Induction and control of supramolecular chirality by light in self-assembled helical nanostructures.

abstract：:Early detection and accurate monitoring of chronic kidney disease (CKD) could improve care and retard progression to end-stage renal disease. Here, using untargeted metabolomics in 2155 participants including patients with stage 1-5 CKD and healthy controls, we identify five metabolites, including 5-methoxytryptophan ...

journal_title：Nature communications

authors： Chen DQ,Cao G,Chen H,Argyopoulos CP,Yu H,Su W,Chen L,Samuels DC,Zhuang S,Bayliss GP,Zhao S,Yu XY,Vaziri ND,Wang M,Liu D,Mao JR,Ma SX,Zhao J,Zhang Y,Shang YQ,Kang H,Ye F,Cheng XH,Li XR,Zhang L,Meng MX,G

更新日期：2019-04-01 00:00:00

abstract：:Structural DNA nanotechnology seeks to build synthetic molecular machinery from DNA. DNA nanomachines are artificially designed assemblies that switch between defined conformations in response to an external cue. Though it has proved possible to create DNA machines and rudimentary walkers, the function of such autonom...

journal_title：Nature communications

authors： Surana S,Bhat JM,Koushika SP,Krishnan Y

更新日期：2011-06-07 00:00:00

abstract：:Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs). However, Notch1 can be stochastically activated to promote carcinogenesis in murine models of SCC. Activat...

journal_title：Nature communications

authors： Natsuizaka M,Whelan KA,Kagawa S,Tanaka K,Giroux V,Chandramouleeswaran PM,Long A,Sahu V,Darling DS,Que J,Yang Y,Katz JP,Wileyto EP,Basu D,Kita Y,Natsugoe S,Naganuma S,Klein-Szanto AJ,Diehl JA,Bass AJ,Wong KK,Rust

更新日期：2017-11-24 00:00:00

abstract：:Phase transitions in amorphous alloys under pressure are an important fundamental problem. Here we report on a first-principles study that reproduces the recently discovered pressure-induced crystallization of amorphous Ce100-xAlx (x<25) alloys and reveals an atomistic transformation mechanism. Contrary to common beli...

journal_title：Nature communications

authors： Wu M,Tse JS,Wang SY,Wang CZ,Jiang JZ

更新日期：2015-03-09 00:00:00

abstract：:The ability to simultaneously image multiple biomolecules in biologically relevant three-dimensional (3D) cell culture environments would contribute greatly to the understanding of complex cellular mechanisms and cell-material interactions. Here, we present a computational framework for label-free quantitative volumet...

journal_title：Nature communications

authors： Kallepitis C,Bergholt MS,Mazo MM,Leonardo V,Skaalure SC,Maynard SA,Stevens MM

更新日期：2017-03-22 00:00:00

abstract：:Although, a number of pathogenic mutations have been found for Alzheimer's disease (AD), only one protective mutation has been identified so far in humans. Here we identify possible protective deletion mutations in the 3'-UTR of the amyloid precursor protein (App) gene in mice. We use an App knock-in mouse model carry...

journal_title：Nature communications

authors： Nagata K,Takahashi M,Matsuba Y,Okuyama-Uchimura F,Sato K,Hashimoto S,Saito T,Saido TC

更新日期：2018-05-04 00:00:00

abstract：:The fields of soft polymers and macromolecular sciences have enjoyed a unique combination of metals and organic frameworks in the name of metallopolymers or organometallic polymers. When metallopolymers carry charged groups, they form a class of metal-containing polyelectrolytes or metallo-polyelectrolytes. This revie...

journal_title：Nature communications

authors： Zhu T,Sha Y,Yan J,Pageni P,Rahman MA,Yan Y,Tang C

更新日期：2018-10-18 00:00:00

abstract：:The clockwork of plant circadian oscillators has been resolved through investigations in Arabidopsis thaliana. The circadian oscillator is an important regulator of much of plant physiology, though many of the mechanisms are unclear. New findings demonstrate that the oscillator adjusts phase and period in response to ...

journal_title：Nature communications

authors： Webb AAR,Seki M,Satake A,Caldana C

更新日期：2019-02-01 00:00:00

abstract：:RNA has emerged as a promising material for nanostructure and microstructure engineering. Although rare, some macroscopic RNA structures have also been constructed using lipid or polymer materials. Here, we report the first example of an enzymatically generated RNA membrane. This robust and free-standing RNA membrane ...

journal_title：Nature communications

authors： Han D,Park Y,Kim H,Lee JB

更新日期：2014-07-04 00:00:00

abstract：:Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a...

journal_title：Nature communications

authors： Zhu Z,Zheng Z,Zhang F,Wu Y,Trzaskowski M,Maier R,Robinson MR,McGrath JJ,Visscher PM,Wray NR,Yang J

