The nuclear pore complex prevents sister chromatid recombination during replicative senescence.

abstract：:Although hexagonal boron nitride (h-BN) is a good candidate for gate-insulating materials by minimizing interaction from substrate, further applications to electronic devices with available two-dimensional semiconductors continue to be limited by flake size. While monolayer h-BN has been synthesized on Pt and Cu foil ...

journal_title：Nature communications

authors： Kim SM,Hsu A,Park MH,Chae SH,Yun SJ,Lee JS,Cho DH,Fang W,Lee C,Palacios T,Dresselhaus M,Kim KK,Lee YH,Kong J

更新日期：2015-10-28 00:00:00

abstract：:Transition metal oxides host a wealth of exotic phenomena ranging from charge, orbital and magnetic order to nontrivial topological phases and superconductivity. In order to translate these unique materials properties into device functionalities these materials must be doped; however, the nature of carriers and their ...

journal_title：Nature communications

authors： Verdi C,Caruso F,Giustino F

更新日期：2017-06-08 00:00:00

abstract：:The shelterin protein TRF2 is essential for chromosome-end protection. Depletion of TRF2 causes chromosome end-to-end fusions, initiating genomic instability that can be cancer promoting. Paradoxically, significant increased levels of TRF2 are observed in a subset of human cancers. Experimental overexpression of TRF2 ...

journal_title：Nature communications

authors： Nera B,Huang HS,Lai T,Xu L

更新日期：2015-12-07 00:00:00

abstract：:Many of the largest known viruses belong to the PRD1-adeno structural lineage characterised by conserved pseudo-hexameric capsomers composed of three copies of a single major capsid protein (MCP). Here, by high-resolution cryo-EM analysis, we show that a class of archaeal viruses possess hetero-hexameric MCPs which mi...

journal_title：Nature communications

authors： De Colibus L,Roine E,Walter TS,Ilca SL,Wang X,Wang N,Roseman AM,Bamford D,Huiskonen JT,Stuart DI

更新日期：2019-03-29 00:00:00

abstract：:The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells, oscillates spontaneously in a wide variety of systems. Although much of the signal cascade regulating myosin activity has been characterized, the origin of such oscillatory behavior is still unclear. Here, we show that basal myosin II oscill...

journal_title：Nature communications

authors： Qin X,Hannezo E,Mangeat T,Liu C,Majumder P,Liu J,Choesmel-Cadamuro V,McDonald JA,Liu Y,Yi B,Wang X

更新日期：2018-03-23 00:00:00

abstract：:Many cancer cells display enhanced glycolysis and suppressed mitochondrial metabolism. This phenomenon, known as the Warburg effect, is critical for tumor development. However, how cancer cells coordinate glucose metabolism through glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle is largely unknown. We ...

journal_title：Nature communications

authors： Nie H,Ju H,Fan J,Shi X,Cheng Y,Cang X,Zheng Z,Duan X,Yi W

更新日期：2020-01-07 00:00:00

abstract：:Staphylococcal pathogens adhere to their human targets with exceptional resilience to mechanical stress, some propagating force to the bacterium via small, Ig-like folds called B domains. We examine the mechanical stability of these folds using atomic force microscopy-based single-molecule force spectroscopy. The forc...

journal_title：Nature communications

authors： Milles LF,Unterauer EM,Nicolaus T,Gaub HE

更新日期：2018-11-12 00:00:00

abstract：:Enzymatic digestion for protein sequencing usually requires much time, and does not always result in high sequence coverage. Here we report the use of aqueous microdroplets to accelerate enzymatic reactions and, in particular, to improve protein sequencing. When a room temperature aqueous solution containing 10 µM myo...

journal_title：Nature communications

authors： Zhong X,Chen H,Zare RN

更新日期：2020-02-26 00:00:00

abstract：:Methane cold seep systems typically exhibit extensive buildups of authigenic carbonate minerals, resulting from local increases in alkalinity driven by methane oxidation. Here, we demonstrate that modern seep authigenic carbonates exhibit anomalously low clumped isotope values (Δ47), as much as ∼0.2‰ lower than expect...

journal_title：Nature communications

authors： Loyd SJ,Sample J,Tripati RE,Defliese WF,Brooks K,Hovland M,Torres M,Marlow J,Hancock LG,Martin R,Lyons T,Tripati AE

更新日期：2016-07-22 00:00:00

abstract：:The role of the histamine H3 receptor (H3R) in cerebral ischaemia/reperfusion (I/R) injury remains unknown. Here we show that H3R expression is upregulated after I/R in two mouse models. H3R antagonists and H3R knockout attenuate I/R injury, which is reversed by an H3R-selective agonist. Interestingly, H1R and H2R ant...

