Physiological constraints to climate warming in fish follow principles of plastic floors and concrete ceilings.

abstract：:Little is known about how archaeal viruses perturb the transcription machinery of their hosts. Here we provide the first example of an archaeo-viral transcription factor that directly targets the host RNA polymerase (RNAP) and efficiently represses its activity. ORF145 from the temperate Acidianus two-tailed virus (AT...

journal_title：Nature communications

authors： Sheppard C,Blombach F,Belsom A,Schulz S,Daviter T,Smollett K,Mahieu E,Erdmann S,Tinnefeld P,Garrett R,Grohmann D,Rappsilber J,Werner F

更新日期：2016-11-24 00:00:00

abstract：:Tessellation of self-assembling molecular building blocks is a promising strategy to design metal-organic materials exhibiting geometrical frustration and ensuing frustrated physical properties. Appearing in two-dimensional quasiperiodic phases, tilings consisting of five-vertex nodes are regarded as approximants for ...

journal_title：Nature communications

authors： Voigt L,Kubus M,Pedersen KS

更新日期：2020-09-17 00:00:00

abstract：:Multiphoton absorption processes enable many technologically important applications, such as in vivo imaging, photodynamic therapy and optical limiting, and so on. Specifically, higher-order nonlinear absorption such as five-photon absorption offers significant advantages of greater spatial confinement, increased pene...

journal_title：Nature communications

authors： Chen W,Bhaumik S,Veldhuis SA,Xing G,Xu Q,Grätzel M,Mhaisalkar S,Mathews N,Sum TC

更新日期：2017-05-12 00:00:00

abstract：:Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behaving biologics is di...

journal_title：Nature communications

authors： Ebo JS,Saunders JC,Devine PWA,Gordon AM,Warwick AS,Schiffrin B,Chin SE,England E,Button JD,Lloyd C,Bond NJ,Ashcroft AE,Radford SE,Lowe DC,Brockwell DJ

更新日期：2020-04-14 00:00:00

abstract：:Hepatitis B virus causes chronic infections in 250 million people worldwide. Chronic hepatitis B virus carriers are at risk of developing fibrosis, cirrhosis, and hepatocellular carcinoma. A prophylactic vaccine exists and currently available antivirals can suppress but rarely cure chronic infections. The study of hep...

journal_title：Nature communications

authors： Winer BY,Huang TS,Pludwinski E,Heller B,Wojcik F,Lipkowitz GE,Parekh A,Cho C,Shrirao A,Muir TW,Novik E,Ploss A

更新日期：2017-07-25 00:00:00

abstract：:Solid-state quantum acoustodynamic (QAD) systems provide a compact platform for quantum information storage and processing by coupling acoustic phonon sources with superconducting or spin qubits. The multi-mode composite high-overtone bulk acoustic wave resonator (HBAR) is a popular phonon source well suited for QAD. ...

journal_title：Nature communications

authors： Gokhale VJ,Downey BP,Katzer DS,Nepal N,Lang AC,Stroud RM,Meyer DJ

更新日期：2020-05-08 00:00:00

abstract：:Predominantly, carbon atoms of various species function as acceptors of noncovalent interactions when they are part of a π-system. Here, we report on the discovery of a halogen bond involving the isocyano carbon lone pair. The co-crystallization or mechanochemical liquid-assisted grinding of model mesityl isocyanide w...

journal_title：Nature communications

authors： Mikherdov AS,Novikov AS,Boyarskiy VP,Kukushkin VY

更新日期：2020-06-10 00:00:00

abstract：:Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 patients with HCC. We...

journal_title：Nature communications

authors： Zhao LH,Liu X,Yan HX,Li WY,Zeng X,Yang Y,Zhao J,Liu SP,Zhuang XH,Lin C,Qin CJ,Zhao Y,Pan ZY,Huang G,Liu H,Zhang J,Wang RY,Yang Y,Wen W,Lv GS,Zhang HL,Wu H,Huang S,Wang MD,Tang L,Cao HZ,Wang L,Lee TL

更新日期：2016-10-05 00:00:00

abstract：:Current knowledge on chromosomal mosaicism in human cell cultures is mostly based on cytogenetic banding methods. The recent development of high-resolution full-genome analysis methods applicable to single cells is providing new insights into genetic and cellular diversity. Here we study the genetic content of 92 indi...

journal_title：Nature communications

authors： Jacobs K,Mertzanidou A,Geens M,Nguyen HT,Staessen C,Spits C

更新日期：2014-06-27 00:00:00

abstract：:Subduction zone magmas are more oxidised on eruption than those at mid-ocean ridges. This is attributed either to oxidising components, derived from subducted lithosphere (slab) and added to the mantle wedge, or to oxidation processes occurring during magma ascent via differentiation. Here we provide direct evidence f...

journal_title：Nature communications

authors： Bénard A,Klimm K,Woodland AB,Arculus RJ,Wilke M,Botcharnikov RE,Shimizu N,Nebel O,Rivard C,Ionov DA