更新日期：2018-01-15 00:00:00

abstract：:Loss of gut mucosal integrity and an aberrant gut microbiota are proposed mechanisms contributing to chronic inflammation and increased morbidity and mortality during antiretroviral-treated HIV disease. Sexual practice has recently been uncovered as a major source of microbiota variation, potentially confounding prior...

journal_title：Nature communications

authors： Vujkovic-Cvijin I,Sortino O,Verheij E,Sklar J,Wit FW,Kootstra NA,Sellers B,Brenchley JM,Ananworanich J,Loeff MSV,Belkaid Y,Reiss P,Sereti I

更新日期：2020-05-15 00:00:00

abstract：:A widely appreciated aspect of developmental robustness is pattern formation in proportion to size. But how such scaling features emerge dynamically remains poorly understood. Here we generate a data set of the expression profiles of six gap genes in Drosophila melanogaster embryos that differ significantly in size. E...

journal_title：Nature communications

authors： Wu H,Manu,Jiao R,Ma J

更新日期：2015-12-08 00:00:00

abstract：:Development of sensitive local probes of magnon dynamics is essential to further understand the physical processes that govern magnon generation, propagation, scattering, and relaxation. Quantum spin sensors like the NV center in diamond have long spin lifetimes and their relaxation can be used to sense magnetic field...

journal_title：Nature communications

authors： McCullian BA,Thabt AM,Gray BA,Melendez AL,Wolf MS,Safonov VL,Pelekhov DV,Bhallamudi VP,Page MR,Hammel PC

更新日期：2020-10-16 00:00:00

abstract：:The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount of data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing dat...

journal_title：Nature communications

authors： Delaneau O,Zagury JF,Robinson MR,Marchini JL,Dermitzakis ET

更新日期：2019-11-28 00:00:00

abstract：:Fluctuations in glacier motion are very common and are thought to be controlled by subglacial hydrology and till deformation. There are few instrumented studies that have monitored seasonal changes. We use the innovative Glacsweb subglacial in situ wireless probes, combined with dGPS and custom geophone data from an I...

journal_title：Nature communications

authors： Hart JK,Martinez K,Basford PJ,Clayton AI,Robson BA,Young DS

更新日期：2019-04-08 00:00:00

abstract：:Alternative splicing and alternative polyadenylation (APA) of pre-mRNAs greatly contribute to transcriptome diversity, coding capacity of a genome and gene regulatory mechanisms in eukaryotes. Second-generation sequencing technologies have been extensively used to analyse transcriptomes. However, a major limitation of...

journal_title：Nature communications

authors： Abdel-Ghany SE,Hamilton M,Jacobi JL,Ngam P,Devitt N,Schilkey F,Ben-Hur A,Reddy AS

更新日期：2016-06-24 00:00:00

abstract：:Lysosomes are the major degradative compartments within cells, harbouring a wide variety of hydrolytic enzymes within their lumen. Release of lysosomal hydrolases from lysosomes into the cell cytoplasm results in cell death. Here we report that damaged lysosomes undergo autophagic turnover. Using a light-induced lysos...

journal_title：Nature communications

authors： Hung YH,Chen LM,Yang JY,Yang WY

更新日期：2013-01-01 00:00:00

abstract：:Interactions between proteins play an essential role in metabolic and signaling pathways, cellular processes and organismal systems. We report the development of splitFAST, a fluorescence complementation system for the visualization of transient protein-protein interactions in living cells. Engineered from the fluorog...

journal_title：Nature communications

authors： Tebo AG,Gautier A

更新日期：2019-06-27 00:00:00

abstract：:Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine modification, N(6)-methyladenine (6mA), has recently been found in mammalian cells. However, the presence and function(s) of 6mA in the mammalian brain remain ...

journal_title：Nature communications

authors： Yao B,Cheng Y,Wang Z,Li Y,Chen L,Huang L,Zhang W,Chen D,Wu H,Tang B,Jin P

更新日期：2017-10-24 00:00:00

abstract：:T cells expressing CD19-targeting chimeric antigen receptors (CARs) reveal high efficacy in the treatment of B cell malignancies. Here, we report that T cell receptor fusion constructs (TRuCs) comprising an antibody-based binding domain fused to T cell receptor (TCR) subunits can effectively reprogram an intact TCR co...

journal_title：Nature communications

authors： Baeuerle PA,Ding J,Patel E,Thorausch N,Horton H,Gierut J,Scarfo I,Choudhary R,Kiner O,Krishnamurthy J,Le B,Morath A,Baldeviano GC,Quinn J,Tavares P,Wei Q,Weiler S,Maus MV,Getts D,Schamel WW,Hofmeister R

更新日期：2019-05-07 00:00:00

abstract：:Magnetic resonance spectroscopy is one of the most important tools in chemical and bio-medical research. However, sensitivity limitations typically restrict imaging resolution to ~ 10 µm. Here we bring quantum control to the detection of chemical systems to demonstrate high-resolution electron spin imaging using the q...

