Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms.

abstract：:Laryngeal squamous cell carcinoma is a frequent and significant cause of morbidity and mortality. Here we explore the biological basis of this aggressive tumour, and identify two cell-cell adhesion genes as recurrently mutated in this malignancy. We first perform exome sequencing of four laryngeal carcinomas and their...

journal_title：Nature communications

authors： Fanjul-Fernández M,Quesada V,Cabanillas R,Cadiñanos J,Fontanil T,Obaya A,Ramsay AJ,Llorente JL,Astudillo A,Cal S,López-Otín C

更新日期：2013-01-01 00:00:00

abstract：:FinO-domain proteins are a widespread family of bacterial RNA-binding proteins with regulatory functions. Their target spectrum ranges from a single RNA pair, in the case of plasmid-encoded FinO, to global RNA regulons, as with enterobacterial ProQ. To assess whether the FinO domain itself is intrinsically selective o...

journal_title：Nature communications

authors： Bauriedl S,Gerovac M,Heidrich N,Bischler T,Barquist L,Vogel J,Schoen C

更新日期：2020-06-04 00:00:00

abstract：:Culturing microorganisms is a critical step in understanding and utilizing microbial life. Here we map the landscape of existing culture media by extracting natural-language media recipes into a Known Media Database (KOMODO), which includes >18,000 strain-media combinations, >3300 media variants and compound concentra...

journal_title：Nature communications

authors： Oberhardt MA,Zarecki R,Gronow S,Lang E,Klenk HP,Gophna U,Ruppin E

更新日期：2015-10-13 00:00:00

abstract：:Centrosome number is tightly controlled during the cell cycle to ensure proper spindle assembly and cell division. However, the underlying mechanism that controls centrosome number remains largely unclear. We show herein that the DNA replication licensing factor Cdc6 is recruited to the proximal side of the centrioles...

journal_title：Nature communications

authors： Xu X,Huang S,Zhang B,Huang F,Chi W,Fu J,Wang G,Li S,Jiang Q,Zhang C

更新日期：2017-04-27 00:00:00

abstract：:The fate of the enormous amount of reactive nitrogen released to the environment by human activities in India is unknown. Here we show occurrence of seasonal stratification and generally low concentrations of dissolved inorganic combined nitrogen, and high molecular nitrogen (N2) to argon ratio, thus suggesting season...

journal_title：Nature communications

authors： Naqvi SWA,Lam P,Narvenkar G,Sarkar A,Naik H,Pratihary A,Shenoy DM,Gauns M,Kurian S,Damare S,Duret M,Lavik G,Kuypers MMM

更新日期：2018-03-28 00:00:00

abstract：:DNA methylation plays important roles in prokaryotes, and their genomic landscapes-prokaryotic epigenomes-have recently begun to be disclosed. However, our knowledge of prokaryotic methylation systems is focused on those of culturable microbes, which are rare in nature. Here, we used single-molecule real-time and circ...

journal_title：Nature communications

authors： Hiraoka S,Okazaki Y,Anda M,Toyoda A,Nakano SI,Iwasaki W

更新日期：2019-01-11 00:00:00

abstract：:Medulloblastoma (MB) is the most common malignant brain tumor in children and among the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient-specific screen leading to the identification of Otx2 and c-MYC as strong Group 3 MB inducers. We validated our findings in human cerebellar organoids...

journal_title：Nature communications

authors： Ballabio C,Anderle M,Gianesello M,Lago C,Miele E,Cardano M,Aiello G,Piazza S,Caron D,Gianno F,Ciolfi A,Pedace L,Mastronuzzi A,Tartaglia M,Locatelli F,Ferretti E,Giangaspero F,Tiberi L

更新日期：2020-01-29 00:00:00

abstract：:Intentional doping is the core of semiconductor technologies to tune electrical and optical properties of semiconductors for electronic devices, however, it has shown to be a grand challenge for halide perovskites. Here, we show that some metal ions, such as silver, strontium, cerium ions, which exist in the precursor...

