Small RNA changes en route to distinct cellular states of induced pluripotency.

abstract：:Trade-offs play an important role in evolution. Without trade-offs, evolution would maximize fitness of all traits leading to a "master of all traits". The shape of trade-offs has been shown to determine evolutionary trajectories and is often assumed to be static and independent of the actual evolutionary process. Her...

journal_title：Nature communications

authors： Huang W,Traulsen A,Werner B,Hiltunen T,Becks L

更新日期：2017-12-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Jiang L,Shen Y,Guo D,Yang D,Liu J,Fei X,Yang Y,Zhang B,Lin Z,Yang F,Wang X,Wang K,Wang J,Cai Z

更新日期：2020-07-16 00:00:00

abstract：:We report color-selective photodetection from intermediate, monolayered, quantum dots buried in between amorphous-oxide semiconductors. The proposed active channel in phototransistors is a hybrid configuration of oxide-quantum dot-oxide layers, where the gate-tunable electrical property of silicon-doped, indium-zinc-o...

journal_title：Nature communications

authors： Cho KS,Heo K,Baik CW,Choi JY,Jeong H,Hwang S,Lee SY

更新日期：2017-10-10 00:00:00

abstract：:Angiogenesis is a necessary process for solid tumor growth. Cellular markers for endothelial cell proliferation are potential targets for identifying the vasculature of tumors in homeostasis. Here we customize the behaviors of engineered cells to recognize Apj, a surface marker of the neovascular endothelium, using sy...

journal_title：Nature communications

authors： Wang Z,Wang F,Zhong J,Zhu T,Zheng Y,Zhao T,Xie Q,Ma F,Li R,Tang Q,Xu F,Tian X,Zhu J

更新日期：2020-05-01 00:00:00

abstract：:Bacterial contamination of biological channels, catheters or water resources is a major threat to public health, which can be amplified by the ability of bacteria to swim upstream. The mechanisms of this 'rheotaxis', the reorientation with respect to flow gradients, are still poorly understood. Here, we follow individ...

journal_title：Nature communications

authors： Mathijssen AJTM,Figueroa-Morales N,Junot G,Clément É,Lindner A,Zöttl A

更新日期：2019-07-31 00:00:00

abstract：:RNA-binding proteins (RBPs) integrate the processing of RNAs into post-transcriptional gene regulation, but the direct contribution of them to myeloid cell specification is poorly understood. Here, we report the first global RBP transcriptomic analysis of myeloid differentiation by combining RNA-seq analysis with myel...

journal_title：Nature communications

authors： Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J

更新日期：2017-11-10 00:00:00

abstract：:The liver integrates multiple metabolic pathways to warrant systemic energy homeostasis. An excessive lipogenic flux due to chronic dietary stimulation contributes to the development of hepatic steatosis, dyslipidemia and hyperglycemia. Here we show that the oxidoreductase retinol saturase (RetSat) is involved in the ...

journal_title：Nature communications

authors： Heidenreich S,Witte N,Weber P,Goehring I,Tolkachov A,von Loeffelholz C,Döcke S,Bauer M,Stockmann M,Pfeiffer AFH,Birkenfeld AL,Pietzke M,Kempa S,Muenzner M,Schupp M

更新日期：2017-08-30 00:00:00

abstract：:Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in industrialized countries. Type I interferon (IFN) is important for control of herpes simplex virus (HSV-1) in the central nervous system (CNS). Here we show that microglia are the main source of HSV-induced type I IFN expression i...

journal_title：Nature communications

authors： Reinert LS,Lopušná K,Winther H,Sun C,Thomsen MK,Nandakumar R,Mogensen TH,Meyer M,Vægter C,Nyengaard JR,Fitzgerald KA,Paludan SR

更新日期：2016-11-10 00:00:00

abstract：:BRCA2 is essential for maintaining genomic integrity. BRCA2-deficient primary cells are either not viable or exhibit severe proliferation defects. Yet, BRCA2 deficiency contributes to tumorigenesis. It is believed that mutations in genes such as TRP53 allow BRCA2 heterozygous cells to overcome growth arrest when they ...

journal_title：Nature communications

authors： Biswas K,Philip S,Yadav A,Martin BK,Burkett S,Singh V,Babbar A,North SL,Chang S,Sharan SK

更新日期：2018-02-07 00:00:00

abstract：:Phonons are the main source of relaxation in molecular nanomagnets, and different mechanisms have been proposed in order to explain the wealth of experimental findings. However, very limited experimental investigations on phonons in these systems have been performed so far, yielding no information about their dispersi...

journal_title：Nature communications

authors： Garlatti E,Tesi L,Lunghi A,Atzori M,Voneshen DJ,Santini P,Sanvito S,Guidi T,Sessoli R,Carretta S

