当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Assembly of complex viruses exemplified by a halophilic euryarchaeal virus.

Assembly of complex viruses exemplified by a halophilic euryarchaeal virus.

Abstract：

:Many of the largest known viruses belong to the PRD1-adeno structural lineage characterised by conserved pseudo-hexameric capsomers composed of three copies of a single major capsid protein (MCP). Here, by high-resolution cryo-EM analysis, we show that a class of archaeal viruses possess hetero-hexameric MCPs which mimic the PRD1-adeno lineage trimer. These hetero-hexamers are built from heterodimers and utilise a jigsaw-puzzle system of pegs and holes, and underlying minor capsid proteins, to assemble the capsid laterally from the 5-fold vertices. At these vertices proteins engage inwards with the internal membrane vesicle whilst 2-fold symmetric horn-like structures protrude outwards. The horns are assembled from repeated globular domains attached to a central spine, presumably facilitating multimeric attachment to the cell receptor. Such viruses may represent precursors of the main PRD1-adeno lineage, similarly engaging cell-receptors via 5-fold spikes and using minor proteins to define particle size.

journal_name

Nat Commun

journal_title

Nature communications

authors

De Colibus L,Roine E,Walter TS,Ilca SL,Wang X,Wang N,Roseman AM,Bamford D,Huiskonen JT,Stuart DI

doi

10.1038/s41467-019-09451-z

subject

Has Abstract

pub_date

2019-03-29 00:00:00

pages

1456

issue

1

issn

2041-1723

pii

10.1038/s41467-019-09451-z

journal_volume

10

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Phasor field diffraction based reconstruction for fast non-line-of-sight imaging systems.

    abstract：:Non-line-of-sight (NLOS) imaging recovers objects using diffusely reflected indirect light using transient illumination devices in combination with a computational inverse method. While capture systems capable of collecting light from the entire NLOS relay surface can be much more light efficient than single pixel poi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15157-4

    authors： Liu X,Bauer S,Velten A

    更新日期：2020-04-02 00:00:00

  • Structural insight into catalytic mechanism of PET hydrolase.

    abstract：:PET hydrolase (PETase), which hydrolyzes polyethylene terephthalate (PET) into soluble building blocks, provides an attractive avenue for the bioconversion of plastics. Here we present the structures of a novel PETase from the PET-consuming microbe Ideonella sakaiensis in complex with substrate and product analogs. Th...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02255-z

    authors： Han X,Liu W,Huang JW,Ma J,Zheng Y,Ko TP,Xu L,Cheng YS,Chen CC,Guo RT

    更新日期：2017-12-13 00:00:00

  • The effectiveness of coral reefs for coastal hazard risk reduction and adaptation.

    abstract：:The world's coastal zones are experiencing rapid development and an increase in storms and flooding. These hazards put coastal communities at heightened risk, which may increase with habitat loss. Here we analyse globally the role and cost effectiveness of coral reefs in risk reduction. Meta-analyses reveal that coral...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4794

    authors： Ferrario F,Beck MW,Storlazzi CD,Micheli F,Shepard CC,Airoldi L

    更新日期：2014-05-13 00:00:00

  • Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors.

    abstract：:The fusion of genome engineering and adoptive cellular therapy holds immense promise for the treatment of genetic disease and cancer. Multiplex genome engineering using targeted nucleases can be used to increase the efficacy and broaden the application of such therapies but carries safety risks associated with uninten...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13007-6

    authors： Webber BR,Lonetree CL,Kluesner MG,Johnson MJ,Pomeroy EJ,Diers MD,Lahr WS,Draper GM,Slipek NJ,Smeester BA,Lovendahl KN,McElroy AN,Gordon WR,Osborn MJ,Moriarity BS

    更新日期：2019-11-19 00:00:00

  • Dynamic changes of muscle insulin sensitivity after metabolic surgery.

    abstract：:The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respirato...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12081-0

    authors： Gancheva S,Ouni M,Jelenik T,Koliaki C,Szendroedi J,Toledo FGS,Markgraf DF,Pesta DH,Mastrototaro L,De Filippo E,Herder C,Jähnert M,Weiss J,Strassburger K,Schlensak M,Schürmann A,Roden M

    更新日期：2019-09-13 00:00:00

  • Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy.

