Structural basis for Ca2+-dependent activation of a plant metacaspase.

abstract：:Soil microorganisms dominate terrestrial biogeochemical cycles; however, we know very little about their spatial distribution and how changes in the distributions of specific groups of microbes translate into landscape and global patterns of biogeochemical processes. In this paper, we use a nested sampling scheme at s...

journal_title：Nature communications

authors： King AJ,Freeman KR,McCormick KF,Lynch RC,Lozupone C,Knight R,Schmidt SK

更新日期：2010-08-10 00:00:00

abstract：:A conspicuous 60° bend of the Hawaiian-Emperor Chain in the north-western Pacific Ocean has variously been interpreted as the result of an abrupt Pacific plate motion change in the Eocene (∼47 Ma), a rapid southward drift of the Hawaiian hotspot before the formation of the bend, or a combination of these two causes. P...

journal_title：Nature communications

authors： Torsvik TH,Doubrovine PV,Steinberger B,Gaina C,Spakman W,Domeier M

更新日期：2017-06-05 00:00:00

abstract：:Following uncontrolled proliferation, a subset of primary tumour cells acquires additional traits/mutations to trigger phenotypic changes that enhance migration and are hypothesized to be the initiators of metastasis. This study reveals an adaptive mechanism that harnesses synergistic paracrine signalling via IL-6/8, ...

journal_title：Nature communications

authors： Jayatilaka H,Tyle P,Chen JJ,Kwak M,Ju J,Kim HJ,Lee JSH,Wu PH,Gilkes DM,Fan R,Wirtz D

更新日期：2017-05-26 00:00:00

abstract：:The original version of this Article contained an error in the last sentence of the first paragraph of the Introduction and incorrectly read 'A proper electron beam control is one of the main challenges towards the Graal of developing a compact alternative of X-ray free-electron lasers by coupling LWFA gigaelectron-vo...

journal_title：Nature communications

authors： André T,Andriyash IA,Loulergue A,Labat M,Roussel E,Ghaith A,Khojoyan M,Thaury C,Valléau M,Briquez F,Marteau F,Tavakoli K,N'Gotta P,Dietrich Y,Lambert G,Malka V,Benabderrahmane C,Vétéran J,Chapuis L,El Ajjouri T,Se

更新日期：2018-05-02 00:00:00

abstract：:Common variable immunodeficiency disorder (CVID) is the most common symptomatic primary immunodeficiency in adults, characterized by B-cell abnormalities and inadequate antibody response. CVID patients have considerable autoimmune comorbidity and we therefore hypothesized that genetic susceptibility to CVID may overla...

journal_title：Nature communications

authors： Li J,Jørgensen SF,Maggadottir SM,Bakay M,Warnatz K,Glessner J,Pandey R,Salzer U,Schmidt RE,Perez E,Resnick E,Goldacker S,Buchta M,Witte T,Padyukov L,Videm V,Folseraas T,Atschekzei F,Elder JT,Nair RP,Winkelmann J,

更新日期：2015-04-20 00:00:00

abstract：:Cullin-RING ubiquitin ligases (CRLs) are critical in ubiquitinating Myc, while COP9 signalosome (CSN) controls neddylation of Cullin in CRL. The mechanistic link between Cullin neddylation and Myc ubiquitination/degradation is unclear. Here we show that Myc is a target of the CSN subunit 6 (CSN6)-Cullin signalling axi...

journal_title：Nature communications

authors： Chen J,Shin JH,Zhao R,Phan L,Wang H,Xue Y,Post SM,Ho Choi H,Chen JS,Wang E,Zhou Z,Tseng C,Gully C,Velazquez-Torres G,Fuentes-Mattei E,Yeung G,Qiao Y,Chou PC,Su CH,Hsieh YC,Hsu SL,Ohshiro K,Shaikenov T,Wang H

更新日期：2014-11-14 00:00:00

abstract：:Ultrasound sensors have wide applications across science and technology. However, improved sensitivity is required for both miniaturisation and increased spatial resolution. Here, we introduce cavity optomechanical ultrasound sensing, where dual optical and mechanical resonances enhance the ultrasound signal. We achie...

journal_title：Nature communications

authors： Basiri-Esfahani S,Armin A,Forstner S,Bowen WP

更新日期：2019-01-10 00:00:00

abstract：:To expand the toolbox of imaging in living cells, we have engineered a single-chain variable fragment binding the linear HA epitope with high affinity and specificity in vivo. The resulting probe, called the HA frankenbody, can light up in multiple colors HA-tagged nuclear, cytoplasmic, membrane, and mitochondrial pro...

journal_title：Nature communications

authors： Zhao N,Kamijo K,Fox PD,Oda H,Morisaki T,Sato Y,Kimura H,Stasevich TJ

更新日期：2019-07-03 00:00:00

abstract：:Carbon forms one of nature's strongest chemical bonds; its allotropes having provided some of the most exciting scientific discoveries in recent times. The possibility of inter-allotropic transformations/hybridization of carbon is hence a topic of immense fundamental and technological interest. Such modifications usua...

