AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control.

abstract：:Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL oligomerization, membrane translocation and membrane disruption, although the precise choreography of events is incompletely understood. Her...

journal_title：Nature communications

authors： Samson AL,Zhang Y,Geoghegan ND,Gavin XJ,Davies KA,Mlodzianoski MJ,Whitehead LW,Frank D,Garnish SE,Fitzgibbon C,Hempel A,Young SN,Jacobsen AV,Cawthorne W,Petrie EJ,Faux MC,Shield-Artin K,Lalaoui N,Hildebrand JM,Silke

更新日期：2020-06-19 00:00:00

abstract：:Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T...

journal_title：Nature communications

authors： Thapa P,Das J,McWilliams D,Shapiro M,Sundsbak R,Nelson-Holte M,Tangen S,Anderson J,Desiderio S,Hiebert S,Sant'angelo DB,Shapiro VS

更新日期：2013-01-01 00:00:00

abstract：:Message RNA poly(A) tails are vital for their function and regulation. However, the full-length sequence of mRNA isoforms with their poly(A) tails remains undetermined. Here, we develop a method at single-cell level sensitivity that enables quantification of poly(A) tails along with the full-length cDNA while reading ...

journal_title：Nature communications

authors： Liu Y,Nie H,Liu H,Lu F

更新日期：2019-11-22 00:00:00

abstract：:New Zealand moa (Aves: Dinornithiformes) are the only late Quaternary megafauna whose extinction was clearly caused by humans. New Zealand offers the best opportunity to estimate the number of people involved in a megafaunal extinction event because, uniquely, both the Polynesian settlement of New Zealand and moa exti...

journal_title：Nature communications

authors： Holdaway RN,Allentoft ME,Jacomb C,Oskam CL,Beavan NR,Bunce M

更新日期：2014-11-07 00:00:00

abstract：:In the originally published version of this Article, the affiliation details for Eric E. Schadt and Radoslav Savic incorrectly omitted 'Sema4, a Mount Sinai venture, Stamford, Connecticut, USA'. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Readhead B,Hartley BJ,Eastwood BJ,Collier DA,Evans D,Farias R,He C,Hoffman G,Sklar P,Dudley JT,Schadt EE,Savić R,Brennand KJ

更新日期：2018-11-19 00:00:00

abstract：:Graphene has various potential applications owing to its unique electronic, optical, mechanical and chemical properties, which are primarily based on its two-dimensional nature. Graphene-based vertical devices can extend the investigations and potential applications range to three dimensions, while interfacial propert...

journal_title：Nature communications

authors： Chen JJ,Meng J,Zhou YB,Wu HC,Bie YQ,Liao ZM,Yu DP

更新日期：2013-01-01 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this article. ...

journal_title：Nature communications

authors： Wang Y,Luo G,Liu J,Sankar R,Wang NL,Chou F,Fu L,Li Z

更新日期：2017-10-12 00:00:00

abstract：:Single impurities with nonzero spin and multiple ground states offer a degree of freedom that can be utilized to store the quantum information. However, Fe(2+) dopant is known for having a single nondegenerate ground state in the bulk host semiconductors and thus is of little use for spintronic applications. Here we s...

journal_title：Nature communications

authors： Smoleński T,Kazimierczuk T,Kobak J,Goryca M,Golnik A,Kossacki P,Pacuski W

更新日期：2016-01-28 00:00:00

abstract：:Experience-dependent plasticity of cell and tissue function is critical for survival by allowing organisms to dynamically adjust physiological processes in response to changing or harsh environmental conditions. Despite the conferred evolutionary advantage, it remains unknown whether emergent experience-dependent prop...

journal_title：Nature communications

authors： Hodson DJ,Schaeffer M,Romanò N,Fontanaud P,Lafont C,Birkenstock J,Molino F,Christian H,Lockey J,Carmignac D,Fernandez-Fuente M,Le Tissier P,Mollard P

更新日期：2012-01-03 00:00:00

abstract：:Group O D-negative blood cells are universal donors in transfusion medicine and methods for converting other blood groups into this universal donor group have been researched. However, conversion of D-positive cells into D-negative is yet to be achieved, although conversion of group A or B cells into O cells has been ...

journal_title：Nature communications

authors： Kim YH,Kim HO,Baek EJ,Kurita R,Cha HJ,Nakamura Y,Kim H

更新日期：2015-06-16 00:00:00

abstract：:Recent crystal structures of G-protein-coupled receptors (GPCRs) have revealed ordered internal water molecules, raising questions about the functional role of those waters for receptor activation that could not be answered by the static structures. Here, we used molecular dynamics simulations to monitor--at atomic an...