更新日期：2018-08-29 00:00:00

abstract：:Inflammasomes regulate innate immune responses by facilitating maturation of inflammatory cytokines, interleukin (IL)-1β and IL-18. NACHT, LRR and PYD domains-containing protein 7 (NALP7) is one inflammasome constituent, but little is known about its cellular handling. Here we show a mechanism for NALP7 protein stabil...

journal_title：Nature communications

authors： Bednash JS,Weathington N,Londino J,Rojas M,Gulick DL,Fort R,Han S,McKelvey AC,Chen BB,Mallampalli RK

更新日期：2017-05-11 00:00:00

abstract：:Multi-drug strategies have been attempted to prolong the efficacy of existing antibiotics, but with limited success. Here we show that the evolution of multi-drug-resistant Escherichia coli can be manipulated in vitro by administering pairs of antibiotics and switching between them in ON/OFF manner. Using a multiplexe...

journal_title：Nature communications

authors： Yoshida M,Reyes SG,Tsuda S,Horinouchi T,Furusawa C,Cronin L

更新日期：2017-06-08 00:00:00

abstract：:Lysosomes are the major degradative compartments within cells, harbouring a wide variety of hydrolytic enzymes within their lumen. Release of lysosomal hydrolases from lysosomes into the cell cytoplasm results in cell death. Here we report that damaged lysosomes undergo autophagic turnover. Using a light-induced lysos...

journal_title：Nature communications

authors： Hung YH,Chen LM,Yang JY,Yang WY

更新日期：2013-01-01 00:00:00

abstract：:Wnt signaling is critical for directing epithelial gland development within the uterine lining to ensure successful gestation in adults. Wnt-dependent, Lgr5-expressing stem/progenitor cells are essential for the development of glandular epithelia in the intestine and stomach, but their existence in the developing repr...

journal_title：Nature communications

authors： Seishima R,Leung C,Yada S,Murad KBA,Tan LT,Hajamohideen A,Tan SH,Itoh H,Murakami K,Ishida Y,Nakamizo S,Yoshikawa Y,Wong E,Barker N

更新日期：2019-11-26 00:00:00

abstract：:Marine low clouds play an important role in the climate system, and their properties are sensitive to cloud condensation nuclei concentrations. While new particle formation represents a major source of cloud condensation nuclei globally, the prevailing view is that new particle formation rarely occurs in remote marine...

journal_title：Nature communications

authors： Zheng G,Wang Y,Wood R,Jensen MP,Kuang C,McCoy IL,Matthews A,Mei F,Tomlinson JM,Shilling JE,Zawadowicz MA,Crosbie E,Moore R,Ziemba L,Andreae MO,Wang J

更新日期：2021-01-22 00:00:00

abstract：:The Amazon river basin receives ~2000 mm of precipitation annually and contributes ~17% of global river freshwater input to the oceans; its hydroclimatic variations can exert profound impacts on the marine ecosystem in the Amazon plume region (APR) and have potential far-reaching influences on hydroclimate over the tr...

journal_title：Nature communications

authors： Liang YC,Lo MH,Lan CW,Seo H,Ummenhofer CC,Yeager S,Wu RJ,Steffen JD

更新日期：2020-09-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Kremer M,Petrides I,Meyer E,Heinrich M,Zilberberg O,Szameit A

更新日期：2020-04-08 00:00:00

abstract：:The preparation of α-functionalized organic acids can be greatly simplified by adopting a protocol involving the catalytic assembly of achiral building blocks. However, the enzymatic assembly of small amino acids and aldehydes to form numerous α-functionalized organic acids is highly desired and remains a significant ...

journal_title：Nature communications

authors： Song W,Wang JH,Wu J,Liu J,Chen XL,Liu LM

更新日期：2018-09-19 00:00:00

abstract：:How spatial and temporal information are integrated to determine the direction of cell migration remains poorly understood. Here, by precise microfluidics emulation of dynamic chemoattractant waves, we demonstrate that, in Dictyostelium, directional movement as well as activation of small guanosine triphosphatase Ras ...

journal_title：Nature communications

authors： Nakajima A,Ishihara S,Imoto D,Sawai S

更新日期：2014-11-06 00:00:00

abstract：:Endogenous opioid peptides and prescription opioid drugs modulate pain, anxiety and stress by activating opioid receptors, currently classified into four subtypes. Here we demonstrate that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines, is a broad-spectrum scavenger of opioid peptides. Ph...

journal_title：Nature communications

authors： Meyrath M,Szpakowska M,Zeiner J,Massotte L,Merz MP,Benkel T,Simon K,Ohnmacht J,Turner JD,Krüger R,Seutin V,Ollert M,Kostenis E,Chevigné A