journal_title：Nature communications

authors： Jung HY,Araujo PT,Kim YL,Jung SM,Jia X,Hong S,Ahn CW,Kong J,Dresselhaus MS,Kar S,Jung YJ

更新日期：2014-09-15 00:00:00

abstract：:When a thin film of active, nematic microtubules and kinesin motor clusters is confined on the surface of a vesicle, four +1/2 topological defects oscillate in a periodic manner between tetrahedral and planar arrangements. Here a theoretical description of nematics, coupled to the relevant hydrodynamic equations, is p...

journal_title：Nature communications

authors： Zhang R,Zhou Y,Rahimi M,de Pablo JJ

更新日期：2016-11-21 00:00:00

abstract：:How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of th...

journal_title：Nature communications

authors： Helfrich RF,Lendner JD,Mander BA,Guillen H,Paff M,Mnatsakanyan L,Vadera S,Walker MP,Lin JJ,Knight RT

更新日期：2019-08-08 00:00:00

abstract：:Scaffolded DNA origami has proven to be a powerful and efficient technique to fabricate functional nanomachines by programming the folding of a single-stranded DNA template strand into three-dimensional (3D) nanostructures, designed to be precisely motion-controlled. Although two-dimensional (2D) imaging of DNA nanoma...

journal_title：Nature communications

authors： Lei D,Marras AE,Liu J,Huang CM,Zhou L,Castro CE,Su HJ,Ren G

更新日期：2018-02-09 00:00:00

abstract：:The cell division cycle requires tight coupling between protein phosphorylation and dephosphorylation. However, understanding the cell cycle roles of multimeric protein phosphatases has been limited by the lack of knowledge of how their diverse regulatory subunits target highly conserved catalytic subunits to their si...

journal_title：Nature communications

authors： Lipinszki Z,Lefevre S,Savoian MS,Singleton MR,Glover DM,Przewloka MR

更新日期：2015-01-06 00:00:00

abstract：:Complex oxide heterointerfaces and van der Waals heterostructures present two versatile but intrinsically different platforms for exploring emergent quantum phenomena and designing new functionalities. The rich opportunity offered by the synergy between these two classes of materials, however, is yet to be charted. He...

journal_title：Nature communications

authors： Li D,Huang X,Xiao Z,Chen H,Zhang L,Hao Y,Song J,Shao DF,Tsymbal EY,Lu Y,Hong X

更新日期：2020-03-17 00:00:00

abstract：:Horizontal gene transfer is a major contributor to the evolution of bacterial genomes and can facilitate the dissemination of antibiotic resistance genes between environmental reservoirs and potential pathogens. Wastewater treatment plants (WWTPs) are believed to play a central role in the dissemination of antibiotic ...

journal_title：Nature communications

authors： Munck C,Albertsen M,Telke A,Ellabaan M,Nielsen PH,Sommer MOA

更新日期：2015-09-30 00:00:00

abstract：:Mitochondrial complex I (CI) deficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease. This heterogeneous group of diseases includes serious or fatal neurological presentations such as Leigh syndrome and there are very limited evidence-based treatment options available. Here...

journal_title：Nature communications

authors： Ehinger JK,Piel S,Ford R,Karlsson M,Sjövall F,Frostner EÅ,Morota S,Taylor RW,Turnbull DM,Cornell C,Moss SJ,Metzsch C,Hansson MJ,Fliri H,Elmér E

更新日期：2016-08-09 00:00:00

abstract：:Anthropogenic CO2 emissions are causing ocean acidification, which can affect the physiology of marine organisms. Here we assess the possible effects of ocean acidification on the metabolic potential of sponge symbionts, inferred by metagenomic analyses of the microbiomes of two sponge species sampled at a shallow vol...

journal_title：Nature communications

authors： Botté ES,Nielsen S,Abdul Wahab MA,Webster J,Robbins S,Thomas T,Webster NS

更新日期：2019-09-12 00:00:00

abstract：:Cytosolic HSP90 requires multiple cochaperones in folding client proteins. However, the function of gp96 (HSP90b1, grp94), an HSP90 paralogue in the endoplasmic reticulum (ER), is believed to be independent of cochaperones. Here, we demonstrate that gp96 chaperones multiple Toll-like receptors (TLRs), but not TLR3, in...

journal_title：Nature communications

authors： Liu B,Yang Y,Qiu Z,Staron M,Hong F,Li Y,Wu S,Li Y,Hao B,Bona R,Han D,Li Z

更新日期：2010-09-21 00:00:00

abstract：:Skill learning is instantiated by changes to functional connectivity within premotor circuits, but whether the specificity of learning depends on structured changes to inhibitory circuitry remains unclear. We used slice electrophysiology to measure connectivity changes associated with song learning in the avian analog...