journal_title：Nature communications

authors： Lin Y,Shao Y,Dai J,Li T,Liu Y,Dai X,Xiao X,Deng Y,Gruverman A,Zeng XC,Huang J

更新日期：2021-01-04 00:00:00

abstract：:MicroRNAs (miRNAs) are critical to somatic cell reprogramming into induced pluripotent stem cells (iPSCs), however, exactly how miRNA expression changes support the transition to pluripotency requires further investigation. Here we use a murine secondary reprogramming system to sample cellular trajectories towards iPS...

journal_title：Nature communications

authors： Clancy JL,Patel HR,Hussein SM,Tonge PD,Cloonan N,Corso AJ,Li M,Lee DS,Shin JY,Wong JJ,Bailey CG,Benevento M,Munoz J,Chuah A,Wood D,Rasko JE,Heck AJ,Grimmond SM,Rogers IM,Seo JS,Wells CA,Puri MC,Nagy A,Preiss

更新日期：2014-12-10 00:00:00

abstract：:Sedimentary rocks are the archives of environmental conditions and ancient planetary surface processes that led to their formation. Reconstructions of Earth's past surface behaviour from the physical sedimentary record remain controversial, however, in part because we lack a quantitative framework to deconvolve intern...

journal_title：Nature communications

authors： Ganti V,Lamb MP,McElroy B

更新日期：2014-02-28 00:00:00

abstract：:Protein expression evolves under greater evolutionary constraint than mRNA levels, and translation efficiency represents a primary determinant of protein levels during stimuli adaptation. This raises the question as to the translatome remodelers that titrate protein output from mRNA populations. Here, we uncover a net...

journal_title：Nature communications

authors： Ho JJD,Balukoff NC,Theodoridis PR,Wang M,Krieger JR,Schatz JH,Lee S

更新日期：2020-05-29 00:00:00

abstract：:Break-induced replication (BIR) is a DNA double-strand break repair pathway that leads to genomic instabilities similar to those observed in cancer. BIR proceeds by a migrating bubble where asynchrony between leading and lagging strand synthesis leads to accumulation of long single-stranded DNA (ssDNA). It remains unk...

journal_title：Nature communications

authors： Elango R,Sheng Z,Jackson J,DeCata J,Ibrahim Y,Pham NT,Liang DH,Sakofsky CJ,Vindigni A,Lobachev KS,Ira G,Malkova A

更新日期：2017-11-27 00:00:00

abstract：:The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early ...

journal_title：Nature communications

authors： Marissal T,Bonifazi P,Picardo MA,Nardou R,Petit LF,Baude A,Fishell GJ,Ben-Ari Y,Cossart R

更新日期：2012-01-01 00:00:00

abstract：:In two-dimensional interfacial assemblies, there is an interplay between molecular ordering and interface geometry, which determines the final morphology and order of entire systems. Here we present the interfacial phenomenon of spontaneous facet formation in a water droplet driven by designed peptide assembly. The id...

journal_title：Nature communications

authors： Jang HS,Lee JH,Park YS,Kim YO,Park J,Yang TY,Jin K,Lee J,Park S,You JM,Jeong KW,Shin A,Oh IS,Kwon MK,Kim YI,Cho HH,Han HN,Kim Y,Chang YH,Paik SR,Nam KT,Lee YS

更新日期：2014-04-11 00:00:00

abstract：:Under pathophysiological conditions in adults, endothelial cells (ECs) sprout from pre-existing blood vessels to form new ones by a process termed angiogenesis. During embryonic development, Apelin (APLN) is robustly expressed in vascular ECs. In adult mice, however, APLN expression in the vasculature is significantly...

journal_title：Nature communications

authors： Liu Q,Hu T,He L,Huang X,Tian X,Zhang H,He L,Pu W,Zhang L,Sun H,Fang J,Yu Y,Duan S,Hu C,Hui L,Zhang H,Quertermous T,Xu Q,Red-Horse K,Wythe JD,Zhou B

