An extremely low-density human population exterminated New Zealand moa.

abstract：:HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case-control samples to investigate mutational signatures and the role of human APOBEC3-induced mutations in viral clearance and cervical carcinogen...

journal_title：Nature communications

authors： Zhu B,Xiao Y,Yeager M,Clifford G,Wentzensen N,Cullen M,Boland JF,Bass S,Steinberg MK,Raine-Bennett T,Lee D,Burk RD,Pinheiro M,Song L,Dean M,Nelson CW,Burdett L,Yu K,Roberson D,Lorey T,Franceschi S,Castle PE,Wa

更新日期：2020-02-14 00:00:00

abstract：:Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated protein kinase pathw...

journal_title：Nature communications

authors： Yeh I,Lang UE,Durieux E,Tee MK,Jorapur A,Shain AH,Haddad V,Pissaloux D,Chen X,Cerroni L,Judson RL,LeBoit PE,McCalmont TH,Bastian BC,de la Fouchardière A

更新日期：2017-09-21 00:00:00

abstract：:The activation of a neuronal ensemble in the central nucleus of the amygdala (CeA) during alcohol withdrawal has been hypothesized to induce high levels of alcohol drinking in dependent rats. In the present study we describe that the CeA neuronal ensemble that is activated by withdrawal from chronic alcohol exposure c...

journal_title：Nature communications

authors： de Guglielmo G,Kallupi M,Pomrenze MB,Crawford E,Simpson S,Schweitzer P,Koob GF,Messing RO,George O

更新日期：2019-03-18 00:00:00

abstract：:Species-specific gamete recognition is a key premise to ensure reproductive success and the maintenance of species boundaries. During plant pollen tube (PT) reception, gametophyte interactions likely allow the species-specific recognition of signals from the PT (male gametophyte) by the embryo sac (female gametophyte)...

journal_title：Nature communications

authors： Müller LM,Lindner H,Pires ND,Gagliardini V,Grossniklaus U

更新日期：2016-03-11 00:00:00

abstract：:Some two-dimensional liquid systems are theoretically predicted to have an anomalous phase transition due to unique intermolecular interactions, for example the first-order transition between two-dimensional high-density water and low-density amorphous ice. However, it has never been experimentally observed, to the be...

journal_title：Nature communications

authors： Li W,Kong L,Feng B,Fu H,Li H,Zeng XC,Wu K,Chen L

更新日期：2018-01-15 00:00:00

abstract：:Because the surface-to-volume ratio of quasi-two-dimensional materials is extremely high, understanding their surface characteristics is crucial for practically controlling their intrinsic properties and fabricating p-type and n-type layered semiconductors. Van der Waals crystals are expected to have an inert surface ...

journal_title：Nature communications

authors： Siao MD,Shen WC,Chen RS,Chang ZW,Shih MC,Chiu YP,Cheng CM

更新日期：2018-04-12 00:00:00

abstract：:In reducing the high operating temperatures (≥800 °C) of solid-oxide fuel cells, use of protonic ceramics as an alternative electrolyte material is attractive due to their high conductivity and low activation energy in a low-temperature regime (≤600 °C). Among many protonic ceramics, yttrium-doped barium zirconate has...

journal_title：Nature communications

authors： Bae K,Jang DY,Choi HJ,Kim D,Hong J,Kim BK,Lee JH,Son JW,Shim JH

更新日期：2017-02-23 00:00:00

abstract：:Tandem organic solar cells are based on the device structure monolithically connecting two solar cells to broaden overall absorption spectrum and utilize the photon energy more efficiently. Herein, we demonstrate a simple strategy of inserting a double bond between the central core and end groups of the small molecule...

journal_title：Nature communications

authors： Jia Z,Qin S,Meng L,Ma Q,Angunawela I,Zhang J,Li X,He Y,Lai W,Li N,Ade H,Brabec CJ,Li Y

更新日期：2021-01-08 00:00:00

abstract：:Glucose-induced insulin secretion is an essential function of pancreatic β-cells that is partially lost in individuals affected by Type 2 diabetes. This unique property of β-cells is acquired through a poorly understood postnatal maturation process involving major modifications in gene expression programs. Here we sho...

journal_title：Nature communications

authors： Jacovetti C,Matkovich SJ,Rodriguez-Trejo A,Guay C,Regazzi R

更新日期：2015-09-02 00:00:00

abstract：:Synthesis of ethanol from non-petroleum carbon resources via syngas (a mixture of H2 and CO) is an important but challenging research target. The current conversion of syngas to ethanol suffers from low selectivity or multiple processes with high energy consumption. Here, we report a high-selective conversion of synga...

journal_title：Nature communications

authors： Kang J,He S,Zhou W,Shen Z,Li Y,Chen M,Zhang Q,Wang Y

更新日期：2020-02-11 00:00:00

abstract：:The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which targets substrates...

