Abstract:
:How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of these cardinal sleep oscillations is organized to support information reactivation and transfer. Here, using human intracranial recordings, we demonstrate that the prefrontal cortex plays a key role in organizing the ripple-mediated information transfer during non-rapid eye movement (NREM) sleep. We reveal a temporally precise form of coupling between prefrontal slow-wave and spindle oscillations, which actively dictates the hippocampal-neocortical dialogue and information transfer. Our results suggest a model of the human sleeping brain in which rapid bidirectional interactions, triggered by the prefrontal cortex, mediate hippocampal activation to optimally time subsequent information transfer to the neocortex during NREM sleep.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Helfrich RF,Lendner JD,Mander BA,Guillen H,Paff M,Mnatsakanyan L,Vadera S,Walker MP,Lin JJ,Knight RTdoi
10.1038/s41467-019-11444-xsubject
Has Abstractpub_date
2019-08-08 00:00:00pages
3572issue
1issn
2041-1723pii
10.1038/s41467-019-11444-xjournal_volume
10pub_type
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