Abstract:
:We have determined the cryo-electron microscopic (cryo-EM) structures of two archaeal type IV pili (T4P), from Pyrobaculum arsenaticum and Saccharolobus solfataricus, at 3.8 Å and 3.4 Å resolution, respectively. This triples the number of high resolution archaeal T4P structures, and allows us to pinpoint the evolutionary divergence of bacterial T4P, archaeal T4P and archaeal flagellar filaments. We suggest that extensive glycosylation previously observed in T4P of Sulfolobus islandicus is a response to an acidic environment, as at even higher temperatures in a neutral environment much less glycosylation is present for Pyrobaculum than for Sulfolobus and Saccharolobus pili. Consequently, the Pyrobaculum filaments do not display the remarkable stability of the Sulfolobus filaments in vitro. We identify the Saccharolobus and Pyrobaculum T4P as host receptors recognized by rudivirus SSRV1 and tristromavirus PFV2, respectively. Our results illuminate the evolutionary relationships among bacterial and archaeal T4P filaments and provide insights into archaeal virus-host interactions.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Wang F,Baquero DP,Su Z,Beltran LC,Prangishvili D,Krupovic M,Egelman EHdoi
10.1038/s41467-020-17268-4subject
Has Abstractpub_date
2020-07-09 00:00:00pages
3424issue
1issn
2041-1723pii
10.1038/s41467-020-17268-4journal_volume
11pub_type
杂志文章abstract::In photosystem II, light-induced water oxidation occurs at the Mn4CaO5 cluster. Here we demonstrate proton releases, dioxygen formation, and substrate water incorporation in response to Mn4CaO5 oxidation in the protein environment, using a quantum mechanical/molecular mechanical approach and molecular dynamics simulat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03545-w
更新日期:2018-03-28 00:00:00
abstract::Cotton is an important natural fiber crop, however, its comprehensive and high-resolution gene map is lacking. Here we integrate four complementary high-throughput techniques, including Pacbio long read Iso-seq, strand-specific RNA-seq, CAGE-seq, and PolyA-seq, to systematically explore the transcription landscape acr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12575-x
更新日期:2019-10-17 00:00:00
abstract::Predicting and controlling quantum mechanical phenomena require knowledge of the system Hamiltonian. A detailed understanding of the quantum pathways used to construct the Hamiltonian is essential for deterministic control and improved performance of coherent control schemes. In complex systems, parameters characteriz...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2405
更新日期:2013-01-01 00:00:00
abstract::In germinal centres (GC) mature B cells undergo intense proliferation and immunoglobulin gene modification before they differentiate into memory B cells or long-lived plasma cells (PC). GC B-cell-to-PC transition involves a major transcriptional switch that promotes a halt in cell proliferation and the production of s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms16067
更新日期:2017-07-05 00:00:00
abstract::Transition metal reagents and catalysts are generally effective to cleave all three bonds (one σ and two π) in a triple bond despite its high bonding energy. Recently, chemistry of single-bond cleavage by using main-group element compounds is rapidly being developed in the absence of transition metals. However, the cl...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5245
更新日期:2014-06-26 00:00:00
abstract::Brain oscillations reflect pattern formation of cell assemblies' activity, which is often disturbed in neurological and psychiatric diseases like depression, schizophrenia and stroke. In the neurobiological analysis and treatment of these conditions, transcranial electric currents applied to the brain proved beneficia...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3032
更新日期:2013-01-01 00:00:00
abstract::Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6969
更新日期:2015-01-19 00:00:00
abstract::Extracellular matrix (ECM) proteins secreted by blood-brain barrier (BBB) endothelial cells (ECs) are implicated in cell trafficking. We discovered that the expression of ECM epidermal growth factor-like protein 7 (EGFL7) is increased in the CNS vasculature of patients with multiple sclerosis (MS), and in mice with ex...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03186-z
更新日期:2018-02-26 00:00:00
abstract::Molecularly targeted therapies for advanced prostate cancer include castration modalities that suppress ligand-dependent transcriptional activity of the androgen receptor (AR). However, persistent AR signalling undermines therapeutic efficacy and promotes progression to lethal castration-resistant prostate cancer (CRP...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13668
更新日期:2016-11-29 00:00:00
abstract::Molecular photoswitches provide an extremely simple solution for solar energy conversion and storage. To convert stored energy to electricity, however, the photoswitch has to be coupled to a semiconducting electrode. In this work, we report on the assembly of an operational solar-energy-storing organic-oxide hybrid in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10263-4
更新日期:2019-06-03 00:00:00
abstract::Measuring the pace at which speciation and extinction occur is fundamental to understanding the origin and evolution of biodiversity. Both the fossil record and molecular phylogenies of living species can provide independent estimates of speciation and extinction rates, but often produce strikingly divergent results. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07622-y
更新日期:2018-12-07 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-11151-7
更新日期:2019-07-22 00:00:00
abstract::Ribosomes are essential intracellular machines composed of proteins and RNA molecules. The DNA sequences (rDNA) encoding ribosomal RNAs (rRNAs) are tandemly repeated and give origin to the nucleolus. Here we develop a computational method for estimating rDNA dosage (copy number) and mitochondrial DNA abundance using w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5850
更新日期:2014-09-11 00:00:00
abstract::The original version of this Article contained an error in the spelling of the author Jianyun Yan, which was incorrectly given as Jiangyun Yan. This has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-017-02617-7
更新日期:2018-01-12 00:00:00