journal_title：Nature communications

authors： Yan H,Zhang X,Hu W,Ma J,Hou W,Zhang X,Wang X,Gao J,Shen Y,Lv J,Ohtsu H,Han F,Wang G,Chen Z

更新日期：2014-02-25 00:00:00

abstract：:Organic conjugated polymers demonstrate great potential in transistors, solar cells and light-emitting diodes, whose performances are fundamentally governed by charge transport. However, the morphology-property relationships and the underpinning charge transport mechanisms remain unclear. Particularly, whether the non...

journal_title：Nature communications

authors： Wang J,Niu J,Shao B,Yang G,Lu C,Li M,Zhou Z,Chuai X,Chen J,Lu N,Huang B,Wang Y,Li L,Liu M

更新日期：2021-01-04 00:00:00

abstract：:Mammalian female meiosis is error prone, with rates of meiotic chromosome missegregations strongly increasing towards the end of the reproductive lifespan. A strong reduction of BubR1 has been observed in oocytes of women approaching menopause and in ovaries of aged mice, which led to the hypothesis that a gradual dec...

journal_title：Nature communications

authors： Touati SA,Buffin E,Cladière D,Hached K,Rachez C,van Deursen JM,Wassmann K

更新日期：2015-04-21 00:00:00

abstract：:Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain. Here, we use bacterial DNA sequencing from serially collected vaginal samples from a cohort of 87 ad...

journal_title：Nature communications

authors： Mitra A,MacIntyre DA,Ntritsos G,Smith A,Tsilidis KK,Marchesi JR,Bennett PR,Moscicki AB,Kyrgiou M

更新日期：2020-04-24 00:00:00

abstract：:Solid organic matter (OM) plays an essential role in the generation, migration, storage, and production of hydrocarbons from economically important shale rock formations. Electron microscopy images have documented spatial heterogeneity in the porosity of OM at nanoscale, and bulk spectroscopy measurements have documen...

journal_title：Nature communications

authors： Yang J,Hatcherian J,Hackley PC,Pomerantz AE

更新日期：2017-12-19 00:00:00

abstract：:The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that...

journal_title：Nature communications

authors： Ogrodnik M,Miwa S,Tchkonia T,Tiniakos D,Wilson CL,Lahat A,Day CP,Burt A,Palmer A,Anstee QM,Grellscheid SN,Hoeijmakers JHJ,Barnhoorn S,Mann DA,Bird TG,Vermeij WP,Kirkland JL,Passos JF,von Zglinicki T,Jurk D

更新日期：2017-06-13 00:00:00

abstract：:Interfacial reactions between electrode and electrolyte are critical, either beneficial or detrimental, for the performance of rechargeable batteries. The general approaches of controlling interfacial reactions are either applying a coating layer on cathode or modifying the electrolyte chemistry. Here we demonstrate a...

journal_title：Nature communications

authors： Zou L,Li J,Liu Z,Wang G,Manthiram A,Wang C

更新日期：2019-08-01 00:00:00

abstract：:DNA-based nanopores are synthetic biomolecular membrane pores, whose geometry and chemical functionality can be tuned using the tools of DNA nanotechnology, making them promising molecular devices for applications in single-molecule biosensing and synthetic biology. Here we introduce a large DNA membrane channel with ...

journal_title：Nature communications

authors： Krishnan S,Ziegler D,Arnaut V,Martin TG,Kapsner K,Henneberg K,Bausch AR,Dietz H,Simmel FC

更新日期：2016-09-23 00:00:00

abstract：:Protein homeostasis (proteostasis) is a potential mechanism that contributes to cancer cell survival and drug resistance. Constitutively active androgen receptor (AR) variants confer anti-androgen resistance in advanced prostate cancer. However, the role of proteostasis involved in next generation anti-androgen resist...

journal_title：Nature communications

authors： Liu C,Lou W,Yang JC,Liu L,Armstrong CM,Lombard AP,Zhao R,Noel ODV,Tepper CG,Chen HW,Dall'Era M,Evans CP,Gao AC

更新日期：2018-11-16 00:00:00

abstract：:The quantum noise of the vacuum limits the achievable sensitivity of quantum sensors. In non-classical measurement schemes the noise can be reduced to overcome this limitation. However, schemes based on squeezed or Schrödinger cat states require alignment of the relative phase between the measured interaction and the ...

journal_title：Nature communications

authors： Wolf F,Shi C,Heip JC,Gessner M,Pezzè L,Smerzi A,Schulte M,Hammerer K,Schmidt PO

