当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum.

AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum.

Abstract：

:To fulfill its role in protein biogenesis, the endoplasmic reticulum (ER) depends on the Hsp70-type molecular chaperone BiP, which requires a constant ATP supply. However, the carrier that catalyzes ATP uptake into the ER was unknown. Here, we report that our screen of gene expression datasets for member(s) of the family of solute carriers that are co-expressed with BiP and are ER membrane proteins identifies SLC35B1 as a potential candidate. Heterologous expression of SLC35B1 in E. coli reveals that SLC35B1 is highly specific for ATP and ADP and acts in antiport mode. Moreover, depletion of SLC35B1 from HeLa cells reduces ER ATP levels and, as a consequence, BiP activity. Thus, human SLC35B1 may provide ATP to the ER and was named AXER (ATP/ADP exchanger in the ER membrane). Furthermore, we propose an ER to cytosol low energy response regulatory axis (termed lowER) that appears as central for maintaining ER ATP supply.

journal_name

Nat Commun

journal_title

Nature communications

authors

Klein MC,Zimmermann K,Schorr S,Landini M,Klemens PAW,Altensell J,Jung M,Krause E,Nguyen D,Helms V,Rettig J,Fecher-Trost C,Cavalié A,Hoth M,Bogeski I,Neuhaus HE,Zimmermann R,Lang S,Haferkamp I

doi

10.1038/s41467-018-06003-9

subject

Has Abstract

pub_date

2018-08-28 00:00:00

pages

3489

issue

1

issn

2041-1723

pii

10.1038/s41467-018-06003-9

journal_volume

9

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Consistent effects of pesticides on community structure and ecosystem function in freshwater systems.

    abstract：:Predicting ecological effects of contaminants remains challenging because of the sheer number of chemicals and their ambiguous role in biodiversity-ecosystem function relationships. We evaluate responses of experimental pond ecosystems to standardized concentrations of 12 pesticides, nested in four pesticide classes a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20192-2

    authors： Rumschlag SL,Mahon MB,Hoverman JT,Raffel TR,Carrick HJ,Hudson PJ,Rohr JR

    更新日期：2020-12-10 00:00:00

  • Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress.

    abstract：:A high-sugar diet has been associated with reduced lifespan in organisms ranging from worms to mammals. However, the mechanisms underlying the harmful effects of glucose are poorly understood. Here we establish a causative relationship between endogenous glucose storage in the form of glycogen, resistance to oxidative...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15868

    authors： Gusarov I,Pani B,Gautier L,Smolentseva O,Eremina S,Shamovsky I,Katkova-Zhukotskaya O,Mironov A,Nudler E

    更新日期：2017-06-19 00:00:00

  • Broadband on-chip single-photon spectrometer.

    abstract：:Single-photon counters are single-pixel binary devices that click upon the absorption of a photon but obscure its spectral information, whereas resolving the color of detected photons has been in critical demand for frontier astronomical observation, spectroscopic imaging and wavelength division multiplexed quantum co...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12149-x

    authors： Cheng R,Zou CL,Guo X,Wang S,Han X,Tang HX

    更新日期：2019-09-10 00:00:00

  • Author Correction: Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-020-17712-5

    authors： Zheng J,Fan R,Wu H,Yao H,Yan Y,Liu J,Ran L,Sun Z,Yi L,Dang L,Gan P,Zheng P,Yang T,Zhang Y,Tang T,Wang Y

    更新日期：2020-07-27 00:00:00

  • Topological phase transitions and chiral inelastic transport induced by the squeezing of light.

    abstract：:There is enormous interest in engineering topological photonic systems. Despite intense activity, most works on topological photonic states (and more generally bosonic states) amount in the end to replicating a well-known fermionic single-particle Hamiltonian. Here we show how the squeezing of light can lead to the fo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10779

    authors： Peano V,Houde M,Brendel C,Marquardt F,Clerk AA

    更新日期：2016-03-02 00:00:00

  • The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function.

    abstract：:Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may regulate thrombosis. Here we show that Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial energetics. We find that Slc44a2 null mic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17254-w

    authors： Bennett JA,Mastrangelo MA,Ture SK,Smith CO,Loelius SG,Berg RA,Shi X,Burke RM,Spinelli SL,Cameron SJ,Carey TE,Brookes PS,Gerszten RE,Sabater-Lleal M,de Vries PS,Huffman JE,Smith NL,Morrell CN,Lowenstein CJ