journal_title：Nature communications

authors： Miller MN,Cheung CYJ,Brainard MS

更新日期：2017-12-13 00:00:00

abstract：:Elevated glucose consumption is fundamental to cancer, but selectively targeting this pathway is challenging. We develop a high-throughput assay for measuring glucose consumption and use it to screen non-small-cell lung cancer cell lines against bioactive small molecules. We identify Milciclib that blocks glucose cons...

journal_title：Nature communications

authors： Ghezzi C,Wong A,Chen BY,Ribalet B,Damoiseaux R,Clark PM

更新日期：2019-11-29 00:00:00

abstract：:Eurasian continent has experienced cold winters over the past two decades in contrast with Arctic warming. Previous studies have suggested that the cold Eurasian winters are associated with Arctic sea-ice loss, while others attributed them to atmospheric internal variability. However, here we show that the Arctic and ...

journal_title：Nature communications

authors： Matsumura S,Kosaka Y

更新日期：2019-08-01 00:00:00

abstract：:Fullerene peapods, which are carbon nanotubes encapsulating fullerene molecules, can offer enhanced functionality with respect to empty nanotubes. Their prospective applications include, for example, data storage devices, single-electron transistors and spin-qubit arrays for quantum computing. However, the present inc...

journal_title：Nature communications

authors： Utko P,Ferone R,Krive IV,Shekhter RI,Jonson M,Monthioux M,Noé L,Nygård J

更新日期：2010-07-13 00:00:00

abstract：:The degradation of intrinsic properties of graphene during the transfer process constitutes a major challenge in graphene device fabrication, stimulating the need for direct growth of graphene on dielectric substrates. Previous attempts of metal-induced transformation of diamond and silicon carbide into graphene suffe...

journal_title：Nature communications

authors： Berman D,Deshmukh SA,Narayanan B,Sankaranarayanan SK,Yan Z,Balandin AA,Zinovev A,Rosenmann D,Sumant AV

更新日期：2016-07-04 00:00:00

abstract：:Ultra-small, magic-sized metal nanoclusters represent an important new class of materials with properties between molecules and particles. However, their small size challenges the conventional methods for structure characterization. Here we present the structure of ultra-stable Au144(SR)60 magic-sized nanoclusters obt...

journal_title：Nature communications

authors： Jensen KM,Juhas P,Tofanelli MA,Heinecke CL,Vaughan G,Ackerson CJ,Billinge SJ

更新日期：2016-06-14 00:00:00

abstract：:Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated translation is unknown. Here we show that reduction of insulin-regulated translation in mice heterozygous f...

journal_title：Nature communications

authors： Brina D,Miluzio A,Ricciardi S,Clarke K,Davidsen PK,Viero G,Tebaldi T,Offenhäuser N,Rozman J,Rathkolb B,Neschen S,Klingenspor M,Wolf E,Gailus-Durner V,Fuchs H,Hrabe de Angelis M,Quattrone A,Falciani F,Biffo S

更新日期：2015-09-18 00:00:00

abstract：:Topological superconductor is attracting growing interest for its potential application to topological quantum computation. The superconducting proximity effect on the topological insulator surface state is one promising way to yield topological superconductivity. The superconductivity realized at the interface betwee...

journal_title：Nature communications

authors： Yasuda K,Yasuda H,Liang T,Yoshimi R,Tsukazaki A,Takahashi KS,Nagaosa N,Kawasaki M,Tokura Y

更新日期：2019-06-21 00:00:00

abstract：:The excellent mechanical properties of carbon nanofibers bring promise for energy-related applications. Through in silico studies and continuum elasticity theory, here we show that the ultra-thin carbon nanothreads-based bundles exhibit a high mechanical energy storage density. Specifically, the gravimetric energy den...

journal_title：Nature communications

authors： Zhan H,Zhang G,Bell JM,Tan VBC,Gu Y

更新日期：2020-04-20 00:00:00

abstract：:To function, biomolecules require sufficient specificity of interaction as well as stability to live in the cell while still being able to move. Thermodynamic stability of only a limited number of specific structures is important so as to prevent promiscuous interactions. The individual interactions in proteins, there...

journal_title：Nature communications

authors： Chen M,Chen X,Schafer NP,Clementi C,Komives EA,Ferreiro DU,Wolynes PG

更新日期：2020-11-23 00:00:00

abstract：:Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we sho...

journal_title：Nature communications

authors： Liu T,Song T,Zhang X,Yuan H,Su L,Li W,Xu J,Liu S,Chen L,Chen T,Zhang M,Gu L,Zhang B,Dou D

更新日期：2014-08-26 00:00:00

abstract：:D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent of the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose metabolism that a...

journal_title：Nature communications

authors： Weimer S,Priebs J,Kuhlow D,Groth M,Priebe S,Mansfeld J,Merry TL,Dubuis S,Laube B,Pfeiffer AF,Schulz TJ,Guthke R,Platzer M,Zamboni N,Zarse K,Ristow M

更新日期：2014-04-08 00:00:00