更新日期：2015-01-19 00:00:00

abstract：:Graphene nanoscrolls are Archimedean-type spirals formed by rolling single-layer graphene sheets. Their unique structure makes them conceptually interesting and understanding their formation gives important information on the manipulation and characteristics of various carbon nanostructures. Here we report a 100% effi...

journal_title：Nature communications

authors： Sharifi T,Gracia-Espino E,Barzegar HR,Jia X,Nitze F,Hu G,Nordblad P,Tai CW,Wågberg T

更新日期：2013-01-01 00:00:00

abstract：:We have determined the cryo-electron microscopic (cryo-EM) structures of two archaeal type IV pili (T4P), from Pyrobaculum arsenaticum and Saccharolobus solfataricus, at 3.8 Å and 3.4 Å resolution, respectively. This triples the number of high resolution archaeal T4P structures, and allows us to pinpoint the evolution...

journal_title：Nature communications

authors： Wang F,Baquero DP,Su Z,Beltran LC,Prangishvili D,Krupovic M,Egelman EH

更新日期：2020-07-09 00:00:00

abstract：:Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific metabolic changes remains unclear. Here we show, using the comprehensive measurement of metabolic enzymes by large-scale targeted proteomics, that the metabolism both carbon and nitrogen is altered during the malignant progression of ...

journal_title：Nature communications

authors： Kodama M,Oshikawa K,Shimizu H,Yoshioka S,Takahashi M,Izumi Y,Bamba T,Tateishi C,Tomonaga T,Matsumoto M,Nakayama KI

更新日期：2020-03-17 00:00:00

abstract：:Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain st...

journal_title：Nature communications

authors： Bittner N,Jockwitz C,Mühleisen TW,Hoffstaedter F,Eickhoff SB,Moebus S,Bayen UJ,Cichon S,Zilles K,Amunts K,Caspers S

更新日期：2019-02-06 00:00:00

abstract：:Planar neural networks and interfaces serve as versatile in vitro models of central nervous system physiology, but adaptations of related methods to three dimensions (3D) have met with limited success. Here, we demonstrate for the first time volumetric functional imaging in a bioengineered neural tissue growing in a t...

journal_title：Nature communications

authors： Dana H,Marom A,Paluch S,Dvorkin R,Brosh I,Shoham S

更新日期：2014-06-05 00:00:00

abstract：:The charge density wave in the high-temperature superconductor YBa2Cu3O7-x (YBCO) has two different ordering tendencies differentiated by their c-axis correlations. These correspond to ferro- (F-CDW) and antiferro- (AF-CDW) couplings between CDWs in neighbouring CuO2 bilayers. This discovery has prompted several funda...

journal_title：Nature communications

authors： Choi J,Ivashko O,Blackburn E,Liang R,Bonn DA,Hardy WN,Holmes AT,Christensen NB,Hücker M,Gerber S,Gutowski O,Rütt U,Zimmermann MV,Forgan EM,Hayden SM,Chang J

更新日期：2020-02-20 00:00:00

abstract：:Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically and industrially important compounds, and are often clustered on chromosomes. Here, we study genomic clustering in the benzylisoquinoline alkaloid (BIA) pathway in opium poppy (Papaver somniferum), exploring relationships between g...

journal_title：Nature communications

authors： Li Q,Ramasamy S,Singh P,Hagel JM,Dunemann SM,Chen X,Chen R,Yu L,Tucker JE,Facchini PJ,Yeaman S

更新日期：2020-03-04 00:00:00

abstract：:Chromosomal rearrangements are essential events in the pathogenesis of both malignant and nonmalignant disorders, yet the factors affecting their formation are incompletely understood. Here we develop a zinc-finger nuclease translocation reporter and screen for factors that modulate rearrangements in human cells. We i...