journal_title：Nature communications

authors： Yuan S,Filipek S,Palczewski K,Vogel H

更新日期：2014-09-09 00:00:00

abstract：:The allotetraploid plant Nicotiana tabacum (common tobacco) is a major crop species and a model organism, for which only very fragmented genomic sequences are currently available. Here we report high-quality draft genomes for three main tobacco varieties. These genomes show both the low divergence of tobacco from its ...

journal_title：Nature communications

authors： Sierro N,Battey JN,Ouadi S,Bakaher N,Bovet L,Willig A,Goepfert S,Peitsch MC,Ivanov NV

更新日期：2014-05-08 00:00:00

abstract：:Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we sho...

journal_title：Nature communications

authors： Liu T,Song T,Zhang X,Yuan H,Su L,Li W,Xu J,Liu S,Chen L,Chen T,Zhang M,Gu L,Zhang B,Dou D

更新日期：2014-08-26 00:00:00

abstract：:Topologically protected pseudospin transport, analogous to the quantum spin Hall effect, cannot be strictly implemented for photons and in general bosons because of the lack of symmetry-protected pseudospins. Here we show that the required protection can be provided by the real-space topological excitation of an inter...

journal_title：Nature communications

authors： Bleu O,Malpuech G,Solnyshkov DD

更新日期：2018-09-28 00:00:00

abstract：:Hundreds of clinical studies have demonstrated associations between the human microbiome and disease, yet fundamental questions remain on how we can generalize this knowledge. Results from individual studies can be inconsistent, and comparing published data is further complicated by a lack of standard processing and a...

journal_title：Nature communications

authors： Duvallet C,Gibbons SM,Gurry T,Irizarry RA,Alm EJ

更新日期：2017-12-05 00:00:00

abstract：:Current approaches to monitor and quantify cell division in live cells, and reliably distinguish between acytokinesis and endoreduplication, are limited and complicate determination of stem cell pool identities. Here we overcome these limitations by generating an in vivo reporter system using the scaffolding protein a...

journal_title：Nature communications

authors： Hesse M,Raulf A,Pilz GA,Haberlandt C,Klein AM,Jabs R,Zaehres H,Fügemann CJ,Zimmermann K,Trebicka J,Welz A,Pfeifer A,Röll W,Kotlikoff MI,Steinhäuser C,Götz M,Schöler HR,Fleischmann BK

更新日期：2012-01-01 00:00:00

abstract：:Weyl semimetals (WSMs) are topological quantum states wherein the electronic bands disperse linearly around pairs of nodes with fixed chirality, the Weyl points. In WSMs, nonorthogonal electric and magnetic fields induce an exotic phenomenon known as the chiral anomaly, resulting in an unconventional negative longitud...

journal_title：Nature communications

authors： Arnold F,Shekhar C,Wu SC,Sun Y,Dos Reis RD,Kumar N,Naumann M,Ajeesh MO,Schmidt M,Grushin AG,Bardarson JH,Baenitz M,Sokolov D,Borrmann H,Nicklas M,Felser C,Hassinger E,Yan B

更新日期：2016-05-17 00:00:00

abstract：:Many-body entanglement is at the heart of the Kondo effect, which has its hallmark in quantum dots as a zero-bias conductance peak at low temperatures. It signals the emergence of a conducting singlet state formed by a localized dot degree of freedom and conduction electrons. Carbon nanotubes offer the possibility to ...

journal_title：Nature communications

authors： Niklas M,Smirnov S,Mantelli D,Margańska M,Nguyen NV,Wernsdorfer W,Cleuziou JP,Grifoni M

更新日期：2016-08-16 00:00:00

abstract：:Crystal structures of G protein-coupled receptor (GPCR) ligand complexes allow a rational design of novel molecular probes and drugs. Here we report the structure-guided design, chemical synthesis and biological investigations of bivalent ligands for dopamine D2 receptor/neurotensin NTS1 receptor (D2R/NTS1R) heterodim...

journal_title：Nature communications

authors： Hübner H,Schellhorn T,Gienger M,Schaab C,Kaindl J,Leeb L,Clark T,Möller D,Gmeiner P

更新日期：2016-07-26 00:00:00

abstract：:The overall survival of patients with acute myeloid leukemia (AML) is poor and identification of new disease-related therapeutic targets remains a major goal for this disease. Here we show that expression of MPP1, a PDZ-domain-containing protein, highly correlated with ABCC4 in AML, is associated with worse overall su...

journal_title：Nature communications

authors： Pitre A,Ge Y,Lin W,Wang Y,Fukuda Y,Temirov J,Phillips AH,Peters JL,Fan Y,Ma J,Nourse A,Sinha C,Lin H,Kriwacki R,Downing JR,Gruber TA,Centonze VE,Naren AP,Chen T,Schuetz JD

更新日期：2017-11-16 00:00:00

abstract：:Considerable interest has been devoted to converting mechanical energy into electricity using polymer nanofibres. In particular, piezoelectric nanofibres produced by electrospinning have shown remarkable mechanical energy-to-electricity conversion ability. However, there is little data for the acoustic-to-electric con...

