Arctic-Eurasian climate linkage induced by tropical ocean variability.

abstract：:SARS-CoV-2 infection is characterized by peak viral load in the upper airway prior to or at the time of symptom onset, an unusual feature that has enabled widespread transmission of the virus and precipitated a global pandemic. How SARS-CoV-2 is able to achieve high titer in the absence of symptoms remains unclear. He...

journal_title：Nature communications

authors： Mick E,Kamm J,Pisco AO,Ratnasiri K,Babik JM,Castañeda G,DeRisi JL,Detweiler AM,Hao SL,Kangelaris KN,Kumar GR,Li LM,Mann SA,Neff N,Prasad PA,Serpa PH,Shah SJ,Spottiswoode N,Tan M,Calfee CS,Christenson SA,Kistler

更新日期：2020-11-17 00:00:00

abstract：:The Clp protease complex degrades a multitude of substrates, which are engaged by a AAA+ chaperone such as ClpX and subsequently digested by the dynamic, barrel-shaped ClpP protease. Acyldepsipeptides (ADEPs) are natural product-derived antibiotics that activate ClpP for chaperone-independent protein digestion. Here w...

journal_title：Nature communications

authors： Gersch M,Famulla K,Dahmen M,Göbl C,Malik I,Richter K,Korotkov VS,Sass P,Rübsamen-Schaeff H,Madl T,Brötz-Oesterhelt H,Sieber SA

更新日期：2015-02-19 00:00:00

abstract：:Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide association study (180 cases, 2677 controls) and replication analysis of NTS bacteraemia in Keny...

journal_title：Nature communications

authors： Gilchrist JJ,Rautanen A,Fairfax BP,Mills TC,Naranbhai V,Trochet H,Pirinen M,Muthumbi E,Mwarumba S,Njuguna P,Mturi N,Msefula CL,Gondwe EN,MacLennan JM,Chapman SJ,Molyneux ME,Knight JC,Spencer CCA,Williams TN,MacLenna

更新日期：2018-03-09 00:00:00

abstract：:The evolution of the seawater oxygen isotopic composition (δ18O) through geological time remains controversial. Yet, the past δ18Oseawater is key to assess past seawater temperatures, providing insights into past climate change and life evolution. Here we provide a new and unprecedentedly precise δ18O value of -1.33 ±...

journal_title：Nature communications

authors： Hodel F,Macouin M,Trindade RIF,Triantafyllou A,Ganne J,Chavagnac V,Berger J,Rospabé M,Destrigneville C,Carlut J,Ennih N,Agrinier P

更新日期：2018-04-13 00:00:00

abstract：:A recent review concluded that earthworm presence increases CO₂ emissions by 33% but does not affect soil organic carbon stocks. However, the findings are controversial and raise new questions. Here we hypothesize that neither an increase in CO₂ emission nor in stabilized carbon would entirely reflect the earthworms' ...

journal_title：Nature communications

authors： Zhang W,Hendrix PF,Dame LE,Burke RA,Wu J,Neher DA,Li J,Shao Y,Fu S

更新日期：2013-01-01 00:00:00

abstract：:Human intestinal bacteria produce butyrate, which has signalling properties and can be used as energy source by enterocytes thus influencing colonic health. However, the pathways and the identity of bacteria involved in this process remain unclear. Here we describe the isolation from the human intestine of Intestinimo...

journal_title：Nature communications

authors： Bui TP,Ritari J,Boeren S,de Waard P,Plugge CM,de Vos WM

更新日期：2015-12-01 00:00:00

abstract：:The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 enzyme Ube2N/Ube2V2....

journal_title：Nature communications

authors： Kiss L,Zeng J,Dickson CF,Mallery DL,Yang JC,McLaughlin SH,Boland A,Neuhaus D,James LC

更新日期：2019-10-03 00:00:00

abstract：:The transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced in Mafb-deficient macrophages. Here, we show the expression of the first protein in the classical comp...

journal_title：Nature communications

authors： Tran MTN,Hamada M,Jeon H,Shiraishi R,Asano K,Hattori M,Nakamura M,Imamura Y,Tsunakawa Y,Fujii R,Usui T,Kulathunga K,Andrea CS,Koshida R,Kamei R,Matsunaga Y,Kobayashi M,Oishi H,Kudo T,Takahashi S

更新日期：2017-11-22 00:00:00

abstract：:The c-Jun/AP-1 transcription factor controls key cellular behaviours, including proliferation and apoptosis, in response to JNK and Ras/MAPK signalling. While the JNK pathway has been well characterized, the mechanism of activation by Ras was elusive. Here we identify the uncharacterized ubiquitin ligase Trim7 as a cr...

journal_title：Nature communications

authors： Chakraborty A,Diefenbacher ME,Mylona A,Kassel O,Behrens A

更新日期：2015-04-08 00:00:00

abstract：:Photovoltaic devices based on metal halide perovskites are rapidly improving in efficiency. Once the Shockley-Queisser limit is reached, charge-carrier extraction will be limited only by radiative bimolecular recombination of electrons with holes. Yet, this fundamental process, and its link with material stoichiometry...

