Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life.

Abstract:

:Multipotent mesenchymal stromal cells (MSCs) are required for skeletal formation, maintenance, and repair throughout life; however, current models posit that postnatally arising long-lived adult MSCs replace transient embryonic progenitor populations. We previously reported exclusive expression and function of the embryonic patterning transcription factor, Hoxa11, in adult skeletal progenitor-enriched MSCs. Here, using a newly generated Hoxa11-CreERT2 lineage-tracing system, we show Hoxa11-lineage marked cells give rise to all skeletal lineages throughout the life of the animal and persist as MSCs. Hoxa11 lineage-positive cells give rise to previously described progenitor-enriched MSC populations marked by LepR-Cre and Osx-CreER, placing them upstream of these populations. Our studies establish that Hox-expressing cells are skeletal stem cells that arise from the earliest stages of skeletal development and self-renew throughout the life of the animal.

journal_name

Nat Commun

journal_title

Nature communications

authors

Pineault KM,Song JY,Kozloff KM,Lucas D,Wellik DM

doi

10.1038/s41467-019-11100-4

subject

Has Abstract

pub_date

2019-07-18 00:00:00

pages

3168

issue

1

issn

2041-1723

pii

10.1038/s41467-019-11100-4

journal_volume

10

pub_type

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