journal_title：Nature communications

authors： Xu Y,Plechanovová A,Simpson P,Marchant J,Leidecker O,Kraatz S,Hay RT,Matthews SJ

更新日期：2014-06-27 00:00:00

abstract：:Single impurities with nonzero spin and multiple ground states offer a degree of freedom that can be utilized to store the quantum information. However, Fe(2+) dopant is known for having a single nondegenerate ground state in the bulk host semiconductors and thus is of little use for spintronic applications. Here we s...

journal_title：Nature communications

authors： Smoleński T,Kazimierczuk T,Kobak J,Goryca M,Golnik A,Kossacki P,Pacuski W

更新日期：2016-01-28 00:00:00

abstract：:Molar tooth structures are ptygmatically folded and microspar-filled structures common in early- and mid-Proterozoic (∼2,500-750 million years ago, Ma) subtidal successions, but extremely rare in rocks <750 Ma. Here, on the basis of Mg and S isotopes, we show that molar tooth structures may have formed within sediment...

journal_title：Nature communications

authors： Shen B,Dong L,Xiao S,Lang X,Huang K,Peng Y,Zhou C,Ke S,Liu P

更新日期：2016-01-07 00:00:00

abstract：:Negative gas adsorption (NGA) in ordered mesoporous solids is associated with giant contractive structural transitions traversing through metastable states. Here, by systematically downsizing the crystal dimensions of a mesoporous MOF (DUT-49) from several micrometers to less than 200 nm, counterintuitive NGA phenomen...

journal_title：Nature communications

authors： Krause S,Bon V,Senkovska I,Többens DM,Wallacher D,Pillai RS,Maurin G,Kaskel S

更新日期：2018-04-20 00:00:00

abstract：:Interest in manipulating the magnetic order by ultrashort laser pulses has thrived since it was observed that such pulses can be used to alter the magnetization on a sub-picosecond timescale. Usually this involves demagnetization by laser heating or, in rare cases, a transient increase of magnetization. Here we demons...

journal_title：Nature communications

authors： Matsubara M,Schroer A,Schmehl A,Melville A,Becher C,Trujillo-Martinez M,Schlom DG,Mannhart J,Kroha J,Fiebig M

更新日期：2015-04-02 00:00:00

abstract：:Repeated cell divisions and aging impair stem cell function. However, the mechanisms by which this occurs are not fully understood. Here we show that protection of telomeres 1A (Pot1a), a component of the Shelterin complex that protects telomeres, improves haematopoietic stem cell (HSC) activity during aging. Pot1a is...

journal_title：Nature communications

authors： Hosokawa K,MacArthur BD,Ikushima YM,Toyama H,Masuhiro Y,Hanazawa S,Suda T,Arai F

更新日期：2017-10-06 00:00:00

abstract：:Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs, including the most commonly prescribed antifungal, fluconazole. Here, we use a combinatorial screening approach to identify a bis-benzodioxolylindolinone (azoffluxin) that synergizes with fluconazole against C. auris. Azoffluxin e...

journal_title：Nature communications

authors： Iyer KR,Camara K,Daniel-Ivad M,Trilles R,Pimentel-Elardo SM,Fossen JL,Marchillo K,Liu Z,Singh S,Muñoz JF,Kim SH,Porco JA Jr,Cuomo CA,Williams NS,Ibrahim AS,Edwards JE Jr,Andes DR,Nodwell JR,Brown LE,Whitesell L,Ro

更新日期：2020-12-22 00:00:00

abstract：:The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and MNK2 in germinal ce...

journal_title：Nature communications

authors： Landon AL,Muniandy PA,Shetty AC,Lehrmann E,Volpon L,Houng S,Zhang Y,Dai B,Peroutka R,Mazan-Mamczarz K,Steinhardt J,Mahurkar A,Becker KG,Borden KL,Gartenhaus RB

更新日期：2014-11-18 00:00:00

abstract：:To date, the vast preponderance of somatic variants observed in the cancer genome have been rare variants, and it is common in practice to encounter in a new tumor variants that have not been observed previously. Here we focus on probability estimation for encountering such hitherto unseen variants. We draw upon stati...

journal_title：Nature communications

authors： Chakraborty S,Arora A,Begg CB,Shen R

更新日期：2019-12-03 00:00:00

abstract：:Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...

journal_title：Nature communications

authors： Besenbacher S,Liu S,Izarzugaza JM,Grove J,Belling K,Bork-Jensen J,Huang S,Als TD,Li S,Yadav R,Rubio-García A,Lescai F,Demontis D,Rao J,Ye W,Mailund T,Friborg RM,Pedersen CN,Xu R,Sun J,Liu H,Wang O,Cheng X,Fl