更新日期：2020-04-09 00:00:00

abstract：:For many stochastic processes, the probability [Formula: see text] of not-having reached a target in unbounded space up to time [Formula: see text] follows a slow algebraic decay at long times, [Formula: see text]. This is typically the case of symmetric compact (i.e. recurrent) random walks. While the persistence exp...

journal_title：Nature communications

authors： Levernier N,Dolgushev M,Bénichou O,Voituriez R,Guérin T

更新日期：2019-07-05 00:00:00

abstract：:Aortic dissection and intramural haematoma comprise an aortopathy involving separation of the aortic wall. Underlying mechanisms of the condition remain unclear. Here we show that granulocyte macrophage colony-stimulating factor (GM-CSF) is a triggering molecule for this condition. Transcription factor Krüppel-like fa...

journal_title：Nature communications

authors： Son BK,Sawaki D,Tomida S,Fujita D,Aizawa K,Aoki H,Akishita M,Manabe I,Komuro I,Friedman SL,Nagai R,Suzuki T

更新日期：2015-04-29 00:00:00

abstract：:Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic loca...

journal_title：Nature communications

authors： Lin WY,Fordham SE,Sunter N,Elstob C,Rahman T,Willmore E,Shepherd C,Strathdee G,Mainou-Fowler T,Piddock R,Mearns H,Barrow T,Houlston RS,Marr H,Wallis J,Summerfield G,Marshall S,Pettitt A,Pepper C,Fegan C,Forconi F

更新日期：2021-01-28 00:00:00

abstract：:Muscle injury triggers inflammation in which infiltrating mononuclear phagocytes are crucial for tissue regeneration. The interaction of the CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axis that guides phagocyte infiltration is incompletely understood. Here, we show that CX3CR1 deficiency promotes muscle repair and rescues ...

journal_title：Nature communications

authors： Arnold L,Perrin H,de Chanville CB,Saclier M,Hermand P,Poupel L,Guyon E,Licata F,Carpentier W,Vilar J,Mounier R,Chazaud B,Benhabiles N,Boissonnas A,Combadiere B,Combadiere C

更新日期：2015-12-03 00:00:00

abstract：:Ti-alloys represent the principal structural materials in both aerospace development and metallic biomaterials. Key to optimizing their mechanical and functional behaviour is in-depth know-how of their phases and the complex interplay of diffusive vs. displacive phase transformations to permit the tailoring of intrica...

journal_title：Nature communications

authors： Bönisch M,Panigrahi A,Stoica M,Calin M,Ahrens E,Zehetbauer M,Skrotzki W,Eckert J

更新日期：2017-11-10 00:00:00

abstract：:Because the surface-to-volume ratio of quasi-two-dimensional materials is extremely high, understanding their surface characteristics is crucial for practically controlling their intrinsic properties and fabricating p-type and n-type layered semiconductors. Van der Waals crystals are expected to have an inert surface ...

journal_title：Nature communications

authors： Siao MD,Shen WC,Chen RS,Chang ZW,Shih MC,Chiu YP,Cheng CM

更新日期：2018-04-12 00:00:00

abstract：:CEP63 is a centrosomal protein that facilitates centriole duplication and is regulated by the DNA damage response. Mutations in CEP63 cause Seckel syndrome, a human disease characterized by microcephaly and dwarfism. Here we demonstrate that Cep63-deficient mice recapitulate Seckel syndrome pathology. The attrition of...

journal_title：Nature communications

authors： Marjanović M,Sánchez-Huertas C,Terré B,Gómez R,Scheel JF,Pacheco S,Knobel PA,Martínez-Marchal A,Aivio S,Palenzuela L,Wolfrum U,McKinnon PJ,Suja JA,Roig I,Costanzo V,Lüders J,Stracker TH

更新日期：2015-07-09 00:00:00

abstract：:Connection of tubules into larger networks is the key process for the development of circulatory systems. In Drosophila development, tip cells of the tracheal system lead the migration of each branch and connect tubules by adhering to each other and simultaneously changing into a torus-shape. We show that as adhesion ...

journal_title：Nature communications

authors： Kato K,Dong B,Wada H,Tanaka-Matakatsu M,Yagi Y,Hayashi S

更新日期：2016-04-12 00:00:00

abstract：:The original version of this Article omitted references to previous experimental reports on solid hydrogen that are relevant for a full understanding of the context of the previous work. The added references are: 47. Akahama, Y. et al. Evidence from x-ray diffraction of orientational ordering in phase III of solid hyd...

journal_title：Nature communications

authors： Dalladay-Simpson P,Binns J,Peña-Alvarez M,Donnelly ME,Greenberg E,Prakapenka V,Chen XJ,Gregoryanz E,Howie RT

更新日期：2019-05-03 00:00:00

abstract：:Several of the steps in protein synthesis on the ribosome utilize hydrolysis of guanosine triphosphate (GTP) as the driving force. This reaction is catalyzed by translation factors that become activated upon binding to the ribosome. The recently determined crystal structure of an elongation factor-Tu ternary complex b...