abstract::One of the primary contributors to forgetting is interference from overlapping memories. Intuitively, this suggests-and prominent theoretical models argue-that memory interference is best avoided by encoding overlapping memories as if they were unrelated. It is therefore surprising that reactivation of older memories ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13377-x
更新日期:2019-11-25 00:00:00
abstract::Because of the potential impact on agriculture and other key human activities, efforts have been dedicated to the local control of precipitation. The most common approach consists of dispersing small particles of dry ice, silver iodide, or other salts in the atmosphere. Here we show, using field experiments conducted ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1462
更新日期:2011-08-30 00:00:00
abstract::Human metapneumovirus (hMPV) is a frequent cause of bronchiolitis in young children. Its F glycoprotein mediates virus-cell membrane fusion and is the primary target of neutralizing antibodies. The inability to produce recombinant hMPV F glycoprotein in the metastable pre-fusion conformation has hindered structural an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01708-9
更新日期:2017-11-16 00:00:00
abstract::Molecular machines carry out their function by equilibrium mechanical motions in environments that are far from thermodynamic equilibrium. The mechanically equilibrated character of the trajectories of the macromolecule has allowed development of a powerful theoretical description, reminiscent of Onsager's trajectory ...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-019-11402-7
更新日期:2019-08-23 00:00:00
abstract::Autophagy-mediated degradation of mitochondria (mitophagy) is a key process in cellular quality control. Although mitophagy impairment is involved in several patho-physiological conditions, valuable methods to induce mitophagy with low toxicity in vivo are still lacking. Herein, we describe a new optogenetic tool to s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09487-1
更新日期:2019-04-04 00:00:00
abstract::The nitrogen-vacancy (NV) centre in diamond is emerging as a promising platform for solid-state quantum information processing and nanoscale metrology. Of interest in these applications is the manipulation of the NV charge, which can be attained by optical excitation. Here, we use two-colour optical microscopy to inve...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12660
更新日期:2016-08-30 00:00:00
abstract::The ability to link soil microbial diversity to soil processes requires technologies that differentiate active microbes from extracellular DNA and dormant cells. Here, we use BONCAT (bioorthogonal non-canonical amino acid tagging) to measure translationally active cells in soils. We compare the active population of tw...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10542-0
更新日期:2019-06-24 00:00:00
abstract::Optical phase change materials (O-PCMs), a unique group of materials featuring exceptional optical property contrast upon a solid-state phase transition, have found widespread adoption in photonic applications such as switches, routers and reconfigurable meta-optics. Current O-PCMs, such as Ge-Sb-Te (GST), exhibit lar...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12196-4
更新日期:2019-09-30 00:00:00
abstract::Working memory is critical to cognition, decoupling behavior from the immediate world. Yet, it is imperfect; internal noise introduces errors into memory representations. Such errors have been shown to accumulate over time and increase with the number of items simultaneously held in working memory. Here, we show that ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11298-3
更新日期:2019-07-29 00:00:00
abstract::In the original version of this Article, extraneous text not belonging to the Article was accidentally appended to the results section. This error has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-04279-5
更新日期:2018-05-08 00:00:00
abstract::Nuclear magnetic resonance (NMR) spectroscopy is a powerful method for analyzing the chemical composition and molecular structure of materials. At the nanometer scale, NMR has the prospect of mapping the atomic-scale structure of individual molecules, provided a method that can sensitively detect single nuclei and mea...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07121-0
更新日期:2018-11-08 00:00:00
abstract::Homologous recombination-based gene targeting is a powerful tool for precise genome modification and has been widely used in organisms ranging from yeast to higher organisms such as Drosophila and mouse. However, gene targeting in higher plants, including the most widely used model plant Arabidopsis thaliana, remains ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04416-0
更新日期:2018-05-17 00:00:00
abstract::Binary transition metal dichalcogenide monolayers share common properties such as a direct optical bandgap, spin-orbit splittings of hundreds of meV, light-matter interaction dominated by robust excitons and coupled spin-valley states. Here we demonstrate spin-orbit-engineering in Mo(1-x)WxSe2 alloy monolayers for opt...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10110
更新日期:2015-12-14 00:00:00
abstract::Clustering of the T-cell receptor (TCR) is thought to initiate downstream signalling. However, the detection of protein clustering with high spatial and temporal resolution remains challenging. Here we establish a Förster resonance energy transfer (FRET) sensor, named CliF, which reports intermolecular associations of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15100
更新日期:2017-04-28 00:00:00
abstract::Many low-thermal-conductivity (κL) crystals show intriguing temperature (T) dependence of κL: κL ∝ T-1 (crystal-like) at intermediate temperatures whereas weak T-dependence (glass-like) at high temperatures. It has been in debate whether thermal transport can still be described by phonons at the Ioffe-Regel limit. In ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16371-w
更新日期:2020-05-22 00:00:00
abstract::Collective cell migration mediates multiple tissue morphogenesis processes. Yet how multi-dimensional mesenchymal cell movements are coordinated remains mostly unknown. Here we report that coordinated mesenchymal cell migration during chicken feather elongation is accompanied by dynamic changes of bioelectric currents...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07661-5
更新日期:2018-12-18 00:00:00