更新日期：2015-01-19 00:00:00

abstract：:Quantifying chemical compositions around nanovoids is a fundamental task for research and development of various materials. Atom probe tomography (APT) and scanning transmission electron microscopy (STEM) are currently the most suitable tools because of their ability to probe materials at the nanoscale. Both technique...

journal_title：Nature communications

authors： Wang X,Hatzoglou C,Sneed B,Fan Z,Guo W,Jin K,Chen D,Bei H,Wang Y,Weber WJ,Zhang Y,Gault B,More KL,Vurpillot F,Poplawsky JD

更新日期：2020-02-24 00:00:00

abstract：:The generation of temporal cavity solitons in microresonators results in coherent low-noise optical frequency combs that are critical for applications in spectroscopy, astronomy, navigation or telecommunications. Breather solitons also form an important part of many different classes of nonlinear wave systems, manifes...

journal_title：Nature communications

authors： Yu M,Jang JK,Okawachi Y,Griffith AG,Luke K,Miller SA,Ji X,Lipson M,Gaeta AL

更新日期：2017-02-24 00:00:00

abstract：:Obesity develops when energy intake exceeds energy expenditure. Promoting brown adipose tissue formation and function increases energy expenditure and hence may counteract obesity. Berberine (BBR) is a compound derived from the Chinese medicinal plant Coptis chinensis. Here we show that BBR increases energy expenditur...

journal_title：Nature communications

authors： Zhang Z,Zhang H,Li B,Meng X,Wang J,Zhang Y,Yao S,Ma Q,Jin L,Yang J,Wang W,Ning G

更新日期：2014-11-25 00:00:00

abstract：:Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic loca...

journal_title：Nature communications

authors： Lin WY,Fordham SE,Sunter N,Elstob C,Rahman T,Willmore E,Shepherd C,Strathdee G,Mainou-Fowler T,Piddock R,Mearns H,Barrow T,Houlston RS,Marr H,Wallis J,Summerfield G,Marshall S,Pettitt A,Pepper C,Fegan C,Forconi F

更新日期：2021-01-28 00:00:00

abstract：:Lysocin E, a 37-membered natural depsipeptide, induces rapid bacteriolysis in methicillin-resistant Staphylococcus aureus via a unique menaquinone-dependent mechanism, presenting a promising therapeutic lead. Despite the great medical importance, exploring the potential utility of its derivatives as new platform struc...

journal_title：Nature communications

authors： Itoh H,Tokumoto K,Kaji T,Paudel A,Panthee S,Hamamoto H,Sekimizu K,Inoue M

更新日期：2019-07-05 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Hirata M,Asano N,Katayama K,Yoshida A,Tsuda Y,Sekimizu M,Mitani S,Kobayashi E,Komiyama M,Fujimoto H,Goto T,Iwamoto Y,Naka N,Iwata S,Nishida Y,Hiruma T,Hiraga H,Kawano H,Motoi T,Oda Y,Matsubara D,Fujita M,Shiba

更新日期：2020-02-19 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) are required for skeletal formation, maintenance, and repair throughout life; however, current models posit that postnatally arising long-lived adult MSCs replace transient embryonic progenitor populations. We previously reported exclusive expression and function of the emb...

journal_title：Nature communications

authors： Pineault KM,Song JY,Kozloff KM,Lucas D,Wellik DM

更新日期：2019-07-18 00:00:00

abstract：:The effective delivery of therapeutics to disease sites significantly contributes to drug efficacy, toxicity and clearance. Here we demonstrate that clinically approved iron oxide nanoparticles (Ferumoxytol) can be utilized to carry one or multiple drugs. These so called 'nanophores' retain their cargo within their po...

journal_title：Nature communications

authors： Kaittanis C,Shaffer TM,Ogirala A,Santra S,Perez JM,Chiosis G,Li Y,Josephson L,Grimm J

更新日期：2014-03-04 00:00:00

abstract：:Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-deficient cells exhibit HR defects, especially in long-tract gene c...

journal_title：Nature communications

authors： Huang JW,Acharya A,Taglialatela A,Nambiar TS,Cuella-Martin R,Leuzzi G,Hayward SB,Joseph SA,Brunette GJ,Anand R,Soni RK,Clark NL,Bernstein KA,Cejka P,Ciccia A

更新日期：2020-06-11 00:00:00

abstract：:While molecular water-oxidation catalysts are remarkably rapid, oxidative and hydrolytic processes in water can convert their active transition metals to colloidal metal oxides or hydroxides that, while quite reactive, are insoluble or susceptible to precipitation. In response, we propose using oxidatively-inert ligan...

journal_title：Nature communications

authors： Chakraborty B,Gan-Or G,Raula M,Gadot E,Weinstock IA

更新日期：2018-11-20 00:00:00