    更新日期：2020-07-13 00:00:00

  • rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.

    abstract：:Knowing which proteins and RNAs directly interact is essential for understanding cellular mechanisms. Unfortunately, discovering such interactions is costly and often unreliable. To overcome these limitations, we developed rec-YnH, a new yeast two and three-hybrid-based screening pipeline capable of detecting interact...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06128-x

    authors： Yang JS,Garriga-Canut M,Link N,Carolis C,Broadbent K,Beltran-Sastre V,Serrano L,Maurer SP

    更新日期：2018-09-14 00:00:00

  • Repurposing DNA-binding agents as H-bonded organic semiconductors.

    abstract：:Organic semiconductors are usually polycyclic aromatic hydrocarbons and their analogs containing heteroatom substitution. Bioinspired materials chemistry of organic electronics promises new charge transport mechanism and specific molecular recognition with biomolecules. We discover organic semiconductors from deoxyrib...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12248-9

    authors： Zhang F,Lemaur V,Choi W,Kafle P,Seki S,Cornil J,Beljonne D,Diao Y

    更新日期：2019-09-16 00:00:00

  • Asymmetric counteranion-directed Lewis acid organocatalysis for the scalable cyanosilylation of aldehydes.

    abstract：:Due to the high versatility of chiral cyanohydrins, the catalytic asymmetric cyanation reaction of carbonyl compounds has attracted widespread interest. However, efficient protocols that function at a preparative scale with low catalyst loading are still rare. Here, asymmetric counteranion-directed Lewis acid organoca...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12478

    authors： Zhang Z,Bae HY,Guin J,Rabalakos C,van Gemmeren M,Leutzsch M,Klussmann M,List B

    更新日期：2016-08-17 00:00:00

  • A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism.

    abstract：:Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alternative strategies ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9143

    authors： Krarup A,Truan D,Furmanova-Hollenstein P,Bogaert L,Bouchier P,Bisschop IJM,Widjojoatmodjo MN,Zahn R,Schuitemaker H,McLellan JS,Langedijk JPM

    更新日期：2015-09-03 00:00:00

  • Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages.

    abstract：:Pulmonary disease increases the risk of developing abdominal aortic aneurysms (AAA). However, the mechanism underlying the pathological dialogue between the lungs and aorta is undefined. Here, we find that inflicting acute lung injury (ALI) to mice doubles their incidence of AAA and accelerates macrophage-driven prote...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18088-2

    authors： Boytard L,Hadi T,Silvestro M,Qu H,Kumpfbeck A,Sleiman R,Fils KH,Alebrahim D,Boccalatte F,Kugler M,Corsica A,Gelb BE,Jacobowitz G,Miller G,Bellini C,Oakes J,Silvestre JS,Zangi L,Ramkhelawon B

    更新日期：2020-08-27 00:00:00

  • Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans.

    abstract：:How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of th...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11444-x

    authors： Helfrich RF,Lendner JD,Mander BA,Guillen H,Paff M,Mnatsakanyan L,Vadera S,Walker MP,Lin JJ,Knight RT

    更新日期：2019-08-08 00:00:00

  • Emergence of chirality and structural complexity in single crystals at the molecular and morphological levels.

    abstract：:Naturally occurring single crystals having a multidomain morphology are a counterintuitive phenonomon: the macroscopic appearance is expected to follow the symmetry of the unit cell. Growing such crystals in the lab is a great challenge, especially from organic molecules. We achieve here uniform metallo-organic crysta...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13925-5

    authors： di Gregorio MC,Shimon LJW,Brumfeld V,Houben L,Lahav M,van der Boom ME

    更新日期：2020-01-20 00:00:00

  • Towards optical polarization control of laser-driven proton acceleration in foils undergoing relativistic transparency.

    abstract：:Control of the collective response of plasma particles to intense laser light is intrinsic to relativistic optics, the development of compact laser-driven particle and radiation sources, as well as investigations of some laboratory astrophysics phenomena. We recently demonstrated that a relativistic plasma aperture pr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12891

    authors： Gonzalez-Izquierdo B,King M,Gray RJ,Wilson R,Dance RJ,Powell H,Maclellan DA,McCreadie J,Butler NMH,Hawkes S,Green JS,Murphy CD,Stockhausen LC,Carroll DC,Booth N,Scott GG,Borghesi M,Neely D,McKenna P