更新日期：2020-06-19 00:00:00

abstract：:Deep learning algorithms have been successfully used in medical image classification. In the next stage, the technology of acquiring explainable knowledge from medical images is highly desired. Here we show that deep learning algorithm enables automated acquisition of explainable features from diagnostic annotation-fr...

journal_title：Nature communications

authors： Yamamoto Y,Tsuzuki T,Akatsuka J,Ueki M,Morikawa H,Numata Y,Takahara T,Tsuyuki T,Tsutsumi K,Nakazawa R,Shimizu A,Maeda I,Tsuchiya S,Kanno H,Kondo Y,Fukumoto M,Tamiya G,Ueda N,Kimura G

更新日期：2019-12-18 00:00:00

abstract：:Amyloid aggregation of α-synuclein (α-syn) is closely associated with Parkinson's disease (PD) and other synucleinopathies. Several single amino-acid mutations (e.g. E46K) of α-syn have been identified causative to the early onset of familial PD. Here, we report the cryo-EM structure of an α-syn fibril formed by N-ter...

journal_title：Nature communications

authors： Zhao K,Li Y,Liu Z,Long H,Zhao C,Luo F,Sun Y,Tao Y,Su XD,Li D,Li X,Liu C

更新日期：2020-05-26 00:00:00

abstract：:Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. ...

journal_title：Nature communications

authors： Garcia-Gomez A,Li T,de la Calle-Fabregat C,Rodríguez-Ubreva J,Ciudad L,Català-Moll F,Godoy-Tena G,Martín-Sánchez M,San-Segundo L,Muntión S,Morales X,Ortiz-de-Solórzano C,Oyarzabal J,San José-Enériz E,Esteller M,Agirre X,P

更新日期：2021-01-18 00:00:00

abstract：:FBXW2 inhibits proliferation of lung cancer cells by targeting SKP2 for degradation. Whether and how FBXW2 regulates tumor invasion and metastasis is previously unknown. Here, we report that FBXW2 is an E3 ligase for β-catenin. FBXW2 binds to β-catenin upon EGF-AKT1-mediated phosphorylation on Ser552, and promotes its...

journal_title：Nature communications

authors： Yang F,Xu J,Li H,Tan M,Xiong X,Sun Y

更新日期：2019-03-27 00:00:00

abstract：:Glucagon is released from pancreatic α-cells to activate pathways that raise blood glucose. Its secretion is regulated by α-cell-intrinsic glucose sensing and paracrine control through insulin and somatostatin. To understand the inadequately high glucagon levels that contribute to hyperglycemia in type-2 diabetes (T2D...

journal_title：Nature communications

authors： Omar-Hmeadi M,Lund PE,Gandasi NR,Tengholm A,Barg S

更新日期：2020-04-20 00:00:00

abstract：:Telomere maintenance is a universal hallmark of cancer. Most tumors including low-grade oligodendrogliomas use telomerase reverse transcriptase (TERT) expression for telomere maintenance while astrocytomas use the alternative lengthening of telomeres (ALT) pathway. Although TERT and ALT are hallmarks of tumor prolifer...

journal_title：Nature communications

authors： Viswanath P,Batsios G,Mukherjee J,Gillespie AM,Larson PEZ,Luchman HA,Phillips JJ,Costello JF,Pieper RO,Ronen SM

更新日期：2021-01-04 00:00:00

abstract：:The development of single molecule white light emitters is extremely challenging for pure phosphorescent metal-free system at room temperature. Here we report a single pure organic phosphor, namely 4-chlorobenzoyldibenzothiophene, emitting white room temperature phosphorescence with Commission Internationale de l'Écla...

journal_title：Nature communications

authors： He Z,Zhao W,Lam JWY,Peng Q,Ma H,Liang G,Shuai Z,Tang BZ

更新日期：2017-09-04 00:00:00

abstract：:Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal fragment (IN) and C-termi...

journal_title：Nature communications

authors： Yao Z,Aboualizadeh F,Kroll J,Akula I,Snider J,Lyakisheva A,Tang P,Kotlyar M,Jurisica I,Boxem M,Stagljar I

更新日期：2020-05-15 00:00:00

abstract：:An industrial process for the selective activation of methane under mild conditions would be highly valuable for controlling emissions to the environment and for utilizing vast new sources of natural gas. The only selective catalysts for methane activation and conversion to methanol under mild conditions are methane m...

journal_title：Nature communications

authors： Blanchette CD,Knipe JM,Stolaroff JK,DeOtte JR,Oakdale JS,Maiti A,Lenhardt JM,Sirajuddin S,Rosenzweig AC,Baker SE

更新日期：2016-06-15 00:00:00

abstract：:Human activity has caused dramatic population declines in many wild species. The resulting bottlenecks have a profound impact on the genetic makeup of a species with unknown consequences for health. A key genetic factor for species survival is the evolution of deleterious mutation load, but how bottleneck strength and...

journal_title：Nature communications

authors： Grossen C,Guillaume F,Keller LF,Croll D

更新日期：2020-02-21 00:00:00