journal_title：Nature communications

authors： Davies CL,Filip MR,Patel JB,Crothers TW,Verdi C,Wright AD,Milot RL,Giustino F,Johnston MB,Herz LM

更新日期：2018-01-18 00:00:00

abstract：:Classic, model-based theory of land-atmosphere interactions across the Sahel promote positive vegetation-rainfall feedbacks dominated by surface albedo mechanism. However, neither the proposed positive vegetation-rainfall feedback nor its underlying albedo mechanism has been convincingly demonstrated using observation...

journal_title：Nature communications

authors： Yu Y,Notaro M,Wang F,Mao J,Shi X,Wei Y

更新日期：2017-11-30 00:00:00

abstract：:Electric gating can strongly modulate a wide variety of physical properties in semiconductors and insulators, such as significant changes of conductivity in silicon, appearance of superconductivity in SrTiO3, the paramagnet-ferromagnet transition in (In,Mn)As, and so on. The key to such modulation is charge accumulati...

journal_title：Nature communications

authors： Dushenko S,Hokazono M,Nakamura K,Ando Y,Shinjo T,Shiraishi M

更新日期：2018-08-07 00:00:00

abstract：:Grains and glasses, widely different materials, arrest their motions upon decreasing temperature and external load, respectively, in common ways, leading to a universal jamming phase diagram conjecture. However, unified theories are lacking, mainly because of the disparate nature of the particle interactions. Here we ...

journal_title：Nature communications

authors： Jose PP,Andricioaei I

更新日期：2012-01-01 00:00:00

abstract：:Type 2 diabetes (T2D) results from the combined effects of genetic and environmental factors on multiple tissues over time. Of the >100 variants associated with T2D and related traits in genome-wide association studies (GWAS), >90% occur in non-coding regions, suggesting a strong regulatory component to T2D risk. Here...

journal_title：Nature communications

authors： Scott LJ,Erdos MR,Huyghe JR,Welch RP,Beck AT,Wolford BN,Chines PS,Didion JP,Narisu N,Stringham HM,Taylor DL,Jackson AU,Vadlamudi S,Bonnycastle LL,Kinnunen L,Saramies J,Sundvall J,Albanus RD,Kiseleva A,Hensley J,Cr

更新日期：2016-06-29 00:00:00

abstract：:During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting mechanical tension. In this context, it is unclear how mechanica...

journal_title：Nature communications

authors： Kale GR,Yang X,Philippe JM,Mani M,Lenne PF,Lecuit T

更新日期：2018-11-27 00:00:00

abstract：:At the initial stage of carcinogenesis single mutated cells appear within an epithelium. Mammalian in vitro experiments show that potentially cancerous cells undergo live apical extrusion from normal monolayers. However, the mechanism underlying this process in vivo remains poorly understood. Mosaic expression of the ...

journal_title：Nature communications

authors： Anton KA,Kajita M,Narumi R,Fujita Y,Tada M

更新日期：2018-11-08 00:00:00

abstract：:Sedimentary rocks are the archives of environmental conditions and ancient planetary surface processes that led to their formation. Reconstructions of Earth's past surface behaviour from the physical sedimentary record remain controversial, however, in part because we lack a quantitative framework to deconvolve intern...

journal_title：Nature communications

authors： Ganti V,Lamb MP,McElroy B

更新日期：2014-02-28 00:00:00

abstract：:A short half-life in the circulation limits the application of therapeutics such as single-domain antibodies (VHHs). We utilize red blood cells to prolong the circulatory half-life of VHHs. Here we present VHHs against botulinum neurotoxin A (BoNT/A) on the surface of red blood cells by expressing chimeric proteins of...

journal_title：Nature communications

authors： Huang NJ,Pishesha N,Mukherjee J,Zhang S,Deshycka R,Sudaryo V,Dong M,Shoemaker CB,Lodish HF

更新日期：2017-09-04 00:00:00

abstract：:Abnormal cancer antioxidant capacity is considered as a potential mechanism of tumor malignancy. Modulation of oxidative stress status is emerging as an anti-cancer treatment. Our previous studies have found that Nestin-knockdown cells were more sensitive to oxidative stress in non-small cell lung cancer (NSCLC). Howe...

journal_title：Nature communications

authors： Wang J,Lu Q,Cai J,Wang Y,Lai X,Qiu Y,Huang Y,Ke Q,Zhang Y,Guan Y,Wu H,Wang Y,Liu X,Shi Y,Zhang K,Wang M,Peng Xiang A

更新日期：2019-11-06 00:00:00

abstract：:Many volcanoes erupt compositionally homogeneous magmas over timescales ranging from decades to millennia. This monotonous activity is thought to reflect a high degree of chemical homogeneity in their magmatic systems, leading to predictable eruptive behaviour. We combine petrological analyses of erupted crystals with...

journal_title：Nature communications

authors： Stock MJ,Geist D,Neave DA,Gleeson MLM,Bernard B,Howard KA,Buisman I,Maclennan J