journal_title：Nature communications

authors： Day TA,Layer JV,Cleary JP,Guha S,Stevenson KE,Tivey T,Kim S,Schinzel AC,Izzo F,Doench J,Root DE,Hahn WC,Price BD,Weinstock DM

更新日期：2017-04-27 00:00:00

abstract：:In the original version of this Article, Supplementary Table 10 contained incorrect primer sequences for the mobility shift assay for SNP rs4776984. These errors have now been fixed and the corrected version of the Supplementary Information PDF is available to download from the HTML version of the Article. ...

journal_title：Nature communications

authors： Pan DZ,Garske KM,Alvarez M,Bhagat YV,Boocock J,Nikkola E,Miao Z,Raulerson CK,Cantor RM,Civelek M,Glastonbury CA,Small KS,Boehnke M,Lusis AJ,Sinsheimer JS,Mohlke KL,Laakso M,Pajukanta P,Ko A

更新日期：2018-08-22 00:00:00

abstract：:The recent levelling of global mean temperatures after the late 1990s, the so-called global warming hiatus or slowdown, ignited a surge of scientific interest into natural global mean surface temperature variability, observed temperature biases, and climate communication, but many questions remain about how these find...

journal_title：Nature communications

authors： Johnson NC,Xie SP,Kosaka Y,Li X

更新日期：2018-04-30 00:00:00

abstract：:The plausibility of any model in science comes from the extent of its interconnections to other models that are grounded in different premises and reasoning. Focusing research on paradoxes in those models, logic whereby they appear to generate unacceptable conclusions from seemingly indisputable premises, helps find t...

journal_title：Nature communications

authors： Benner SA

更新日期：2018-12-12 00:00:00

abstract：:In response to virus infection, RIG-I-like receptors (RLRs) sense virus RNA and induce MAVS to form prion-like aggregates to further propagate antiviral signalling. Although monomeric MAVS recombinant protein can assemble into prion-like filaments spontaneously in vitro, endogenous MAVS in cells is prevented from aggr...

journal_title：Nature communications

authors： Qi N,Shi Y,Zhang R,Zhu W,Yuan B,Li X,Wang C,Zhang X,Hou F

更新日期：2017-06-13 00:00:00

abstract：:Covalent organic frameworks (COFs) have emerged as a promising light-harvesting module for artificial photosynthesis and photovoltaics. For efficient generation of free charge carriers, the donor-acceptor (D-A) conjugation has been adopted for two-dimensional (2D) COFs recently. In the 2D D-A COFs, photoexcitation wou...

journal_title：Nature communications

authors： Kim TW,Jun S,Ha Y,Yadav RK,Kumar A,Yoo CY,Oh I,Lim HK,Shin JW,Ryoo R,Kim H,Kim J,Baeg JO,Ihee H

更新日期：2019-04-23 00:00:00

abstract：:In quantizing magnetic fields, graphene superlattices exhibit a complex fractal spectrum often referred to as the Hofstadter butterfly. It can be viewed as a collection of Landau levels that arise from quantization of Brown-Zak minibands recurring at rational (p/q) fractions of the magnetic flux quantum per superlatti...

journal_title：Nature communications

authors： Barrier J,Kumaravadivel P,Krishna Kumar R,Ponomarenko LA,Xin N,Holwill M,Mullan C,Kim M,Gorbachev RV,Thompson MD,Prance JR,Taniguchi T,Watanabe K,Grigorieva IV,Novoselov KS,Mishchenko A,Fal'ko VI,Geim AK,Berdyugin AI

更新日期：2020-11-13 00:00:00

abstract：:Organic light-emitting diodes utilizing thermally activated delayed fluorescence is a potential solution for achieving stable blue devices. Sky-blue devices (CIEy < 0.4) with high stability and high external quantum efficiency (>15%) at 1000 cd m-2 based on either delayed fluorescence or phosphorescence are still limi...

journal_title：Nature communications

authors： Chan CY,Tanaka M,Nakanotani H,Adachi C

更新日期：2018-11-28 00:00:00