    abstract：:The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patients vary. Here we report a non-invasive quantitativ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11838

    authors： Pérez-Medina C,Abdel-Atti D,Tang J,Zhao Y,Fayad ZA,Lewis JS,Mulder WJM,Reiner T

    更新日期：2016-06-20 00:00:00

  • ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types.

    abstract：:Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive cancer types and the leading cause of cancer-associated deaths. The EMT-inducing transcriptional repressor ZEB1 is a crucial stimulator of these processes, particularly by coupling the activation of cellular motility with stemne...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10498

    authors： Lehmann W,Mossmann D,Kleemann J,Mock K,Meisinger C,Brummer T,Herr R,Brabletz S,Stemmler MP,Brabletz T

    更新日期：2016-02-15 00:00:00

  • A tetrahelical DNA fold adopted by tandem repeats of alternating GGG and GCG tracts.

    abstract：:DNA can form diverse higher-order structures, whose details are greatly dependent on nucleotide sequence. G-rich sequences containing four or more repeats of three guanines are expected to form G-quadruplexes. Here we show that DNA sequences with GGGAGCG repeats found in the regulatory region of the PLEKHG3 gene are c...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6831

    authors： Kocman V,Plavec J

    更新日期：2014-12-15 00:00:00

  • Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy.

    abstract：:Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically and industrially important compounds, and are often clustered on chromosomes. Here, we study genomic clustering in the benzylisoquinoline alkaloid (BIA) pathway in opium poppy (Papaver somniferum), exploring relationships between g...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15040-2

    authors： Li Q,Ramasamy S,Singh P,Hagel JM,Dunemann SM,Chen X,Chen R,Yu L,Tucker JE,Facchini PJ,Yeaman S

    更新日期：2020-03-04 00:00:00

  • Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons.

    abstract：:Orexins are associated with drug relapse in rodents. Here, we show that acute restraint stress in mice activates lateral hypothalamic (LH) orexin neurons, increases levels of orexin A and 2-arachidonoylglycerol (2-AG) in the ventral tegmental area (VTA), and reinstates extinguished cocaine-conditioned place preference...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12199

    authors： Tung LW,Lu GL,Lee YH,Yu L,Lee HJ,Leishman E,Bradshaw H,Hwang LL,Hung MS,Mackie K,Zimmer A,Chiou LC

    更新日期：2016-07-22 00:00:00

  • The Capsaspora genome reveals a complex unicellular prehistory of animals.

    abstract：:To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported to date. Here we completely sequence the genome of the filastere...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3325

    authors： Suga H,Chen Z,de Mendoza A,Sebé-Pedrós A,Brown MW,Kramer E,Carr M,Kerner P,Vervoort M,Sánchez-Pons N,Torruella G,Derelle R,Manning G,Lang BF,Russ C,Haas BJ,Roger AJ,Nusbaum C,Ruiz-Trillo I

    更新日期：2013-01-01 00:00:00

  • Silicon carbide-derived carbon nanocomposite as a substitute for mercury in the catalytic hydrochlorination of acetylene.

    abstract：:Acetylene hydrochlorination is an important coal-based technology for the industrial production of vinyl chloride, however it is plagued by the toxicity of the mercury chloride catalyst. Therefore extensive efforts have been made to explore alternative catalysts with various metals. Here we report that a nanocomposite...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4688

    authors： Li X,Pan X,Yu L,Ren P,Wu X,Sun L,Jiao F,Bao X

    更新日期：2014-04-22 00:00:00

  • Long-range ballistic transport of Brown-Zak fermions in graphene superlattices.

    abstract：:In quantizing magnetic fields, graphene superlattices exhibit a complex fractal spectrum often referred to as the Hofstadter butterfly. It can be viewed as a collection of Landau levels that arise from quantization of Brown-Zak minibands recurring at rational (p/q) fractions of the magnetic flux quantum per superlatti...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19604-0

    authors： Barrier J,Kumaravadivel P,Krishna Kumar R,Ponomarenko LA,Xin N,Holwill M,Mullan C,Kim M,Gorbachev RV,Thompson MD,Prance JR,Taniguchi T,Watanabe K,Grigorieva IV,Novoselov KS,Mishchenko A,Fal'ko VI,Geim AK,Berdyugin AI

    更新日期：2020-11-13 00:00:00

  • Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior.