更新日期：2020-07-28 00:00:00

abstract：:Oxygen vacancies, especially their distribution, are directly coupled to the electromagnetic properties of oxides and related emergent functionalities that have implications for device applications. Here using a homoepitaxial strontium titanate thin film, we demonstrate a controlled manipulation of the oxygen vacancy ...

journal_title：Nature communications

authors： Das S,Wang B,Cao Y,Rae Cho M,Jae Shin Y,Mo Yang S,Wang L,Kim M,Kalinin SV,Chen LQ,Noh TW

更新日期：2017-09-20 00:00:00

abstract：:Selected groups of peptides, including those that are presented by major histocompatibility complex (MHC) proteins, have been proposed to transmit information to the olfactory system of vertebrates via their ability to stimulate chemosensory neurons. However, the lack of knowledge about such peptides in natural source...

journal_title：Nature communications

authors： Sturm T,Leinders-Zufall T,Maček B,Walzer M,Jung S,Pömmerl B,Stevanović S,Zufall F,Overath P,Rammensee HG

更新日期：2013-01-01 00:00:00

abstract：:Biodegradable polyesters with various tacticities have been synthesized by means of stereoselective ring-opening polymerization of racemic lactide and β-lactones but with limited side-chain groups. However, stereoselective synthesis of functional polyesters remains challenging from O-carboxyanhydrides that have abunda...

journal_title：Nature communications

authors： Feng Q,Yang L,Zhong Y,Guo D,Liu G,Xie L,Huang W,Tong R

更新日期：2018-04-19 00:00:00

abstract：:The extent and importance of endogenous viral elements have been extensively described in animals but are much less well understood in plants. Here we describe a new genus of Caulimoviridae called 'Florendovirus', members of which have colonized the genomes of a large diversity of flowering plants, sometimes at very h...

journal_title：Nature communications

authors： Geering AD,Maumus F,Copetti D,Choisne N,Zwickl DJ,Zytnicki M,McTaggart AR,Scalabrin S,Vezzulli S,Wing RA,Quesneville H,Teycheney PY

更新日期：2014-11-10 00:00:00

abstract：:Macrophages are a major immune cell type infiltrating tumors and promoting tumor growth and metastasis. To elucidate the mechanism of macrophage recruitment, we utilize an overgrowth tumor model ("undead" model) in larval Drosophila imaginal discs that are attached by numerous macrophages. Here we report that changes ...

journal_title：Nature communications

authors： Diwanji N,Bergmann A

更新日期：2020-07-20 00:00:00

abstract：:Even a single-component liquid may have more than two liquid states. The transition between them is called a 'liquid-liquid transition' (LLT). Such LLTs have recently attracted considerable attention mainly because of the fundamental interest in the physical origin of this counter-intuitive phenomenon. In this study, ...

journal_title：Nature communications

authors： Murata K,Tanaka H

更新日期：2010-05-04 00:00:00

abstract：:The cycling of carbon between Earth's surface and interior governs the long-term habitability of the planet. But how carbon migrates in the deep Earth is not well understood. In particular, the potential role of hydrocarbon fluids in the deep carbon cycle has long been controversial. Here we show that immiscible isobu...

journal_title：Nature communications

authors： Huang F,Daniel I,Cardon H,Montagnac G,Sverjensky DA

更新日期：2017-06-12 00:00:00

abstract：:The advent of super-resolution imaging (SRI) has created a need for optimized labelling strategies. We present a new method relying on fluorophore-conjugated monomeric streptavidin (mSA) to label membrane proteins carrying a short, enzymatically biotinylated tag, compatible with SRI techniques including uPAINT, STED a...

journal_title：Nature communications

authors： Chamma I,Letellier M,Butler C,Tessier B,Lim KH,Gauthereau I,Choquet D,Sibarita JB,Park S,Sainlos M,Thoumine O

更新日期：2016-03-16 00:00:00

abstract：:The striking diversity of bird beak shapes is an outcome of natural selection, yet the relative importance of the limitations imposed by the process of beak development on generating such variation is unclear. Untangling these factors requires mapping developmental mechanisms over a phylogeny far exceeding model syste...

journal_title：Nature communications

authors： Fritz JA,Brancale J,Tokita M,Burns KJ,Hawkins MB,Abzhanov A,Brenner MP

更新日期：2014-04-16 00:00:00

abstract：:Covalent organic frameworks (COFs) have emerged as a promising light-harvesting module for artificial photosynthesis and photovoltaics. For efficient generation of free charge carriers, the donor-acceptor (D-A) conjugation has been adopted for two-dimensional (2D) COFs recently. In the 2D D-A COFs, photoexcitation wou...

journal_title：Nature communications

authors： Kim TW,Jun S,Ha Y,Yadav RK,Kumar A,Yoo CY,Oh I,Lim HK,Shin JW,Ryoo R,Kim H,Kim J,Baeg JO,Ihee H

更新日期：2019-04-23 00:00:00