    更新日期：2016-09-14 00:00:00

  • Citizen science provides a reliable and scalable tool to track disease-carrying mosquitoes.

    abstract：:Recent outbreaks of Zika, chikungunya and dengue highlight the importance of better understanding the spread of disease-carrying mosquitoes across multiple spatio-temporal scales. Traditional surveillance tools are limited by jurisdictional boundaries and cost constraints. Here we show how a scalable citizen science s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00914-9

    authors： Palmer JRB,Oltra A,Collantes F,Delgado JA,Lucientes J,Delacour S,Bengoa M,Eritja R,Bartumeus F

    更新日期：2017-10-24 00:00:00

  • Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.

    abstract：:Germline removal provokes longevity in several species and shifts resources towards survival and repair. Several Caenorhabditis elegans transcription factors regulate longevity arising from germline removal; yet, how they work together is unknown. Here we identify a Myc-like HLH transcription factor network comprised ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10944

    authors： Nakamura S,Karalay Ö,Jäger PS,Horikawa M,Klein C,Nakamura K,Latza C,Templer SE,Dieterich C,Antebi A

    更新日期：2016-03-22 00:00:00

  • STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression.

    abstract：:Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a robust pro-inflammatory response that is dependent on metabolic reprogramming. These innate metabolic changes have been compared to aerobic glycolysis in tumour cells. However, the mechanisms by w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17669-5

    authors： Balic JJ,Albargy H,Luu K,Kirby FJ,Jayasekara WSN,Mansell F,Garama DJ,De Nardo D,Baschuk N,Louis C,Humphries F,Fitzgerald K,Latz E,Gough DJ,Mansell A

    更新日期：2020-07-30 00:00:00

  • Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy.

    abstract：:The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in ten prostate cancer patients with fatal disease, and investigate them in conjunction with histopathology and tum...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18843-5

    authors： Woodcock DJ,Riabchenko E,Taavitsainen S,Kankainen M,Gundem G,Brewer DS,Ellonen P,Lepistö M,Golubeva YA,Warner AC,Tolonen T,Jasu J,Isaacs WB,Emmert-Buck MR,Nykter M,Visakorpi T,Bova GS,Wedge DC

    更新日期：2020-10-08 00:00:00

  • Loss of amino-terminal acetylation suppresses a prion phenotype by modulating global protein folding.

    abstract：:Amino-terminal acetylation is among the most ubiquitous of protein modifications in eukaryotes. Although loss of N-terminal acetylation is associated with many abnormalities, the molecular basis of these effects is known for only a few cases, where acetylation of single factors has been linked to binding avidity or me...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5383

    authors： Holmes WM,Mannakee BK,Gutenkunst RN,Serio TR

    更新日期：2014-07-15 00:00:00

  • The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.

    abstract：:Autophagy can degrade cargos with the help of selective autophagy receptors such as p62/SQSTM1, which facilitates the degradation of ubiquitinated cargo. While the process of autophagy has been linked to aging, the impact of selective autophagy in lifespan regulation remains unclear. We have recently shown in Caenorha...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13540-4

    authors： Kumsta C,Chang JT,Lee R,Tan EP,Yang Y,Loureiro R,Choy EH,Lim SHY,Saez I,Springhorn A,Hoppe T,Vilchez D,Hansen M

    更新日期：2019-12-11 00:00:00

  • Ultrafast photoinduced band splitting and carrier dynamics in chiral tellurium nanosheets.

    abstract：:Trigonal tellurium (Te) is a chiral semiconductor that lacks both mirror and inversion symmetries, resulting in complex band structures with Weyl crossings and unique spin textures. Detailed time-resolved polarized reflectance spectroscopy is used to investigate its band structure and carrier dynamics. The polarized t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17766-5

    authors： Jnawali G,Xiang Y,Linser SM,Shojaei IA,Wang R,Qiu G,Lian C,Wong BM,Wu W,Ye PD,Leng Y,Jackson HE,Smith LM

    更新日期：2020-08-10 00:00:00

  • Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.