    abstract：:There is increasing concern about potential long-term effects of antibiotics on children's health. Epidemiological studies have revealed that early-life antibiotic exposure can increase the risk of developing immune and metabolic diseases, and rodent studies have shown that administration of high doses of antibiotics ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15062

    authors： Leclercq S,Mian FM,Stanisz AM,Bindels LB,Cambier E,Ben-Amram H,Koren O,Forsythe P,Bienenstock J

    更新日期：2017-04-04 00:00:00

  • Tug-of-war between actomyosin-driven antagonistic forces determines the positioning symmetry in cell-sized confinement.

    abstract：:Symmetric or asymmetric positioning of intracellular structures including the nucleus and mitotic spindle steers various biological processes such as cell migration, division, and embryogenesis. In typical animal cells, both a sparse actomyosin meshwork in the cytoplasm and a dense actomyosin cortex underneath the cel...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16677-9

    authors： Sakamoto R,Tanabe M,Hiraiwa T,Suzuki K,Ishiwata S,Maeda YT,Miyazaki M

    更新日期：2020-06-15 00:00:00

  • Quantitative volumetric Raman imaging of three dimensional cell cultures.

    abstract：:The ability to simultaneously image multiple biomolecules in biologically relevant three-dimensional (3D) cell culture environments would contribute greatly to the understanding of complex cellular mechanisms and cell-material interactions. Here, we present a computational framework for label-free quantitative volumet...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14843

    authors： Kallepitis C,Bergholt MS,Mazo MM,Leonardo V,Skaalure SC,Maynard SA,Stevens MM

    更新日期：2017-03-22 00:00:00

  • Anomalous X-ray diffraction studies of ion transport in K+ channels.

    abstract：:Potassium ion channels utilize a highly selective filter to rapidly transport K+ ions across cellular membranes. This selectivity filter is composed of four binding sites which display almost equal electron density in crystal structures with high potassium ion concentrations. This electron density can be interpreted t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06957-w

    authors： Langan PS,Vandavasi VG,Weiss KL,Afonine PV,El Omari K,Duman R,Wagner A,Coates L

    更新日期：2018-10-31 00:00:00

  • Integrating an electrically active colloidal quantum dot photodiode with a graphene phototransistor.

    abstract：:The realization of low-cost photodetectors with high sensitivity, high quantum efficiency, high gain and fast photoresponse in the visible and short-wave infrared remains one of the challenges in optoelectronics. Two classes of photodetectors that have been developed are photodiodes and phototransistors, each of them ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11954

    authors： Nikitskiy I,Goossens S,Kufer D,Lasanta T,Navickaite G,Koppens FH,Konstantatos G

    更新日期：2016-06-17 00:00:00

  • Tuning charge-discharge induced unit cell breathing in layer-structured cathode materials for lithium-ion batteries.

    abstract：:For LiMO2 (M=Co, Ni, Mn) cathode materials, lattice parameters, a(b), contract during charge. Here we report such changes in opposite directions for lithium molybdenum trioxide (Li2MoO3). A 'unit cell breathing' mechanism is proposed based on crystal and electronic structural changes of transition metal oxides during ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6381

    authors： Zhou YN,Ma J,Hu E,Yu X,Gu L,Nam KW,Chen L,Wang Z,Yang XQ

    更新日期：2014-11-18 00:00:00

  • Author Correction: A standard for near-scarless plasmid construction using reusable DNA parts.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-019-11859-6

    authors： Ma X,Liang H,Cui X,Liu Y,Lu H,Ning W,Poon NY,Ho B,Zhou K

    更新日期：2019-08-21 00:00:00

  • A robust gene-stacking method utilizing yeast assembly for plant synthetic biology.

    abstract：:The advent and growth of synthetic biology has demonstrated its potential as a promising avenue of research to address many societal needs. However, plant synthetic biology efforts have been hampered by a dearth of DNA part libraries, versatile transformation vectors and efficient assembly strategies. Here, we describ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13215

    authors： Shih PM,Vuu K,Mansoori N,Ayad L,Louie KB,Bowen BP,Northen TR,Loqué D

    更新日期：2016-10-26 00:00:00

  • Quantifying exchange forces of a spin spiral on the atomic scale.

    abstract：:The large interest in chiral magnetic structures for realization of nanoscale magnetic storage or logic devices has necessitated methods which can quantify magnetic interactions at the atomic scale. To overcome the limitations of the typically used current-based sensing of atomic-scale exchange interactions, a force-b...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15024-2

    authors： Hauptmann N,Haldar S,Hung TC,Jolie W,Gutzeit M,Wegner D,Heinze S,Khajetoorians AA