更新日期：2019-07-02 00:00:00

abstract：:Liquid sensors composed of ionic liquids are rising as alternatives to solid semiconductors for flexible and self-healing electronics. However, the fluidic nature may give rise to leakage problems in cases of accidental damages. Here, we proposed a liquid sensor based on a binary ionic liquid system, in which a flowin...

journal_title：Nature communications

authors： Gao N,He Y,Tao X,Xu XQ,Wu X,Wang Y

更新日期：2019-02-01 00:00:00

abstract：:Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most common form of age-related degenerative whole-joint disease. No disease-modifying treatments for OA are currently available. Although OA is primarily characterized by cartilage destruction, our understanding of the processes c...

journal_title：Nature communications

authors： Park DR,Kim J,Kim GM,Lee H,Kim M,Hwang D,Lee H,Kim HS,Kim W,Park MC,Shim H,Lee SY

更新日期：2020-08-28 00:00:00

abstract：:Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is ge...

journal_title：Nature communications

authors： Kachuri L,Johansson M,Rashkin SR,Graff RE,Bossé Y,Manem V,Caporaso NE,Landi MT,Christiani DC,Vineis P,Liu G,Scelo G,Zaridze D,Shete SS,Albanes D,Aldrich MC,Tardón A,Rennert G,Chen C,Goodman GE,Doherty JA,Bickebö

更新日期：2020-01-07 00:00:00

abstract：:Memories of experiences that occur around the same time are linked together by a shared temporal context, represented by shared patterns of neural activity. However, shared temporal context may be problematic for selective retrieval of specific memories. Here, we examine intracranial EEG (iEEG) in the human temporal l...

journal_title：Nature communications

authors： El-Kalliny MM,Wittig JH Jr,Sheehan TC,Sreekumar V,Inati SK,Zaghloul KA

更新日期：2019-01-14 00:00:00

abstract：:Seeded propagation of amyloid-beta (Aβ) pathology is suggested to contribute to the progression of Alzheimer's disease. Local overproduction of aggregation-prone Aβ variants could explain the focal initiation of a seeding cascade that subsequently triggers widespread pathology. Several animal models support this seedi...

journal_title：Nature communications

authors： Sowade RF,Jahn TR

更新日期：2017-09-11 00:00:00

abstract：:Aviation emissions of nitrogen oxides (NOx) alter the composition of the atmosphere, perturbing the greenhouse gases ozone and methane, resulting in positive and negative radiative forcing effects, respectively. In 1981, the International Civil Aviation Organization adopted a first certification standard for the regul...

journal_title：Nature communications

authors： Skowron A,Lee DS,De León RR,Lim LL,Owen B

更新日期：2021-01-25 00:00:00

abstract：:Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of ...

journal_title：Nature communications

authors： Adhireksan Z,Palermo G,Riedel T,Ma Z,Muhammad R,Rothlisberger U,Dyson PJ,Davey CA

更新日期：2017-03-30 00:00:00

abstract：:There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of ris...

journal_title：Nature communications

authors： Taylor JL,Debost JPG,Morton SU,Wigdor EM,Heyne HO,Lal D,Howrigan DP,Bloemendal A,Larsen JT,Kosmicki JA,Weiner DJ,Homsy J,Seidman JG,Seidman CE,Agerbo E,McGrath JJ,Mortensen PB,Petersen L,Daly MJ,Robinson EB

更新日期：2019-07-10 00:00:00

abstract：:Density functional theory (DFT) is the standard formalism to study the electronic structure of matter at the atomic scale. In Kohn-Sham DFT simulations, the balance between accuracy and computational cost depends on the choice of exchange and correlation functional, which only exists in approximate form. Here, we prop...

journal_title：Nature communications

authors： Dick S,Fernandez-Serra M

更新日期：2020-07-14 00:00:00

abstract：:The mammalian neocortex is subdivided into cytoarchitectural areas with distinct connectivity, gene expression and neural functions. Areal identity is initially specified by rostrocaudal and mediolateral gene expression gradients in neuroepithelial and radial glial progenitors (the 'protomap'). On further differentiat...

journal_title：Nature communications

authors： Alfano C,Magrinelli E,Harb K,Hevner RF,Studer M

更新日期：2014-12-05 00:00:00

abstract：:Plant metacaspases mediate programmed cell death in development, biotic and abiotic stresses, damage-induced immune response, and resistance to pathogen attack. Most metacaspases require Ca2+ for their activation and substrate processing. However, the Ca2+-dependent activation mechanism remains elusive. Here we report...

journal_title：Nature communications

authors： Zhu P,Yu XH,Wang C,Zhang Q,Liu W,McSweeney S,Shanklin J,Lam E,Liu Q

更新日期：2020-05-07 00:00:00