journal_title：Nature communications

authors： Simpson DA,Ryan RG,Hall LT,Panchenko E,Drew SC,Petrou S,Donnelly PS,Mulvaney P,Hollenberg LCL

更新日期：2017-09-06 00:00:00

abstract：:The Nuclear Pore Complex (NPC) has emerged as an important hub for processing various types of DNA damage. Here, we uncover that fusing a DNA binding domain to the NPC basket protein Nup1 reduces telomere relocalization to nuclear pores early after telomerase inactivation. This Nup1 modification also impairs the reloc...

journal_title：Nature communications

authors： Aguilera P,Whalen J,Minguet C,Churikov D,Freudenreich C,Simon MN,Géli V

更新日期：2020-01-09 00:00:00

abstract：:Due to the surge of natural gas production, feedstocks for chemicals shift towards lighter hydrocarbons, particularly methane. The success of a Gas-to-Chemicals process via synthesis gas (CO and H2) depends on the ability of catalysts to suppress methane and carbon dioxide formation. We designed a Co/Mn/Na/S catalyst,...

journal_title：Nature communications

authors： Xie J,Paalanen PP,van Deelen TW,Weckhuysen BM,Louwerse MJ,de Jong KP

更新日期：2019-01-11 00:00:00

abstract：:The presence of a di-unsaturated highly branched isoprenoid (HBI) lipid biomarker (diene II) in Southern Ocean sediments has previously been proposed as a proxy measure of palaeo Antarctic sea ice. Here we show that a source of diene II is the sympagic diatom Berkeleya adeliensis Medlin. Furthermore, the propensity fo...

journal_title：Nature communications

authors： Belt ST,Smik L,Brown TA,Kim JH,Rowland SJ,Allen CS,Gal JK,Shin KH,Lee JI,Taylor KW

更新日期：2016-08-30 00:00:00

abstract：:In the enteric pathogen Salmonella enterica serovar Typhimurium, invasion and motility are coordinated by the master regulator HilD, which induces expression of the type III secretion system 1 (T3SS1) and motility genes. Methyl-accepting chemotaxis proteins (MCPs) detect specific ligands and control the direction of t...

journal_title：Nature communications

authors： Cooper KG,Chong A,Kari L,Jeffrey B,Starr T,Martens C,McClurg M,Posada VR,Laughlin RC,Whitfield-Cargile C,Garry Adams L,Bryan LK,Little SV,Krath M,Lawhon SD,Steele-Mortimer O

更新日期：2021-01-13 00:00:00

abstract：:Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reservoirs to humans has only been reported in Australia and South/Southeast Asia. However, a recent study discovered numerous HNV clades in African bat samples. To determine the potential for HNV spillover events among humans in Africa,...

journal_title：Nature communications

authors： Pernet O,Schneider BS,Beaty SM,LeBreton M,Yun TE,Park A,Zachariah TT,Bowden TA,Hitchens P,Ramirez CM,Daszak P,Mazet J,Freiberg AN,Wolfe ND,Lee B

更新日期：2014-11-18 00:00:00

abstract：:Frequency tuning within the auditory papilla of most non-mammalian species is electrical, deriving from ion-channel resonance within their sensory hair cells. In contrast, tuning within the mammalian cochlea is mechanical, stemming from active mechanisms within outer hair cells that amplify the basilar membrane travel...

journal_title：Nature communications

authors： Xia A,Liu X,Raphael PD,Applegate BE,Oghalai JS

更新日期：2016-10-31 00:00:00

abstract：:N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibility for subtype-specific targeting by pharmacological means for treatme...

journal_title：Nature communications

authors： Wang JX,Irvine MW,Burnell ES,Sapkota K,Thatcher RJ,Li M,Simorowski N,Volianskis A,Collingridge GL,Monaghan DT,Jane DE,Furukawa H

更新日期：2020-01-22 00:00:00

abstract：:Amazon forests have experienced frequent and severe droughts in the past two decades. However, little is known about the large-scale legacy of droughts on carbon stocks and dynamics of forests. Using systematic sampling of forest structure measured by LiDAR waveforms from 2003 to 2008, here we show a significant loss ...

journal_title：Nature communications

authors： Yang Y,Saatchi SS,Xu L,Yu Y,Choi S,Phillips N,Kennedy R,Keller M,Knyazikhin Y,Myneni RB

更新日期：2018-08-09 00:00:00

abstract：:High-field magnets of up to tens of teslas in strength advance applications in physics, chemistry and the life sciences. However, progress in generating such high fields has not been matched by corresponding advances in magnetic field measurement. Based mostly on nuclear magnetic resonance, dynamic high-field magnetom...

journal_title：Nature communications

authors： Gross S,Barmet C,Dietrich BE,Brunner DO,Schmid T,Pruessmann KP

更新日期：2016-12-02 00:00:00