journal_title：Nature communications

authors： Wallin G,Kamerlin SC,Aqvist J

更新日期：2013-01-01 00:00:00

abstract：:Erythropoietin (Epo) supports both primitive erythropoiesis in the yolk sac and definitive erythropoiesis in the fetal liver and bone marrow. Although definitive erythropoiesis requires kidney- and liver-secreted Epo, it is unclear which cells produce Epo for primitive erythropoiesis. Here we find neural Epo-producing...

journal_title：Nature communications

authors： Suzuki N,Hirano I,Pan X,Minegishi N,Yamamoto M

更新日期：2013-01-01 00:00:00

abstract：:EGFR is required for animal development, and dysregulation of EGFR is critically implicated in malignant transformation. However, the molecular mechanism underlying the regulation of EGFR expression remains poorly explored. Here we report that the zinc-finger protein ZNF516 is a transcription repressor. ZNF516 is phys...

journal_title：Nature communications

authors： Li L,Liu X,He L,Yang J,Pei F,Li W,Liu S,Chen Z,Xie G,Xu B,Ting X,Zhang Z,Jin T,Liu X,Zhang W,Yuan S,Yang Z,Wu C,Zhang Y,Yang X,Yi X,Liang J,Shang Y,Sun L

更新日期：2017-09-25 00:00:00

abstract：:Primitive carbonaceous chondrites contain a large array of organic compounds dominated by insoluble organic matter (IOM). A striking feature of this IOM is the systematic enrichment in deuterium compared with the solar hydrogen reservoir. This enrichment has been taken as a sign of low-temperature ion-molecule or gas-...

journal_title：Nature communications

authors： Laurent B,Roskosz M,Remusat L,Robert F,Leroux H,Vezin H,Depecker C,Nuns N,Lefebvre JM

更新日期：2015-10-13 00:00:00

abstract：:Experimental data accumulated over more than 120 years show not only that diffusion coefficients of impurities ordinarily obey the Arrhenius law in crystalline solids, but also that diffusion pre-exponential factors measured in a same solid increase exponentially with activation energies. This so-called compensation e...

journal_title：Nature communications

authors： Gelin S,Champagne-Ruel A,Mousseau N

更新日期：2020-08-07 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms15317. ...

journal_title：Nature communications

authors： Lovrak M,Hendriksen WEJ,Maity C,Mytnyk S,van Steijn V,Eelkema R,van Esch JH

更新日期：2017-06-30 00:00:00

abstract：:Epigenomic data sets provide critical information about the dynamic role of chromatin states in gene regulation, but a key question of how chromatin state segmentations vary under different conditions across the genome has remained unaddressed. Here we present ChromDiff, a group-wise chromatin state comparison method ...

journal_title：Nature communications

authors： Yen A,Kellis M

更新日期：2015-08-18 00:00:00

abstract：:Flicker or 1/f noise in metal-oxide-semiconductor field-effect transistors (MOSFETs) has been identified as the main source of noise at low frequency. It often originates from an ensemble of a huge number of charges becoming trapped and de-trapped. However, as a deviation from the well-known model of 1/f noise is obse...

journal_title：Nature communications

authors： Clément N,Nishiguchi K,Fujiwara A,Vuillaume D

更新日期：2010-10-19 00:00:00

abstract：:Whispering-gallery-mode resonators have been extensively used in conjunction with different materials for the development of a variety of photonic devices. Among the latter, hybrid structures, consisting of dielectric microspheres and colloidal core/shell semiconductor nanocrystals as gain media, have attracted intere...

journal_title：Nature communications

authors： Grivas C,Li C,Andreakou P,Wang P,Ding M,Brambilla G,Manna L,Lagoudakis P

更新日期：2013-01-01 00:00:00

abstract：:Because monoclonal antibodies (mAbs) have exceptional specificity and favorable pharmacology, substantial efforts have been made to functionalize them, either with potent cytotoxins, biologics, radionuclides, or fluorescent groups for therapeutic benefit and/or use as theranostic agents. To exploit our recently discov...

journal_title：Nature communications

authors： Bzymek KP,Puckett JW,Zer C,Xie J,Ma Y,King JD,Goodstein LH,Avery KN,Colcher D,Singh G,Horne DA,Williams JC

更新日期：2018-04-20 00:00:00

abstract：:Circadian rhythms of cell division have been observed in several lineages of eukaryotes, especially photosynthetic unicellular eukaryotes. However, the mechanism underlying the circadian regulation of the cell cycle and the nature of the advantage conferred remain unknown. Here, using the unicellular red alga Cyanidio...

journal_title：Nature communications

authors： Miyagishima SY,Fujiwara T,Sumiya N,Hirooka S,Nakano A,Kabeya Y,Nakamura M

更新日期：2014-05-08 00:00:00