    更新日期：2020-03-05 00:00:00

  • Auditory experience-dependent cortical circuit shaping for memory formation in bird song learning.

    abstract：:As in human speech acquisition, songbird vocal learning depends on early auditory experience. During development, juvenile songbirds listen to and form auditory memories of adult tutor songs, which they use to shape their own vocalizations in later sensorimotor learning. The higher-level auditory cortex, called the ca...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11946

    authors： Yanagihara S,Yazaki-Sugiyama Y

    更新日期：2016-06-21 00:00:00

  • Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection.

    abstract：:Central nervous system (CNS) injuries persist for years, and currently there are no therapeutics that can address the complex injury cascade that develops over this time-scale. 17β-estradiol (E2) has broad tropism within the CNS, targeting and inducing beneficial phenotypic changes in myriad cells following injury. To...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12835-w

    authors： D'Amato AR,Puhl DL,Ellman SAT,Balouch B,Gilbert RJ,Palermo EF

    更新日期：2019-10-23 00:00:00

  • Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.

    abstract：:Plasma membrane Ca2+-ATPases (PMCAs) are key regulators of global Ca2+ homeostasis and local intracellular Ca2+ dynamics. Recently, Neuroplastin (NPTN) and basigin were identified as previously unrecognized obligatory subunits of PMCAs that dramatically increase the efficiency of PMCA-mediated Ca2+ clearance. Here, we...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06075-7

    authors： Gong D,Chi X,Ren K,Huang G,Zhou G,Yan N,Lei J,Zhou Q

    更新日期：2018-09-06 00:00:00

  • Auditory sequence processing reveals evolutionarily conserved regions of frontal cortex in macaques and humans.

    abstract：:An evolutionary account of human language as a neurobiological system must distinguish between human-unique neurocognitive processes supporting language and evolutionarily conserved, domain-general processes that can be traced back to our primate ancestors. Neuroimaging studies across species may determine whether can...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9901

    authors： Wilson B,Kikuchi Y,Sun L,Hunter D,Dick F,Smith K,Thiele A,Griffiths TD,Marslen-Wilson WD,Petkov CI

    更新日期：2015-11-17 00:00:00

  • Durable and controlled depletion of neutrophils in mice.

    abstract：:Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective, transient or lack specificity. Here we report that neutrophil...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16596-9

    authors： Boivin G,Faget J,Ancey PB,Gkasti A,Mussard J,Engblom C,Pfirschke C,Contat C,Pascual J,Vazquez J,Bendriss-Vermare N,Caux C,Vozenin MC,Pittet MJ,Gunzer M,Meylan E

    更新日期：2020-06-02 00:00:00

  • Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells.

    abstract：:Type I interferon (IFN) is a key driver of immunity to infections and cancer. Plasmacytoid dendritic cells (pDCs) are uniquely equipped to produce large quantities of type I IFN but the mechanisms that control this process are poorly understood. Here we report on a droplet-based microfluidic platform to investigate ty...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05784-3

    authors： Wimmers F,Subedi N,van Buuringen N,Heister D,Vivié J,Beeren-Reinieren I,Woestenenk R,Dolstra H,Piruska A,Jacobs JFM,van Oudenaarden A,Figdor CG,Huck WTS,de Vries IJM,Tel J

    更新日期：2018-08-20 00:00:00

  • Emerging magnetic order in platinum atomic contacts and chains.

    abstract：:The development of atomic-scale structures revealing novel transport phenomena is a major goal of nanotechnology. Examples include chains of atoms that form while stretching a transition metal contact or the predicted formation of magnetic order in these chains, the existence of which is still debated. Here we report ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7172

    authors： Strigl F,Espy C,Bückle M,Scheer E,Pietsch T

    更新日期：2015-02-04 00:00:00

  • An intrinsic timer specifies distal structures of the vertebrate limb.

    abstract：:How the positional values along the proximo-distal axis (stylopod-zeugopod-autopod) of the limb are specified is intensely debated. Early work suggested that cells intrinsically change their proximo-distal positional values by measuring time. Recently, however, it is suggested that instructive extrinsic signals from t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9108

    authors： Saiz-Lopez P,Chinnaiya K,Campa VM,Delgado I,Ros MA,Towers M

    更新日期：2015-09-18 00:00:00