journal_title：Nature communications

authors： Lang C,Fang J,Shao H,Ding X,Lin T

更新日期：2016-03-23 00:00:00

abstract：:Electron-rich dienes have revolutionized the synthesis of complex compounds since the discovery of the legendary Diels-Alder cycloaddition reaction. This highly efficient bond-forming process has served as a fundamental strategy to assemble many structurally formidable molecules. Amino silyloxy butadienes are arguably...

journal_title：Nature communications

authors： Li X,Peng S,Li L,Huang Y

更新日期：2015-04-21 00:00:00

abstract：:FinO-domain proteins are a widespread family of bacterial RNA-binding proteins with regulatory functions. Their target spectrum ranges from a single RNA pair, in the case of plasmid-encoded FinO, to global RNA regulons, as with enterobacterial ProQ. To assess whether the FinO domain itself is intrinsically selective o...

journal_title：Nature communications

authors： Bauriedl S,Gerovac M,Heidrich N,Bischler T,Barquist L,Vogel J,Schoen C

更新日期：2020-06-04 00:00:00

abstract：:In bulk superfluid 3He at zero magnetic field, two phases emerge with the B-phase stable everywhere except at high pressures and temperatures, where the A-phase is favoured. Aerogels with nanostructure smaller than the superfluid coherence length are the only means to introduce disorder into the superfluid. Here we us...

journal_title：Nature communications

authors： Zhelev N,Reichl M,Abhilash TS,Smith EN,Nguyen KX,Mueller EJ,Parpia JM

更新日期：2016-09-27 00:00:00

abstract：:Conventional lithium-ion batteries embrace graphite anodes which operate at potential as low as metallic lithium, subjected to poor rate capability and safety issues. Among possible alternatives, oxides based on titanium redox couple, such as spinel Li4Ti5O12, have received renewed attention. Here we further expand th...

journal_title：Nature communications

authors： Zhang L,Zhang X,Tian G,Zhang Q,Knapp M,Ehrenberg H,Chen G,Shen Z,Yang G,Gu L,Du F

更新日期：2020-07-13 00:00:00

abstract：:The proton-activated sodium channel ASIC1 belongs to the ENaC/Degenerins family of ion channels. Little is known about gating of the pore in any member of this class. Here we outline the shape of the ion pathway of ASIC1 in the open and closed conformations by measuring apparent rates of cysteine modification by thiol...

journal_title：Nature communications

authors： Li T,Yang Y,Canessa CM

更新日期：2011-07-19 00:00:00

abstract：:Human APOBEC3A (A3A) cytidine deaminase is a host enzyme that can introduce mutations into chromosomal DNA. As APOBEC3B (A3B) encodes a C-terminal catalytic domain ~91% identical to A3A, we examined its genotoxic potential as well as that of a highly prevalent chimaeric A3A-A3B deletion allele (ΔA3B), which is linked ...

journal_title：Nature communications

authors： Caval V,Suspène R,Shapira M,Vartanian JP,Wain-Hobson S

更新日期：2014-10-09 00:00:00

abstract：:Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. Here we identify Nedd4 as an IRS-2 ubiquitin ligase. Ne...

journal_title：Nature communications

authors： Fukushima T,Yoshihara H,Furuta H,Kamei H,Hakuno F,Luan J,Duan C,Saeki Y,Tanaka K,Iemura S,Natsume T,Chida K,Nakatsu Y,Kamata H,Asano T,Takahashi S

更新日期：2015-04-16 00:00:00

abstract：:Creatine kinase (CK) and lactate dehydrogenase (LDH) are widely used markers of tissue damage. To search for sequence variants influencing serum levels of CK and LDH, 28.3 million sequence variants identified through whole-genome sequencing of 2,636 Icelanders were imputed into 63,159 and 98,585 people with CK and LDH...

journal_title：Nature communications

authors： Kristjansson RP,Oddsson A,Helgason H,Sveinbjornsson G,Arnadottir GA,Jensson BO,Jonasdottir A,Jonasdottir A,Bragi Walters G,Sulem G,Oskarsdottir A,Benonisdottir S,Davidsson OB,Masson G,Magnusson OT,Holm H,Sigurdardottir O

更新日期：2016-02-03 00:00:00

abstract：:Naturally heat-resistant coral populations hold significant potential for facilitating coral reef survival under rapid climate change. However, it remains poorly understood whether they can acclimatize to ocean warming when superimposed on their already thermally-extreme habitats. Furthermore, it is unknown whether th...

journal_title：Nature communications

authors： Schoepf V,Carrion SA,Pfeifer SM,Naugle M,Dugal L,Bruyn J,McCulloch MT

更新日期：2019-09-17 00:00:00