    abstract：:DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single-stranded (ss) 5'-flaps one nucleotide into duplex (ds) DNA. Yet, how FEN1 selects for but does not incise the ss 5'-flap was enigmatic. Here we combine...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15855

    authors： Tsutakawa SE,Thompson MJ,Arvai AS,Neil AJ,Shaw SJ,Algasaier SI,Kim JC,Finger LD,Jardine E,Gotham VJB,Sarker AH,Her MZ,Rashid F,Hamdan SM,Mirkin SM,Grasby JA,Tainer JA

    更新日期：2017-06-27 00:00:00

  • IL-17-producing γδ T cells enhance bone regeneration.

    abstract：:Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not en...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10928

    authors： Ono T,Okamoto K,Nakashima T,Nitta T,Hori S,Iwakura Y,Takayanagi H

    更新日期：2016-03-11 00:00:00

  • Tuneable reflexes control antennal positioning in flying hawkmoths.

    abstract：:Complex behaviours may be viewed as sequences of modular actions, each elicited by specific sensory cues in their characteristic timescales. From this perspective, we can construct models in which unitary behavioural modules are hierarchically placed in context of related actions. Here, we analyse antennal positioning...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13595-3

    authors： Natesan D,Saxena N,Ekeberg Ö,Sane SP

    更新日期：2019-12-06 00:00:00

  • Low-frequency vibrational modes of stable glasses.

    abstract：:Unusual features of the vibrational density of states D(ω) of glasses allow one to rationalize their peculiar low-temperature properties. Simulational studies of D(ω) have been restricted to studying poorly annealed glasses that may not be relevant to experiments. Here we report on D(ω) of zero-temperature glasses wit...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07978-1

    authors： Wang L,Ninarello A,Guan P,Berthier L,Szamel G,Flenner E

    更新日期：2019-01-03 00:00:00

  • Quantifying contact status and the air-breakdown model of charge-excitation triboelectric nanogenerators to maximize charge density.

    abstract：:Surface charge density is the key factor for developing high performance triboelectric nanogenerators (TENG). The previously invented charge excitation TENG provides a most efficient way to achieve maximum charge output of a TENG device. Herein, criteria to quantitatively evaluate the contact efficiency and air breakd...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15368-9

    authors： Liu Y,Liu W,Wang Z,He W,Tang Q,Xi Y,Wang X,Guo H,Hu C

    更新日期：2020-03-27 00:00:00

  • Chiral spin torque arising from proximity-induced magnetization.

    abstract：:Domain walls can be driven by current at very high speeds in nanowires formed from ultra-thin, perpendicularly magnetized cobalt layers and cobalt/nickel multilayers deposited on platinum underlayers due to a chiral spin torque. An important feature of this torque is a magnetic chiral exchange field that each domain w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4910

    authors： Ryu KS,Yang SH,Thomas L,Parkin SS

    更新日期：2014-05-23 00:00:00

  • Modular coherent photonic-aided payload receiver for communications satellites.

    abstract：:Ubiquitous satellite communications are in a leading position for bridging the digital divide. Fulfilling such a mission will require satellite services on par with fibre services, both in bandwidth and cost. Achieving such a performance requires a new generation of communications payloads powered by large-scale proce...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10077-4

    authors： Duarte VC,Prata JG,Ribeiro CF,Nogueira RN,Winzer G,Zimmermann L,Walker R,Clements S,Filipowicz M,Napierała M,Nasiłowski T,Crabb J,Kechagias M,Stampoulidis L,Anzalchi J,Drummond MV

    更新日期：2019-04-30 00:00:00

  • Rise to modern levels of ocean oxygenation coincided with the Cambrian radiation of animals.

    abstract：:The early diversification of animals (∼ 630 Ma), and their development into both motile and macroscopic forms (∼ 575-565 Ma), has been linked to stepwise increases in the oxygenation of Earth's surface environment. However, establishing such a linkage between oxygen and evolution for the later Cambrian 'explosion' (54...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8142

    authors： Chen X,Ling HF,Vance D,Shields-Zhou GA,Zhu M,Poulton SW,Och LM,Jiang SY,Li D,Cremonese L,Archer C

    更新日期：2015-05-18 00:00:00

  • Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages.

    abstract：:The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells....

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04295-5

    authors： Bunnik EM,Cook KB,Varoquaux N,Batugedara G,Prudhomme J,Cort A,Shi L,Andolina C,Ross LS,Brady D,Fidock DA,Nosten F,Tewari R,Sinnis P,Ay F,Vert JP,Noble WS,Le Roch KG

    更新日期：2018-05-15 00:00:00