coureuil M,Morand PC,Lafont F,Nassif X,Marullo S,Bourdoulous Sdoi
10.1038/ncomms15764subject
Has Abstractpub_date
2017-06-01 00:00:00pages
15764issn
2041-1723pii
ncomms15764journal_volume
8pub_type
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