Abstract:
:Multipotent mesenchymal stromal cells (MSCs) are required for skeletal formation, maintenance, and repair throughout life; however, current models posit that postnatally arising long-lived adult MSCs replace transient embryonic progenitor populations. We previously reported exclusive expression and function of the embryonic patterning transcription factor, Hoxa11, in adult skeletal progenitor-enriched MSCs. Here, using a newly generated Hoxa11-CreERT2 lineage-tracing system, we show Hoxa11-lineage marked cells give rise to all skeletal lineages throughout the life of the animal and persist as MSCs. Hoxa11 lineage-positive cells give rise to previously described progenitor-enriched MSC populations marked by LepR-Cre and Osx-CreER, placing them upstream of these populations. Our studies establish that Hox-expressing cells are skeletal stem cells that arise from the earliest stages of skeletal development and self-renew throughout the life of the animal.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Pineault KM,Song JY,Kozloff KM,Lucas D,Wellik DMdoi
10.1038/s41467-019-11100-4subject
Has Abstractpub_date
2019-07-18 00:00:00pages
3168issue
1issn
2041-1723pii
10.1038/s41467-019-11100-4journal_volume
10pub_type
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